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How Accurate Is Inverse Electrocardiographic Mapping? A Systematic In Vivo Evaluation.

Bear LR, LeGrice IJ, Sands GB, Lever NA, Loiselle DS, Paterson DJ, Cheng LK, Smaill BH.

Circ Arrhythm Electrophysiol. 2018 May;11(5):e006108. doi: 10.1161/CIRCEP.117.006108.


Calcium mishandling impairs contraction in right ventricular hypertrophy prior to overt heart failure.

Power AS, Hickey AJ, Crossman DJ, Loiselle DS, Ward ML.

Pflugers Arch. 2018 Jul;470(7):1115-1126. doi: 10.1007/s00424-018-2125-0. Epub 2018 Mar 10.


Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure.

Han JC, Guild SJ, Pham T, Nisbet L, Tran K, Taberner AJ, Loiselle DS.

Front Physiol. 2018 Jan 9;8:1115. doi: 10.3389/fphys.2017.01115. eCollection 2017.


Pulmonary arterial hypertension reduces energy efficiency of right, but not left, rat ventricular trabeculae.

Pham T, Nisbet L, Taberner A, Loiselle D, Han JC.

J Physiol. 2018 Apr 1;596(7):1153-1166. doi: 10.1113/JP275578. Epub 2018 Feb 25.


Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M.

Cell Rep. 2017 Nov 14;21(7):1883-1895. doi: 10.1016/j.celrep.2017.10.074.


Real-time model-based control of afterload for in vitro cardiac tissue experimentation.

Garrett AS, Pham T, Loiselle DS, June-Chiew Han, Taberner AJ.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1287-1290. doi: 10.1109/EMBC.2017.8037067.


The ineluctable constraints of thermodynamics in the aetiology of obesity.

Loiselle DS, Barclay CJ.

Clin Exp Pharmacol Physiol. 2018 Mar;45(3):219-225. doi: 10.1111/1440-1681.12869. Epub 2017 Nov 29. Review.


Cellular fatty acid synthase is required for late stages of HIV-1 replication.

Kulkarni MM, Ratcliff AN, Bhat M, Alwarawrah Y, Hughes P, Arcos J, Loiselle D, Torrelles JB, Funderburg NT, Haystead TA, Kwiek JJ.

Retrovirology. 2017 Sep 29;14(1):45. doi: 10.1186/s12977-017-0368-z.


Do right-ventricular trabeculae gain energetic advantage from having a greater velocity of shortening?

Pham T, Han JC, Taberner A, Loiselle D.

J Physiol. 2017 Oct 15;595(20):6477-6488. doi: 10.1113/JP274837. Epub 2017 Sep 24.


Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.

Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, Derbyshire ER.

Cell Chem Biol. 2017 Aug 17;24(8):1029-1039.e7. doi: 10.1016/j.chembiol.2017.07.011.


Experimental and modelling evidence of shortening heat in cardiac muscle.

Tran K, Han JC, Crampin EJ, Taberner AJ, Loiselle DS.

J Physiol. 2017 Oct 1;595(19):6313-6326. doi: 10.1113/JP274680. Epub 2017 Aug 22.


Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?

Pham T, Tran K, Mellor KM, Hickey A, Power A, Ward ML, Taberner A, Han JC, Loiselle D.

J Physiol. 2017 Jul 15;595(14):4725-4733. doi: 10.1113/JP274174. Epub 2017 Jun 1.


Cardiac muscle energetics: Improved normalisation of heat using optical coherence tomography.

Cheuk ML, Johnston CM, June-Chiew Han, Loiselle DS, Nielsen PM, Taberner AJ.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:2905-2908. doi: 10.1109/EMBC.2016.7591337.


A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.

Crowe LB, Hughes PF, Alcorta DA, Osada T, Smith AP, Totzke J, Loiselle DR, Lutz ID, Gargesha M, Roy D, Roques J, Darr D, Lyerly HK, Spector NL, Haystead TAJ.

ACS Chem Biol. 2017 Apr 21;12(4):1047-1055. doi: 10.1021/acschembio.7b00006. Epub 2017 Feb 23.


Thermodynamic analysis questions claims of improved cardiac efficiency by dietary fish oil.

Loiselle DS, Han JC, Goo E, Chapman B, Barclay CJ, Hickey AJ, Taberner AJ.

J Gen Physiol. 2016 Sep;148(3):183-93. doi: 10.1085/jgp.201611620.


Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.

Spencer WJ, Pearring JN, Salinas RY, Loiselle DR, Skiba NP, Arshavsky VY.

Biochemistry. 2016 Sep 13;55(36):5028-37. doi: 10.1021/acs.biochem.6b00489. Epub 2016 Aug 30.


Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension.

