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Items: 1 to 50 of 98

1.

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme.

Schaden LM, Wimmer-Teubenbacher M, Poms J, Laggner P, Lohner K, Sacher S, Khinast JG, Salar-Behzadi S.

Pharm Res. 2018 May 7;35(7):135. doi: 10.1007/s11095-018-2417-2.

PMID:
29736628
2.

Synergism of Antimicrobial Frog Peptides Couples to Membrane Intrinsic Curvature Strain.

Leber R, Pachler M, Kabelka I, Svoboda I, Enkoller D, Vácha R, Lohner K, Pabst G.

Biophys J. 2018 Apr 24;114(8):1945-1954. doi: 10.1016/j.bpj.2018.03.006.

3.

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.

de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, Ravensbergen E, Franken M, van der Heijde T, Boekema BK, Kwakman PHS, Kamp N, El Ghalbzouri A, Lohner K, Zaat SAJ, Drijfhout JW, Nibbering PH.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaan4044. doi: 10.1126/scitranslmed.aan4044. Erratum in: Sci Transl Med. 2018 Mar 21;10 (433):.

PMID:
29321257
4.

In vitro and in vivo cytotoxic activity of human lactoferricin derived antitumor peptide R-DIM-P-LF11-334 on human malignant melanoma.

Riedl S, Rinner B, Schaider H, Liegl-Atzwanger B, Meditz K, Preishuber-Pflügl J, Grissenberger S, Lohner K, Zweytick D.

Oncotarget. 2017 May 11;8(42):71817-71832. doi: 10.18632/oncotarget.17823. eCollection 2017 Sep 22.

5.

Rapid Targeted Genomics in Critically Ill Newborns.

van Diemen CC, Kerstjens-Frederikse WS, Bergman KA, de Koning TJ, Sikkema-Raddatz B, van der Velde JK, Abbott KM, Herkert JC, Löhner K, Rump P, Meems-Veldhuis MT, Neerincx PBT, Jongbloed JDH, van Ravenswaaij-Arts CM, Swertz MA, Sinke RJ, van Langen IM, Wijmenga C.

Pediatrics. 2017 Oct;140(4). pii: e20162854. doi: 10.1542/peds.2016-2854.

PMID:
28939701
6.

Membrane-active Antimicrobial Peptides as Template Structures for Novel Antibiotic Agents.

Lohner K.

Curr Top Med Chem. 2017;17(5):508-519. Review.

PMID:
28117020
7.

Antimicrobial Peptides Targeting Gram-Positive Bacteria.

Malanovic N, Lohner K.

Pharmaceuticals (Basel). 2016 Sep 20;9(3). pii: E59. doi: 10.3390/ph9030059. Review.

8.

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.

Lelieveld SH, Reijnders MR, Pfundt R, Yntema HG, Kamsteeg EJ, de Vries P, de Vries BB, Willemsen MH, Kleefstra T, Löhner K, Vreeburg M, Stevens SJ, van der Burgt I, Bongers EM, Stegmann AP, Rump P, Rinne T, Nelen MR, Veltman JA, Vissers LE, Brunner HG, Gilissen C.

Nat Neurosci. 2016 Sep;19(9):1194-6. doi: 10.1038/nn.4352. Epub 2016 Aug 1. Review.

PMID:
27479843
9.

Membrane-active Antimicrobial Peptides as Template Structures for Novel Antibiotic Agents.

Lohner K.

Curr Top Med Chem. 2016 Jul 13. [Epub ahead of print]

PMID:
27411329
10.

Antimicrobial peptides: Cell Membrane and Microbial Surface Interactions.

Lohner K, Hilpert K.

Biochim Biophys Acta. 2016 May;1858(5):915-7. doi: 10.1016/j.bbamem.2016.03.005. Epub 2016 Mar 8. No abstract available.

11.

Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis.

Brandenburg K, Heinbockel L, Correa W, Lohner K.

Biochim Biophys Acta. 2016 May;1858(5):971-9. doi: 10.1016/j.bbamem.2016.01.011. Epub 2016 Jan 20. Review.

12.

Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides.

Malanovic N, Lohner K.

