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Items: 1 to 50 of 314

1.

Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3).

Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C.

Mol Pharmacol. 2019 May 15. pii: mol.118.115477. doi: 10.1124/mol.118.115477. [Epub ahead of print]

2.

Quantitative Single-Residue Bioorthogonal Labeling of G Protein-Coupled Receptors in Live Cells.

Serfling R, Seidel L, Bock A, Lohse MJ, Annibale P, Coin I.

ACS Chem Biol. 2019 Jun 21;14(6):1141-1149. doi: 10.1021/acschembio.8b01115. Epub 2019 May 23.

PMID:
31074969
3.

Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement.

Grushevskyi EO, Kukaj T, Schmauder R, Bock A, Zabel U, Schwabe T, Benndorf K, Lohse MJ.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10150-10155. doi: 10.1073/pnas.1900261116. Epub 2019 Apr 25.

4.

Publisher Correction: Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription.

Godbole A, Lyga S, Lohse MJ, Calebiro D.

Nat Commun. 2018 Dec 19;9(1):5459. doi: 10.1038/s41467-018-07821-7.

5.

A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.

Hommers LG, Richter J, Yang Y, Raab A, Baumann C, Lang K, Schiele MA, Weber H, Wittmann A, Wolf C, Alpers GW, Arolt V, Domschke K, Fehm L, Fydrich T, Gerlach A, Gloster AT, Hamm AO, Helbig-Lang S, Kircher T, Lang T, Pané-Farré CA, Pauli P, Pfleiderer B, Reif A, Romanos M, Straube B, Ströhle A, Wittchen HU, Frantz S, Ertl G, Lohse MJ, Lueken U, Deckert J.

Transl Psychiatry. 2018 Oct 19;8(1):226. doi: 10.1038/s41398-018-0278-4.

6.

Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.

Picard LP, Schönegge AM, Lohse MJ, Bouvier M.

Commun Biol. 2018 Aug 7;1:106. doi: 10.1038/s42003-018-0101-z. eCollection 2018.

7.

A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics.

Schihada H, Vandenabeele S, Zabel U, Frank M, Lohse MJ, Maiellaro I.

Commun Biol. 2018 Aug 7;1:105. doi: 10.1038/s42003-018-0072-0. eCollection 2018.

8.

Cyclopeptide COR-1 to treat beta1-adrenergic receptor antibody-induced heart failure.

Boivin-Jahns V, Uhland K, Holthoff HP, Beyersdorf N, Kocoski V, Kerkau T, Münch G, Lohse MJ, Ungerer M, Jahns R.

PLoS One. 2018 Aug 20;13(8):e0201160. doi: 10.1371/journal.pone.0201160. eCollection 2018.

9.

Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations.

Meral D, Provasi D, Prada-Gracia D, Möller J, Marino K, Lohse MJ, Filizola M.

Sci Rep. 2018 May 16;8(1):7705. doi: 10.1038/s41598-018-26070-8.

10.

All-optical microscope autofocus based on an electrically tunable lens and a totally internally reflected IR laser.

Bathe-Peters M, Annibale P, Lohse MJ.

Opt Express. 2018 Feb 5;26(3):2359-2368. doi: 10.1364/OE.26.002359.

11.

Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.

Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M.

J Med Chem. 2018 Feb 22;61(4):1646-1663. doi: 10.1021/acs.jmedchem.7b01760. Epub 2018 Feb 5.

PMID:
29400965
12.

Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.

Schönegge AM, Gallion J, Picard LP, Wilkins AD, Le Gouill C, Audet M, Stallaert W, Lohse MJ, Kimmel M, Lichtarge O, Bouvier M.

Nat Commun. 2017 Dec 18;8(1):2169. doi: 10.1038/s41467-017-02257-x.

13.

Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation.

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO.

FASEB J. 2018 Feb;32(2):1059-1069. doi: 10.1096/fj.201700486R. Epub 2018 Jan 3.

PMID:
29079700
14.

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.

Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D.

Nature. 2017 Oct 26;550(7677):543-547. doi: 10.1038/nature24264. Epub 2017 Oct 18.

PMID:
29045395
15.

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription.

Godbole A, Lyga S, Lohse MJ, Calebiro D.

Nat Commun. 2017 Sep 5;8(1):443. doi: 10.1038/s41467-017-00357-2. Erratum in: Nat Commun. 2018 Dec 19;9(1):5459.

16.

Increased fear learning, spatial learning as well as neophobia in Rgs2-/- mice.

Raab A, Popp S, Lesch KP, Lohse MJ, Fischer M, Deckert J, Hommers L.

Genes Brain Behav. 2018 Apr;17(4):e12420. doi: 10.1111/gbb.12420. Epub 2017 Sep 22.

PMID:
28846187
17.

Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor.

Bermudez M, Bock A, Krebs F, Holzgrabe U, Mohr K, Lohse MJ, Wolber G.

ACS Chem Biol. 2017 Jul 21;12(7):1743-1748. doi: 10.1021/acschembio.7b00275. Epub 2017 Jun 12.

PMID:
28585805
18.

Experimental and mathematical analysis of cAMP nanodomains.

Lohse C, Bock A, Maiellaro I, Hannawacker A, Schad LR, Lohse MJ, Bauer WR.

PLoS One. 2017 Apr 13;12(4):e0174856. doi: 10.1371/journal.pone.0174856. eCollection 2017.

19.

cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons.

Maiellaro I, Lohse MJ, Kittel RJ, Calebiro D.

Cell Rep. 2016 Oct 25;17(5):1238-1246. doi: 10.1016/j.celrep.2016.09.090.

20.

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.

Bock A, Bermudez M, Krebs F, Matera C, Chirinda B, Sydow D, Dallanoce C, Holzgrabe U, De Amici M, Lohse MJ, Wolber G, Mohr K.

J Biol Chem. 2016 Jul 29;291(31):16375-89. doi: 10.1074/jbc.M116.735431. Epub 2016 Jun 13.

21.

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C.

Nature. 2016 Mar 31;531(7596):661-4. doi: 10.1038/nature17198. Epub 2016 Mar 23.

22.

Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.

Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c. No abstract available.

PMID:
26845407
23.

Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles.

Lyga S, Volpe S, Werthmann RC, Götz K, Sungkaworn T, Lohse MJ, Calebiro D.

Endocrinology. 2016 Apr;157(4):1613-21. doi: 10.1210/en.2015-1945. Epub 2016 Feb 1.

PMID:
26828746
24.

Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.

Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K.

Nat Med. 2015 Nov;21(11):1298-306. doi: 10.1038/nm.3972. Epub 2015 Oct 19. Erratum in: Nat Med. 2016 Feb;22(2):217.

PMID:
26479924
25.

Single-Molecule Fluorescence Microscopy for the Analysis of Fast Receptor Dynamics.

Wagner J, Sungkaworn T, Heinze KG, Lohse MJ, Calebiro D.

Methods Mol Biol. 2015;1335:53-66. doi: 10.1007/978-1-4939-2914-6_5.

PMID:
26260594
26.

The ins and outs of adrenergic signaling.

Lohse MJ.

J Mol Med (Berl). 2015 Sep;93(9):955-62. doi: 10.1007/s00109-015-1323-x. Epub 2015 Jul 23. Review.

PMID:
26199112
27.

Spatial and Temporal Aspects of Signaling by G-Protein-Coupled Receptors.

Lohse MJ, Hofmann KP.

Mol Pharmacol. 2015 Sep;88(3):572-8. doi: 10.1124/mol.115.100248. Epub 2015 Jul 16. Review.

PMID:
26184590
28.

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

Bohn LM, Lohse MJ, Nitabach MN, Taghert PH, Smit MJ.

Mol Pharmacol. 2015 Sep;88(3):534-5. doi: 10.1124/mol.115.100750. Epub 2015 Jul 10.

PMID:
26162863
29.

MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.

Hommers L, Raab A, Bohl A, Weber H, Scholz CJ, Erhardt A, Binder E, Arolt V, Gerlach A, Gloster A, Kalisch R, Kircher T, Lonsdorf T, Ströhle A, Zwanzger P, Mattheisen M, Cichon S, Lesch KP, Domschke K, Reif A, Lohse MJ, Deckert J.

Am J Med Genet B Neuropsychiatr Genet. 2015 Jun;168B(4):296-306. doi: 10.1002/ajmg.b.32312. Epub 2015 Apr 2.

PMID:
25847876
30.

Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Müller J, Schmidt D, Kocoski V, Kerkau T, Hünig T, Ertl G, Lohse MJ, Jahns R.

PLoS One. 2015 Feb 20;10(2):e0117589. doi: 10.1371/journal.pone.0117589. eCollection 2015.

31.

Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers.

Wittmann T, Lohse MJ, Schmitt JP.

J Mol Cell Cardiol. 2015 Mar;80:90-7. doi: 10.1016/j.yjmcc.2014.12.020. Epub 2015 Jan 3.

PMID:
25562800
32.

Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy.

Holthoff HP, Goebel S, Li Z, Faßbender J, Reimann A, Zeibig S, Lohse MJ, Münch G, Ungerer M.

Endocrinology. 2015 Apr;156(4):1577-89. doi: 10.1210/en.2014-1813. Epub 2015 Jan 6.

PMID:
25562617
33.

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ.

Nat Commun. 2014 Dec 5;5:5680. doi: 10.1038/ncomms6680.

