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Items: 1 to 50 of 161

1.

In-vitro and in-vivo antileishmanial activity of inexpensive Amphotericin B formulations: Heated Amphotericin B and Amphotericin B-loaded microemulsion.

Rochelle do Vale Morais A, Silva AL, Cojean S, Balaraman K, Bories C, Pomel S, Barratt G, do Egito EST, Loiseau PM.

Exp Parasitol. 2018 Sep;192:85-92. doi: 10.1016/j.exppara.2018.07.017. Epub 2018 Aug 1.

PMID:
30075233
2.

Surface-dependent endocytosis of poly(isobutylcyanoacrylate) nanoparticles by Trichomonas vaginalis.

Malli S, Bories C, Bourge M, Loiseau PM, Bouchemal K.

Int J Pharm. 2018 Sep 5;548(1):276-287. doi: 10.1016/j.ijpharm.2018.07.006. Epub 2018 Jul 3.

PMID:
29991450
3.

Polysorbate Surfactants as Drug Carriers: Tween 20-Amphotericin B Conjugates as Anti-Fungal and Anti-Leishmanial Agents.

Ravichandran V, Kesavan V, Cojean S, Loiseau PM, Jayakrishnan A.

Curr Drug Deliv. 2018;15(7):1028-1037. doi: 10.2174/1567201815666180503122829.

PMID:
29732967
4.

Phase solubility studies and anti-Trichomonas vaginalis activity evaluations of metronidazole and methylated β-cyclodextrin complexes: Comparison of CRYSMEB and RAMEB.

Malli S, Bories C, Ponchel G, Loiseau PM, Bouchemal K.

Exp Parasitol. 2018 Jun;189:72-75. doi: 10.1016/j.exppara.2018.04.019. Epub 2018 Apr 27.

PMID:
29730454
5.

Enrichment of free-living amoebae in biofilms developed at upper water levels in drinking water storage towers: An inter- and intra-seasonal study.

Taravaud A, Ali M, Lafosse B, Nicolas V, Féliers C, Thibert S, Lévi Y, Loiseau PM, Pomel S.

Sci Total Environ. 2018 Aug 15;633:157-166. doi: 10.1016/j.scitotenv.2018.03.178. Epub 2018 Mar 21.

PMID:
29573682
6.

Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives.

Jagu E, Pomel S, Diez-Martinez A, Rascol E, Pethe S, Loiseau PM, Labruère R.

Eur J Med Chem. 2018 Apr 25;150:655-666. doi: 10.1016/j.ejmech.2018.02.087. Epub 2018 Mar 6.

PMID:
29567458
7.

Synthetic Polysaccharides as Drug Carriers: Synthesis of Polyglucose-Amphotericin B Conjugates and In Vitro Evaluation of Their Anti-Fungal and Anti-Leishmanial Activities.

Ravichandran V, Kothandaraman GP, Bories C, Loiseau PM, Jayakrishnan A.

J Nanosci Nanotechnol. 2018 Apr 1;18(4):2405-2414. doi: 10.1166/jnn.2018.14296.

PMID:
29442909
8.

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.

Wu Y, Pons V, Goudet A, Panigai L, Fischer A, Herweg JA, Kali S, Davey RA, Laporte J, Bouclier C, Yousfi R, Aubenque C, Merer G, Gobbo E, Lopez R, Gillet C, Cojean S, Popoff MR, Clayette P, Le Grand R, Boulogne C, Tordo N, Lemichez E, Loiseau PM, Rudel T, Sauvaire D, Cintrat JC, Gillet D, Barbier J.

Sci Rep. 2017 Nov 14;7(1):15567. doi: 10.1038/s41598-017-15466-7.

9.

In vitro evaluation of antimicrobial agents on Acanthamoeba sp. and evidence of a natural resilience to amphotericin B.

Taravaud A, Loiseau PM, Pomel S.

Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):328-336. doi: 10.1016/j.ijpddr.2017.09.002. Epub 2017 Sep 8.

10.

Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru).

Vásquez-Ocmín P, Cojean S, Rengifo E, Suyyagh-Albouz S, Amasifuen Guerra CA, Pomel S, Cabanillas B, Mejía K, Loiseau PM, Figadère B, Maciuk A.

J Ethnopharmacol. 2018 Jan 10;210:372-385. doi: 10.1016/j.jep.2017.08.039. Epub 2017 Sep 5.

PMID:
28887215
11.

Polyamine-based analogs and conjugates as antikinetoplastid agents.

Jagu E, Pomel S, Pethe S, Loiseau PM, Labruère R.

Eur J Med Chem. 2017 Oct 20;139:982-1015. doi: 10.1016/j.ejmech.2017.08.014. Epub 2017 Aug 5. Review.

PMID:
28886510
12.

Strategies for Prevention and Treatment of Trichomonas vaginalis Infections.

Bouchemal K, Bories C, Loiseau PM.

Clin Microbiol Rev. 2017 Jul;30(3):811-825. doi: 10.1128/CMR.00109-16. Review.

13.

Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads.

Mao W, Daligaux P, Lazar N, Ha-Duong T, Cavé C, van Tilbeurgh H, Loiseau PM, Pomel S.

Sci Rep. 2017 Apr 7;7(1):751. doi: 10.1038/s41598-017-00848-8.

14.

Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.

Fox Ramos AE, Alcover C, Evanno L, Maciuk A, Litaudon M, Duplais C, Bernadat G, Gallard JF, Jullian JC, Mouray E, Grellier P, Loiseau PM, Pomel S, Poupon E, Champy P, Beniddir MA.

J Nat Prod. 2017 Apr 28;80(4):1007-1014. doi: 10.1021/acs.jnatprod.6b01013. Epub 2017 Mar 10.

PMID:
28282127
15.

Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model.

Grisin T, Bories C, Bombardi M, Loiseau PM, Rouffiac V, Solgadi A, Mallet JM, Ponchel G, Bouchemal K.

Pharm Res. 2017 May;34(5):1067-1082. doi: 10.1007/s11095-017-2117-3. Epub 2017 Feb 6.

PMID:
28168390
16.

Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice.

Grisin T, Bories C, Loiseau PM, Bouchemal K.

Int J Pharm. 2017 Mar 15;519(1-2):381-389. doi: 10.1016/j.ijpharm.2017.01.048. Epub 2017 Jan 24.

PMID:
28130196
17.

In situ forming pluronic® F127/chitosan hydrogel limits metronidazole transmucosal absorption.

Malli S, Bories C, Pradines B, Loiseau PM, Ponchel G, Bouchemal K.

Eur J Pharm Biopharm. 2017 Mar;112:143-147. doi: 10.1016/j.ejpb.2016.11.024. Epub 2016 Nov 24.

PMID:
27890510
18.

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.

Jagu E, Pomel S, Diez-Martinez A, Ramiandrasoa F, Krauth-Siegel RL, Pethe S, Blonski C, Labruère R, Loiseau PM.

Bioorg Med Chem. 2017 Jan 1;25(1):84-90. doi: 10.1016/j.bmc.2016.10.013. Epub 2016 Oct 12.

PMID:
27793448
19.

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales.

Gupta N, Noël R, Goudet A, Hinsinger K, Michau A, Pons V, Abdelkafi H, Secher T, Shima A, Shtanko O, Sakurai Y, Cojean S, Pomel S, Liévin-Le Moal V, Leignel V, Herweg JA, Fischer A, Johannes L, Harrison K, Beard PM, Clayette P, Le Grand R, Rayner JO, Rudel T, Vacus J, Loiseau PM, Davey RA, Oswald E, Cintrat JC, Barbier J, Gillet D.