Biochim Biophys Acta. 2016 May;1858(5):936-46. doi: 10.1016/j.bbamem.2015.11.004. Epub 2015 Nov 11. Review.

13.

Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine.

Riedl S, Leber R, Rinner B, Schaider H, Lohner K, Zweytick D.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt A):2918-31. doi: 10.1016/j.bbamem.2015.07.018. Epub 2015 Aug 1.

14.

Phospholipid-driven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems.

Malanovic N, Leber R, Schmuck M, Kriechbaum M, Cordfunke RA, Drijfhout JW, de Breij A, Nibbering PH, Kolb D, Lohner K.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2437-47. doi: 10.1016/j.bbamem.2015.07.010. Epub 2015 Jul 23.

15.

Antimicrobial activity of synthetic cationic peptides and lipopeptides derived from human lactoferricin against Pseudomonas aeruginosa planktonic cultures and biofilms.

Sánchez-Gómez S, Ferrer-Espada R, Stewart PS, Pitts B, Lohner K, Martínez de Tejada G.

BMC Microbiol. 2015 Jul 7;15:137. doi: 10.1186/s12866-015-0473-x.

16.

Optimizing rapid solvent exchange preparation of multilamellar vesicles.

Rieder AA, Koller D, Lohner K, Pabst G.

Chem Phys Lipids. 2015 Feb;186:39-44. doi: 10.1016/j.chemphyslip.2014.12.001. Epub 2014 Dec 20.

PMID:
25532812
17.

Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.

Hofbauer HF, Schopf FH, Schleifer H, Knittelfelder OL, Pieber B, Rechberger GN, Wolinski H, Gaspar ML, Kappe CO, Stadlmann J, Mechtler K, Zenz A, Lohner K, Tehlivets O, Henry SA, Kohlwein SD.

Dev Cell. 2014 Jun 23;29(6):729-39. doi: 10.1016/j.devcel.2014.04.025.

18.

The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes.

Koller D, Lohner K.

Biochim Biophys Acta. 2014 Sep;1838(9):2250-9. doi: 10.1016/j.bbamem.2014.05.013. Epub 2014 May 20. Review.

19.

Killing of melanoma cells and their metastases by human lactoferricin derivatives requires interaction with the cancer marker phosphatidylserine.

Riedl S, Rinner B, Schaider H, Lohner K, Zweytick D.

Biometals. 2014 Oct;27(5):981-97. doi: 10.1007/s10534-014-9749-0. Epub 2014 May 18.

20.

Antimicrobial mechanisms: a sponge against fungal infections.

Lohner K.

Nat Chem Biol. 2014 Jun;10(6):411-2. doi: 10.1038/nchembio.1518. Epub 2014 Apr 20.

PMID:
24747527
21.

N-acylated peptides derived from human lactoferricin perturb organization of cardiolipin and phosphatidylethanolamine in cell membranes and induce defects in Escherichia coli cell division.

Zweytick D, Japelj B, Mileykovskaya E, Zorko M, Dowhan W, Blondelle SE, Riedl S, Jerala R, Lohner K.

PLoS One. 2014 Mar 3;9(3):e90228. doi: 10.1371/journal.pone.0090228. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99324.

22.

I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.

Scheruebel S, Koyani CN, Hallström S, Lang P, Platzer D, Mächler H, Lohner K, Malle E, Zorn-Pauly K, Pelzmann B.

J Mol Cell Cardiol. 2014 Jul;72:64-73. doi: 10.1016/j.yjmcc.2014.02.010. Epub 2014 Feb 25.

23.

Scattering techniques in biology--Marking the contributions to the field from Peter Laggner on the occasion of his 68th birthday.

Pabst G, Prassl R, Amenitsch H, Rappolt M, Lohner K.

Eur Biophys J. 2012 Oct;41(10):777-929. doi: 10.1007/s00249-012-0853-1. Epub 2012 Sep 27. No abstract available.

PMID:
23015062
24.

Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.

Martínez de Tejada G, Sánchez-Gómez S, Rázquin-Olazaran I, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Lohner K, Gutsmann T, David SA, Brandenburg K.

