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Items: 1 to 50 of 121

1.

Evidence for internal initiation of RNA synthesis by the Hepatitis C virus RNA-dependent RNA polymerase NS5B in cellulo.

Schult P, Nattermann M, Lauber C, Seitz S, Lohmann V.

J Virol. 2019 Jul 17. pii: JVI.00525-19. doi: 10.1128/JVI.00525-19. [Epub ahead of print]

PMID:
31315989
2.

Indelibly Stamped by Hepatitis C Virus Infection: Persistent Epigenetic Signatures Increasing Liver Cancer Risk.

Lohmann V, Bartenschlager R.

Gastroenterology. 2019 Jun;156(8):2130-2133. doi: 10.1053/j.gastro.2019.04.033. Epub 2019 Apr 26. No abstract available.

PMID:
31034828
3.

[Hepatitis C: From Individual Cure to Worldwide Elimination?]

Boettler T, Lohmann V, Bartenschlager R.

Dtsch Med Wochenschr. 2019 Apr;144(8):535-542. doi: 10.1055/a-0837-2424. Epub 2019 Apr 15. Review. German.

PMID:
30986861
4.

Inhibition of Hepatitis C Replication by Targeting the Molecular Chaperone Hsp90: Synthesis and Biological Evaluation of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole Derivatives.

Lillsunde KE, Tomašič T, Schult P, Lohmann V, Kikelj D, Tammela P.

ChemMedChem. 2019 Feb 5;14(3):334-342. doi: 10.1002/cmdc.201800724. Epub 2019 Jan 22.

PMID:
30548820
5.

SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.

Costa R, Todt D, Zapatero-Belinchón F, Schenk C, Anastasiou OE, Walker A, Hertel B, Timmer L, Bojkova D, Ruckert M, Sarrazin C, Timm J, Lohmann V, Manns MP, Steinmann E, von Hahn T, Ciesek S.

J Hepatol. 2019 Apr;70(4):603-614. doi: 10.1016/j.jhep.2018.11.012. Epub 2018 Nov 23.

PMID:
30472319
6.

Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development.

Lohmann V.

Med Microbiol Immunol. 2019 Feb;208(1):3-24. doi: 10.1007/s00430-018-0566-x. Epub 2018 Oct 8. Review.

PMID:
30298360
7.

Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation.

Schenk C, Meyrath M, Warnken U, Schnölzer M, Mier W, Harak C, Lohmann V.

J Virol. 2018 Nov 27;92(24). pii: e00737-18. doi: 10.1128/JVI.00737-18. Print 2018 Dec 15.

8.

PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases.

Delang L, Harak C, Benkheil M, Khan H, Leyssen P, Andrews M, Lohmann V, Neyts J.

J Antimicrob Chemother. 2018 Dec 1;73(12):3375-3384. doi: 10.1093/jac/dky327.

PMID:
30219827
9.

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site.

Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V.

Nat Commun. 2018 Jul 4;9(1):2613. doi: 10.1038/s41467-018-05053-3.

10.

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes.

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V.

Gastroenterology. 2018 Jun;154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. Epub 2018 Mar 11.

11.

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T.

Virus Res. 2018 Mar 15;248:53-62. doi: 10.1016/j.virusres.2018.02.016. Epub 2018 Mar 2. Review.

12.

Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis.

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A.

J Hepatol. 2018 Mar;68(3):421-430. doi: 10.1016/j.jhep.2017.10.021. Epub 2017 Nov 1.

PMID:
29100993
13.

Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells.

Klöss V, Grünvogel O, Wabnitz G, Eigenbrod T, Ehrhardt S, Lasitschka F, Lohmann V, Dalpke AH.

Front Immunol. 2017 Sep 29;8:1238. doi: 10.3389/fimmu.2017.01238. eCollection 2017.

14.

Membrane alterations induced by nonstructural proteins of human norovirus.

Doerflinger SY, Cortese M, Romero-Brey I, Menne Z, Tubiana T, Schenk C, White PA, Bartenschlager R, Bressanelli S, Hansman GS, Lohmann V.

PLoS Pathog. 2017 Oct 27;13(10):e1006705. doi: 10.1371/journal.ppat.1006705. eCollection 2017 Oct.

15.

Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis.

Stoeck IK, Lee JY, Tabata K, Romero-Brey I, Paul D, Schult P, Lohmann V, Kaderali L, Bartenschlager R.

J Virol. 2017 Dec 14;92(1). pii: e01196-17. doi: 10.1128/JVI.01196-17. Print 2018 Jan 1.