Tran K, Han JC, Taberner AJ, Barrett CJ, Crampin EJ, Loiselle DS.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H563-71. doi: 10.1152/ajpheart.00396.2016. Epub 2016 Jul 8.


The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M.

Nat Commun. 2016 Jun 29;7:12037. doi: 10.1038/ncomms12037.


Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.

Alwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA.

Cell Chem Biol. 2016 Jun 23;23(6):678-88. doi: 10.1016/j.chembiol.2016.04.011. Epub 2016 Jun 2.


Four-Dimensional Imaging of Cardiac Trabeculae Contracting In Vitro Using Gated OCT.

Cheuk ML, Anderson AJ, Han JC, Lippok N, Vanholsbeeck F, Ruddy BP, Loiselle DS, Nielsen PM, Taberner AJ.

IEEE Trans Biomed Eng. 2017 Jan;64(1):218-224. doi: 10.1109/TBME.2016.2553154. Epub 2016 Apr 12.


Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts.

Power AS, Pham T, Loiselle DS, Crossman DH, Ward ML, Hickey AJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1649-57. doi: 10.1152/ajpheart.00050.2016. Epub 2016 Apr 15.


An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.

Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA.

Antiviral Res. 2016 Jun;130:81-92. doi: 10.1016/j.antiviral.2016.03.017. Epub 2016 Apr 4.


Cardiac activation heat remains inversely dependent on temperature over the range 27-37°C.

Johnston CM, Han JC, Loiselle DS, Nielsen PM, Taberner AJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1512-9. doi: 10.1152/ajpheart.00903.2015. Epub 2016 Mar 25.


Thermodynamics and kinetics of the FoF1-ATPase: application of the probability isotherm.

Chapman B, Loiselle D.

R Soc Open Sci. 2016 Feb 10;3(2):150379. doi: 10.1098/rsos.150379. eCollection 2016 Feb.


Measuring the mechanical efficiency of a working cardiac muscle sample at body temperature using a flow-through calorimeter.

Taberner AJ, Johnston CM, Pham T, June-Chiew Han, Ruddy BP, Loiselle DS, Nielsen PM.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:7966-9. doi: 10.1109/EMBC.2015.7320240.


Muscle heat: a window into the thermodynamics of a molecular machine.

Loiselle DS, Johnston CM, Han JC, Nielsen PM, Taberner AJ.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H311-25. doi: 10.1152/ajpheart.00569.2015. Epub 2015 Nov 20. Review.


A counterview of 'An investigation of the false discovery rate and the misinterpretation of p-values' by Colquhoun (2014).

Loiselle D, Ramchandra R.

R Soc Open Sci. 2015 Aug 19;2(8):150217. doi: 10.1098/rsos.150217. eCollection 2015 Aug. No abstract available.


c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M.

Cell Rep. 2015 Aug 11;12(6):1006-18. doi: 10.1016/j.celrep.2015.07.004. Epub 2015 Jul 30.


Regulation of cardiac cellular bioenergetics: mechanisms and consequences.

Tran K, Loiselle DS, Crampin EJ.

Physiol Rep. 2015 Jul;3(7). pii: e12464. doi: 10.14814/phy2.12464.


Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.

Lontay B, Bodoor K, Sipos A, Weitzel DH, Loiselle D, Safi R, Zheng D, Devente J, Hickner RC, McDonnell DP, Ribar T, Haystead TA.

J Biol Chem. 2015 Jul 17;290(29):17985-98. doi: 10.1074/jbc.M115.658120. Epub 2015 Jun 5.


Does reduced myocardial efficiency in systemic hypertensive-hypertrophy correlate with increased left-ventricular wall thickness?

Han JC, Barrett CJ, Taberner AJ, Loiselle DS.

Hypertens Res. 2015 Aug;38(8):530-8. doi: 10.1038/hr.2015.37. Epub 2015 Mar 19.


Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: implications for fatigue.

Cairns SP, Leader JP, Loiselle DS, Higgins A, Lin W, Renaud JM.

J Appl Physiol (1985). 2015 Mar 15;118(6):662-74. doi: 10.1152/japplphysiol.00705.2013. Epub 2015 Jan 8.


Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA.

Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11.


Reduced mechanical efficiency in left-ventricular trabeculae of the spontaneously hypertensive rat.

Han JC, Tran K, Johnston CM, Nielsen PM, Barrett CJ, Taberner AJ, Loiselle DS.

Physiol Rep. 2014 Nov 20;2(11). pii: e12211. doi: 10.14814/phy2.12211. Print 2014 Nov 1.


Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.

Pham T, Loiselle D, Power A, Hickey AJ.

Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C499-507. doi: 10.1152/ajpcell.00006.2014. Epub 2014 Jun 11.


Dietary supplementation with either saturated or unsaturated fatty acids does not affect the mechanoenergetics of the isolated rat heart.

