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Items: 1 to 50 of 217

1.

Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-αl variants in embryonic mouse brain.

Xiao L, Yang X, Sharma VK, Loh YP.

FASEB J. 2018 Jul 31:fj201800359R. doi: 10.1096/fj.201800359R. [Epub ahead of print]

PMID:
30063439
2.

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.

Yan T, Ooi WF, Qamra A, Cheung A, Ma D, Sundaram GM, Xu C, Xing M, Poon L, Wang J, Loh YP, Ho JHJ, Ng JJQ, Ramlee MK, Aswad L, Rozen SG, Ghosh S, Bard FA, Sampath P, Tergaonkar V, Davies JOJ, Hughes JR, Goh E, Bi X, Fullwood MJ, Tan P, Li S.

Nat Commun. 2018 Jan 8;9(1):100. doi: 10.1038/s41467-017-02601-1.

3.

Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes.

Jonklaas J, Murthy S, Liu D, Klubo-Gwiezdzinska J, Krishnan J, Burman KD, Boyle L, Carrol N, Felger E, Loh YP.

Future Sci OA. 2017 Sep 22;4(1):FSO249. doi: 10.4155/fsoa-2017-0087. eCollection 2018 Jan.

4.

A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.

Cong L, Cheng Y, Cawley NX, Murthy SR, Loh YP.

PLoS One. 2017 Jan 23;12(1):e0170169. doi: 10.1371/journal.pone.0170169. eCollection 2017.

5.

A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.

Qin XY, Wu HT, Cao C, Loh YP, Cheng Y.

Mol Psychiatry. 2017 Sep;22(9):1306-1312. doi: 10.1038/mp.2016.235. Epub 2017 Jan 10.

PMID:
28070123
6.

A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.

Cheng Y, Cawley NX, Yanik T, Murthy SR, Liu C, Kasikci F, Abebe D, Loh YP.

Transl Psychiatry. 2016 Dec 6;6(12):e973. doi: 10.1038/tp.2016.237.

7.

Neurotrophic Factor-α1: A Key Wnt-β-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic Neural Stem Cell Differentiation to Astrocytes in Neurodevelopment.

Selvaraj P, Xiao L, Lee C, Murthy SR, Cawley NX, Lane M, Merchenthaler I, Ahn S, Loh YP.

Stem Cells. 2017 Mar;35(3):557-571. doi: 10.1002/stem.2511. Epub 2016 Oct 26.

8.

The Chromogranin A-derived sympathomimetic serpinin depresses myocardial performance in teleost and amphibian hearts.

Imbrogno S, Mazza R, Pugliese C, Filice M, Angelone T, Loh YP, Tota B, Cerra MC.

Gen Comp Endocrinol. 2017 Jan 1;240:1-9. doi: 10.1016/j.ygcen.2016.09.004. Epub 2016 Sep 12.

PMID:
27633326
9.

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.

Qin XY, Zhang SP, Cao C, Loh YP, Cheng Y.

JAMA Neurol. 2016 Nov 1;73(11):1316-1324. doi: 10.1001/jamaneurol.2016.2742. Review.

PMID:
27668667
10.

Association of Peripheral Blood Levels of Brain-Derived Neurotrophic Factor With Autism Spectrum Disorder in Children: A Systematic Review and Meta-analysis.

Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y.

JAMA Pediatr. 2016 Nov 1;170(11):1079-1086. doi: 10.1001/jamapediatrics.2016.1626. Review.

PMID:
27654278
11.

Neuroprotective effects of LMW and HMW FGF2 against amyloid beta toxicity in primary cultured hippocampal neurons.

Cheng Y, Li Z, Kardami E, Loh YP.

Neurosci Lett. 2016 Oct 6;632:109-13. doi: 10.1016/j.neulet.2016.08.031. Epub 2016 Aug 18.

12.

Neuroserpin Attenuates H2O2-Induced Oxidative Stress in Hippocampal Neurons via AKT and BCL-2 Signaling Pathways.

Cheng Y, Loh YP, Birch NP.

J Mol Neurosci. 2017 Jan;61(1):123-131. doi: 10.1007/s12031-016-0807-7. Epub 2016 Aug 11.

PMID:
27510267
13.

Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.

Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K, Rosin-Arbesfeld R.

Oncogene. 2016 Dec 15;35(50):6416-6428. doi: 10.1038/onc.2016.173. Epub 2016 Jul 4.

PMID:
27375026
14.

Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277).

Qin XY, Cao C, Cawley NX, Liu TT, Yuan J, Loh YP, Cheng Y.

Mol Psychiatry. 2017 Feb;22(2):312-320. doi: 10.1038/mp.2016.62. Epub 2016 Apr 26.

PMID:
27113997
15.

60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.

Cawley NX, Li Z, Loh YP.