Curr Drug Targets. 2012 Aug;13(9):1121-30.

25.

Use of X-ray scattering to aid the design and delivery of membrane-active drugs.

Pabst G, Zweytick D, Prassl R, Lohner K.

Eur Biophys J. 2012 Oct;41(10):915-29. doi: 10.1007/s00249-012-0821-9. Epub 2012 Jun 2. Review.

PMID:
22660649
26.

Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae.

Spanova M, Zweytick D, Lohner K, Klug L, Leitner E, Hermetter A, Daum G.

Biochim Biophys Acta. 2012 Apr;1821(4):647-53. doi: 10.1016/j.bbalip.2012.01.015. Epub 2012 Feb 8.

27.

Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs.

Riedl S, Zweytick D, Lohner K.

Chem Phys Lipids. 2011 Nov;164(8):766-81. doi: 10.1016/j.chemphyslip.2011.09.004. Epub 2011 Sep 16. Review.

28.

Functional characterization of codCath, the mature cathelicidin antimicrobial peptide from Atlantic cod (Gadus morhua).

Broekman DC, Zenz A, Gudmundsdottir BK, Lohner K, Maier VH, Gudmundsson GH.

Peptides. 2011 Oct;32(10):2044-51. doi: 10.1016/j.peptides.2011.09.012. Epub 2011 Sep 16.

PMID:
21945422
29.

In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy.

Riedl S, Rinner B, Asslaber M, Schaider H, Walzer S, Novak A, Lohner K, Zweytick D.

Biochim Biophys Acta. 2011 Nov;1808(11):2638-45. doi: 10.1016/j.bbamem.2011.07.026. Epub 2011 Jul 26.

30.

Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells.

Weghuber J, Aichinger MC, Brameshuber M, Wieser S, Ruprecht V, Plochberger B, Madl J, Horner A, Reipert S, Lohner K, Henics T, Schütz GJ.

Biochim Biophys Acta. 2011 Oct;1808(10):2581-90. doi: 10.1016/j.bbamem.2011.06.007. Epub 2011 Jun 28.

31.

Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides.

Zweytick D, Deutsch G, Andrä J, Blondelle SE, Vollmer E, Jerala R, Lohner K.

J Biol Chem. 2011 Jun 17;286(24):21266-76. doi: 10.1074/jbc.M110.195412. Epub 2011 Apr 22.

32.

Substrate specificity of a peptidyl-aminoacyl-L/D-isomerase from frog skin.

Jilek A, Mollay C, Lohner K, Kreil G.

Amino Acids. 2012 May;42(5):1757-64. doi: 10.1007/s00726-011-0890-6. Epub 2011 Mar 22.

33.

Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo.

Sánchez-Gómez S, Japelj B, Jerala R, Moriyón I, Fernández Alonso M, Leiva J, Blondelle SE, Andrä J, Brandenburg K, Lohner K, Martínez de Tejada G.

Antimicrob Agents Chemother. 2011 Jan;55(1):218-28. doi: 10.1128/AAC.00904-10. Epub 2010 Oct 18.

34.

Optimization and high-throughput screening of antimicrobial peptides.

Blondelle SE, Lohner K.

Curr Pharm Des. 2010;16(28):3204-11. Review.

PMID:
20687884
35.

Packing behaviour of two predominant anionic phospholipids of bacterial cytoplasmic membranes.

Prossnigg F, Hickel A, Pabst G, Lohner K.

Biophys Chem. 2010 Aug;150(1-3):129-35. doi: 10.1016/j.bpc.2010.04.004. Epub 2010 Apr 22.

36.

A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase.

Binter A, Staunig N, Jelesarov I, Lohner K, Palfey BA, Deller S, Gruber K, Macheroux P.

FEBS J. 2009 Sep;276(18):5263-74. doi: 10.1111/j.1742-4658.2009.07222.x. Epub 2009 Aug 13.

37.

New strategies for novel antibiotics: peptides targeting bacterial cell membranes.

Lohner K.

Gen Physiol Biophys. 2009 Jun;28(2):105-16. Review.

PMID:
19592707
38.

Biological activity and structural aspects of PGLa interaction with membrane mimetic systems.

