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Environmental ototoxicants, a potential new class of chemical stressors.

Fábelová L, Loffredo CA, Klánová J, Hilscherová K, Horvat M, Tihányi J, Richterová D, Palkovičová Murínová Ľ, Wimmerová S, Sisto R, Moleti A, Trnovec T.

Environ Res. 2019 Apr;171:378-394. doi: 10.1016/j.envres.2019.01.042. Epub 2019 Jan 26. Review.


Body mass index modifies bladder cancer risk associated with low estrogen exposure among Egyptian women after menopause.

Amr S, Wolpert BJ, St George DM, James I, Loffredo CA.

Cancer Causes Control. 2019 Mar;30(3):249-258. doi: 10.1007/s10552-019-1131-7. Epub 2019 Jan 21.


IFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections.

Minas TZ, Tang W, Smith CJ, Onabajo OO, Obajemu A, Dorsey TH, Jordan SV, Obadi OM, Ryan BM, Prokunina-Olsson L, Loffredo CA, Ambs S.

Commun Biol. 2018 Nov 14;1:191. doi: 10.1038/s42003-018-0193-5. eCollection 2018.


Racial and Ethnic Differences in the Relationship between Aspirin Use and Non-Small Cell Lung Cancer Risk and Survival.

Erickson P, Gardner LD, Loffredo CA, St George DM, Bowman ED, Deepak J, Mitchell K, Meaney CL, Langenberg P, Bernat DH, Amr S, Ryan BM.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1518-1526. doi: 10.1158/1055-9965.EPI-18-0366. Epub 2018 Aug 31.


Epidemiological Investigation of Type 2 Diabetes and Alzheimer's Disease in a Pakistani Population.

Noreen Z, DeJesus J, Bhatti A, Loffredo CA, John P, Khan JS, Nunlee-Bland G, Ghosh S.

Int J Environ Res Public Health. 2018 Jul 26;15(8). pii: E1582. doi: 10.3390/ijerph15081582.


IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.

Tang W, Wallace TA, Yi M, Magi-Galluzzi C, Dorsey TH, Onabajo OO, Obajemu A, Jordan SV, Loffredo CA, Stephens RM, Silverman RH, Stark GR, Klein EA, Prokunina-Olsson L, Ambs S.

Clin Cancer Res. 2018 Nov 1;24(21):5471-5481. doi: 10.1158/1078-0432.CCR-18-1060. Epub 2018 Jul 16.


Author Correction: Strong associations between chromosomal aberrations in blood lymphocytes and the risk of urothelial and squamous cell carcinoma of the bladder.

Wang H, Wang Y, Kota KK, Sun B, Kallakury B, Mikhail NN, Sayed D, Mokhtar A, Maximous D, Yassin EH, Sun SX, Chen X, Loffredo CA, Zheng YL.

Sci Rep. 2018 May 22;8(1):8183. doi: 10.1038/s41598-018-26488-0.


Association of Anthropometric Measures with Prostate Cancer among African American Men in the NCI-Maryland Prostate Cancer Case-Control Study.

Pichardo MS, Smith CJ, Dorsey TH, Loffredo CA, Ambs S.

Cancer Epidemiol Biomarkers Prev. 2018 Aug;27(8):936-944. doi: 10.1158/1055-9965.EPI-18-0242. Epub 2018 May 21.


Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation?

Kyritsi F, Loffredo CA, Zheng YL, Philips G, Amr S.

Adv Urol. 2018 Mar 13;2018:3453808. doi: 10.1155/2018/3453808. eCollection 2018.


PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations.

Ghosh S, Loffredo CA, Mitra PS, Trnovec T, Palkovicova Murinova L, Sovcikova E, Hoffman EP, Makambi KH, Dutta SK.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16493-16507. doi: 10.1007/s11356-017-0149-1. Epub 2017 Nov 15.


Familial co-occurrence of congenital heart defects follows distinct patterns.

Ellesøe SG, Workman CT, Bouvagnet P, Loffredo CA, McBride KL, Hinton RB, van Engelen K, Gertsen EC, Mulder BJM, Postma AV, Anderson RH, Hjortdal VE, Brunak S, Larsen LA.

Eur Heart J. 2018 Mar 21;39(12):1015-1022. doi: 10.1093/eurheartj/ehx314.


Strong associations between chromosomal aberrations in blood lymphocytes and the risk of urothelial and squamous cell carcinoma of the bladder.

