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Items: 34

1.

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7.

2.

Inhibition of a viral prolyl hydroxylase.

Langley GW, Abboud MI, Lohans CT, Schofield CJ.

Bioorg Med Chem. 2019 Jan 23. pii: S0968-0896(18)31936-9. doi: 10.1016/j.bmc.2019.01.018. [Epub ahead of print]

PMID:
30737136
3.

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants.

Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1990-1994. doi: 10.1002/anie.201809424. Epub 2019 Jan 21.

4.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.

Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield CJ.

Chemistry. 2019 Feb 6;25(8):2019-2024. doi: 10.1002/chem.201804790. Epub 2019 Jan 8.

PMID:
30427558
5.

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis.

Rabe P, Kamps JJAG, Schofield CJ, Lohans CT.

Nat Prod Rep. 2018 Aug 15;35(8):735-756. doi: 10.1039/c8np00002f. Review.

6.

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ.

Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.

7.

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1282-1285. doi: 10.1002/anie.201711308. Epub 2018 Jan 5.

8.

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

Lohans CT, Brem J, Schofield CJ.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01224-17. doi: 10.1128/AAC.01224-17. Print 2017 Dec. No abstract available.

9.

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB.

Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21.

10.

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.

Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ.

Org Biomol Chem. 2017 Jul 19;15(28):6024-6032. doi: 10.1039/c7ob01514c.

PMID:
28678295
11.

IFPTarget: A Customized Virtual Target Identification Method Based on Protein-Ligand Interaction Fingerprinting Analyses.

Li GB, Yu ZJ, Liu S, Huang LY, Yang LL, Lohans CT, Yang SY.

J Chem Inf Model. 2017 Jul 24;57(7):1640-1651. doi: 10.1021/acs.jcim.7b00225. Epub 2017 Jul 10.

PMID:
28661143
12.

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ.

Chem Commun (Camb). 2017 May 30;53(43):5806-5809. doi: 10.1039/c7cc02394d.

13.

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors.

Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ.

Chem Sci. 2017 Feb 1;8(2):928-937. doi: 10.1039/c6sc04524c. Epub 2016 Dec 14.

14.

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4667-4672. doi: 10.1073/pnas.1617760114. Epub 2017 Apr 18.

15.

Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria.

Acedo JZ, Towle KM, Lohans CT, Miskolzie M, McKay RT, Doerksen TA, Vederas JC, Martin-Visscher LA.

FEBS Lett. 2017 May;591(10):1349-1359. doi: 10.1002/1873-3468.12648. Epub 2017 Apr 27.

16.

Cyclic Boronates Inhibit All Classes of β-Lactamases.

Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02260-16. doi: 10.1128/AAC.02260-16. Print 2017 Apr.

17.

Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from Staphylococcus aureus.

Towle KM, Lohans CT, Miskolzie M, Acedo JZ, van Belkum MJ, Vederas JC.

Biochemistry. 2016 Aug 30;55(34):4798-806. doi: 10.1021/acs.biochem.6b00615. Epub 2016 Aug 15.

18.

Draft Genome Sequence of the Bacteriocin-Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subsp. fulvus).

Arbulu S, Frantzen C, Lohans CT, Cintas LM, Herranz C, Holo H, Diep DB, Vederas JC, Hernández PE.

Genome Announc. 2016 Mar 24;4(2). pii: e00055-16. doi: 10.1128/genomeA.00055-16.

19.

Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.

Acedo JZ, van Belkum MJ, Lohans CT, Towle KM, Miskolzie M, Vederas JC.

Biochemistry. 2016 Feb 2;55(4):733-42. doi: 10.1021/acs.biochem.5b01306. Epub 2016 Jan 15.

PMID:
26771761
20.

Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31.

Arbulu S, Lohans CT, van Belkum MJ, Cintas LM, Herranz C, Vederas JC, Hernández PE.

J Agric Food Chem. 2015 Dec 16;63(49):10689-95. doi: 10.1021/acs.jafc.5b03882. Epub 2015 Dec 1.

PMID:
26585399
21.

Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria.

Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC.