PMID:
25477193
34.

Pilot the pulse: controlling the multiplicity of receptor dynamics.

Bock A, Kostenis E, Tränkle C, Lohse MJ, Mohr K.

Trends Pharmacol Sci. 2014 Dec;35(12):630-8. doi: 10.1016/j.tips.2014.10.002. Epub 2014 Oct 31.

PMID:
25455830
35.

Trafficking and function of GPCRs in the endosomal compartment.

Calebiro D, Godbole A, Lyga S, Lohse MJ.

Methods Mol Biol. 2015;1234:197-211. doi: 10.1007/978-1-4939-1755-6_16.

PMID:
25304358
36.

High-resolution spatiotemporal analysis of receptor dynamics by single-molecule fluorescence microscopy.

Sungkaworn T, Rieken F, Lohse MJ, Calebiro D.

J Vis Exp. 2014 Jul 25;(89):e51784. doi: 10.3791/51784.

37.

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.

Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP.

Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14.

38.

Role of membrane microdomains in compartmentation of cAMP signaling.

Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD.

PLoS One. 2014 Apr 21;9(4):e95835. doi: 10.1371/journal.pone.0095835. eCollection 2014.

39.

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B.

N Engl J Med. 2014 Mar 13;370(11):1019-28. doi: 10.1056/NEJMoa1310359. Epub 2014 Feb 26.

40.

Kinetics and mechanism of G protein-coupled receptor activation.

Lohse MJ, Maiellaro I, Calebiro D.

Curr Opin Cell Biol. 2014 Apr;27:87-93. doi: 10.1016/j.ceb.2013.11.009. Epub 2013 Dec 17. Review.

PMID:
24530699
41.

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X.

Pharmacol Rev. 2014 Feb 10;66(2):413-34. doi: 10.1124/pr.113.008052. Print 2014. Review.

42.

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.

Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR.

Cell. 2014 Jan 30;156(3):456-68. doi: 10.1016/j.cell.2014.01.006.

43.

Arrestin interactions with G protein-coupled receptors.

Lohse MJ, Hoffmann C.

Handb Exp Pharmacol. 2014;219:15-56. doi: 10.1007/978-3-642-41199-1_2.

PMID:
24292823
44.

Gene amplification and functional diversification of melanocortin 4 receptor at an extremely polymorphic locus controlling sexual maturation in the platyfish.

Volff JN, Selz Y, Hoffmann C, Froschauer A, Schultheis C, Schmidt C, Zhou Q, Bernhardt W, Hanel R, Böhne A, Brunet F, Ségurens B, Couloux A, Bernard-Samain S, Barbe V, Ozouf-Costaz C, Galiana D, Lohse MJ, Schartl M.

Genetics. 2013 Dec;195(4):1337-52. doi: 10.1534/genetics.113.155952. Epub 2013 Sep 27.

45.

Time-resolved fluorescence ligand binding for G protein-coupled receptors.

Emami-Nemini A, Roux T, Leblay M, Bourrier E, Lamarque L, Trinquet E, Lohse MJ.

Nat Protoc. 2013;8(7):1307-20. doi: 10.1038/nprot.2013.073. Epub 2013 Jun 13.

PMID:
23764938
46.

Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy.

Ruppert C, Deiss K, Herrmann S, Vidal M, Oezkur M, Gorski A, Weidemann F, Lohse MJ, Lorenz K.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7440-5. doi: 10.1073/pnas.1221999110. Epub 2013 Apr 15.

47.

Cell biology: Receptor signals come in waves.

Lohse MJ, Calebiro D.

Nature. 2013 Mar 28;495(7442):457-8. doi: 10.1038/nature12086. Epub 2013 Mar 20. No abstract available.

PMID:
23515157
48.

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization.

Calebiro D, Rieken F, Wagner J, Sungkaworn T, Zabel U, Borzi A, Cocucci E, Zürn A, Lohse MJ.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):743-8. doi: 10.1073/pnas.1205798110. Epub 2012 Dec 24.

49.

Antibodies to cardiac receptors.

Boivin-Jahns V, Schlipp A, Hartmann S, Panjwani P, Klingel K, Lohse MJ, Ertl G, Jahns R.

Herz. 2012 Dec;37(8):843-8. doi: 10.1007/s00059-012-3699-5.

PMID:
23183584
50.

Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters.

Münch G, Boivin-Jahns V, Holthoff HP, Adler K, Lappo M, Truöl S, Degen H, Steiger N, Lohse MJ, Jahns R, Ungerer M.

Eur J Heart Fail. 2012 Nov;14(11):1230-9. doi: 10.1093/eurjhf/hfs118. Epub 2012 Sep 11. Erratum in: Eur J Heart Fail. 2013 Apr;15(4):478. Dosage error in article text.

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