Wang H, Wang Y, Kota KK, Sun B, Kallakury B, Mikhail NN, Sayed D, Mokhtar A, Maximous D, Yassin EH, Sun SX, Chen X, Loffredo CA, Zheng YL.

Sci Rep. 2017 Oct 18;7(1):13493. doi: 10.1038/s41598-017-13976-y. Erratum in: Sci Rep. 2018 May 22;8(1):8183.


Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.

Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW; TIGER-LC Consortium.

Cancer Cell. 2017 Jul 10;32(1):57-70.e3. doi: 10.1016/j.ccell.2017.05.009. Epub 2017 Jun 22.


Changes in the diagnosis of congenital cardiovascular malformations during the 1st year of life: impacts on epidemiological risk factor associations.

Firl KC, King JS, Makambi KH, Loffredo CA.

Cardiol Young. 2017 May;27(4):770-781. doi: 10.1017/S104795111600130X.


Aspirin Use Reduces the Risk of Aggressive Prostate Cancer and Disease Recurrence in African-American Men.

Smith CJ, Dorsey TH, Tang W, Jordan SV, Loffredo CA, Ambs S.

Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):845-853. doi: 10.1158/1055-9965.EPI-16-1027. Epub 2017 Mar 14.


Menthol Smokers: Metabolomic Profiling and Smoking Behavior.

Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG.

Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):51-60. doi: 10.1158/1055-9965.EPI-16-0124. Epub 2016 Sep 14.


Metabolomic profiles of current cigarette smokers.

Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG.

Mol Carcinog. 2017 Feb;56(2):594-606. doi: 10.1002/mc.22519. Epub 2016 Aug 22.


Circulating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non- Inflammatory Breast Cancer.

Hamdi K, Blancato J, Goerlitz D, Islam M, Neili B, Abidi A, Gat A, Ayed FB, Chivi S, Loffredo C, Jillson I, Elgaaied AB, Marrakchi R.

Asian Pac J Cancer Prev. 2016;17(4):1801-10.


PM2.5 as a marker of exposure to tobacco smoke and other sources of particulate matter in Cairo, Egypt.

Loffredo CA, Tang Y, Momen M, Makambi K, Radwan GN, Aboul-Foutoh A.

Int J Tuberc Lung Dis. 2016 Mar;20(3):417-22. doi: 10.5588/ijtld.15.0316.


Nonoccupational exposure to agricultural work and risk of urinary bladder cancer among Egyptian women.

Jackson SS, St George DM, Loffredo CA, Amr S.

Arch Environ Occup Health. 2017 May 4;72(3):166-172. doi: 10.1080/19338244.2016.1169155. Epub 2016 Mar 30.


An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers.

Prueitt RL, Wallace TA, Glynn SA, Yi M, Tang W, Luo J, Dorsey TH, Stagliano KE, Gillespie JW, Hudson RS, Terunuma A, Shoe JL, Haines DC, Yfantis HG, Han M, Martin DN, Jordan SV, Borin JF, Naslund MJ, Alexander RB, Stephens RM, Loffredo CA, Lee DH, Putluri N, Sreekumar A, Hurwitz AA, Ambs S.

Cancer Res. 2016 Mar 1;76(5):1055-1065. doi: 10.1158/0008-5472.CAN-14-3630. Epub 2015 Dec 30.


Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans.

Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):488-97. doi: 10.1158/1055-9965.EPI-15-0378. Epub 2015 Dec 28.


Parental perceptions of congenital cardiovascular malformations in their children.

Ezzat S, Saeedi O, Saleh DA, Hamzeh H, Hamid MA, Crowell N, Boostrom C, Loffredo CA, Jillson IA.

Cardiol Young. 2016 Aug;26(6):1158-67. doi: 10.1017/S104795111500253X. Epub 2015 Nov 12.


Simple reaction time in 8-9-year old children environmentally exposed to PCBs.

Šovčíková E, Wimmerová S, Strémy M, Kotianová J, Loffredo CA, Murínová ĽP, Chovancová J, Čonka K, Lancz K, Trnovec T.

Neurotoxicology. 2015 Dec;51:138-44. doi: 10.1016/j.neuro.2015.10.005. Epub 2015 Oct 19.


Viral transmission risk factors in an Egyptian population with high hepatitis C prevalence.

Mohlman MK, Saleh DA, Ezzat S, Abdel-Hamid M, Korba B, Shetty K, Amr S, Loffredo CA.