Chem Biol Interact. 2017 Apr 1;267:96-103. doi: 10.1016/j.cbi.2016.10.005. Epub 2016 Oct 3.

PMID:
27712998
20.

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids.

Viira B, Gendron T, Lanfranchi DA, Cojean S, Horvath D, Marcou G, Varnek A, Maes L, Maran U, Loiseau PM, Davioud-Charvet E.

Molecules. 2016 Jun 29;21(7). pii: E853. doi: 10.3390/molecules21070853.

21.

Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana.

Komlaga G, Cojean S, Dickson RA, Beniddir MA, Suyyagh-Albouz S, Mensah ML, Agyare C, Champy P, Loiseau PM.

Parasitol Res. 2016 Aug;115(8):3185-95. doi: 10.1007/s00436-016-5080-8. Epub 2016 May 13.

PMID:
27174028
22.

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.

Bosc D, Mouray E, Cojean S, Franco CH, Loiseau PM, Freitas-Junior LH, Moraes CB, Grellier P, Dubois J.

Eur J Med Chem. 2016 Feb 15;109:173-86. doi: 10.1016/j.ejmech.2015.12.045. Epub 2015 Dec 29.

PMID:
26774924
23.

Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities.

Daligaux P, Pomel S, Leblanc K, Loiseau PM, Cavé C.

Mol Divers. 2016 May;20(2):507-19. doi: 10.1007/s11030-015-9652-9. Epub 2016 Jan 11.

PMID:
26754628
24.

In vitro and in vivo antileishmanial properties of a 2-n-propylquinoline hydroxypropyl β-cyclodextrin formulation and pharmacokinetics via intravenous route.

Balaraman K, Vieira NC, Moussa F, Vacus J, Cojean S, Pomel S, Bories C, Figadère B, Kesavan V, Loiseau PM.

Biomed Pharmacother. 2015 Dec;76:127-33. doi: 10.1016/j.biopha.2015.10.028. Epub 2015 Nov 18.

PMID:
26653559
25.

Leishmania hijacking of the macrophage intracellular compartments.

Liévin-Le Moal V, Loiseau PM.

FEBS J. 2016 Feb;283(4):598-607. doi: 10.1111/febs.13601. Epub 2015 Dec 14. Review.

26.

Comparative study of structural models of Leishmania donovani and human GDP-mannose pyrophosphorylases.

Daligaux P, Bernadat G, Tran L, Cavé C, Loiseau PM, Pomel S, Ha-Duong T.

Eur J Med Chem. 2016 Jan 1;107:109-18. doi: 10.1016/j.ejmech.2015.10.037. Epub 2015 Oct 30.

PMID:
26562546
27.

Bioactive phloroglucinols from Mallotus oppositifolius.

Kabran FA, Okpekon TA, Roblot F, Séon-Méniel B, Leblanc K, Bories C, Champy P, Yolou SF, Loiseau PM, Djakouré LA, Figadère B, Maciuk A.

Fitoterapia. 2015 Dec;107:100-104. doi: 10.1016/j.fitote.2015.09.015. Epub 2015 Oct 14.

PMID:
26463755
28.

Gelation and micellization behaviors of pluronic(®) F127 hydrogel containing poly(isobutylcyanoacrylate) nanoparticles specifically designed for mucosal application.

Pradines B, Djabourov M, Vauthier C, Loiseau PM, Ponchel G, Bouchemal K.

Colloids Surf B Biointerfaces. 2015 Nov 1;135:669-76. doi: 10.1016/j.colsurfb.2015.08.021. Epub 2015 Aug 22.

PMID:
26340355
29.

Medicinal plants and finished marketed herbal products used in the treatment of malaria in the Ashanti region, Ghana.

Komlaga G, Agyare C, Dickson RA, Mensah ML, Annan K, Loiseau PM, Champy P.

