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Monitoring kinetics reveals critical parameters of IgA-dependent granulocyte-mediated anti-tumor cell cytotoxicity.

Zwick A, Bernhard M, Knoerck A, Linxweiler M, Schick B, Heinzelmann J, Smola S, Lohse S.

J Immunol Methods. 2019 Oct;473:112644. doi: 10.1016/j.jim.2019.112644. Epub 2019 Aug 9.


A quartz amplifier for high-sensitivity Fourier-transform ion-cyclotron-resonance measurements with trapped ions.

Lohse S, Berrocal J, Block M, Chenmarev S, Cornejo JM, Ramírez JG, Rodríguez D.

Rev Sci Instrum. 2019 Jun;90(6):063202. doi: 10.1063/1.5094428.


Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.

Venuti A, Lohse S, Tommasino M, Smola S.

Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180287. doi: 10.1098/rstb.2018.0287.


Bare surface of gold nanoparticle induces inflammation through unfolding of plasma fibrinogen.

Kharazian B, Lohse SE, Ghasemi F, Raoufi M, Saei AA, Hashemi F, Farvadi F, Alimohamadi R, Jalali SA, Shokrgozar MA, Hadipour NL, Ejtehadi MR, Mahmoudi M.

Sci Rep. 2018 Aug 22;8(1):12557. doi: 10.1038/s41598-018-30915-7.


Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

Peretti A, Geoghegan EM, Pastrana DV, Smola S, Feld P, Sauter M, Lohse S, Ramesh M, Lim ES, Wang D, Borgogna C, FitzGerald PC, Bliskovsky V, Starrett GJ, Law EK, Harris RS, Killian JK, Zhu J, Pineda M, Meltzer PS, Boldorini R, Gariglio M, Buck CB.

Cell Host Microbe. 2018 May 9;23(5):628-635.e7. doi: 10.1016/j.chom.2018.04.005.


Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPβ to Induce Pro-Inflammatory S100A8/A9 Proteins.

Podgórska M, Ołdak M, Marthaler A, Fingerle A, Walch-Rückheim B, Lohse S, Müller CSL, Vogt T, Ustav M, Wnorowski A, Malejczyk M, Majewski S, Smola S.

Front Microbiol. 2018 Mar 7;9:392. doi: 10.3389/fmicb.2018.00392. eCollection 2018.


Cascading Effects of Nanoparticle Coatings: Surface Functionalization Dictates the Assemblage of Complexed Proteins and Subsequent Interaction with Model Cell Membranes.

Melby ES, Lohse SE, Park JE, Vartanian AM, Putans RA, Abbott HB, Hamers RJ, Murphy CJ, Pedersen JA.

ACS Nano. 2017 Jun 27;11(6):5489-5499. doi: 10.1021/acsnano.7b00231. Epub 2017 May 22.


Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

Lohse S, Loew S, Kretschmer A, Jansen JHM, Meyer S, Ten Broeke T, Rösner T, Dechant M, Derer S, Klausz K, Kellner C, Schwanbeck R, French RR, Tipton TRW, Cragg MS, Schewe DM, Peipp M, Leusen JHW, Valerius T.

Br J Haematol. 2018 May;181(3):413-417. doi: 10.1111/bjh.14624. Epub 2017 Apr 27. No abstract available.


Influence of gold nanoparticle surface chemistry and diameter upon Alzheimer's disease amyloid-β protein aggregation.

Moore KA, Pate KM, Soto-Ortega DD, Lohse S, van der Munnik N, Lim M, Jackson KS, Lyles VD, Jones L, Glassgow N, Napumecheno VM, Mobley S, Uline MJ, Mahtab R, Murphy CJ, Moss MA.

J Biol Eng. 2017 Feb 6;11:5. doi: 10.1186/s13036-017-0047-6. eCollection 2017.


Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.

Scheler U, Brandt W, Porzel A, Rothe K, Manzano D, Božić D, Papaefthimiou D, Balcke GU, Henning A, Lohse S, Marillonnet S, Kanellis AK, Ferrer A, Tissier A.

Nat Commun. 2016 Oct 5;7:12942. doi: 10.1038/ncomms12942.


An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

Lohse S, Meyer S, Meulenbroek LA, Jansen JH, Nederend M, Kretschmer A, Klausz K, Möginger U, Derer S, Rösner T, Kellner C, Schewe D, Sondermann P, Tiwari S, Kolarich D, Peipp M, Leusen JH, Valerius T.

