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Items: 1 to 50 of 81

1.

A surface-exposed GH26 β-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B.

Bågenholm V, Wiemann M, Reddy SK, Bhattacharya A, Rosengren A, Logan DT, Stålbrand H.

J Biol Chem. 2019 Jun 7;294(23):9100-9117. doi: 10.1074/jbc.RA118.007171. Epub 2019 Apr 18.

2.

Refinement of protein structures using a combination of quantum-mechanical calculations with neutron and X-ray crystallographic data.

Caldararu O, Manzoni F, Oksanen E, Logan DT, Ryde U.

Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):368-380. doi: 10.1107/S205979831900175X. Epub 2019 Mar 28.

3.

Structural Basis for YjbH Adaptor-Mediated Recognition of Transcription Factor Spx.

Awad W, Al-Eryani Y, Ekström S, Logan DT, von Wachenfeldt C.

Structure. 2019 Jun 4;27(6):923-936.e6. doi: 10.1016/j.str.2019.03.009. Epub 2019 Apr 11.

PMID:
30982633
4.

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.

Korkmaz B, Lesner A, Wysocka M, Gieldon A, Håkansson M, Gauthier F, Logan DT, Jenne DE, Lauritzen C, Pedersen J.

Biochem Pharmacol. 2019 Jun;164:349-367. doi: 10.1016/j.bcp.2019.04.006. Epub 2019 Apr 9.

PMID:
30978322
5.

Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an α-eudesmol synthase.

Kracht ON, Correia Cordeiro RS, Håkansson M, Stockmann J, Sander D, Bandow J, Senges CHR, Logan DT, Kourist R.

J Biotechnol. 2019 May 20;297:71-77. doi: 10.1016/j.jbiotec.2019.03.006. Epub 2019 Mar 27.

PMID:
30928538
6.

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.

Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A, Håkansson M, Logan DT, Welin M, Chattopadhyay S, Harms BD, Nielsen UB, Schoeberl B, Lugovskoy AA, MacBeath G.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7533-7542. doi: 10.1073/pnas.1819085116. Epub 2019 Mar 21.

PMID:
30898885
7.

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.

Kumar R, Peterson K, Misini Ignjatović M, Leffler H, Ryde U, Nilsson UJ, Logan DT.

Org Biomol Chem. 2019 Jan 31;17(5):1081-1089. doi: 10.1039/c8ob02888e.

PMID:
30632578
8.

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding.

Verteramo ML, Stenström O, Ignjatović MM, Caldararu O, Olsson MA, Manzoni F, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M.

J Am Chem Soc. 2019 Feb 6;141(5):2012-2026. doi: 10.1021/jacs.8b11099. Epub 2019 Jan 23.

PMID:
30618244
9.

Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions.

Ruggieri F, van Langen LM, Logan DT, Walse B, Berglund P.

ChemCatChem. 2018 Nov 7;10(21):5012-5018. doi: 10.1002/cctc.201801049. Epub 2018 Oct 11.

10.

The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1.

Yang F, Wang H, Logan DT, Mu X, Danielsson J, Oliveberg M.

J Am Chem Soc. 2018 Dec 5;140(48):16570-16579. doi: 10.1021/jacs.8b08141. Epub 2018 Nov 27.

PMID:
30359015
11.

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

Noresson AL, Aurelius O, Öberg CT, Engström O, Sundin AP, Håkansson M, Stenström O, Akke M, Logan DT, Leffler H, Nilsson UJ.

Chem Sci. 2017 Dec 4;9(4):1014-1021. doi: 10.1039/c7sc04749e. eCollection 2018 Jan 28.

12.

Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design.

Manzoni F, Wallerstein J, Schrader TE, Ostermann A, Coates L, Akke M, Blakeley MP, Oksanen E, Logan DT.

J Med Chem. 2018 May 24;61(10):4412-4420. doi: 10.1021/acs.jmedchem.8b00081. Epub 2018 May 3.

13.

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.

Rozman Grinberg I, Lundin D, Hasan M, Crona M, Jonna VR, Loderer C, Sahlin M, Markova N, Borovok I, Berggren G, Hofer A, Logan DT, Sjöberg BM.

Elife. 2018 Feb 1;7. pii: e31529. doi: 10.7554/eLife.31529.

14.

