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Chronic Critical Illness Patients Fail to Respond to Current Evidence-Based Intensive Care Nutrition Secondarily to Persistent Inflammation, Immunosuppression, and Catabolic Syndrome.

Rosenthal MD, Bala T, Wang Z, Loftus T, Moore F.

JPEN J Parenter Enteral Nutr. 2020 Feb 6. doi: 10.1002/jpen.1794. [Epub ahead of print]


Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients.

Lysak N, Hashemighouchani H, Davoudi A, Pourafshar N, Loftus TJ, Ruppert M, Efron PA, Rashidi P, Bihorac A, Ozrazgat-Baslanti T.

BJS Open. 2020 Feb;4(1):145-156. doi: 10.1002/bjs5.50232. Epub 2019 Nov 29.


Modulation of the HGF/c-Met axis impacts prolonged hematopoietic progenitor mobilization following trauma and chronic stress.

Loftus TJ, Kannan KB, Mira JC, Brakenridge SC, Efron PA, Mohr AM.

Shock. 2020 Jan 3. doi: 10.1097/SHK.0000000000001506. [Epub ahead of print]


COPD Care Bundle in Emergency Department Observation Unit Reduces Emergency Department Revisits.

Zafar MA, Loftus TM, Palmer JP, Phillips M, Ko J, Ward SR, Foertsch M, Dalhover A, Doers ME, Mueller EW, Alessandrini EA, Panos RJ.

Respir Care. 2020 Jan;65(1):1-10. doi: 10.4187/respcare.07088.


Impact of Injury Severity on the Inflammatory State and Severe Anemia.

Apple CG, Miller ES, Loftus TJ, Kannan KB, Parvataneni HK, Hagen JE, Efron PA, Mohr AM.

J Surg Res. 2019 Dec 24;248:109-116. doi: 10.1016/j.jss.2019.10.046. [Epub ahead of print]


Delayed interhospital transfer of critically ill patients with surgical sepsis.

Loftus TJ, Wu Q, Wang Z, Lysak N, Moore FA, Bihorac A, Efron PA, Mohr AM, Brakenridge SC.

J Trauma Acute Care Surg. 2020 Jan;88(1):169-175. doi: 10.1097/TA.0000000000002476.


Artificial Intelligence and Surgical Decision-Making.

Loftus TJ, Tighe PJ, Filiberto AC, Efron PA, Brakenridge SC, Mohr AM, Rashidi P, Upchurch GR Jr, Bihorac A.

JAMA Surg. 2019 Dec 11. doi: 10.1001/jamasurg.2019.4917. [Epub ahead of print]


Impact of the 2016 World Health Organization Classification of Tumours of the Central Nervous System: an Irish experience.

Fearon C, Loftus T, Byrne AL, Heffernan J, Cooney M, Heeney C, Walsh A, Lorigan J, Beausang A, Cryan J, Farrell M, Brett F.

Ir J Med Sci. 2019 Dec 4. doi: 10.1007/s11845-019-02144-y. [Epub ahead of print] Review.


Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells.

Phillippi B, Singh M, Loftus T, Smith H, Muccioli M, Wright J, Pate M, Benencia F.

Immunobiology. 2019 Nov 10:151854. doi: 10.1016/j.imbio.2019.10.003. [Epub ahead of print]


Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.

Apple CG, Miller ES, Loftus TJ, Kannan KB, Thompson CW, Lopez MC, Baker HV, Moldawer LL, Efron PA, Mohr AM.

J Am Coll Surg. 2020 Jan;230(1):121-129. doi: 10.1016/j.jamcollsurg.2019.09.011. Epub 2019 Oct 28.


Associations Between National Board Exam Performance and Residency Program Emphasis on Patient Safety and Interprofessional Teamwork.

Loftus TJ, Hall DJ, Malaty JZ, Kuruppacherry SB, Sarosi GA Jr, Shaw CM, Tan SA, Taylor J, Morris DS, Meyer LE, Hobbs JA.

Acad Psychiatry. 2019 Dec;43(6):581-584. doi: 10.1007/s40596-019-01106-x. Epub 2019 Aug 27.