BMC Public Health. 2015 Oct 7;15:1030. doi: 10.1186/s12889-015-2369-y.


Strong association between long and heterogeneous telomere length in blood lymphocytes and bladder cancer risk in Egyptian.

Wang H, Wang Y, Kota KK, Kallakury B, Mikhail NN, Sayed D, Mokhtar A, Maximous D, Yassin EH, Gouda I, Sobitan A, Sun B, Loffredo CA, Zheng YL.

Carcinogenesis. 2015 Nov;36(11):1284-90. doi: 10.1093/carcin/bgv121. Epub 2015 Sep 5.


Preventing hepatocellular carcinoma in Egypt: results of a Pilot Health Education Intervention Study.

Saleh DA, Amr S, Jillson IA, Wang JH, Crowell N, Loffredo CA.

BMC Res Notes. 2015 Aug 29;8:384. doi: 10.1186/s13104-015-1351-1.


Hepatitis C virus Genotype 1a core gene nucleotide patterns associated with hepatocellular carcinoma risk.

Korba B, Shetty K, Medvedev A, Viswanathan P, Varghese R, Zhou B, Roy R, Makambi K, Ressom H, Loffredo CA.

J Gen Virol. 2015 Sep;96(9):2928-37. doi: 10.1099/jgv.0.000219. Epub 2015 Jul 3.


Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers.

Weng DY, Chen J, Taslim C, Hsu PC, Marian C, David SP, Loffredo CA, Shields PG.

Mol Carcinog. 2016 Oct;55(10):1424-37. doi: 10.1002/mc.22385. Epub 2015 Aug 21.


[Radiobiological Human Tissue repository: progress and perspectives for solving the problems of radiation safety and health protection of personnel and population].

Kirillova EN, Romanov SA, Loffredo CA, Zakharova ML, Revina VS, Sokolova SN, Goerlitz DS, Zubkova OV, Lukianova TV, Uriadnitzkaia TI, Pavlova OS, Slukinova UV, Kolosova AV, Muksinova KN.

Radiats Biol Radioecol. 2014 Nov-Dec;54(6):565-81. Russian.


Telomere length variation: A potential new telomere biomarker for lung cancer risk.

Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL.

Lung Cancer. 2015 Jun;88(3):297-303. doi: 10.1016/j.lungcan.2015.03.011. Epub 2015 Mar 20.


Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: indicator of disease and disorder development in humans.

Ghosh S, Mitra PS, Loffredo CA, Trnovec T, Murinova L, Sovcikova E, Ghimbovschi S, Zang S, Hoffman EP, Dutta SK.

Environ Res. 2015 Apr;138:202-16. doi: 10.1016/j.envres.2014.12.031. Epub 2015 Feb 27.


Substance use by Egyptian youth: current patterns and potential avenues for prevention.

Loffredo CA, Boulos DN, Saleh DA, Jillson IA, Garas M, Loza N, Samuel P, Shaker YE, Ostrowski MJ, Amr S.

Subst Use Misuse. 2015 Apr;50(5):609-18. doi: 10.3109/10826084.2014.997391. Epub 2015 Jan 28.


Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations.

Adhikari S, Chetram MA, Woodrick J, Mitra PS, Manthena PV, Khatkar P, Dakshanamurthy S, Dixon M, Karmahapatra SK, Nuthalapati NK, Gupta S, Narasimhan G, Mazumder R, Loffredo CA, Üren A, Roy R.

J Biol Chem. 2015 Feb 20;290(8):4966-80. doi: 10.1074/jbc.M114.627000. Epub 2014 Dec 23.


Mediation analysis of gestational age, congenital heart defects, and infant birth-weight.

Wogu AF, Loffredo CA, Bebu I, Luta G.

BMC Res Notes. 2014 Dec 17;7:926. doi: 10.1186/1756-0500-7-926.


Multiple pregnancies, hepatitis C, and risk for hepatocellular carcinoma in Egyptian women.

Amr S, Iarocci EA, Nasr GR, Saleh D, Blancato J, Shetty K, Loffredo CA.

BMC Cancer. 2014 Nov 29;14:893. doi: 10.1186/1471-2407-14-893.


Biomarkers linking PCB exposure and obesity.

Ghosh S, Murinova L, Trnovec T, Loffredo CA, Washington K, Mitra PS, Dutta SK.

Curr Pharm Biotechnol. 2014;15(11):1058-68. Review.


Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling.

