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Advances in the Molecular and Cellular Biology of Strongyloides spp.

Jaleta TG, Lok JB.

Curr Trop Med Rep. 2019 Dec;6(4):161-178. doi: 10.1007/s40475-019-00186-x. Epub 2019 Sep 13.


CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models.

Huizing FJ, Garousi J, Lok J, Franssen G, Hoeben BAW, Frejd FY, Boerman OC, Bussink J, Tolmachev V, Heskamp S.

Sci Rep. 2019 Dec 11;9(1):18898. doi: 10.1038/s41598-019-54824-5.


Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice.

Liu N, Jiang Y, Chung JY, Li Y, Yu Z, Kim JW, Lok JM, Whalen MJ, Wang X.

Int J Mol Sci. 2019 Dec 5;20(24). pii: E6125. doi: 10.3390/ijms20246125.


Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes.

Meijer TWH, Looijen-Salamon MG, Lok J, van den Heuvel M, Tops B, Kaanders JHAM, Span PN, Bussink J.

Thorac Cancer. 2019 Dec;10(12):2289-2299. doi: 10.1111/1759-7714.13226. Epub 2019 Oct 30.


Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing.

Doyle SR, Sankaranarayanan G, Allan F, Berger D, Jimenez Castro PD, Collins JB, Crellen T, Duque-Correa MA, Ellis P, Jaleta TG, Laing R, Maitland K, McCarthy C, Moundai T, Softley B, Thiele E, Ouakou PT, Tushabe JV, Webster JP, Weiss AJ, Lok J, Devaney E, Kaplan RM, Cotton JA, Berriman M, Holroyd N.

Front Genet. 2019 Sep 20;10:826. doi: 10.3389/fgene.2019.00826. eCollection 2019.


Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion.

Ohtomo R, Kinoshita K, Ohtomo G, Takase H, Hamanaka G, Washida K, Islam MR, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K.

Transl Stroke Res. 2019 Oct 12. doi: 10.1007/s12975-019-00734-7. [Epub ahead of print]


Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro.

Charuchaibovorn S, Sanprasert V, Sutthanont N, Hu Y, Abraham A, Ostroff GR, Aroian RV, Jaleta TG, Lok JB, Nuchprayoon S.

Am J Trop Med Hyg. 2019 Nov;101(5):1177-1182. doi: 10.4269/ajtmh.19-0083.


CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes.

Lok JB.

Front Genet. 2019 Jul 16;10:656. doi: 10.3389/fgene.2019.00656. eCollection 2019. Review.


OCT Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study.

Sun Z, Tang F, Wong R, Lok J, Szeto SKH, Chan JCK, Chan CKM, Tham CC, Ng DS, Cheung CY.

Ophthalmology. 2019 Dec;126(12):1675-1684. doi: 10.1016/j.ophtha.2019.06.016. Epub 2019 Jun 26.



Yang S, Lok JJ.

Stat Sin. 2018 Oct;28(4):1703-1723. doi: 10.5705/ss.202016.0133.


Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells.

Egawa N, Shindo A, Hikawa R, Kinoshita H, Liang AC, Itoh K, Lok J, Maki T, Takahashi R, Lo EH, Arai K.

Glia. 2019 Apr;67(4):718-728. doi: 10.1002/glia.23567. Epub 2018 Nov 28.


Liposome-based transfection enhances RNAi and CRISPR-mediated mutagenesis in non-model nematode systems.

Adams S, Pathak P, Shao H, Lok JB, Pires-daSilva A.

Sci Rep. 2019 Jan 24;9(1):483. doi: 10.1038/s41598-018-37036-1.


White-matter repair: Interaction between oligodendrocytes and the neurovascular unit.

Hamanaka G, Ohtomo R, Takase H, Lok J, Arai K.

Brain Circ. 2018 Jul-Sep;4(3):118-123. doi: 10.4103/bc.bc_15_18. Epub 2018 Oct 9. Review.


Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus.

Szeto SKH, Wong R, Lok J, Tang F, Sun Z, Tso T, Lam TCH, Tham CC, Ng DS, Cheung CY.

Br J Ophthalmol. 2019 Sep;103(9):1327-1331. doi: 10.1136/bjophthalmol-2018-311924. Epub 2018 Oct 31.


Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS).

Evans SR, Follmann D, Liu Y, Holland T, Doernberg SB, Rouphael N, Hamasaki T, Jiang Y, Lok JJ, Tran TTT, Harris AD, Fowler VG, Boucher H, Kreiswirth BN, Bonomo RA, Van Duin D, Paterson DL, Chambers H.

Clin Infect Dis. 2019 May 17;68(11):1961-1967. doi: 10.1093/cid/ciy912.


Comparing the Experience of and Factors Perpetuating Chronic Insomnia Severity Among Young, Middle-Aged, and Older Adults.

Sidani S, Ibrahim S, Lok J, O'Rourke H, Collins L, Fox M.

Clin Nurs Res. 2018 Oct 15:1054773818806164. doi: 10.1177/1054773818806164. [Epub ahead of print]


Proceedings of the Neuro-Ophthalmology Program of the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, 8-11 February 2018.

Chan NCY, Cheng ACO, Ho JCH, Lok JKH, Chan CKM.

Neuroophthalmology. 2018 May 23;42(5):326-333. doi: 10.1080/01658107.2018.1463386. eCollection 2018 Oct.


Functional Genomic Study in Strongyloides and Related Parasitic Nematodes by Transgenesis and CRISPR/Cas9 Mutagenesis.

Lok JB.

J Parasitol. 2018 Aug 31. doi: 10.1645/18-134. [Epub ahead of print] No abstract available.


A radical scavenger edaravone and oligodendrocyte protection/regeneration.

Takase H, Lok J, Arai K.

Neural Regen Res. 2018 Sep;13(9):1550-1551. doi: 10.4103/1673-5374.237116. No abstract available.


Role of oligodendrocyte-neurovascular unit in white matter repair.

Hamanaka G, Ohtomo R, Takase H, Lok J, Arai K.

Neurosci Lett. 2018 Sep 25;684:175-180. doi: 10.1016/j.neulet.2018.07.016. Epub 2018 Jul 10. Review.


Repetitive head injury in adolescent mice: A role for vascular inflammation.

Wu L, Chung JY, Saith S, Tozzi L, Buckley EM, Sanders B, Franceschini MA, Lule S, Izzy S, Lok J, Edmiston WJ 3rd, McAllister LM, Mebane S, Jin G, Lu J, Sherwood JS, Willwerth S, Hickman S, Khoury JE, Lo EH, Kaplan D, Whalen MJ.

J Cereb Blood Flow Metab. 2019 Nov;39(11):2196-2209. doi: 10.1177/0271678X18786633. Epub 2018 Jul 13.


Trends in the incidence of retinopathy of prematurity over a 10-year period.

Chow PPC, Yip WWK, Ho M, Lok JYC, Lau HHW, Young AL.

Int Ophthalmol. 2019 Apr;39(4):903-909. doi: 10.1007/s10792-018-0896-0. Epub 2018 Jun 16.


Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study.

Tang F, Sun Z, Wong R, Lok J, Lam A, Tham CC, Chan CK, Mohamed S, Lam TC, Szeto SK, Ng DS, Cheung CY.

Br J Ophthalmol. 2018 Jun 4. pii: bjophthalmol-2017-312010. doi: 10.1136/bjophthalmol-2018-312010. [Epub ahead of print]


Impact of virtual reality simulation on learning barriers of phacoemulsification perceived by residents.

Ng DS, Sun Z, Young AL, Ko ST, Lok JK, Lai TY, Sikder S, Tham CC.

Clin Ophthalmol. 2018 May 11;12:885-893. doi: 10.2147/OPTH.S140411. eCollection 2018.


Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice.

Chung JY, Krapp N, Wu L, Lule S, McAllister LM, Edmiston WJ 3rd, Martin S, Levy E, Songtachalert T, Sherwood JS, Buckley EM, Sanders B, Izzy S, Hickman S, Guo S, Lok J, El Khoury J, Lo EH, Kaplan D, Whalen MJ.

J Neurotrauma. 2019 Jan 15;36(2):370-379. doi: 10.1089/neu.2018.5659. Epub 2018 Aug 3.