J Ethnopharmacol. 2015 Aug 22;172:333-46. doi: 10.1016/j.jep.2015.06.041. Epub 2015 Jul 4.

PMID:
26151245
30.

Cell line-dependent cytotoxicity of poly(isobutylcyanoacrylate) nanoparticles coated with chitosan and thiolated chitosan: Insights from cultured human epithelial HeLa, Caco2/TC7 and HT-29/MTX cells.

Pradines B, Lievin-Le Moal V, Vauthier C, Ponchel G, Loiseau PM, Bouchemal K.

Int J Pharm. 2015 Aug 1;491(1-2):17-20. doi: 10.1016/j.ijpharm.2015.06.001. Epub 2015 Jun 5.

PMID:
26051544
31.

Synthesis of 5-isoxazol-3-yl-pyrimidine nucleosides as potential antileishmanial agents.

Guo S, Wang J, Zhang X, Cojean S, Loiseau PM, Fan X.

Bioorg Med Chem Lett. 2015 Jul 1;25(13):2617-20. doi: 10.1016/j.bmcl.2015.04.097. Epub 2015 May 6.

PMID:
25987374
32.

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.

Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F.

J Infect Dis. 2015 Nov 1;212(9):1439-48. doi: 10.1093/infdis/jiv228. Epub 2015 Apr 15.

33.

New heterocyclic compounds: Synthesis and antitrypanosomal properties.

Pomel S, Dubar F, Forge D, Loiseau PM, Biot C.

Bioorg Med Chem. 2015 Aug 15;23(16):5168-74. doi: 10.1016/j.bmc.2015.03.029. Epub 2015 Mar 20.

PMID:
25835356
34.

Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection.

Veljkovic V, Loiseau PM, Figadere B, Glisic S, Veljkovic N, Perovic VR, Cavanaugh DP, Branch DR.

F1000Res. 2015 Feb 2;4:34. doi: 10.12688/f1000research.6110.1. eCollection 2015.

35.

The unexpected increase of clotrimazole apparent solubility using randomly methylated β-cyclodextrin.

Pradines B, Gallard JF, Iorga BI, Gueutin C, Ponchel G, Loiseau PM, Bouchemal K.

J Mol Recognit. 2015 Feb;28(2):96-102. doi: 10.1002/jmr.2432. Epub 2015 Jan 21.

PMID:
25604751
36.

"Squalenoylcurcumin" nanoassemblies as water-dispersible drug candidates with antileishmanial activity.

Cheikh-Ali Z, Caron J, Cojean S, Bories C, Couvreur P, Loiseau PM, Desmaële D, Poupon E, Champy P.

ChemMedChem. 2015 Feb;10(2):411-8. doi: 10.1002/cmdc.201402449. Epub 2014 Dec 18.

PMID:
25523035
37.

Design, synthesis and in vitro antikinetoplastid evaluation of N-acylated putrescine, spermidine and spermine derivatives.

Jagu E, Djilali R, Pomel S, Ramiandrasoa F, Pethe S, Labruère R, Loiseau PM, Blonski C.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):207-9. doi: 10.1016/j.bmcl.2014.11.073. Epub 2014 Dec 4.

PMID:
25499437
38.

Targeting sterol metabolism for the development of antileishmanials.

Pomel S, Cojean S, Loiseau PM.

Trends Parasitol. 2015 Jan;31(1):5-7. doi: 10.1016/j.pt.2014.11.007. Epub 2014 Dec 12.

PMID:
25498194
39.

Drug-free chitosan coated poly(isobutylcyanoacrylate) nanoparticles are active against trichomonas vaginalis and non-toxic towards pig vaginal mucosa.

Pradines B, Bories C, Vauthier C, Ponchel G, Loiseau PM, Bouchemal K.

Pharm Res. 2015 Apr;32(4):1229-36. doi: 10.1007/s11095-014-1528-7. Epub 2014 Oct 16.

PMID:
25319099
40.