16.

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F.

Biochemistry. 2017 Jun 20;56(24):3029-3048. doi: 10.1021/acs.biochem.7b00212. Epub 2017 Jun 7.

PMID:
28535337
17.

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A.

MBio. 2017 Apr 18;8(2). pii: e00488-17. doi: 10.1128/mBio.00488-17. No abstract available.

18.

Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.

Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, Lohmann V, Koh S, Bertoletti A, Chen M.

J Virol. 2017 Apr 13;91(9). pii: e00010-17. doi: 10.1128/JVI.00010-17. Print 2017 May 1.

19.

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening.

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M.

Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. Epub 2017 Jan 26.

20.

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Florian WR, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2017 Jan 23;2:17012. doi: 10.1038/nmicrobiol.2017.12. No abstract available.

PMID:
28112725
21.

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A.

MBio. 2017 Jan 10;8(1). pii: e02150-16. doi: 10.1128/mBio.02150-16. Erratum in: MBio. 2017 Apr 18;8(2):.

22.

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2016 Dec 19;2:16247. doi: 10.1038/nmicrobiol.2016.247. Erratum in: Nat Microbiol. 2017 Jan 23;2:17012.

PMID:
27991882
23.

Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

Dorobantu CM, Harak C, Klein R, van der Linden L, Strating JR, van der Schaar HM, Lohmann V, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6. doi: 10.1128/AAC.01331-16. Print 2016 Oct.

24.

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein.

Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.

mSphere. 2016 May 11;1(3). pii: e00068-16. doi: 10.1128/mSphere.00068-16. eCollection 2016 May-Jun.

25.

Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.

Berryman S, Moffat K, Harak C, Lohmann V, Jackson T.

J Gen Virol. 2016 Aug;97(8):1841-52. doi: 10.1099/jgv.0.000485. Epub 2016 Apr 19.

26.

Type I and type II interferon responses in two human liver cell lines (Huh-7 and HuH6).

Grünvogel O, Esser-Nobis K, Windisch MP, Frese M, Trippler M, Bartenschlager R, Lohmann V, Binder M.

Genom Data. 2015 Dec 28;7:166-70. doi: 10.1016/j.gdata.2015.12.017. eCollection 2016 Mar.

27.

The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation.

Esser-Nobis K, Schmidt J, Nitschke K, Neumann-Haefelin C, Thimme R, Lohmann V.

J Hepatol. 2016 Jun;64(6):1305-14. doi: 10.1016/j.jhep.2016.02.027. Epub 2016 Feb 26.

PMID:
26921685
28.

Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus.

Dorobantu CM, Albulescu L, Harak C, Feng Q, van Kampen M, Strating JR, Gorbalenya AE, Lohmann V, van der Schaar HM, van Kuppeveld FJ.

PLoS Pathog. 2015 Sep 25;11(9):e1005185. doi: 10.1371/journal.ppat.1005185. eCollection 2015 Sep.

29.

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture.

Grünvogel O, Esser-Nobis K, Reustle A, Schult P, Müller B, Metz P, Trippler M, Windisch MP, Frese M, Binder M, Fackler O, Bartenschlager R, Ruggieri A, Lohmann V.

J Virol. 2015 Oct;89(20):10548-68. doi: 10.1128/JVI.01297-15. Epub 2015 Aug 12.

30.

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication.

Romero-Brey I, Berger C, Kallis S, Kolovou A, Paul D, Lohmann V, Bartenschlager R.

MBio. 2015 Jul 7;6(4):e00759. doi: 10.1128/mBio.00759-15.

31.

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R.

J Hepatol. 2015 Oct;63(4):829-37. doi: 10.1016/j.jhep.2015.04.015. Epub 2015 Apr 20.

32.

Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication.

Esser-Nobis K, Harak C, Schult P, Kusov Y, Lohmann V.

Hepatology. 2015 Aug;62(2):397-408. doi: 10.1002/hep.27847. Epub 2015 May 20.

PMID:
25866017
33.

Ultrastructure of the replication sites of positive-strand RNA viruses.

Harak C, Lohmann V.

Virology. 2015 May;479-480:418-33. doi: 10.1016/j.virol.2015.02.029. Epub 2015 Mar 6. Review.

34.

Identification of HNRNPK as regulator of hepatitis C virus particle production.

Poenisch M, Metz P, Blankenburg H, Ruggieri A, Lee JY, Rupp D, Rebhan I, Diederich K, Kaderali L, Domingues FS, Albrecht M, Lohmann V, Erfle H, Bartenschlager R.