Implementing the Integrated Strategy for the Cultural Adaptation of Evidence-Based Interventions: An Illustration.

Sidani S, Ibrahim S, Lok J, Fan L, Fox M.

Can J Nurs Res. 2018 Dec;50(4):214-221. doi: 10.1177/0844562118774493. Epub 2018 May 15.


Author Correction: Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes.

Tang FY, Ng DS, Lam A, Luk F, Wong R, Chan C, Mohamed S, Fong A, Lok J, Tso T, Lai F, Brelen M, Wong TY, Tham CC, Cheung CY.

Sci Rep. 2018 May 4;8(1):7314. doi: 10.1038/s41598-018-25619-x.


Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion.

Maki T, Morancho A, Martinez-San Segundo P, Hayakawa K, Takase H, Liang AC, Gabriel-Salazar M, Medina-Gutiérrez E, Washida K, Montaner J, Lok J, Lo EH, Arai K, Rosell A.

Stroke. 2018 Apr;49(4):1003-1010. doi: 10.1161/STROKEAHA.117.019346. Epub 2018 Mar 6.


The Relationship of Quantitative Retinal Capillary Network to Kidney Function in Type 2 Diabetes.

Cheung CY, Tang F, Ng DS, Wong R, Lok J, Sun Z, Tso T, Lam A, Brelén M, Chong KK, Luk AO, Chan JC, Wong TY, Tham CC.

Am J Kidney Dis. 2018 Jun;71(6):916-918. doi: 10.1053/j.ajkd.2017.12.010. Epub 2018 Feb 28. No abstract available.


Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis.

Arifin N, Yunus MH, Nolan TJ, Lok JB, Noordin R.

Am J Trop Med Hyg. 2018 Apr;98(4):1165-1170. doi: 10.4269/ajtmh.17-0697. Epub 2018 Feb 8.


Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress.

Takase H, Liang AC, Miyamoto N, Hamanaka G, Ohtomo R, Maki T, Pham LD, Lok J, Lo EH, Arai K.

Neurosci Lett. 2018 Mar 6;668:120-125. doi: 10.1016/j.neulet.2018.01.018. Epub 2018 Jan 11.


Improved Evaluation of Antivascular Cancer Therapy Using Constrained Tracer-Kinetic Modeling for Multiagent Dynamic Contrast-Enhanced MRI.

Hectors SJ, Jacobs I, Lok J, Peters J, Bussink J, Hoeben FJ, Keizer HM, Janssen HM, Nicolay K, Schabel MC, Strijkers GJ.

Cancer Res. 2018 Mar 15;78(6):1561-1570. doi: 10.1158/0008-5472.CAN-17-2569. Epub 2018 Jan 9.


A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter.

Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K.

Stem Cells. 2018 May;36(5):751-760. doi: 10.1002/stem.2771. Epub 2018 Jan 22.


Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice.

Patton JB, Bonne-Année S, Deckman J, Hess JA, Torigian A, Nolan TJ, Wang Z, Kliewer SA, Durham AC, Lee JJ, Eberhard ML, Mangelsdorf DJ, Lok JB, Abraham D.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):204-209. doi: 10.1073/pnas.1712235114. Epub 2017 Dec 4.


Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.

van Duin D, Lok JJ, Earley M, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Doi Y, Kaye KS, Fowler VG Jr, Paterson DL, Bonomo RA, Evans S; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2018 Jan 6;66(2):163-171. doi: 10.1093/cid/cix783.


The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection.

Erlandson KM, Kitch D, Wester CW, Kalayjian RC, Overton ET, Castillo-Mancilla J, Koletar SL, Benson CA, Campbell TB, Robertson K, Lok JJ.

Clin Infect Dis. 2017 Nov 29;65(12):2042-2049. doi: 10.1093/cid/cix645.


The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents.

Iversen AB, Busk M, Bertelsen LB, Laustsen C, Munk OL, Nielsen T, Wittenborn TR, Bussink J, Lok J, Stødkilde-Jørgensen H, Horsman MR.

Acta Oncol. 2017 Nov;56(11):1626-1633. doi: 10.1080/0284186X.2017.1351622. Epub 2017 Aug 25.