Malki A, Elbayaa RY, Ashour HM, Loffredo CA, Youssef AM.

J Enzyme Inhib Med Chem. 2015;30(5):786-95. doi: 10.3109/14756366.2014.971781.


Relationship of birth weight with congenital cardiovascular malformations in a population-based study.

Petrossian RA, Kuehl KS, Loffredo CA.

Cardiol Young. 2015 Aug;25(6):1086-92. doi: 10.1017/S1047951114001644. Epub 2014 Aug 28.


Knowledge, attitudes, and beliefs of patients with chronic liver disease.

Burnham B, Wallington S, Jillson IA, Trandafili H, Shetty K, Wang J, Loffredo CA.

Am J Health Behav. 2014 Sep;38(5):737-44. doi: 10.5993/AJHB.38.5.11.


Knowledge and perceptions of hepatitis C infection and pesticides use in two rural villages in Egypt.

Saleh DA, Amr S, Jillson IA, Wang JH, Khairy WA, Loffredo CA.

BMC Public Health. 2014 May 24;14:501. doi: 10.1186/1471-2458-14-501.


Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.

Wallace TA, Downey RF, Seufert CJ, Schetter A, Dorsey TH, Johnson CA, Goldman R, Loffredo CA, Yan P, Sullivan FJ, Giles FJ, Wang-Johanning F, Ambs S, Glynn SA.

Carcinogenesis. 2014 Sep;35(9):2074-83. doi: 10.1093/carcin/bgu114. Epub 2014 May 23.


Associations of depression and neuroticism with smoking behavior and motives among men in rural Qalyubia (Egypt).

Radwan GN, Loffredo CA, Abdelaziz H, Amr S.

J Egypt Public Health Assoc. 2014 Apr;89(1):16-21. doi: 10.1097/01.EPX.0000444060.91661.6f.


Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.

Amr S, Dawson R, Saleh DA, Magder LS, St George DM, El-Daly M, Squibb K, Mikhail NN, Abdel-Hamid M, Khaled H, Loffredo CA.

Arch Environ Occup Health. 2015;70(1):19-26. doi: 10.1080/19338244.2013.853646.


Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.

Goerlitz D, Amr S, Dash C, Saleh DA, El Daly M, Abdel-Hamid M, El Kafrawy S, Hifnawy T, Ezzat S, Abdel-Aziz MA, Khaled H, Zheng YL, Mikhail N, Loffredo CA.

Urol Oncol. 2014 Jan;32(1):47.e15-20. doi: 10.1016/j.urolonc.2013.06.016. Epub 2013 Sep 10.


Agricultural workers and urinary bladder cancer risk in Egypt.

Amr S, Dawson R, Saleh DA, Magder LS, Mikhail NN, St George DM, Squibb K, Khaled H, Loffredo CA.

Arch Environ Occup Health. 2014;69(1):3-10. doi: 10.1080/19338244.2012.719556.


Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.

Zhu WW, Guo JJ, Guo L, Jia HL, Zhu M, Zhang JB, Loffredo CA, Forgues M, Huang H, Xing XJ, Ren N, Dong QZ, Zhou HJ, Ren ZG, Zhao NQ, Wang XW, Tang ZY, Qin LX, Ye QH.

Clin Cancer Res. 2013 Jul 15;19(14):3944-54. doi: 10.1158/1078-0432.CCR-12-3363. Epub 2013 May 29.


Identifying early events of gene expression in breast cancer with systems biology phylogenetics.

Abu-Asab MS, Abu-Asab N, Loffredo CA, Clarke R, Amri H.

Cytogenet Genome Res. 2013;139(3):206-14. doi: 10.1159/000348433. Epub 2013 Apr 3.


Knowledge and willingness to provide research biospecimens among foreign-born Latinos using safety-net clinics.

Loffredo CA, Luta G, Wallington S, Makgoeng SB, Selsky C, Mandelblatt JS, Adams-Campbell LL; Region 1 Bio-specimen Management of Cancer Health Disparities Program.

J Community Health. 2013 Aug;38(4):652-9. doi: 10.1007/s10900-013-9660-6.


A randomized, controlled community-wide intervention to reduce environmental tobacco smoke exposure.

Mohlman MK, Boulos DN, El Setouhy M, Radwan G, Makambi K, Jillson I, Loffredo CA.

Nicotine Tob Res. 2013 Aug;15(8):1372-81. doi: 10.1093/ntr/nts333. Epub 2013 Jan 17.

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