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Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V.

PLoS Comput Biol. 2018 Oct 16;14(10):e1006539. doi: 10.1371/journal.pcbi.1006539. eCollection 2018 Oct.


Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.


Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate.

Delgado-Ramírez M, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Arreola J, Adney SK, Villalba-Galea CA, Logothetis DE, Rodríguez-Menchaca AA.

Sci Rep. 2018 Jan 29;8(1):1769. doi: 10.1038/s41598-018-20280-w.


Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).

Ha J, Xu Y, Kawano T, Hendon T, Baki L, Garai S, Papapetropoulos A, Thakur GA, Plant LD, Logothetis DE.

J Biol Chem. 2018 Mar 9;293(10):3546-3561. doi: 10.1074/jbc.RA117.001679. Epub 2018 Jan 9.


Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflakes and K+ Channels.

Gu Z, Plant LD, Meng XY, Perez-Aguilar JM, Wang Z, Dong M, Logothetis DE, Zhou R.

ACS Nano. 2018 Jan 23;12(1):705-717. doi: 10.1021/acsnano.7b07871. Epub 2017 Dec 28.


Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels.

Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Marom M, Haitin Y, Logothetis DE, Hirsch JA, Attali B.

Channels (Austin). 2017 Nov 2;11(6):686-695. doi: 10.1080/19336950.2017.1388478. Epub 2017 Nov 17.


Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V.

PLoS Comput Biol. 2017 Feb 13;13(2):e1005376. doi: 10.1371/journal.pcbi.1005376. eCollection 2017 Feb. Erratum in: PLoS Comput Biol. 2018 Oct 16;14(10):e1006539.


Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.

Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Marom M, Haitin Y, Logothetis DE, Hirsch JA, Attali B.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E869-E878. doi: 10.1073/pnas.1612622114. Epub 2017 Jan 17.


Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.

Li J, Xiao S, Xie X, Zhou H, Pang C, Li S, Zhang H, Logothetis DE, Zhan Y, An H.

Proteins. 2016 Dec;84(12):1929-1937. doi: 10.1002/prot.25176. Epub 2016 Oct 25.


The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.

Meng XY, Liu S, Cui M, Zhou R, Logothetis DE.

Sci Rep. 2016 Jul 21;6:29399. doi: 10.1038/srep29399.


Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.

Younkin J, Gaitonde SA, Ellaithy A, Vekariya R, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukat M, Glennon RA.

ACS Chem Neurosci. 2016 Sep 21;7(9):1292-9. doi: 10.1021/acschemneuro.6b00162. Epub 2016 Jul 19.


The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2.

Deng W, Mahajan R, Baumgarten CM, Logothetis DE.

Pflugers Arch. 2016 May;468(5):817-24. doi: 10.1007/s00424-016-1794-9. Epub 2016 Feb 2.


Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.

Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park G, Vysotskaya Z, Narahari A, Sealfon SC, Gonzalez-Maeso J, Logothetis DE.

Pflugers Arch. 2016 May;468(5):775-93. doi: 10.1007/s00424-015-1780-7. Epub 2016 Jan 16.


Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J.

Sci Signal. 2016 Jan 12;9(410):ra5. doi: 10.1126/scisignal.aab0467.


Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.

Tang QY, Zhang FF, Xu J, Wang R, Chen J, Logothetis DE, Zhang Z.

Cell Rep. 2016 Jan 5;14(1):129-139. doi: 10.1016/j.celrep.2015.12.019. Epub 2015 Dec 24.


A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels.

Adney SK, Ha J, Meng XY, Kawano T, Logothetis DE.

J Neurosci. 2015 Oct 21;35(42):14397-405. doi: 10.1523/JNEUROSCI.1415-15.2015.


Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides.

Logothetis DE, Mahajan R, Adney SK, Ha J, Kawano T, Meng XY, Cui M.

Int Rev Neurobiol. 2015;123:1-26. doi: 10.1016/bs.irn.2015.05.013. Epub 2015 Jun 22. Review.


Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.

Zhang M, Meng XY, Zhang JF, Cui M, Logothetis DE.

Sci Adv. 2015 Jun 3;1(6):e1500008.


Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment.

Ellaithy A, Younkin J, González-Maeso J, Logothetis DE.

Trends Neurosci. 2015 Aug;38(8):506-16. doi: 10.1016/j.tins.2015.06.002. Epub 2015 Jul 4. Review.


Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.

Li J, Lü S, Liu Y, Pang C, Chen Y, Zhang S, Yu H, Long M, Zhang H, Logothetis DE, Zhan Y, An H.

Sci Rep. 2015 Jun 11;5:11289. doi: 10.1038/srep11289.


Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels.

Tang QY, Larry T, Hendra K, Yamamoto E, Bell J, Cui M, Logothetis DE, Boland LM.

J Biol Chem. 2015 Jul 3;290(27):16517-29. doi: 10.1074/jbc.M115.640409. Epub 2015 May 8.


Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation.

Mastorodemos V, Kanavouras K, Sundaram S, Providaki M, Petraki Z, Kokkinidis M, Zaganas I, Logothetis DE, Plaitakis A.

J Neurochem. 2015 Apr;133(1):73-82. doi: 10.1111/jnc.13019. Epub 2015 Jan 26.


G protein-coupled receptor signaling to Kir channels in Xenopus oocytes.

Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE.

Curr Pharm Biotechnol. 2014;15(10):987-95. Review.


Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.

Li J, Xie X, Liu J, Yu H, Zhang S, Zhan Y, Zhang H, Logothetis DE, An H.

PLoS One. 2014 Oct 28;9(10):e111372. doi: 10.1371/journal.pone.0111372. eCollection 2014.


Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.

Logothetis DE, Petrou VI, Zhang M, Mahajan R, Meng XY, Adney SK, Cui M, Baki L.

Annu Rev Physiol. 2015;77:81-104. doi: 10.1146/annurev-physiol-021113-170358. Epub 2014 Oct 2. Review.


Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.

Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF.

Nat Chem Biol. 2014 Sep;10(9):753-9. doi: 10.1038/nchembio.1592. Epub 2014 Aug 10.


Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism.

Spyridaki K, Matsoukas MT, Cordomi A, Gkountelias K, Papadokostaki M, Mavromoustakos T, Logothetis DE, Margioris AN, Pardo L, Liapakis G.

J Biol Chem. 2014 Jul 4;289(27):18966-77. doi: 10.1074/jbc.M113.544460. Epub 2014 May 16.


Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.

Tang QY, Zhang Z, Meng XY, Cui M, Logothetis DE.

J Biol Chem. 2014 Jul 4;289(27):18860-72. doi: 10.1074/jbc.M113.538033. Epub 2014 Apr 28.


Identification of novel cholesterol-binding regions in Kir2 channels.

Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I.

J Biol Chem. 2013 Oct 25;288(43):31154-64. doi: 10.1074/jbc.M113.496117. Epub 2013 Sep 9.


A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.

Mahajan R, Ha J, Zhang M, Kawano T, Kozasa T, Logothetis DE.

Sci Signal. 2013 Aug 13;6(288):ra69. doi: 10.1126/scisignal.2004075.


Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Rosenhouse-Dantsker A, Noskov S, Logothetis DE, Levitan I.

Channels (Austin). 2013 Jul-Aug;7(4):303-12. Epub 2013 Jun 27.


SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.

Zhang Z, Tang QY, Alaimo JT, Davies AG, Bettinger JC, Logothetis DE.

Channels (Austin). 2013 May-Jun;7(3):194-205. doi: 10.4161/chan.24492. Epub 2013 Apr 16.


The where and how of PIP regulation of cone photoreceptor CNG channels.

Zhou L, Logothetis DE.

J Gen Physiol. 2013 Apr;141(4):403-7. doi: 10.1085/jgp.201310981. No abstract available.


Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).

Rodríguez-Menchaca AA, Adney SK, Zhou L, Logothetis DE.

Front Pharmacol. 2012 Sep 25;3:170. doi: 10.3389/fphar.2012.00170. eCollection 2012.


The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.

An HL, Lü SQ, Li JW, Meng XY, Zhan Y, Cui M, Long M, Zhang HL, Logothetis DE.

J Biol Chem. 2012 Dec 7;287(50):42278-87. doi: 10.1074/jbc.M112.418640. Epub 2012 Oct 2.


Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I.

J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20.


PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker.

Rodriguez-Menchaca AA, Adney SK, Tang QY, Meng XY, Rosenhouse-Dantsker A, Cui M, Logothetis DE.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):E2399-408. doi: 10.1073/pnas.1207901109. Epub 2012 Aug 13.


The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel.

Meng XY, Zhang HX, Logothetis DE, Cui M.

Biophys J. 2012 May 2;102(9):2049-59. doi: 10.1016/j.bpj.2012.03.050.


A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge.

Wells GD, Tang QY, Heler R, Tompkins-MacDonald GJ, Pritchard EN, Leys SP, Logothetis DE, Boland LM.

J Exp Biol. 2012 Jul 15;215(Pt 14):2435-44. doi: 10.1242/jeb.066233.


Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.

Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A.

J Biol Chem. 2012 Feb 10;287(7):4925-35. doi: 10.1074/jbc.M111.306134. Epub 2011 Dec 15.


Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE.

Cell. 2011 Nov 23;147(5):1011-23. doi: 10.1016/j.cell.2011.09.055.


Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.

Rosenhouse-Dantsker A, Logothetis DE, Levitan I.

Biophys J. 2011 Jan 19;100(2):381-9. doi: 10.1016/j.bpj.2010.11.086.


Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation.

Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L.

Pflugers Arch. 2011 Mar;461(3):387-97. doi: 10.1007/s00424-010-0904-3. Epub 2010 Nov 24.


G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels.

Styer AM, Mirshahi UL, Wang C, Girard L, Jin T, Logothetis DE, Mirshahi T.

J Biol Chem. 2010 Dec 31;285(53):41290-9. doi: 10.1074/jbc.M110.178541. Epub 2010 Nov 2.


Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers.

Leal-Pinto E, Gómez-Llorente Y, Sundaram S, Tang QY, Ivanova-Nikolova T, Mahajan R, Baki L, Zhang Z, Chavez J, Ubarretxena-Belandia I, Logothetis DE.

J Biol Chem. 2010 Dec 17;285(51):39790-800. doi: 10.1074/jbc.M110.151373. Epub 2010 Oct 6.


The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.

Zhang Z, Rosenhouse-Dantsker A, Tang QY, Noskov S, Logothetis DE.

J Neurosci. 2010 Jun 2;30(22):7554-62. doi: 10.1523/JNEUROSCI.0525-10.2010.


Channelopathies linked to plasma membrane phosphoinositides.

Logothetis DE, Petrou VI, Adney SK, Mahajan R.

Pflugers Arch. 2010 Jul;460(2):321-41. doi: 10.1007/s00424-010-0828-y. Epub 2010 Apr 16. Review.


Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition.

Tang QY, Zhang Z, Xia J, Ren D, Logothetis DE.

J Biol Chem. 2010 Jun 18;285(25):19259-66. doi: 10.1074/jbc.M109.100156. Epub 2010 Apr 14.


A molecular dynamics investigation of lipid bilayer perturbation by PIP2.

Lupyan D, Mezei M, Logothetis DE, Osman R.

Biophys J. 2010 Jan 20;98(2):240-7. doi: 10.1016/j.bpj.2009.09.063.


Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop.

Rosenhouse-Dantsker A, Leal-Pinto E, Logothetis DE, Levitan I.

Channels (Austin). 2010 Jan-Feb;4(1):63-6. Epub 2010 Jan 20.

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