PLoS Pathog. 2015 Jan 8;11(1):e1004573. doi: 10.1371/journal.ppat.1004573. eCollection 2015 Jan.

35.

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R.

Gastroenterology. 2014 Nov;147(5):1094-105.e25. doi: 10.1053/j.gastro.2014.07.019. Epub 2014 Jul 18.

36.

Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.

Harak C, Radujkovic D, Taveneau C, Reiss S, Klein R, Bressanelli S, Lohmann V.

J Virol. 2014 Sep 1;88(17):9909-26. doi: 10.1128/JVI.01063-14. Epub 2014 Jun 11.

37.

Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.

Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R.

J Hepatol. 2014 Sep;61(3):538-43. doi: 10.1016/j.jhep.2014.05.043. Epub 2014 Jun 4.

PMID:
24905492
38.

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

Wuestenberg A, Kah J, Singethan K, Sirma H, Keller AD, Rosal SR, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse AW, Tiegs G, Sass G.

PLoS One. 2014 May 6;9(5):e96533. doi: 10.1371/journal.pone.0096533. eCollection 2014.

39.

Monocytes activate natural killer cells via inflammasome-induced interleukin 18 in response to hepatitis C virus replication.

Serti E, Werner JM, Chattergoon M, Cox AL, Lohmann V, Rehermann B.

Gastroenterology. 2014 Jul;147(1):209-220.e3. doi: 10.1053/j.gastro.2014.03.046. Epub 2014 Mar 28.

40.

Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation.

Madan V, Paul D, Lohmann V, Bartenschlager R.

Gastroenterology. 2014 May;146(5):1361-72.e1-9. doi: 10.1053/j.gastro.2014.01.055. Epub 2014 Jan 31.

PMID:
24486951
41.

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor.

Nkongolo S, Ni Y, Lempp FA, Kaufman C, Lindner T, Esser-Nobis K, Lohmann V, Mier W, Mehrle S, Urban S.

J Hepatol. 2014 Apr;60(4):723-31. doi: 10.1016/j.jhep.2013.11.022. Epub 2013 Dec 1.

PMID:
24295872
42.

On the history of hepatitis C virus cell culture systems.

Lohmann V, Bartenschlager R.

J Med Chem. 2014 Mar 13;57(5):1627-42. doi: 10.1021/jm401401n. Epub 2013 Nov 21. Review.

PMID:
24164647
43.

Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle.

Binder M, Sulaimanov N, Clausznitzer D, Schulze M, Hüber CM, Lenz SM, Schlöder JP, Trippler M, Bartenschlager R, Lohmann V, Kaderali L.

PLoS Pathog. 2013;9(8):e1003561. doi: 10.1371/journal.ppat.1003561. Epub 2013 Aug 22.

44.

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.

Bartenschlager R, Lohmann V, Penin F.

Nat Rev Microbiol. 2013 Jul;11(7):482-96. doi: 10.1038/nrmicro3046. Epub 2013 Jun 10. Review.

PMID:
23748342
45.

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V.

PLoS Pathog. 2013 May;9(5):e1003359. doi: 10.1371/journal.ppat.1003359. Epub 2013 May 9.

46.

Hepatitis C virus RNA replication.

Lohmann V.

Curr Top Microbiol Immunol. 2013;369:167-98. doi: 10.1007/978-3-642-27340-7_7. Review.

PMID:
23463201
47.

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V.

Hepatology. 2013 Mar;57(3):953-63. doi: 10.1002/hep.26260. Epub 2013 Feb 7.

48.

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.

Schmidt J, Iversen AK, Tenzer S, Gostick E, Price DA, Lohmann V, Distler U, Bowness P, Schild H, Blum HE, Klenerman P, Neumann-Haefelin C, Thimme R.

PLoS Pathog. 2012;8(11):e1003042. doi: 10.1371/journal.ppat.1003042. Epub 2012 Nov 29.

49.

Hepatitis C virus replicons volume 3 and 4.

Lohmann V, Bartenschlager R.

Gastroenterology. 2013 Jan;144(1):13-5. doi: 10.1053/j.gastro.2012.11.013. Epub 2012 Nov 16. No abstract available.

PMID:
23164572
50.

Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo.

Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R.

Gastroenterology. 2013 Feb;144(2):426-36. doi: 10.1053/j.gastro.2012.10.047. Epub 2012 Nov 7.

PMID:
23142136

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