Age-dependent response to multimodal therapy for stage II-III rectal cancer.

Delitto D, Loftus TJ, Iqbal A.

Oncotarget. 2019 Jul 23;10(45):4615. doi: 10.18632/oncotarget.27084. eCollection 2019 Jul 23. No abstract available.


Gender differences among surgical fellowship program directors.

Filiberto AC, Le CB, Loftus TJ, Cooper LA, Shaw C, Sarosi GA Jr, Iqbal A, Tan SA.

Surgery. 2019 Nov;166(5):735-737. doi: 10.1016/j.surg.2019.05.017. Epub 2019 Jun 27.


Sigmoido-rectal intussusception.

Filiberto AC, Loftus TJ, Tan SA, Read TE, Iqbal A.

SAGE Open Med Case Rep. 2019 Jun 9;7:2050313X19856242. doi: 10.1177/2050313X19856242. eCollection 2019.


Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making.

Loftus TJ, Upchurch GR Jr, Bihorac A.

JAMA Surg. 2019 Jun 19. doi: 10.1001/jamasurg.2019.1510. [Epub ahead of print] No abstract available.


Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.

Miller ES, Loftus TJ, Kannan KB, Plazas JM, Efron PA, Mohr AM.

J Surg Res. 2019 Nov;243:220-228. doi: 10.1016/j.jss.2019.05.033. Epub 2019 Jun 14.


Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification.

Loftus TJ, Brown MP, Slish JH, Rosenthal MD.

Nutr Clin Pract. 2019 Jun;34(3):340-348. doi: 10.1002/ncp.10271. Epub 2019 Mar 25. Review.


The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.

Loftus TJ, Miller ES, Millar JK, Kannan KB, Alamo IG, Efron PA, Mohr AM.

Am J Surg. 2019 Nov;218(5):858-863. doi: 10.1016/j.amjsurg.2019.02.023. Epub 2019 Feb 21.


DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning.

Shickel B, Loftus TJ, Adhikari L, Ozrazgat-Baslanti T, Bihorac A, Rashidi P.

Sci Rep. 2019 Feb 12;9(1):1879. doi: 10.1038/s41598-019-38491-0.


Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.

Jacobs C, Loftus TJ, Manning EW 3rd, Moore FA, Brakenridge SC.

J Trauma Acute Care Surg. 2019 Apr;86(4):755-757. doi: 10.1097/TA.0000000000002189. No abstract available.


Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.

Muccioli M, Nandigam H, Loftus T, Singh M, Venkatesh A, Wright J, Pate M, McCall K, Benencia F.

Oncotarget. 2018 Nov 30;9(94):36666-36683. doi: 10.18632/oncotarget.26378. eCollection 2018 Nov 30.


The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.

Loftus TJ, Efron PA, Bala TM, Rosenthal MD, Croft CA, Walters MS, Smith RS, Moore FA, Mohr AM, Brakenridge SC.

J Trauma Acute Care Surg. 2019 Apr;86(4):670-678. doi: 10.1097/TA.0000000000002170.


Occult bowel injury after blunt abdominal trauma.

Loftus TJ, Morrow ML, Lottenberg L, Rosenthal MD, Croft CA, Smith RS, Moore FA, Brakenridge SC, Borrego R, Efron PA, Mohr AM.

Am J Surg. 2019 Aug;218(2):266-270. doi: 10.1016/j.amjsurg.2018.11.018. Epub 2018 Nov 28.


Persistent inflammation and anemia among critically ill septic patients.

Loftus TJ, Mira JC, Stortz JA, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Brumback BA, Ungaro RF, Bihorac A, Leeuwenburgh C, Moore FA, Moldawer LL, Brakenridge SC, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2019 Feb;86(2):260-267. doi: 10.1097/TA.0000000000002147.


Pathologic stage dictates survival after neoadjuvant radiation for rectal cancer.

Delitto D, Loftus TJ, Iqbal A.

Oncotarget. 2018 Oct 26;9(84):35474-35475. doi: 10.18632/oncotarget.26262. eCollection 2018 Oct 26. No abstract available.


