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Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.

Gambaryan S, Kobsar A, Rukoyatkina N, Herterich S, Geiger J, Smolenski A, Lohmann SM, Walter U.

J Biol Chem. 2010 Jun 11;285(24):18352-63. doi: 10.1074/jbc.M109.077602. Epub 2010 Mar 31.


NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity.

Gambaryan S, Kobsar A, Hartmann S, Birschmann I, Kuhlencordt PJ, Müller-Esterl W, Lohmann SM, Walter U.

J Thromb Haemost. 2008 Aug;6(8):1376-84. doi: 10.1111/j.1538-7836.2008.03014.x. Epub 2008 May 14.


Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte.

Das A, Smolenski A, Lohmann SM, Kukreja RC.

J Biol Chem. 2006 Dec 15;281(50):38644-52. Epub 2006 Oct 12.


cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes.

Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM, Wollert KC.

J Biol Chem. 2006 Oct 27;281(43):32831-40. Epub 2006 Aug 29.


Tracking functions of cGMP-dependent protein kinases (cGK).

Lohmann SM, Walter U.

Front Biosci. 2005 May 1;10:1313-28. Review.


cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.

Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M.

J Biol Chem. 2005 Apr 29;280(17):16642-50. Epub 2005 Feb 18.


Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins.

Wang HG, Lu FM, Jin I, Udo H, Kandel ER, de Vente J, Walter U, Lohmann SM, Hawkins RD, Antonova I.

Neuron. 2005 Feb 3;45(3):389-403.


MKP-1 expression and stabilization and cGK Ialpha prevent diabetes- associated abnormalities in VSMC migration.

Jacob A, Smolenski A, Lohmann SM, Begum N.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C1077-86.


Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes.

Tongers J, Fiedler B, König D, Kempf T, Klein G, Heineke J, Kraft T, Gambaryan S, Lohmann SM, Drexler H, Wollert KC.

Cardiovasc Res. 2004 Aug 15;63(3):545-52.


Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling.

Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM.

Genomics. 2004 Apr;83(4):577-87.


Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice.

Feil R, Lohmann SM, de Jonge H, Walter U, Hofmann F.

Circ Res. 2003 Nov 14;93(10):907-16. Review.


Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice.

Schröder F, Klein G, Fiedler B, Bastein M, Schnasse N, Hillmer A, Ames S, Gambaryan S, Drexler H, Walter U, Lohmann SM, Wollert KC.

Cardiovasc Res. 2003 Nov 1;60(2):268-77.


Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I.

Wollert KC, Yurukova S, Kilic A, Begrow F, Fiedler B, Gambaryan S, Walter U, Lohmann SM, Kuhn M.

Br J Pharmacol. 2003 Dec;140(7):1227-36. Epub 2003 Nov 10.


Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected].

Münzel T, Feil R, Mülsch A, Lohmann SM, Hofmann F, Walter U.

Circulation. 2003 Nov 4;108(18):2172-83. Review. No abstract available. Erratum in: Circulation. 2003 Dec 23;108(25):3165.


Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy.

Heineke J, Kempf T, Kraft T, Hilfiker A, Morawietz H, Scheubel RJ, Caroni P, Lohmann SM, Drexler H, Wollert KC.

Circulation. 2003 Mar 18;107(10):1424-32.


Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.

Fiedler B, Lohmann SM, Smolenski A, Linnemuller S, Pieske B, Schroder F, Molkentin JD, Drexler H, Wollert KC.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11363-8. Epub 2002 Aug 12.


Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.

Jacob A, Molkentin JD, Smolenski A, Lohmann SM, Begum N.

Am J Physiol Cell Physiol. 2002 Sep;283(3):C704-13.


Inhibition of cGMP-dependent protein kinase II by its own splice isoform.

Gambaryan S, Palmetshofer A, Glazova M, Smolenski A, Kristjansson GI, Zimmer M, Lohmann SM.

Biochem Biophys Res Commun. 2002 May 24;293(5):1438-44.


Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice.

Pierkes M, Gambaryan S, Bokník P, Lohmann SM, Schmitz W, Potthast R, Holtwick R, Kuhn M.

Cardiovasc Res. 2002 Mar;53(4):852-61.


Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.

Wollert KC, Fiedler B, Gambaryan S, Smolenski A, Heineke J, Butt E, Trautwein C, Lohmann SM, Drexler H.

Hypertension. 2002 Jan;39(1):87-92.


Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A.

J Biol Chem. 2002 Feb 22;277(8):6214-22. Epub 2001 Dec 5.


Localization of cGMP-dependent protein kinase type II in rat brain.

de Vente J, Asan E, Gambaryan S, Markerink-van Ittersum M, Axer H, Gallatz K, Lohmann SM, Palkovits M.

Neuroscience. 2001;108(1):27-49.


Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle.

Hanada S, Terada Y, Inoshita S, Sasaki S, Lohmann SM, Smolenski A, Marumo F.

Am J Physiol Renal Physiol. 2001 May;280(5):F851-9.


Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation.

Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS, Hawkins RD.

J Neurosci. 2001 Jan 1;21(1):143-9.


