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Items: 24

1.

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology.

Viant MR, Ebbels TMD, Beger RD, Ekman DR, Epps DJT, Kamp H, Leonards PEG, Loizou GD, MacRae JI, van Ravenzwaay B, Rocca-Serra P, Salek RM, Walk T, Weber RJM.

Nat Commun. 2019 Jul 10;10(1):3041. doi: 10.1038/s41467-019-10900-y. Review.

2.

Evidence for non-linear metabolism at low benzene exposures? A reanalysis of data.

McNally K, Sams C, Loizou GD, Jones K.

Chem Biol Interact. 2017 Dec 25;278:256-268. doi: 10.1016/j.cbi.2017.09.002. Epub 2017 Sep 9.

3.

Animal-Free Chemical Safety Assessment.

Loizou GD.

Front Pharmacol. 2016 Jul 21;7:218. doi: 10.3389/fphar.2016.00218. eCollection 2016. Review.

4.

A probabilistic model of human variability in physiology for future application to dose reconstruction and QIVIVE.

McNally K, Loizou GD.

Front Pharmacol. 2015 Oct 12;6:213. doi: 10.3389/fphar.2015.00213. eCollection 2015.

5.

The application of global sensitivity analysis in the development of a physiologically based pharmacokinetic model for m-xylene and ethanol co-exposure in humans.

Loizou GD, McNally K, Jones K, Cocker J.

Front Pharmacol. 2015 Jun 30;6:135. doi: 10.3389/fphar.2015.00135. eCollection 2015.

6.

Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system.

Lumen A, McNally K, George N, Fisher JW, Loizou GD.

Front Pharmacol. 2015 May 27;6:107. doi: 10.3389/fphar.2015.00107. eCollection 2015.

7.

A Workflow for Global Sensitivity Analysis of PBPK Models.

McNally K, Cotton R, Loizou GD.

Front Pharmacol. 2011 Jun 23;2:31. doi: 10.3389/fphar.2011.00031. eCollection 2011.

8.

Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63.

Bouvier d'Yvoire M, Prieto P, Blaauboer BJ, Bois FY, Boobis A, Brochot C, Coecke S, Freidig A, Gundert-Remy U, Hartung T, Jacobs MN, Lavé T, Leahy DE, Lennernäs H, Loizou GD, Meek B, Pease C, Rowland M, Spendiff M, Yang J, Zeilmaker M.

Altern Lab Anim. 2007 Dec;35(6):661-71. No abstract available.

PMID:
18186671
9.

Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol.

Franks SJ, Spendiff MK, Cocker J, Loizou GD.

Toxicol Lett. 2006 Apr 10;162(2-3):164-73. Epub 2005 Oct 24.

PMID:
16246510
10.

A human PBPK model for ethanol describing inhibition of gastric motility.

Loizou GD, Spendiff M.

J Mol Histol. 2004 Sep;35(7):687-96.

PMID:
15614624
11.

Metabolism of ethylbenzene by human liver microsomes and recombinant human cytochrome P450s (CYP).

Sams C, Loizou GD, Cocker J, Lennard MS.

Toxicol Lett. 2004 Mar 7;147(3):253-60.

PMID:
15104117
12.
13.

Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions.

Lewis DF, Lake BG, Bird MG, Loizou GD, Dickins M, Goldfarb PS.

Toxicol In Vitro. 2003 Feb;17(1):93-105.

PMID:
12537967
15.
16.

The utility of PBPK in the safety assessment of chloroform and carbon tetrachloride.

Delic JI, Lilly PD, MacDonald AJ, Loizou GD.

Regul Toxicol Pharmacol. 2000 Oct;32(2):144-55.

PMID:
11067771
17.
18.

Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane.

Loizou GD, Tran CL, Anders MW.

Xenobiotica. 1997 Jan;27(1):87-99.

PMID:
9041681
19.
20.

Gas-uptake pharmacokinetics of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123).

Loizou GD, Urban G, Dekant W, Anders MW.

Drug Metab Dispos. 1994 Jul-Aug;22(4):511-7.

PMID:
7956723
21.

Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).

Loizou GD, Anders MW.

Drug Metab Dispos. 1993 Jul-Aug;21(4):634-9.

PMID:
8104122
22.

Adenosine 5'-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle.

Hourani SM, Welford LA, Loizou GD, Cusak NJ.

Eur J Pharmacol. 1988 Feb 16;147(1):131-6.

PMID:
3371408
23.
24.

Pharmacological effects of L-AMP-PCP on ATP receptors in smooth muscle.

Hourani SM, Loizou GD, Cusack NJ.

Eur J Pharmacol. 1986 Nov 12;131(1):99-103.

PMID:
3816951

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