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Items: 1 to 50 of 599

1.

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.

Chao PK, Chang HF, Chang WT, Yeh TK, Ou LC, Chuang JY, Tsu-An Hsu J, Tao PL, Loh HH, Shih C, Ueng SH, Yeh SH.

Neuropharmacology. 2019 Jul 3:107678. doi: 10.1016/j.neuropharm.2019.107678. [Epub ahead of print]

PMID:
31278929
2.

Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice.

Yang PP, Yeh TK, Loh HH, Law PY, Wang Y, Tao PL.

Eur J Pharmacol. 2019 Jun 5;852:265-273. doi: 10.1016/j.ejphar.2019.04.009. Epub 2019 Apr 6.

PMID:
30959048
3.

Safety of Ramadan fasting in young patients with type 1 diabetes: A systematic review and meta-analysis.

Loh HH, Lim LL, Loh HS, Yee A.

J Diabetes Investig. 2019 Apr 2. doi: 10.1111/jdi.13054. [Epub ahead of print]

4.

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.

Chao PK, Chang HF, Ou LC, Chuang JY, Lee PT, Chang WT, Chen SC, Ueng SH, Hsu JT, Tao PL, Law PY, Loh HH, Yeh SH.

Sci Rep. 2019 Feb 20;9(1):2405. doi: 10.1038/s41598-019-39555-x.

5.

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH.

Eur J Med Chem. 2019 Apr 1;167:312-323. doi: 10.1016/j.ejmech.2019.01.063. Epub 2019 Feb 2.

PMID:
30776693
6.

Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis.

Loh HH, Lim LL, Yee A, Loh HS.

BMC Psychiatry. 2019 Jan 8;19(1):12. doi: 10.1186/s12888-018-2006-2.

7.

Bone health among patients with primary aldosteronism: a systematic review and meta-analysis.

Loh HH, Yee A, Loh HS.

Minerva Endocrinol. 2018 Nov 26. doi: 10.23736/S0391-1977.18.02867-5. [Epub ahead of print]

PMID:
30482008
8.

Morphine regulates adult neurogenesis and contextual memory extinction via the PKCε/Prox1 pathway.

Fan W, Wang H, Zhang Y, Loh HH, Law PY, Xu C.

Neuropharmacology. 2018 Oct;141:126-138. doi: 10.1016/j.neuropharm.2018.08.031. Epub 2018 Aug 28.

PMID:
30170081
9.

High Proportion of Adults With Type 2 Diabetes and Poor Glycated Hemoglobin Perceived That Their Diabetes Control Was Excellent.

Shahar MA, Omar AM, Loh HH.

Can J Diabetes. 2019 Mar;43(2):98-104.e7. doi: 10.1016/j.jcjd.2018.06.003. Epub 2018 Jun 20.

PMID:
30145243
10.

Cultural adaptation and validity of the Malay version of the brief psychiatric rating scale (BPRS-M) among patients with schizophrenia in a psychiatric clinic.

Yee A, Ng BS, Hashim HMH, Danaee M, Loh HH.

BMC Psychiatry. 2017 Dec 2;17(1):384. doi: 10.1186/s12888-017-1553-2.

11.

Temporal effect of manipulating NeuroD1 expression with the synthetic small molecule KHS101 on morphine contextual memory.

Zhang Y, Kibaly C, Xu C, Loh HH, Law PY.

Neuropharmacology. 2017 Nov;126:58-69. doi: 10.1016/j.neuropharm.2017.08.030. Epub 2017 Aug 24.

PMID:
28842345
12.

Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal.

Zhang L, Kibaly C, Wang YJ, Xu C, Song KY, McGarrah PW, Loh HH, Liu JG, Law PY.

EMBO Mol Med. 2017 Nov;9(11):1521-1536. doi: 10.15252/emmm.201607324.

13.

Differential regulation of mouse and human Mu opioid receptor gene depends on the single stranded DNA structure of its promoter and α-complex protein 1.

Lee DS, Law PY, Ln W, Loh HH, Song KY, Choi HS.

Biomed Rep. 2017 May;6(5):532-538. doi: 10.3892/br.2017.877. Epub 2017 Mar 21.

14.

Effect of vitamin D replacement in primary hyperparathyroidism with concurrent vitamin D deficiency: a systematic review and meta-analysis.

Loh HH, Lim LL, Yee A, Loh HS, Vethakkan SR.