Activation of cGMP-dependent protein kinase Ibeta inhibits interleukin 2 release and proliferation of T cell receptor-stimulated human peripheral T cells.

Fischer TA, Palmetshofer A, Gambaryan S, Butt E, Jassoy C, Walter U, Sopper S, Lohmann SM.

J Biol Chem. 2001 Feb 23;276(8):5967-74. Epub 2000 Nov 9.


Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.

Smolenski A, Poller W, Walter U, Lohmann SM.

J Biol Chem. 2000 Aug 18;275(33):25723-32.


Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle.

Sauzeau V, Le Jeune H, Cario-Toumaniantz C, Smolenski A, Lohmann SM, Bertoglio J, Chardin P, Pacaud P, Loirand G.

J Biol Chem. 2000 Jul 14;275(28):21722-9.


Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases.

Butt E, Bernhardt M, Smolenski A, Kotsonis P, Fröhlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH.

J Biol Chem. 2000 Feb 18;275(7):5179-87.


Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase.

Gudi T, Hong GK, Vaandrager AB, Lohmann SM, Pilz RB.

FASEB J. 1999 Dec;13(15):2143-52.


Atrial natriuretic peptide-stimulated Ca2+ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II.

Hoenderop JG, Vaandrager AB, Dijkink L, Smolenski A, Gambaryan S, Lohmann SM, de Jonge HR, Willems PH, Bindels RJ.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6084-9.


Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression.

Eigenthaler M, Lohmann SM, Walter U, Pilz RB.

Rev Physiol Biochem Pharmacol. 1999;135:173-209. Review. No abstract available.


Mitosis-specific phosphorylation and subcellular redistribution of the RIIalpha regulatory subunit of cAMP-dependent protein kinase.

Keryer G, Yassenko M, Labbé JC, Castro A, Lohmann SM, Evain-Brion D, Taskén K.

J Biol Chem. 1998 Dec 18;273(51):34594-602.


Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway.

Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB.

Mol Cell Biol. 1998 Dec;18(12):6983-94.


Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects.

Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):134-9. Review.


Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells.

Gambaryan S, Wagner C, Smolenski A, Walter U, Poller W, Haase W, Kurtz A, Lohmann SM.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9003-8.


Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.

Vaandrager AB, Smolenski A, Tilly BC, Houtsmuller AB, Ehlert EM, Bot AG, Edixhoven M, Boomaars WE, Lohmann SM, de Jonge HR.

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1466-71.


Distinct and specific functions of cGMP-dependent protein kinases.

Lohmann SM, Vaandrager AB, Smolenski A, Walter U, De Jonge HR.

Trends Biochem Sci. 1997 Aug;22(8):307-12. Review.


cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta.

Vaandrager AB, Tilly BC, Smolenski A, Schneider-Rasp S, Bot AG, Edixhoven M, Scholte BJ, Jarchau T, Walter U, Lohmann SM, Poller WC, de Jonge HR.

J Biol Chem. 1997 Feb 14;272(7):4195-200.


Structural order of the slow and fast intrasubunit cGMP-binding sites of type I alpha cGMP-dependent protein kinase.

Reed RB, Sandberg M, Jahnsen T, Lohmann SM, Francis SH, Corbin JD.

Adv Second Messenger Phosphoprotein Res. 1997;31:205-17. No abstract available.


Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.

Gambaryan S, Häusler C, Markert T, Pöhler D, Jarchau T, Walter U, Haase W, Kurtz A, Lohmann SM.

J Clin Invest. 1996 Aug 1;98(3):662-70.


Fast and slow cyclic nucleotide-dissociation sites in cAMP-dependent protein kinase are transposed in type Ibeta cGMP-dependent protein kinase.

Reed RB, Sandberg M, Jahnsen T, Lohmann SM, Francis SH, Corbin JD.

J Biol Chem. 1996 Jul 19;271(29):17570-5.


Retinoylation of the type II cAMP-binding regulatory subunit of cAMP-dependent protein kinase is increased in psoriatic human fibroblasts.

Tournier S, Raynaud F, Gerbaud P, Lohmann SM, Anderson WB, Evain-Brion D.

J Cell Physiol. 1996 May;167(2):196-203.


N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.

Vaandrager AB, Ehlert EM, Jarchau T, Lohmann SM, de Jonge HR.

J Biol Chem. 1996 Mar 22;271(12):7025-9.


Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter.

Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB.

J Biol Chem. 1996 Mar 1;271(9):4597-600.


Regulation of olfactory signalling via cGMP-dependent protein kinase.

Kroner C, Boekhoff I, Lohmann SM, Genieser HG, Breer H.

Eur J Biochem. 1996 Mar 1;236(2):632-7.


Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.

Kwak BR, Hermans MM, De Jonge HR, Lohmann SM, Jongsma HJ, Chanson M.

Mol Biol Cell. 1995 Dec;6(12):1707-19.


Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system.

Pöhler D, Butt E, Meissner J, Müller S, Lohse M, Walter U, Lohmann SM, Jarchau T.

FEBS Lett. 1995 Nov 6;374(3):419-25.

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