Investigation of the complexation of albendazole with cyclodextrins for the design of new antiparasitic formulations.

Pradines B, Gallard JF, Iorga BI, Gueutin C, Loiseau PM, Ponchel G, Bouchemal K.

Carbohydr Res. 2014 Oct 29;398:50-5. doi: 10.1016/j.carres.2014.06.008. Epub 2014 Jun 17.

PMID:
25240182
41.

Sitamaquine-resistance in Leishmania donovani affects drug accumulation and lipid metabolism.

Imbert L, Cojean S, Libong D, Chaminade P, Loiseau PM.

Biomed Pharmacother. 2014 Sep;68(7):893-7. doi: 10.1016/j.biopha.2014.08.009. Epub 2014 Aug 19.

PMID:
25201056
42.

New anti-malarial drugs: who cares?

Picot S, Loiseau PM, Bienvenu AL.

Curr Top Med Chem. 2014;14(14):1637-42.

PMID:
25116585
43.

Development of antileishmanial lipid nanocomplexes.

Pham TT, Gueutin C, Cheron M, Abreu S, Chaminade P, Loiseau PM, Barratt G.

Biochimie. 2014 Dec;107 Pt A:143-53. doi: 10.1016/j.biochi.2014.06.007. Epub 2014 Jun 18.

PMID:
24952352
44.

Adsorption of antisense oligonucleotides targeting malarial topoisomerase II on cationic nanoemulsions optimized by a full factorial design.

Bruxel F, Bochot A, Diel D, Wild L, Carvalho EL, Cojean S, Loiseau PM, Fattal E, Teixeira HF.

Curr Top Med Chem. 2014;14(9):1161-71.

PMID:
24678706
45.

Strategies for the design of orally bioavailable antileishmanial treatments.

Pham TT, Loiseau PM, Barratt G.

Int J Pharm. 2013 Sep 15;454(1):539-52. doi: 10.1016/j.ijpharm.2013.07.035. Epub 2013 Jul 17. Review.

PMID:
23871737
46.

Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.

Abada Z, Cojean S, Pomel S, Ferrié L, Akagah B, Lormier AT, Loiseau PM, Figadère B.

Eur J Med Chem. 2013 Sep;67:158-65. doi: 10.1016/j.ejmech.2013.06.002. Epub 2013 Jun 12.

PMID:
23851117
47.

Clotrimazole-loaded nanostructured lipid carrier hydrogels: thermal analysis and in vitro studies.

Ravani L, Esposito E, Bories C, Moal VL, Loiseau PM, Djabourov M, Cortesi R, Bouchemal K.

Int J Pharm. 2013 Oct 1;454(2):695-702. doi: 10.1016/j.ijpharm.2013.06.015. Epub 2013 Jun 21.

PMID:
23792467
48.

Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.

Fromentin Y, Gaboriaud-Kolar N, Lenta BN, Wansi JD, Buisson D, Mouray E, Grellier P, Loiseau PM, Lallemand MC, Michel S.

Eur J Med Chem. 2013 Jul;65:284-94. doi: 10.1016/j.ejmech.2013.04.066. Epub 2013 May 10.

PMID:
23727538
49.

Antimalarial activity of axidjiferosides, new β-galactosylceramides from the African sponge Axinyssa djiferi.

Farokhi F, Grellier P, Clément M, Roussakis C, Loiseau PM, Genin-Seward E, Kornprobst JM, Barnathan G, Wielgosz-Collin G.

Mar Drugs. 2013 Apr 17;11(4):1304-15. doi: 10.3390/md11041304.

50.

Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates.

Pham TT, Barratt G, Michel JP, Loiseau PM, Saint-Pierre-Chazalet M.

Colloids Surf B Biointerfaces. 2013 Jun 1;106:224-33. doi: 10.1016/j.colsurfb.2013.01.041. Epub 2013 Jan 29.

PMID:
23434716

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