Angiographic embolization followed by piecemeal resection of giant posterior mediastinal schwannoma: Case report and concise review.

Loftus TJ, Pipkin M, Machuca T, Oduntan O.

Int J Surg Case Rep. 2018;53:250-253. doi: 10.1016/j.ijscr.2018.10.055. Epub 2018 Oct 29.


The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.

Loftus TJ, Morrow ML, Lottenberg L, Rosenthal MD, Croft CA, Smith RS, Moore FA, Brakenridge SC, Borrego R, Efron PA, Mohr AM.

World J Surg. 2019 Feb;43(2):457-465. doi: 10.1007/s00268-018-4792-6.


Packed red blood cell donor age affects overall survival in transfused patients undergoing hepatectomy for non-hepatocellular malignancy.

Loftus TJ, Lopez AN, Jenkins TK, Downey EM, Sikora JR, Pelletier JPR, Zendejas IR, Sarosi GA, Thomas RM.

Am J Surg. 2019 Jan;217(1):71-77. doi: 10.1016/j.amjsurg.2018.08.011. Epub 2018 Aug 27.


The effects of beta blockade and clonidine on persistent injury-associated anemia.

Loftus TJ, Rosenthal MD, Croft CA, Smith RS, Moore FA, Brakenridge SC, Efron PA, Mohr AM.

J Surg Res. 2018 Oct;230:175-180. doi: 10.1016/j.jss.2018.06.001. Epub 2018 Jun 28.


Anemia and blood transfusion in elderly trauma patients.

Loftus TJ, Brakenridge SC, Murphy TW, Nguyen LL, Moore FA, Efron PA, Mohr AM.

J Surg Res. 2018 Sep;229:288-293. doi: 10.1016/j.jss.2018.04.021.


Machine learning: a useful radiological adjunct in determination of a newly diagnosed glioma's grade and IDH status.

De Looze C, Beausang A, Cryan J, Loftus T, Buckley PG, Farrell M, Looby S, Reilly R, Brett F, Kearney H.

J Neurooncol. 2018 Sep;139(2):491-499. doi: 10.1007/s11060-018-2895-4. Epub 2018 May 16.


The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.

Loftus TJ, Mira JC, Miller ES, Kannan KB, Plazas JM, Delitto D, Stortz JA, Hagen JE, Parvataneni HK, Sadasivan KK, Brakenridge SC, Moore FA, Moldawer LL, Efron PA, Mohr AM.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):629-638. doi: 10.1164/rccm.201712-2536OC.


Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.

Horiguchi H, Loftus TJ, Hawkins RB, Raymond SL, Stortz JA, Hollen MK, Weiss BP, Miller ES, Bihorac A, Larson SD, Mohr AM, Brakenridge SC, Tsujimoto H, Ueno H, Moore FA, Moldawer LL, Efron PA; Sepsis and Critical Illness Research Center Investigators.

Front Immunol. 2018 Apr 4;9:595. doi: 10.3389/fimmu.2018.00595. eCollection 2018. Review.


Patient-Specific and Hospital Resource-Specific Considerations in Operative Versus Nonoperative Management of Acute Appendicitis.

Loftus TJ, Jordan JR.

J Surg Res. 2019 May;237:110-111. doi: 10.1016/j.jss.2018.03.005. Epub 2018 Apr 3. No abstract available.


Mouse Injury Model of Polytrauma and Shock.

Mira JC, Nacionales DC, Loftus TJ, Ungaro R, Mathias B, Mohr AM, Moldawer LL, Efron PA.

Methods Mol Biol. 2018;1717:1-15. doi: 10.1007/978-1-4939-7526-6_1. Review.


Persistent injury-associated anemia and aging: Novel insights.

Loftus TJ, Kannan KB, Carter CS, Plazas JM, Mira JC, Brakenridge SC, Leeuwenburgh C, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2018 Mar;84(3):490-496. doi: 10.1097/TA.0000000000001766.


A protocol for non-operative management of uncomplicated appendicitis.

Loftus TJ, Dessaigne CG, Croft CA, Smith RS, Efron PA, Moore FA, Brakenridge SC, Mohr AM, Jordan JR.