Synthesis of branched and linear 1,4-linked galactan oligosaccharides.

Andersen MCF, Boos I, Kinnaert C, Awan SI, Pedersen HL, Kračun SK, Lanz G, Rydahl MG, Kjærulff L, Håkansson M, Kimbung R, Logan DT, Gotfredsen CH, Willats WGT, Clausen MH.

Org Biomol Chem. 2018 Feb 14;16(7):1157-1162. doi: 10.1039/c7ob03035e.

PMID:
29367995
15.

Structural and Biophysical Characterization of Human EXTL3: Domain Organization, Glycosylation, and Solution Structure.

Awad W, Kjellström S, Svensson Birkedal G, Mani K, Logan DT.

Biochemistry. 2018 Feb 20;57(7):1166-1177. doi: 10.1021/acs.biochem.7b00557. Epub 2018 Feb 5.

PMID:
29346724
16.

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ.

J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11.

17.

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions.

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ.

ChemMedChem. 2018 Jan 22;13(2):133-137. doi: 10.1002/cmdc.201700744. Epub 2018 Jan 15.

PMID:
29194992
18.

Three-dimensional structures and functional studies of two GH43 arabinofuranosidases from Weissella sp. strain 142 and Lactobacillus brevis.

Linares-Pastén JA, Falck P, Albasri K, Kjellström S, Adlercreutz P, Logan DT, Karlsson EN.

FEBS J. 2017 Jul;284(13):2019-2036. doi: 10.1111/febs.14101. Epub 2017 Jun 18.

19.

Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides.

Kulkarni TS, Khan S, Villagomez R, Mahmood T, Lindahl S, Logan DT, Linares-Pastén JA, Nordberg Karlsson E.

Proteins. 2017 May;85(5):872-884. doi: 10.1002/prot.25256. Epub 2017 Mar 8.

PMID:
28142197
20.

Crystal structure of human chondroadherin: solving a difficult molecular-replacement problem using de novo models.

Rämisch S, Pramhed A, Tillgren V, Aspberg A, Logan DT.

Acta Crystallogr D Struct Biol. 2017 Jan 1;73(Pt 1):53-63. doi: 10.1107/S205979831601980X. Epub 2017 Jan 1.

PMID:
28045385
21.

Galactomannan Catabolism Conferred by a Polysaccharide Utilization Locus of Bacteroides ovatus: ENZYME SYNERGY AND CRYSTAL STRUCTURE OF A β-MANNANASE.

Bågenholm V, Reddy SK, Bouraoui H, Morrill J, Kulcinskaja E, Bahr CM, Aurelius O, Rogers T, Xiao Y, Logan DT, Martens EC, Koropatkin NM, Stålbrand H.

J Biol Chem. 2017 Jan 6;292(1):229-243. doi: 10.1074/jbc.M116.746438. Epub 2016 Nov 21.

22.

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C.

Manzoni F, Saraboji K, Sprenger J, Kumar R, Noresson AL, Nilsson UJ, Leffler H, Fisher SZ, Schrader TE, Ostermann A, Coates L, Blakeley MP, Oksanen E, Logan DT.

Acta Crystallogr D Struct Biol. 2016 Nov 1;72(Pt 11):1194-1202. Epub 2016 Oct 28.

23.

Tricking a Protein To Swap Strands.

Wang H, Lang L, Logan DT, Danielsson J, Oliveberg M.

J Am Chem Soc. 2016 Dec 7;138(48):15571-15579. Epub 2016 Nov 22.

PMID:
27783493
24.

Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.

Johansson R, Jonna VR, Kumar R, Nayeri N, Lundin D, Sjöberg BM, Hofer A, Logan DT.

Structure. 2016 Aug 2;24(8):1432-1434. doi: 10.1016/j.str.2016.07.006. Epub 2016 Aug 2. No abstract available.

25.

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.

Badarau A, Rouha H, Malafa S, Battles MB, Walker L, Nielson N, Dolezilkova I, Teubenbacher A, Banerjee S, Maierhofer B, Weber S, Stulik L, Logan DT, Welin M, Mirkina I, Pleban C, Zauner G, Gross K, Jägerhofer M, Magyarics Z, Nagy E.

MAbs. 2016 Oct;8(7):1347-1360. Epub 2016 Jul 28.

26.