J Mol Endocrinol. 2016 May;56(4):T77-97. doi: 10.1530/JME-15-0323. Epub 2016 Feb 15. Review.

16.

Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma.

Huang SF, Wu HD, Chen YT, Murthy SR, Chiu YT, Chang Y, Chang IC, Yang X, Loh YP.

Tumour Biol. 2016 Jul;37(7):9745-53. doi: 10.1007/s13277-016-4814-7. Epub 2016 Jan 23.

PMID:
26803519
17.

Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells.

Cawley NX, Rathod T, Young S, Lou H, Birch N, Loh YP.

Mol Endocrinol. 2016 Jan;30(1):37-47. doi: 10.1210/me.2015-1166. Epub 2015 Dec 8.

18.

Neurotrophic factor-α1 modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons.

Selvaraj P, Huang JS, Chen A, Skalka N, Rosin-Arbesfeld R, Loh YP.

Mol Cell Neurosci. 2015 Sep;68:222-33. doi: 10.1016/j.mcn.2015.08.005. Epub 2015 Aug 11.

PMID:
26276171
19.

Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection.

Thouennon E, Cheng Y, Falahatian V, Cawley NX, Loh YP.

J Neurochem. 2015 Aug;134(3):463-70. doi: 10.1111/jnc.13152. Epub 2015 Jun 1.

20.

carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.

Qin XY, Cheng Y, Murthy SR, Selvaraj P, Loh YP.

PLoS One. 2014 Nov 26;9(11):e112996. doi: 10.1371/journal.pone.0112996. eCollection 2014.

21.

Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.

Cheng Y, Rodriguiz RM, Murthy SR, Senatorov V, Thouennon E, Cawley NX, Aryal DK, Ahn S, Lecka-Czernik B, Wetsel WC, Loh YP.

Mol Psychiatry. 2015 Jun;20(6):744-54. doi: 10.1038/mp.2014.136. Epub 2014 Oct 21.

22.

Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection.

Cheng Y, Cawley NX, Loh YP.

Neurosci Bull. 2014 Aug;30(4):692-6. doi: 10.1007/s12264-013-1430-z. Epub 2014 Apr 1. Review.

23.

Carboxypeptidase E/NFα1: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways.

Cheng Y, Cawley NX, Loh YP.

PLoS One. 2013 Aug 15;8(8):e71578. doi: 10.1371/journal.pone.0071578. eCollection 2013.

24.

Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.

Murthy SRK, Dupart E, Al-Sweel N, Chen A, Cawley NX, Loh YP.

Cancer Lett. 2013 Dec 1;341(2):204-13. doi: 10.1016/j.canlet.2013.08.011. Epub 2013 Aug 11.

25.

Carboxypeptidase E protects hippocampal neurons during stress in male mice by up-regulating prosurvival BCL2 protein expression.

Murthy SR, Thouennon E, Li WS, Cheng Y, Bhupatkar J, Cawley NX, Lane M, Merchenthaler I, Loh YP.

Endocrinology. 2013 Sep;154(9):3284-93. doi: 10.1210/en.2013-1118. Epub 2013 Jul 3.

26.

The molecular profiles of neural stem cell niche in the adult subventricular zone.

Lee C, Hu J, Ralls S, Kitamura T, Loh YP, Yang Y, Mukouyama YS, Ahn S.

PLoS One. 2012;7(11):e50501. doi: 10.1371/journal.pone.0050501. Epub 2012 Nov 29.

27.

A new chromogranin A-dependent angiogenic switch activated by thrombin.

Crippa L, Bianco M, Colombo B, Gasparri AM, Ferrero E, Loh YP, Curnis F, Corti A.

Blood. 2013 Jan 10;121(2):392-402. doi: 10.1182/blood-2012-05-430314. Epub 2012 Nov 27.

28.

Cellular mechanisms for the biogenesis and transport of synaptic and dense-core vesicles.

Gondré-Lewis MC, Park JJ, Loh YP.

Int Rev Cell Mol Biol. 2012;299:27-115. doi: 10.1016/B978-0-12-394310-1.00002-3. Review.

PMID:
22959301
29.

Serpinins: role in granule biogenesis, inhibition of cell death and cardiac function.

Loh YP, Koshimizu H, Cawley NX, Tota B.

Curr Med Chem. 2012;19(24):4086-92.

30.

Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.

Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R.

Oncogene. 2013 Jun 6;32(23):2836-47. doi: 10.1038/onc.2012.308. Epub 2012 Jul 23.

31.

γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus.

Lou H, Park JJ, Phillips A, Loh YP.

J Mol Neurosci. 2013 Jan;49(1):1-10. doi: 10.1007/s12031-012-9827-0. Epub 2012 Jun 17.

32.