Minerva Endocrinol. 2019 Jun;44(2):221-231. doi: 10.23736/S0391-1977.17.02584-6. Epub 2017 Mar 14.

PMID:
28294593
15.

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.

Chao PK, Ueng SH, Ou LC, Yeh TK, Chang WT, Chang HF, Chen SC, Tao PL, Law PY, Loh HH, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH.

Anesthesiology. 2017 May;126(5):952-966. doi: 10.1097/ALN.0000000000001568.

PMID:
28212204
16.

Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.

Kibaly C, Lin HY, Loh HH, Law PY.

Pharmacol Res. 2017 May;119:153-168. doi: 10.1016/j.phrs.2017.01.033. Epub 2017 Feb 4.

17.

Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein Kinase 1.

Wagley Y, Law PY, Wei LN, Loh HH.

Mol Pharmacol. 2017 Apr;91(4):357-372. doi: 10.1124/mol.116.106567. Epub 2017 Feb 2.

18.

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers.

Ke YY, Huang YH, Chien WC, Loh HH, Chuang JY, Yeh SH.

Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):336-343. doi: 10.1016/j.bbapap.2016.12.010. Epub 2016 Dec 22.

PMID:
28012872
19.

Improvement of bone turnover markers and bone mineral density following treatment of primary aldosteronism.

Loh HH, Kamaruddin NA, Zakaria R, Sukor N.

Minerva Endocrinol. 2018 Jun;43(2):117-125. doi: 10.23736/S0391-1977.16.02553-0. Epub 2016 Dec 20.

PMID:
28001017
21.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, Ueng SH.

Eur J Med Chem. 2017 Jan 27;126:202-217. doi: 10.1016/j.ejmech.2016.09.003. Epub 2016 Sep 20.

PMID:
27776274
22.

A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain.

Kibaly C, Loh HH, Law PY.

Int Rev Cell Mol Biol. 2016;327:89-161. doi: 10.1016/bs.ircmb.2016.06.002. Epub 2016 Jul 30. Review.

PMID:
27692181
23.

Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice.

Yang PP, Yeh GC, Yeh TK, Xi J, Loh HH, Law PY, Tao PL.

Pharmacol Res. 2016 Sep;111:867-876. doi: 10.1016/j.phrs.2016.05.034. Epub 2016 Aug 2.

PMID:
27496654
24.

Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1.

Song KY, Choi HS, Law PY, Wei LN, Loh HH.

J Cell Physiol. 2017 Mar;232(3):576-584. doi: 10.1002/jcp.25455. Epub 2016 Jun 24.

25.

Effect of Opioid on Adult Hippocampal Neurogenesis.

Zhang Y, Loh HH, Law PY.

ScientificWorldJournal. 2016;2016:2601264. doi: 10.1155/2016/2601264. Epub 2016 Apr 5. Review.

26.

Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors.

Zhang Y, Xu C, Zheng H, Loh HH, Law PY.

PLoS One. 2016 Apr 14;11(4):e0153628. doi: 10.1371/journal.pone.0153628. eCollection 2016.

27.

Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels.

Huang Z, Liang L, Li L, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D, Zheng H.

Lipids Health Dis. 2016 Mar 8;15:47. doi: 10.1186/s12944-016-0212-9.

28.

The natural progression and outcomes of adrenal incidentaloma: a systematic review and meta-analysis.

Loh HH, Yee A, Loh HS, Sukor N, Kamaruddin NA.

Minerva Endocrinol. 2017 Mar;42(1):77-87. doi: 10.23736/S0391-1977.16.02394-4. Epub 2015 Dec 23. Review.

PMID:
26698544
29.

Effects of addictive drugs on adult neural stem/progenitor cells.

Xu C, Loh HH, Law PY.

Cell Mol Life Sci. 2016 Jan;73(2):327-48. doi: 10.1007/s00018-015-2067-z. Epub 2015 Oct 14. Review.

30.

Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis.

Loh HH, Yee A, Loh HS, Sukor N, Kamaruddin NA.

Prim Care Diabetes. 2016 Jun;10(3):210-9. doi: 10.1016/j.pcd.2015.09.001. Epub 2015 Oct 5. Review.

PMID:
26392074
31.

Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice.

Yang PP, Yeh GC, Huang EY, Law PY, Loh HH, Tao PL.

J Biomed Sci. 2015 Sep 22;22:81. doi: 10.1186/s12929-015-0186-3.