A De Novo Designed Coiled-Coil Peptide with a Reversible pH-Induced Oligomerization Switch.

Lizatović R, Aurelius O, Stenström O, Drakenberg T, Akke M, Logan DT, André I.

Structure. 2016 Jun 7;24(6):946-55. doi: 10.1016/j.str.2016.03.027. Epub 2016 May 5.

27.

Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.

Johansson R, Jonna VR, Kumar R, Nayeri N, Lundin D, Sjöberg BM, Hofer A, Logan DT.

Structure. 2016 Jun 7;24(6):906-17. doi: 10.1016/j.str.2016.03.025. Epub 2016 Apr 28. Erratum in: Structure. 2016 Aug 2;24(8):1432-1434.

28.

Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins.

Nilsson LM, Green LC, Muralidharan SV, Demir D, Welin M, Bhadury J, Logan DT, Walse B, Nilsson JA.

Cancer Res. 2016 Apr 15;76(8):2376-83. doi: 10.1158/0008-5472.CAN-15-2721. Epub 2016 Mar 3.

29.

Neutron crystallographic studies reveal hydrogen bond and water-mediated interactions between a carbohydrate-binding module and its bound carbohydrate ligand.

Fisher SZ, von Schantz L, Håkansson M, Logan DT, Ohlin M.

Biochemistry. 2015 Oct 27;54(42):6435-8. doi: 10.1021/acs.biochem.5b01058. Epub 2015 Oct 13.

PMID:
26451738
30.

Thermodynamics of protein destabilization in live cells.

Danielsson J, Mu X, Lang L, Wang H, Binolfi A, Theillet FX, Bekei B, Logan DT, Selenko P, Wennerström H, Oliveberg M.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12402-7. doi: 10.1073/pnas.1511308112. Epub 2015 Sep 21.

31.

Crystallization, neutron data collection, initial structure refinement and analysis of a xyloglucan heptamer bound to an engineered carbohydrate-binding module from xylanase.

Ohlin M, von Schantz L, Schrader TE, Ostermann A, Logan DT, Fisher SZ.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1072-7. doi: 10.1107/S2053230X15011383. Epub 2015 Jul 29.

32.

Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.

Awad W, Adamczyk B, Örnros J, Karlsson NG, Mani K, Logan DT.

J Biol Chem. 2015 Sep 18;290(38):22991-3008. doi: 10.1074/jbc.M115.660878. Epub 2015 Jul 22.

33.

The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.

Aurelius O, Johansson R, Bågenholm V, Lundin D, Tholander F, Balhuizen A, Beck T, Sahlin M, Sjöberg BM, Mulliez E, Logan DT.

PLoS One. 2015 Jul 6;10(7):e0128199. doi: 10.1371/journal.pone.0128199. eCollection 2015.

34.

The origin and evolution of ribonucleotide reduction.

Lundin D, Berggren G, Logan DT, Sjöberg BM.

Life (Basel). 2015 Feb 27;5(1):604-36. doi: 10.3390/life5010604. Review.

35.

Structure-function analysis of heterodimer formation, oligomerization, and receptor binding of the Staphylococcus aureus bi-component toxin LukGH.

Badarau A, Rouha H, Malafa S, Logan DT, Håkansson M, Stulik L, Dolezilkova I, Teubenbacher A, Gross K, Maierhofer B, Weber S, Jägerhofer M, Hoffman D, Nagy E.

J Biol Chem. 2015 Jan 2;290(1):142-56. doi: 10.1074/jbc.M114.598110. Epub 2014 Nov 3.

36.

Carbohydrate binding module recognition of xyloglucan defined by polar contacts with branching xyloses and CH-Π interactions.

von Schantz L, Håkansson M, Logan DT, Nordberg-Karlsson E, Ohlin M.

Proteins. 2014 Dec;82(12):3466-75. doi: 10.1002/prot.24700. Epub 2014 Oct 21.

PMID:
25302425
37.

An Aspergillus nidulans β-mannanase with high transglycosylation capacity revealed through comparative studies within glycosidase family 5.

Rosengren A, Reddy SK, Sjöberg JS, Aurelius O, Logan DT, Kolenová K, Stålbrand H.

Appl Microbiol Biotechnol. 2014 Dec;98(24):10091-104. doi: 10.1007/s00253-014-5871-8. Epub 2014 Jun 21.