Lohner K, Prossnigg F.

Biochim Biophys Acta. 2009 Aug;1788(8):1656-66. doi: 10.1016/j.bbamem.2009.05.012. Epub 2009 May 29. Review.

39.

Membrane-targeted synergistic activity of docosahexaenoic acid and lysozyme against Pseudomonas aeruginosa.

Martinez JG, Waldon M, Huang Q, Alvarez S, Oren A, Sandoval N, Du M, Zhou F, Zenz A, Lohner K, Desharnais R, Porter E.

Biochem J. 2009 Apr 1;419(1):193-200. doi: 10.1042/BJ20081505.

40.

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides.

Sánchez-Gómez S, Lamata M, Leiva J, Blondelle SE, Jerala R, Andrä J, Brandenburg K, Lohner K, Moriyón I, Martínez-de-Tejada G.

BMC Microbiol. 2008 Nov 11;8:196. doi: 10.1186/1471-2180-8-196.

41.

Serum-free transfection of CHO-cells with tailor-made unilamellar vesicles.

Reisinger H, Sevcsik E, Vorauer-Uhl K, Lohner K, Katinger H, Kunert R.

Cytotechnology. 2007 Jul;54(3):157-68. doi: 10.1007/s10616-007-9070-7. Epub 2007 Jul 13.

42.

Membrane thickening by the antimicrobial peptide PGLa.

Pabst G, Grage SL, Danner-Pongratz S, Jing W, Ulrich AS, Watts A, Lohner K, Hickel A.

Biophys J. 2008 Dec 15;95(12):5779-88. doi: 10.1529/biophysj.108.141630. Epub 2008 Oct 3.

43.

Structures of the glycine-rich diastereomeric peptides bombinin H2 and H4.

Zangger K, Gössler R, Khatai L, Lohner K, Jilek A.

Toxicon. 2008 Aug 1;52(2):246-54. doi: 10.1016/j.toxicon.2008.05.011. Epub 2008 Jun 3.

PMID:
18586045
44.

Influence of antimicrobial peptides on the formation of nonlamellar lipid mesophases.

Hickel A, Danner-Pongratz S, Amenitsch H, Degovics G, Rappolt M, Lohner K, Pabst G.

Biochim Biophys Acta. 2008 Oct;1778(10):2325-33. doi: 10.1016/j.bbamem.2008.05.014. Epub 2008 Jun 5.

45.

Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae.

Czabany T, Wagner A, Zweytick D, Lohner K, Leitner E, Ingolic E, Daum G.

J Biol Chem. 2008 Jun 20;283(25):17065-74. doi: 10.1074/jbc.M800401200. Epub 2008 Apr 22.

46.

Interaction of LL-37 with model membrane systems of different complexity: influence of the lipid matrix.

Sevcsik E, Pabst G, Richter W, Danner S, Amenitsch H, Lohner K.

Biophys J. 2008 Jun;94(12):4688-99. doi: 10.1529/biophysj.107.123620. Epub 2008 Mar 7.

47.

Membrane curvature stress and antibacterial activity of lactoferricin derivatives.

Zweytick D, Tumer S, Blondelle SE, Lohner K.

Biochem Biophys Res Commun. 2008 May 2;369(2):395-400. doi: 10.1016/j.bbrc.2008.01.176. Epub 2008 Feb 20.

PMID:
18282464
48.

Structure and thermotropic behavior of the Staphylococcus aureus lipid lysyl-dipalmitoylphosphatidylglycerol.

Danner S, Pabst G, Lohner K, Hickel A.

Biophys J. 2008 Mar 15;94(6):2150-9. Epub 2007 Nov 30.

49.

How lipids influence the mode of action of membrane-active peptides.

Sevcsik E, Pabst G, Jilek A, Lohner K.

Biochim Biophys Acta. 2007 Oct;1768(10):2586-95. Epub 2007 Jun 23.

50.

Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo.

Lohner K, Schnäbele K, Daniel H, Oesterle D, Rechkemmer G, Göttlicher M, Wenzel U.

Mol Nutr Food Res. 2007 Mar;51(3):293-300.

PMID:
17295420

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