32.
33.

Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12.

Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ, Qiu Y.

CNS Neurosci Ther. 2015 Jul;21(7):591-8. doi: 10.1111/cns.12409.

34.

Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion.

Kibaly C, Kam AY, Loh HH, Law PY.

Biol Psychiatry. 2016 Jun 1;79(11):906-16. doi: 10.1016/j.biopsych.2015.04.019. Epub 2015 May 2.

35.
36.

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling.

Lee PT, Chao PK, Ou LC, Chuang JY, Lin YC, Chen SC, Chang HF, Law PY, Loh HH, Chao YS, Su TP, Yeh SH.

Nucleic Acids Res. 2014 Dec 1;42(21):13012-25. doi: 10.1093/nar/gku1016. Epub 2014 Oct 31.

37.

Analysis of epigenetic mechanisms regulating opioid receptor gene transcription.

Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH.

Methods Mol Biol. 2015;1230:39-51. doi: 10.1007/978-1-4939-1708-2_3.

PMID:
25293314
38.

μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling.

Wang Y, Wang YX, Liu T, Law PY, Loh HH, Qiu Y, Chen HZ.

CNS Neurosci Ther. 2015 Jan;21(1):8-14. doi: 10.1111/cns.12316. Epub 2014 Aug 21.

39.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.

Cheng MF, Ou LC, Chen SC, Chang WT, Law PY, Loh HH, Chao YS, Shih C, Yeh SH, Ueng SH.

Bioorg Med Chem. 2014 Sep 1;22(17):4694-703. doi: 10.1016/j.bmc.2014.07.012. Epub 2014 Jul 16.

PMID:
25087049
40.

Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms.

Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H.

Biol Psychiatry. 2014 Nov 15;76(10):775-84. doi: 10.1016/j.biopsych.2014.05.013. Epub 2014 Jun 2.

41.

Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level.

Xu C, Zhang Y, Zheng H, Loh HH, Law PY.

Stem Cells. 2014 Nov;32(11):2961-72. doi: 10.1002/stem.1774.

42.

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.

Kao JH, Gao MJ, Yang PP, Law PY, Loh HH, Tao PL.

Br J Pharmacol. 2015 Jan;172(2):630-41. doi: 10.1111/bph.12790.

43.

The use of hemodialysis in refractory hypercalcemia secondary to parathyroid carcinoma.

Loh HH, Mohd Noor N.

Case Rep Crit Care. 2014;2014:140906. doi: 10.1155/2014/140906. Epub 2014 Jan 21.

44.

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.

Yan YH, Wang Y, Zhao LX, Jiang S, Loh HH, Law PY, Chen HZ, Qiu Y.

Neurosci Lett. 2014 Apr 30;566:231-235. doi: 10.1016/j.neulet.2014.02.059. Epub 2014 Mar 6.

45.

β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia.

Feng X, Wu CY, Burton FH, Loh HH, Wei LN.

Cell Death Differ. 2014 Mar;21(3):397-406. doi: 10.1038/cdd.2013.152. Epub 2013 Oct 25.

46.

Pancytopenia in a Patient with Grave's Disease.

Loh HH, Tan F.

Med J Malaysia. 2013 Aug;68(4):372-3.

47.

FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.

Qiu Y, Zhao W, Wang Y, Xu JR, Huie E, Jiang S, Yan YH, Loh HH, Chen HZ, Law PY.

Mol Pharmacol. 2014 Jan;85(1):37-49. doi: 10.1124/mol.113.087825. Epub 2013 Oct 10.

48.

A novel noncanonical signaling pathway for the μ-opioid receptor.

Zhang L, Loh HH, Law PY.

Mol Pharmacol. 2013 Dec;84(6):844-53. doi: 10.1124/mol.113.088278. Epub 2013 Sep 23.

49.

Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences.

Kang DH, Song KY, Wei LN, Law PY, Loh HH, Choi HS.

Int J Mol Med. 2013 Nov;32(5):1187-94. doi: 10.3892/ijmm.2013.1488. Epub 2013 Sep 11.

50.

Opioid receptors: toward separation of analgesic from undesirable effects.

Law PY, Reggio PH, Loh HH.

Trends Biochem Sci. 2013 Jun;38(6):275-82. doi: 10.1016/j.tibs.2013.03.003. Epub 2013 Apr 16. Review.

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