Structural and developmental expression of Ss-riok-2, an RIO protein kinase encoding gene of Strongyloides stercoralis.

Lei WQ, Lok JB, Yuan W, Zhang YZ, Stoltzfus JD, Gasser RB, He SY, Zhou H, Zhou R, Zhao JL, Hu M.

Sci Rep. 2017 Aug 18;7(1):8693. doi: 10.1038/s41598-017-07991-2.


Different but overlapping populations of Strongyloides stercoralis in dogs and humans-Dogs as a possible source for zoonotic strongyloidiasis.

Jaleta TG, Zhou S, Bemm FM, Schär F, Khieu V, Muth S, Odermatt P, Lok JB, Streit A.

PLoS Negl Trop Dis. 2017 Aug 9;11(8):e0005752. doi: 10.1371/journal.pntd.0005752. eCollection 2017 Aug.


Preclinical validation of 111In-girentuximab-F(ab')2 as a tracer to image hypoxia related marker CAIX expression in head and neck cancer xenografts.

Huizing FJ, Hoeben BAW, Franssen G, Lok J, Heskamp S, Oosterwijk E, Boerman OC, Bussink J.

Radiother Oncol. 2017 Sep;124(3):521-525. doi: 10.1016/j.radonc.2017.07.025. Epub 2017 Aug 5.


Functional genomic exploration reveals that Ss-RIOK-1 is essential for the development and survival of Strongyloides stercoralis larvae.

Yuan W, Zhou H, Lok JB, Lei W, He S, Gasser RB, Zhou R, Fang R, Zhou Y, Zhao J, Hu M.

Int J Parasitol. 2017 Dec;47(14):933-940. doi: 10.1016/j.ijpara.2017.06.005. Epub 2017 Aug 3.



Lok JJ.

Ann Stat. 2017 Apr;45(2):461-499. doi: 10.1214/15-AOS1433. Epub 2017 May 16.


Heritable genetic transformation of Strongyloides stercoralis by microinjection of plasmid DNA constructs into the male germline.

Shao H, Li X, Lok JB.

Int J Parasitol. 2017 Aug;47(9):511-515. doi: 10.1016/j.ijpara.2017.04.003. Epub 2017 Jun 1.


Re: Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong.

Chan KK, Lok JY, Yip WW, Young AL.

Hong Kong Med J. 2017 Jun;23(3):316. doi: 10.12809/hkmj176306. No abstract available.


Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes.

Tang FY, Ng DS, Lam A, Luk F, Wong R, Chan C, Mohamed S, Fong A, Lok J, Tso T, Lai F, Brelen M, Wong TY, Tham CC, Cheung CY.

Sci Rep. 2017 May 31;7(1):2575. doi: 10.1038/s41598-017-02767-0. Erratum in: Sci Rep. 2018 May 4;8(1):7314.


A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells.

Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K.

Stem Cells Dev. 2017 Jul 15;26(14):1078-1085. doi: 10.1089/scd.2016.0306. Epub 2017 May 24.


Fundamentals and Catalytic Innovation: The Statistical and Data Management Center of the Antibacterial Resistance Leadership Group.

Huvane J, Komarow L, Hill C, Tran TT, Pereira C, Rosenkranz SL, Finnemeyer M, Earley M, Jiang HJ, Wang R, Lok J, Evans SR; Statistical and Data Management Center of the Antibacterial Resistance Leadership Group (ARLG).

Clin Infect Dis. 2017 Mar 15;64(suppl_1):S18-S23. doi: 10.1093/cid/ciw827.


Estimation of the cumulative incidence function under multiple dependent and independent censoring mechanisms.

Lok JJ, Yang S, Sharkey B, Hughes MD.

Lifetime Data Anal. 2018 Apr;24(2):201-223. doi: 10.1007/s10985-017-9393-4. Epub 2017 Feb 25.


Two-Stage Isothermal Enzymatic Amplification for Concurrent Multiplex Molecular Detection.

Song J, Liu C, Mauk MG, Rankin SC, Lok JB, Greenberg RM, Bau HH.

Clin Chem. 2017 Mar;63(3):714-722. doi: 10.1373/clinchem.2016.263665. Epub 2017 Jan 10.

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