J Trauma Acute Care Surg. 2018 Feb;84(2):358-364. doi: 10.1097/TA.0000000000001709.


Effect of Time to Operation on Value of Care in Acute Care Surgery.

Loftus TJ, Rosenthal MD, Croft CA, Stephen Smith R, Efron PA, Moore FA, Mohr AM, Brakenridge SC.

World J Surg. 2018 Aug;42(8):2356-2363. doi: 10.1007/s00268-018-4476-2.


Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells.

Venkatesh A, Nandigam H, Muccioli M, Singh M, Loftus T, Lewis D, Pate M, Benencia F.

Immunobiology. 2018 Jun - Jul;223(6-7):466-476. doi: 10.1016/j.imbio.2017.11.005. Epub 2017 Nov 22.


Persistent injury-associated anemia in aged rats.

Loftus TJ, Kannan KB, Carter CS, Plazas JM, Mira JC, Brakenridge SC, Leeuwenburgh C, Efron PA, Mohr AM.

Exp Gerontol. 2018 Mar;103:63-68. doi: 10.1016/j.exger.2018.01.001. Epub 2018 Jan 4.


Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol.

O'Regan CJ, Kearney H, Beausang A, Farrell MA, Brett FM, Cryan JB, Loftus TE, Buckley PG.

J Neurooncol. 2018 Apr;137(2):233-240. doi: 10.1007/s11060-017-2722-3. Epub 2017 Dec 20.


Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

Stortz JA, Mira JC, Raymond SL, Loftus TJ, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Leeuwenburgh C, Segal MS, Bihorac A, Brumback BA, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

J Trauma Acute Care Surg. 2018 Feb;84(2):342-349. doi: 10.1097/TA.0000000000001758.


Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy.

Delitto D, George TJ Jr, Loftus TJ, Qiu P, Chang GJ, Allegra CJ, Hall WA, Hughes SJ, Tan SA, Shaw CM, Iqbal A.

J Natl Cancer Inst. 2018 May 1;110(5):460-466. doi: 10.1093/jnci/djx228.


Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.

Loftus TJ, Brakenridge SC, Croft CA, Stephen Smith R, Efron PA, Moore FA, Mohr AM, Jordan JR.

J Surg Res. 2018 Feb;222:212-218.e2. doi: 10.1016/j.jss.2017.10.006. Epub 2017 Nov 13.


Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.

Loftus TJ, Efron PA, Bala TM, Rosenthal MD, Croft CA, Smith RS, Moore FA, Mohr AM, Brakenridge SC.

J Trauma Acute Care Surg. 2018 Feb;84(2):350-357. doi: 10.1097/TA.0000000000001730.


Response to Er and Tez: the use of artificial neural networks in medical prognostication.

Loftus TJ, Jordan JR.

J Surg Res. 2018 Feb;222:226. doi: 10.1016/j.jss.2017.10.005. Epub 2017 Oct 27. No abstract available.


Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.

Loftus TJ, Mohr AM, Moldawer LL.

Curr Opin Hematol. 2018 Jan;25(1):37-43. doi: 10.1097/MOH.0000000000000395. Review.


ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome.

Loftus TJ, Moore FA, Moldawer LL.

Crit Care Med. 2017 Nov;45(11):e1184. doi: 10.1097/CCM.0000000000002576. No abstract available.


Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.

Stortz JA, Murphy TJ, Raymond SL, Mira JC, Ungaro R, Dirain ML, Nacionales DC, Loftus TJ, Wang Z, Ozrazgat-Baslanti T, Ghita GL, Brumback BA, Mohr AM, Bihorac A, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

Shock. 2018 Mar;49(3):249-258. doi: 10.1097/SHK.0000000000000981.


EBV driven natural killer cell disease of the central nervous system presenting as subacute cognitive decline.

Brett FM, Flavin R, Chen D, Loftus T, Looby S, McCarthy A, de Gascun C, Jaffe ES, Nor N, Javadpour M, McCabe D.

Hum Pathol (N Y). 2017 Nov;10:64-68. doi: 10.1016/j.ehpc.2017.06.007.

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