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Items: 26

1.

Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.

Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K.

J Clin Invest. 2019 Aug 26. pii: 128903. doi: 10.1172/JCI128903. [Epub ahead of print]

2.

Synthetic lethal interactions for kinase deficiencies to DNA damage chemotherapeutics.

Robinson-Garcia L, Ferreira da Silva J, Loizou JI.

Cancer Res. 2019 Aug 6. pii: canres.1364.2019. doi: 10.1158/0008-5472.CAN-19-1364. [Epub ahead of print]

PMID:
31387919
3.

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.

Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Loizou JI, Kain R, Bidmon-Fliegenschnee B, Schickel JN, Glauzy S, Huemer J, Garncarz W, Salzer E, Pierides I, Bilic I, Thiel J, Priftakis P, Banerjee PP, Förster-Waldl E, Medgyesi D, Huber WD, Orange JS, Meffre E, Sansom DM, Bryceson YT, Altman A, Boztug K.

Nat Commun. 2019 Jul 15;10(1):3106. doi: 10.1038/s41467-019-10812-x.

4.

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.

Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R.

Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986. [Epub ahead of print]

5.

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.

Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116. Epub 2019 Feb 11.

6.

Mapping the Human Kinome in Response to DNA Damage.

Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P, Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD, Loizou JI.

Cell Rep. 2019 Jan 15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.

7.

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.

Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V.

Cancer Discov. 2018 Jul;8(7):884-897. doi: 10.1158/2159-8290.CD-17-0912. Epub 2018 Jun 13.

8.

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI.

Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.

9.

Validating the concept of mutational signatures with isogenic cell models.

Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S.

Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8.

10.

Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH.

Mazouzi A, Battistini F, Moser SC, Ferreira da Silva J, Wiedner M, Owusu M, Lardeau CH, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JI.

Mol Cell. 2017 Nov 16;68(4):797-807.e7. doi: 10.1016/j.molcel.2017.10.021.

11.

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.

Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI.

Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.

12.

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.

Smida M, Fece de la Cruz F, Kerzendorfer C, Uras IZ, Mair B, Mazouzi A, Suchankova T, Konopka T, Katz AM, Paz K, Nagy-Bojarszky K, Muellner MK, Bago-Horvath Z, Haura EB, Loizou JI, Nijman SM.

Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701.

13.

Perturbed hematopoiesis in mice lacking ATMIN.

Anjos-Afonso F, Loizou JI, Bradburn A, Kanu N, Purewal S, Da Costa C, Bonnet D, Behrens A.

Blood. 2016 Oct 20;128(16):2017-2021. doi: 10.1182/blood-2015-09-672980. Epub 2016 Aug 31.

14.

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI.

Cell Rep. 2016 Apr 26;15(4):893-908. doi: 10.1016/j.celrep.2016.03.077. Epub 2016 Apr 14.

15.

DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.

Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, Moder M, Turchinovich G, Hladik A, Gurnhofer E, Hayday A, Behrens A, Knapp S, Kenner L, Ellmeier W, Loizou JI.

PLoS Genet. 2015 Nov 6;11(11):e1005645. doi: 10.1371/journal.pgen.1005645. eCollection 2015 Nov.

16.

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease.

Prochazkova J, Loizou JI.

Immunology. 2016 Jan;147(1):11-20. doi: 10.1111/imm.12547. Epub 2015 Nov 18. Review.

17.

DNA replication stress: causes, resolution and disease.

Mazouzi A, Velimezi G, Loizou JI.

Exp Cell Res. 2014 Nov 15;329(1):85-93. doi: 10.1016/j.yexcr.2014.09.030. Epub 2014 Sep 30. Review.

18.

ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress.

Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, Loizou JI.

DNA Repair (Amst). 2014 Dec;24:122-130. doi: 10.1016/j.dnarep.2014.09.001. Epub 2014 Sep 26.

19.

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G.

Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2.

20.

Competition between NBS1 and ATMIN controls ATM signaling pathway choice.

Zhang T, Penicud K, Bruhn C, Loizou JI, Kanu N, Wang ZQ, Behrens A.

Cell Rep. 2012 Dec 27;2(6):1498-504. doi: 10.1016/j.celrep.2012.11.002. Epub 2012 Dec 6.

21.

ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.

Loizou JI, Sancho R, Kanu N, Bolland DJ, Yang F, Rada C, Corcoran AE, Behrens A.

Cancer Cell. 2011 May 17;19(5):587-600. doi: 10.1016/j.ccr.2011.03.022.

22.

Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool.

Loizou JI, Oser G, Shukla V, Sawan C, Murr R, Wang ZQ, Trumpp A, Herceg Z.

J Immunol. 2009 Nov 15;183(10):6422-31. doi: 10.4049/jimmunol.0901969. Epub 2009 Oct 30.

23.

Epigenetic information in chromatin: the code of entry for DNA repair.

Loizou JI, Murr R, Finkbeiner MG, Sawan C, Wang ZQ, Herceg Z.

Cell Cycle. 2006 Apr;5(7):696-701. Epub 2006 Apr 1. Review.

PMID:
16582631
24.

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.

Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, Herceg Z.

Nat Cell Biol. 2006 Jan;8(1):91-9. Epub 2005 Dec 11.

PMID:
16341205
25.

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW.

Cell. 2004 Apr 2;117(1):17-28.

26.

Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1.

Iftner T, Elbel M, Schopp B, Hiller T, Loizou JI, Caldecott KW, Stubenrauch F.

EMBO J. 2002 Sep 2;21(17):4741-8.

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