Goo S, Han JC, Nisbet LA, Legrice IJ, Taberner AJ, Loiselle DS.

Physiol Rep. 2014 Mar 1;2(3):e00272. doi: 10.1002/phy2.272. Print 2014.


Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae.

Han JC, Tran K, Nielsen PM, Taberner AJ, Loiselle DS.

Cardiovasc Diabetol. 2014 Apr 15;13:79. doi: 10.1186/1475-2840-13-79.


Dietary pre-exposure of rats to fish oil does not enhance myocardial efficiency of isolated working hearts or their left ventricular trabeculae.

Goo S, Han JC, Nisbet LA, LeGrice IJ, Taberner AJ, Loiselle DS.

J Physiol. 2014 Apr 15;592(8):1795-808. doi: 10.1113/jphysiol.2013.269977. Epub 2014 Feb 17.


The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes.

Han JC, Goo S, Barrett CJ, Mellor KM, Taberner AJ, Loiselle DS.

Cardiovasc Diabetol. 2014 Jan 5;13:4. doi: 10.1186/1475-2840-13-4.


The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules.

Yasuda K, Zhang H, Loiselle D, Haystead T, Macara IG, Mili S.

J Cell Biol. 2013 Dec 9;203(5):737-46. doi: 10.1083/jcb.201306058. Epub 2013 Dec 2.


Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA.

Chem Biol. 2013 Sep 19;20(9):1187-97. doi: 10.1016/j.chembiol.2013.08.004. Epub 2013 Sep 12.


Multiscale measurement of cardiac energetics.

Goo S, Pham T, Han JC, Nielsen P, Taberner A, Hickey A, Loiselle D.

Clin Exp Pharmacol Physiol. 2013 Sep;40(9):671-81. doi: 10.1111/1440-1681.12139.


Design and development of a novel intra-vaginal pressure sensor.

Kruger J, Hayward L, Nielsen P, Loiselle D, Kirton R.

Int Urogynecol J. 2013 Oct;24(10):1715-21. doi: 10.1007/s00192-013-2097-8. Epub 2013 May 3.


Interventricular comparison of the energetics of contraction of trabeculae carneae isolated from the rat heart.

Han JC, Taberner AJ, Nielsen PM, Loiselle DS.

J Physiol. 2013 Feb 1;591(3):701-17. doi: 10.1113/jphysiol.2012.242719. Epub 2012 Nov 26.


Comparison of the Gibbs and Suga formulations of cardiac energetics: the demise of "isoefficiency".

Han JC, Taberner AJ, Tran K, Goo S, Nickerson DP, Nash MP, Nielsen PM, Crampin EJ, Loiselle DS.

J Appl Physiol (1985). 2012 Oct;113(7):996-1003. doi: 10.1152/japplphysiol.00693.2011. Epub 2012 Aug 9. Review.


Relating components of pressure-volume area in Suga's formulation of cardiac energetics to components of the stress-time integral.

Han JC, Taberner AJ, Tran K, Nickerson DP, Nash MP, Nielsen PM, Crampin EJ, Loiselle DS.

J Appl Physiol (1985). 2012 Oct;113(7):988-95. doi: 10.1152/japplphysiol.00438.2012. Epub 2012 Jul 26. Review.


Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: experiments and modelling.

Han JC, Tran K, Taberner AJ, Nickerson DP, Kirton RS, Nielsen PM, Ward ML, Nash MP, Crampin EJ, Loiselle DS.

J Physiol. 2012 Sep 15;590(18):4603-22. doi: 10.1113/jphysiol.2012.228965. Epub 2012 May 8.


A highly selective Hsp90 affinity chromatography resin with a cleavable linker.

Hughes PF, Barrott JJ, Carlson DA, Loiselle DR, Speer BL, Bodoor K, Rund LA, Haystead TA.

Bioorg Med Chem. 2012 May 15;20(10):3298-305. doi: 10.1016/j.bmc.2012.03.043. Epub 2012 Mar 29.


A work-loop calorimeter for measuring the force-length-heat relationship of working excised cardiac muscle fibers.

Taberner AJ, Han JC, Loiselle DS, Nielsen PM.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1901-4. doi: 10.1109/IEMBS.2011.6090538.


An innovative work-loop calorimeter for in vitro measurement of the mechanics and energetics of working cardiac trabeculae.

Taberner AJ, Han JC, Loiselle DS, Nielsen PM.

J Appl Physiol (1985). 2011 Dec;111(6):1798-803. doi: 10.1152/japplphysiol.00752.2011. Epub 2011 Sep 8. Erratum in: J Appl Physiol. 2012 Mar;112(6):1090. Nielsen, Paul M F [corrected to Nielsen, Poul M F].

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