Cancer Res. 2016 Jan 15;76(2):403-17. doi: 10.1158/0008-5472.CAN-15-1232. Epub 2015 Dec 3.


A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

Derer S, Cossham M, Rösner T, Kellner C, Beurskens FJ, Schwanbeck R, Lohse S, Sina C, Peipp M, Valerius T.

J Immunol. 2015 Nov 15;195(10):5077-87. doi: 10.4049/jimmunol.1501458. Epub 2015 Oct 16.


Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing.

Brandsma AM, Ten Broeke T, Nederend M, Meulenbroek LA, van Tetering G, Meyer S, Jansen JH, Beltrán Buitrago MA, Nagelkerke SQ, Németh I, Ubink R, Rouwendal G, Lohse S, Valerius T, Leusen JH, Boross P.

Cancer Immunol Res. 2015 Dec;3(12):1316-24. doi: 10.1158/2326-6066.CIR-15-0099-T. Epub 2015 Sep 25.


HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity.

Peipp M, Derer S, Lohse S, Staudinger M, Klausz K, Valerius T, Gramatzki M, Kellner C.

Oncotarget. 2015 Oct 13;6(31):32075-88. doi: 10.18632/oncotarget.5135.


Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria.

Feng ZV, Gunsolus IL, Qiu TA, Hurley KR, Nyberg LH, Frew H, Johnson KP, Vartanian AM, Jacob LM, Lohse SE, Torelli MD, Hamers RJ, Murphy CJ, Haynes CL.

Chem Sci. 2015 Sep 1;6(9):5186-5196. doi: 10.1039/c5sc00792e. Epub 2015 Jun 16.


Lipopolysaccharide Density and Structure Govern the Extent and Distance of Nanoparticle Interaction with Actual and Model Bacterial Outer Membranes.

Jacobson KH, Gunsolus IL, Kuech TR, Troiano JM, Melby ES, Lohse SE, Hu D, Chrisler WB, Murphy CJ, Orr G, Geiger FM, Haynes CL, Pedersen JA.

Environ Sci Technol. 2015 Sep 1;49(17):10642-50. doi: 10.1021/acs.est.5b01841. Epub 2015 Aug 12.


Effects of charge and surface ligand properties of nanoparticles on oxidative stress and gene expression within the gut of Daphnia magna.

Dominguez GA, Lohse SE, Torelli MD, Murphy CJ, Hamers RJ, Orr G, Klaper RD.

Aquat Toxicol. 2015 May;162:1-9. doi: 10.1016/j.aquatox.2015.02.015. Epub 2015 Feb 28.


Quantitative determination of ligand densities on nanomaterials by X-ray photoelectron spectroscopy.

Torelli MD, Putans RA, Tan Y, Lohse SE, Murphy CJ, Hamers RJ.

ACS Appl Mater Interfaces. 2015 Jan 28;7(3):1720-5. doi: 10.1021/am507300x. Epub 2015 Jan 15.


Epidermal growth factor receptor targeting IgG3 triggers complement-mediated lysis of decay-accelerating factor expressing tumor cells through the alternative pathway amplification loop.

Rösner T, Lohse S, Peipp M, Valerius T, Derer S.

J Immunol. 2014 Aug 1;193(3):1485-95. doi: 10.4049/jimmunol.1400329. Epub 2014 Jun 27.


Homing peptide-conjugated gold nanorods: the effect of amino acid sequence display on nanorod uptake and cellular proliferation.

Alkilany AM, Boulos SP, Lohse SE, Thompson LB, Murphy CJ.

Bioconjug Chem. 2014 Jun 18;25(6):1162-71. doi: 10.1021/bc500174b. Epub 2014 Jun 3.


Facile method to stain the bacterial cell surface for super-resolution fluorescence microscopy.

Gunsolus IL, Hu D, Mihai C, Lohse SE, Lee CS, Torelli MD, Hamers RJ, Murhpy CJ, Orr G, Haynes CL.

Analyst. 2014 Jun 21;139(12):3174-8. doi: 10.1039/c4an00574k. Epub 2014 May 9.


Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

Brunke C, Lohse S, Derer S, Peipp M, Boross P, Kellner C, Beyer T, Dechant M, Royle L, Liew LP, Leusen JH, Valerius T.

MAbs. 2013 Nov-Dec;5(6):936-45. doi: 10.4161/mabs.26396.


Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity.

Derer S, Glorius P, Schlaeth M, Lohse S, Klausz K, Muchhal U, Desjarlais JR, Humpe A, Valerius T, Peipp M.

MAbs. 2014 Mar-Apr;6(2):409-21. doi: 10.4161/mabs.27457. Epub 2013 Dec 11.


Variation of protein corona composition of gold nanoparticles following plasmonic heating.

Mahmoudi M, Lohse SE, Murphy CJ, Fathizadeh A, Montazeri A, Suslick KS.

Nano Lett. 2014 Jan 8;14(1):6-12. doi: 10.1021/nl403419e. Epub 2013 Dec 12.


Tuning cellular response to nanoparticles via surface chemistry and aggregation.

Yang JA, Lohse SE, Murphy CJ.

Small. 2014 Apr 24;10(8):1642-51. doi: 10.1002/smll.201302835. Epub 2013 Dec 9.


Nanoparticle-protein interactions: a thermodynamic and kinetic study of the adsorption of bovine serum albumin to gold nanoparticle surfaces.

Boulos SP, Davis TA, Yang JA, Lohse SE, Alkilany AM, Holland LA, Murphy CJ.

Langmuir. 2013 Dec 3;29(48):14984-96. doi: 10.1021/la402920f. Epub 2013 Nov 20.


IgA EGFR antibodies mediate tumour killing in vivo.

Boross P, Lohse S, Nederend M, Jansen JH, van Tetering G, Dechant M, Peipp M, Royle L, Liew LP, Boon L, van Rooijen N, Bleeker WK, Parren PW, van de Winkel JG, Valerius T, Leusen JH.

EMBO Mol Med. 2013 Aug;5(8):1213-26. doi: 10.1002/emmm.201201929.


EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies.

Derer S, Lohse S, Valerius T.

Oncoimmunology. 2013 May 1;2(5):e24052.


A simple millifluidic benchtop reactor system for the high-throughput synthesis and functionalization of gold nanoparticles with different sizes and shapes.

Lohse SE, Eller JR, Sivapalan ST, Plews MR, Murphy CJ.

ACS Nano. 2013 May 28;7(5):4135-50. doi: 10.1021/nn4005022. Epub 2013 May 7.


An IgG3 switch variant of rituximab mediates enhanced complement-dependent cytotoxicity against tumour cells with low CD20 expression levels.

Rösner T, Derer S, Kellner C, Dechant M, Lohse S, Vidarsson G, Peipp M, Valerius T.

Br J Haematol. 2013 Apr;161(2):282-6. doi: 10.1111/bjh.12209. Epub 2013 Jan 7. No abstract available.


Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies.

Derer S, Bauer P, Lohse S, Scheel AH, Berger S, Kellner C, Peipp M, Valerius T.

J Immunol. 2012 Dec 1;189(11):5230-9. doi: 10.4049/jimmunol.1202037. Epub 2012 Oct 24.


Applications of colloidal inorganic nanoparticles: from medicine to energy.

Lohse SE, Murphy CJ.

J Am Chem Soc. 2012 Sep 26;134(38):15607-20. Epub 2012 Sep 17.


The gold standard: gold nanoparticle libraries to understand the nano-bio interface.

Alkilany AM, Lohse SE, Murphy CJ.

Acc Chem Res. 2013 Mar 19;46(3):650-61. doi: 10.1021/ar300015b. Epub 2012 Jun 25.


Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

Lohse S, Brunke C, Derer S, Peipp M, Boross P, Kellner C, Beyer T, Dechant M, van der Winkel JG, Leusen JH, Valerius T.

J Biol Chem. 2012 Jul 20;287(30):25139-50. doi: 10.1074/jbc.M112.353060. Epub 2012 Jun 7.


Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression.

Derer S, Berger S, Schlaeth M, Schneider-Merck T, Klausz K, Lohse S, Overdijk MB, Dechant M, Kellner C, Nagelmeier I, Scheel AH, Lammerts van Bueren JJ, van de Winkel JG, Parren PW, Peipp M, Valerius T.

Neoplasia. 2012 Mar;14(3):190-205.


Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).

Klausz K, Berger S, Lammerts van Bueren JJ, Derer S, Lohse S, Dechant M, van de Winkel JG, Peipp M, Parren PW, Valerius T.

Cancer Sci. 2011 Oct;102(10):1761-8. doi: 10.1111/j.1349-7006.2011.02019.x. Epub 2011 Aug 4.


Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.

Bakema JE, Ganzevles SH, Fluitsma DM, Schilham MW, Beelen RH, Valerius T, Lohse S, Glennie MJ, Medema JP, van Egmond M.

J Immunol. 2011 Jul 15;187(2):726-32. doi: 10.4049/jimmunol.1002581. Epub 2011 Jun 8.


Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

Lohse S, Derer S, Beyer T, Klausz K, Peipp M, Leusen JH, van de Winkel JG, Dechant M, Valerius T.

J Immunol. 2011 Mar 15;186(6):3770-8. doi: 10.4049/jimmunol.1003082. Epub 2011 Feb 11.


Interactions between natural organic matter and gold nanoparticles stabilized with different organic capping agents.

Stankus DP, Lohse SE, Hutchison JE, Nason JA.

Environ Sci Technol. 2011 Apr 15;45(8):3238-44. doi: 10.1021/es102603p. Epub 2010 Dec 16.


Validation of spontaneous abortion diagnoses in the Danish National Registry of Patients.

Lohse SR, Farkas DK, Lohse N, Skouby SO, Nielsen FE, Lash TL, Ehrenstein V.

Clin Epidemiol. 2010 Oct 27;2:247-50. doi: 10.2147/CLEP.S13815.


Impact of human IgA antibodies on complement-dependent cytotoxicity mediated by combinations of EGF-R-directed antibodies.

Lohse S, Peipp M, Beyer T, Valerius T, Dechant M.

Arch Immunol Ther Exp (Warsz). 2010 Aug;58(4):303-12. doi: 10.1007/s00005-010-0081-2. Epub 2010 May 28.


Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells.

Schlaeth M, Berger S, Derer S, Klausz K, Lohse S, Dechant M, Lazar GA, Schneider-Merck T, Peipp M, Valerius T.

Cancer Sci. 2010 May;101(5):1080-8. doi: 10.1111/j.1349-7006.2010.01505.x. Epub 2010 Jan 20.


Direct synthesis of large water-soluble functionalized gold nanoparticles using Bunte salts as ligand precursors.

Lohse SE, Dahl JA, Hutchison JE.

Langmuir. 2010 May 18;26(10):7504-11. doi: 10.1021/la904306a.


Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage.

Schneider-Merck T, Lammerts van Bueren JJ, Berger S, Rossen K, van Berkel PH, Derer S, Beyer T, Lohse S, Bleeker WK, Peipp M, Parren PW, van de Winkel JG, Valerius T, Dechant M.

J Immunol. 2010 Jan 1;184(1):512-20. doi: 10.4049/jimmunol.0900847. Epub 2009 Nov 30.


Serum-free production and purification of chimeric IgA antibodies.

Beyer T, Lohse S, Berger S, Peipp M, Valerius T, Dechant M.

J Immunol Methods. 2009 Jul 31;346(1-2):26-37. doi: 10.1016/j.jim.2009.05.002. Epub 2009 May 7.


A novel method for determining residence time distribution in intricately structured microreactors.

Lohse S, Kohnen BT, Janasek D, Dittrich PS, Franzke J, Agar DW.

Lab Chip. 2008 Mar;8(3):431-8. doi: 10.1039/b714190d. Epub 2008 Feb 14.


"Chromoplast" development in arbuscular mycorrhizal roots.

Fester T, Lohse S, Halfmann K.

Phytochemistry. 2007 Jan;68(1):92-100. Epub 2006 Nov 29.


FtsZ characterization and immunolocalization in the two phases of plastid reorganization in arbuscular mycorrhizal roots of Medicago truncatula.

Lohse S, Hause B, Hause G, Fester T.

Plant Cell Physiol. 2006 Aug;47(8):1124-34. Epub 2006 Jul 18.


Organization and metabolism of plastids and mitochondria in arbuscular mycorrhizal roots of Medicago truncatula.

Lohse S, Schliemann W, Ammer C, Kopka J, Strack D, Fester T.

Plant Physiol. 2005 Sep;139(1):329-40. Epub 2005 Aug 26.


Stimulation of carotenoid metabolism in arbuscular mycorrhizal roots.

Fester T, Schmidt D, Lohse S, Walter MH, Giuliano G, Bramley PM, Fraser PD, Hause B, Strack D.

Planta. 2002 Nov;216(1):148-54. Epub 2002 Nov 12.


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