Org Biomol Chem. 2015 Jun 7;13(21):6073-81. doi: 10.1039/c5ob00780a.

PMID:
25959079
22.
23.

Solution structure of acidocin B, a circular bacteriocin produced by Lactobacillus acidophilus M46.

Acedo JZ, van Belkum MJ, Lohans CT, McKay RT, Miskolzie M, Vederas JC.

Appl Environ Microbiol. 2015 Apr;81(8):2910-8. doi: 10.1128/AEM.04265-14. Epub 2015 Feb 13.

24.

Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri.

Lin XB, Lohans CT, Duar R, Zheng J, Vederas JC, Walter J, Gänzle M.

Appl Environ Microbiol. 2015 Mar;81(6):2032-41. doi: 10.1128/AEM.03691-14. Epub 2015 Jan 9.

25.

Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids.

Lohans CT, Li JL, Vederas JC.

J Am Chem Soc. 2014 Sep 24;136(38):13150-3. doi: 10.1021/ja5070813. Epub 2014 Sep 10.

PMID:
25207953
26.

Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1).

Cochrane SA, Lohans CT, Brandelli JR, Mulvey G, Armstrong GD, Vederas JC.

J Med Chem. 2014 Feb 13;57(3):1127-31. doi: 10.1021/jm401779d. Epub 2014 Jan 30.

PMID:
24479847
27.

Purification and characterization of antimicrobial peptides from fish isolate Carnobacterium maltaromaticum C2: Carnobacteriocin X and carnolysins A1 and A2.

Tulini FL, Lohans CT, Bordon KC, Zheng J, Arantes EC, Vederas JC, De Martinis EC.

Int J Food Microbiol. 2014 Mar 3;173:81-8. doi: 10.1016/j.ijfoodmicro.2013.12.019. Epub 2013 Dec 28.

PMID:
24412962
28.

Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni.

Lohans CT, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC.

Chembiochem. 2014 Jan 24;15(2):243-9. doi: 10.1002/cbic.201300595. Epub 2013 Dec 30.

PMID:
24382692
29.

Structural characterization of thioether-bridged bacteriocins.

Lohans CT, Vederas JC.

J Antibiot (Tokyo). 2014 Jan;67(1):23-30. doi: 10.1038/ja.2013.81. Epub 2013 Sep 11. Review.

PMID:
24022605
30.

Solution structures of the linear leaderless bacteriocins enterocin 7A and 7B resemble carnocyclin A, a circular antimicrobial peptide.

Lohans CT, Towle KM, Miskolzie M, McKay RT, van Belkum MJ, McMullen LM, Vederas JC.

Biochemistry. 2013 Jun 11;52(23):3987-94. doi: 10.1021/bi400359z. Epub 2013 May 31.

PMID:
23725536
31.

Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy.

Lohans CT, Huang Z, van Belkum MJ, Giroud M, Sit CS, Steels EM, Zheng J, Whittal RM, McMullen LM, Vederas JC.

J Am Chem Soc. 2012 Dec 5;134(48):19540-3. doi: 10.1021/ja3089229. Epub 2012 Nov 20.

PMID:
23167271
32.

Development of Class IIa Bacteriocins as Therapeutic Agents.

Lohans CT, Vederas JC.

Int J Microbiol. 2012;2012:386410. doi: 10.1155/2012/386410. Epub 2011 Nov 30.

33.

Substitution of a conserved disulfide in the type IIa bacteriocin, leucocin A, with L-leucine and L-serine residues: effects on activity and three-dimensional structure.

Sit CS, Lohans CT, van Belkum MJ, Campbell CD, Miskolzie M, Vederas JC.

Chembiochem. 2012 Jan 2;13(1):35-8. doi: 10.1002/cbic.201100634. Epub 2011 Nov 25. No abstract available.

PMID:
22121114
34.

The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against gram-negative bacteria in combination with EDTA treatment.

Martin-Visscher LA, Yoganathan S, Sit CS, Lohans CT, Vederas JC.

FEMS Microbiol Lett. 2011 Apr;317(2):152-9. doi: 10.1111/j.1574-6968.2011.02223.x. Epub 2011 Feb 7.

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