38.

Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.

Awad W, Svensson Birkedal G, Thunnissen MM, Mani K, Logan DT.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2524-33. doi: 10.1107/S0907444913025250. Epub 2013 Nov 19.

39.

The macromolecular crystallography beamline I911-3 at the MAX IV laboratory.

Ursby T, Unge J, Appio R, Logan DT, Fredslund F, Svensson C, Larsson K, Labrador A, Thunnissen MM.

J Synchrotron Radiat. 2013 Jul;20(Pt 4):648-53. doi: 10.1107/S0909049513011734. Epub 2013 May 18.

40.

Global structural motions from the strain of a single hydrogen bond.

Danielsson J, Awad W, Saraboji K, Kurnik M, Lang L, Leinartaite L, Marklund SL, Logan DT, Oliveberg M.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3829-34. doi: 10.1073/pnas.1217306110. Epub 2013 Feb 19.

41.

Structural basis for carbohydrate-binding specificity--a comparative assessment of two engineered carbohydrate-binding modules.

von Schantz L, Håkansson M, Logan DT, Walse B, Osterlin J, Nordberg-Karlsson E, Ohlin M.

Glycobiology. 2012 Jul;22(7):948-61. doi: 10.1093/glycob/cws063. Epub 2012 Mar 20.

PMID:
22434778
42.

Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.

Svensson G, Awad W, Håkansson M, Mani K, Logan DT.

J Biol Chem. 2012 Apr 20;287(17):14040-51. doi: 10.1074/jbc.M111.322487. Epub 2012 Feb 20.

43.

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP.

Humble MS, Cassimjee KE, Håkansson M, Kimbung YR, Walse B, Abedi V, Federsel HJ, Berglund P, Logan DT.

FEBS J. 2012 Mar;279(5):779-92. doi: 10.1111/j.1742-4658.2012.08468.x. Epub 2012 Jan 23.

44.

Trimming down a protein structure to its bare foldons: spatial organization of the cooperative unit.

Haglund E, Danielsson J, Kadhirvel S, Lindberg MO, Logan DT, Oliveberg M.

J Biol Chem. 2012 Jan 20;287(4):2731-8. doi: 10.1074/jbc.M111.312447. Epub 2011 Nov 22.

45.

The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.

Saraboji K, Håkansson M, Genheden S, Diehl C, Qvist J, Weininger U, Nilsson UJ, Leffler H, Ryde U, Akke M, Logan DT.

Biochemistry. 2012 Jan 10;51(1):296-306. doi: 10.1021/bi201459p. Epub 2011 Dec 7.

46.

DNA building blocks: keeping control of manufacture.

Hofer A, Crona M, Logan DT, Sjöberg BM.

Crit Rev Biochem Mol Biol. 2012 Jan-Feb;47(1):50-63. doi: 10.3109/10409238.2011.630372. Epub 2011 Nov 3. Review.

47.

Implications of the inability of Listeria monocytogenes EGD-e to grow anaerobically due to a deletion in the class III NrdD ribonucleotide reductase for its use as a model laboratory strain.

Ofer A, Kreft J, Logan DT, Cohen G, Borovok I, Aharonowitz Y.

J Bacteriol. 2011 Jun;193(12):2931-40. doi: 10.1128/JB.01405-10. Epub 2011 Apr 8.

48.

Small-angle X-ray scattering study of a Rex family repressor: conformational response to NADH and NAD+ binding in solution.

Wang E, Ikonen TP, Knaapila M, Svergun D, Logan DT, von Wachenfeldt C.

J Mol Biol. 2011 May 13;408(4):670-83. doi: 10.1016/j.jmb.2011.02.050. Epub 2011 Mar 21.

PMID:
21402078
49.

Closing the circle on ribonucleotide reductases.

Logan DT.

Nat Struct Mol Biol. 2011 Mar;18(3):251-3. doi: 10.1038/nsmb0311-251. No abstract available.

PMID:
21372851
50.

High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states--an unusual flavodoxin. Structural biology.

Johansson R, Torrents E, Lundin D, Sprenger J, Sahlin M, Sjöberg BM, Logan DT.

FEBS J. 2010 Oct;277(20):4265-77. doi: 10.1111/j.1742-4658.2010.07815.x. Epub 2010 Sep 10.

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