Commentary: granins, secretory granule biogenesis, and transport.

Loh YP, Corti A.

J Mol Neurosci. 2012 Oct;48(2):315-6. No abstract available.

PMID:
22614097
33.

Proceedings of the 16th International Symposium on Chromaffin Cell Biology.

Loh YP, Zhou Z, Kao LS.

J Mol Neurosci. 2012 Oct;48(2):313-4. No abstract available.

PMID:
22588979
34.

Commentary: neurotransmitter secretion and cell signaling.

Kao LS, Loh YP.

J Mol Neurosci. 2012 Oct;48(2):427-8. No abstract available.

PMID:
22588978
35.

Commentary: ion channels, fusion pores and exocytosis.

Carbone E, Guérineau NC, Loh YP, Zhou Z.

J Mol Neurosci. 2012 Oct;48(2):357-9. No abstract available.

PMID:
22588977
36.

The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac β-adrenergic-like inotropes.

Tota B, Gentile S, Pasqua T, Bassino E, Koshimizu H, Cawley NX, Cerra MC, Loh YP, Angelone T.

FASEB J. 2012 Jul;26(7):2888-98. doi: 10.1096/fj.11-201111. Epub 2012 Mar 29.

37.

New roles of carboxypeptidase E in endocrine and neural function and cancer.

Cawley NX, Wetsel WC, Murthy SR, Park JJ, Pacak K, Loh YP.

Endocr Rev. 2012 Apr;33(2):216-53. doi: 10.1210/er.2011-1039. Epub 2012 Mar 7. Review.

38.

Chromogranin A and derived peptides in health and disease.

Loh YP, Cheng Y, Mahata SK, Corti A, Tota B.

J Mol Neurosci. 2012 Oct;48(2):347-56. Epub 2012 Mar 3. Review.

39.

Visualization of peptide secretory vesicles in living nerve cells.

Park JJ, Loh YP.

Methods Mol Biol. 2011;789:137-45. doi: 10.1007/978-1-61779-310-3_8.

40.

The extended granin family: structure, function, and biomedical implications.

Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR.

Endocr Rev. 2011 Dec;32(6):755-97. doi: 10.1210/er.2010-0027. Epub 2011 Aug 23. Review.

41.

Yapsin 1 immunoreactivity in {alpha}-cells of human pancreatic islets: implications for the processing of human proglucagon by mammalian aspartic proteases.

Cawley NX, Portela-Gomes G, Lou H, Loh YP.

J Endocrinol. 2011 Aug;210(2):181-7. doi: 10.1530/JOE-11-0121. Epub 2011 Jun 1.

42.

Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death.

Koshimizu H, Cawley NX, Yergy AL, Loh YP.

J Mol Neurosci. 2011 Oct;45(2):294-303. doi: 10.1007/s12031-011-9521-7. Epub 2011 May 3.

43.

Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.

Koshimizu H, Cawley NX, Kim T, Yergey AL, Loh YP.

Mol Endocrinol. 2011 May;25(5):732-44. doi: 10.1210/me.2010-0124. Epub 2011 Mar 24.

44.

A distinct trans-Golgi network subcompartment for sorting of synaptic and granule proteins in neurons and neuroendocrine cells.

Park JJ, Gondré-Lewis MC, Eiden LE, Loh YP.

J Cell Sci. 2011 Mar 1;124(Pt 5):735-44. doi: 10.1242/jcs.076372.

45.

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP.

J Clin Invest. 2011 Mar;121(3):880-92. doi: 10.1172/JCI40433.

46.

Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.

Murthy SR, Pacak K, Loh YP.

Cell Mol Neurobiol. 2010 Nov;30(8):1377-81. doi: 10.1007/s10571-010-9592-y.

47.

Reprint of: Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis.

Koshimizu H, Kim T, Cawley NX, Loh YP.

Regul Pept. 2010 Nov 30;165(1):95-101. doi: 10.1016/j.regpep.2010.09.006. Epub 2010 Oct 13.

48.

Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland.

Voutetakis A, Cotrim AP, Rowzee A, Zheng C, Rathod T, Yanik T, Loh YP, Baum BJ, Cawley NX.

Endocrinology. 2010 Sep;151(9):4566-72. doi: 10.1210/en.2010-0193. Epub 2010 Jul 7.

49.

Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic pre-synaptic terminals.

Lou H, Park JJ, Cawley NX, Sarcon A, Sun L, Adams T, Loh YP.

J Neurochem. 2010 Aug;114(3):886-96. doi: 10.1111/j.1471-4159.2010.06820.x. Epub 2010 May 18.

50.

Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density.

Cawley NX, Yanik T, Woronowicz A, Chang W, Marini JC, Loh YP.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E189-97. doi: 10.1152/ajpendo.00516.2009. Epub 2010 May 11.

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