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Items: 44


Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.

Penton D, Moser S, Wengi A, Czogalla J, Rosenbaek LL, Rigendinger F, Faresse N, Martins JR, Fenton RA, Loffing-Cueni D, Loffing J.

J Am Soc Nephrol. 2019 May;30(5):737-750. doi: 10.1681/ASN.2018050540. Epub 2019 Mar 22.


Gitelman's Syndrome: characterization of a novel c.1181G>A point mutation and functional classification of the known mutations.

Ravarotto V, Loffing J, Loffing-Cueni D, Heidemeyer M, Pagnin E, Calò LA, Rossi GP.

Hypertens Res. 2018 Aug;41(8):578-588. doi: 10.1038/s41440-018-0061-1. Epub 2018 Jun 20.


Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific γENaC Knockout.

Boscardin E, Perrier R, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Koesters R, Rossier BC, Hummler E.

J Am Soc Nephrol. 2018 Mar;29(3):977-990. doi: 10.1681/ASN.2017030345. Epub 2018 Jan 25.


Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule.

Sugano Y, Cianciolo Cosentino C, Loffing-Cueni D, Neuhauss SCF, Loffing J.

Pflugers Arch. 2017 Aug;469(7-8):859-867. doi: 10.1007/s00424-017-2009-8. Epub 2017 Jun 27.


Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.

Boscardin E, Perrier R, Sergi C, Maillard M, Loffing J, Loffing-Cueni D, Koesters R, Rossier BC, Hummler E.

Pflugers Arch. 2017 Oct;469(10):1387-1399. doi: 10.1007/s00424-017-1990-2. Epub 2017 May 31.


Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl- -dependent and independent mechanisms.

Penton D, Czogalla J, Wengi A, Himmerkus N, Loffing-Cueni D, Carrel M, Rajaram RD, Staub O, Bleich M, Schweda F, Loffing J.

J Physiol. 2016 Nov 1;594(21):6319-6331. doi: 10.1113/JP272504. Epub 2016 Sep 11.


Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Canonica J, Sergi C, Maillard M, Klusonova P, Odermatt A, Koesters R, Loffing-Cueni D, Loffing J, Rossier B, Frateschi S, Hummler E.

Pflugers Arch. 2016 May;468(5):895-908. doi: 10.1007/s00424-015-1785-2. Epub 2016 Jan 14.


Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.

Perrier R, Boscardin E, Malsure S, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Sørensen MV, Koesters R, Rossier BC, Frateschi S, Hummler E.

J Am Soc Nephrol. 2016 Aug;27(8):2309-18. doi: 10.1681/ASN.2015020154. Epub 2015 Dec 23.


Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.

Di Chiara M, Glaudemans B, Loffing-Cueni D, Odermatt A, Al-Hasani H, Devuyst O, Faresse N, Loffing J.

Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F779-90. doi: 10.1152/ajprenal.00139.2015. Epub 2015 Sep 2.


ENaC activity in collecting ducts modulates NCC in cirrhotic mice.

Mordasini D, Loffing-Cueni D, Loffing J, Beatrice R, Maillard MP, Hummler E, Burnier M, Escher G, Vogt B.

Pflugers Arch. 2015 Dec;467(12):2529-39. doi: 10.1007/s00424-015-1711-7. Epub 2015 Jun 10.


Deletion of both Rab-GTPase-activating proteins TBC14KO and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport. Diabetes 2015;64:746-759.

Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H.

Diabetes. 2015 Apr;64(4):1492. doi: 10.2337/db15-er04. No abstract available.


“Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport [corrected].

Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H.

Diabetes. 2015 Mar;64(3):746-59. doi: 10.2337/db14-0368. Epub 2014 Sep 23. Erratum in: Diabetes. 2015 Apr;64(4):1492.


Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency.

Todkar A, Picard N, Loffing-Cueni D, Sorensen MV, Mihailova M, Nesterov V, Makhanova N, Korbmacher C, Wagner CA, Loffing J.

J Am Soc Nephrol. 2015 Feb;26(2):425-38. doi: 10.1681/ASN.2013111156. Epub 2014 Jul 28.


Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.

Picard N, Trompf K, Yang CL, Miller RL, Carrel M, Loffing-Cueni D, Fenton RA, Ellison DH, Loffing J.

J Am Soc Nephrol. 2014 Mar;25(3):511-22. doi: 10.1681/ASN.2012121202. Epub 2013 Nov 14.


Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice.

Sorensen MV, Grossmann S, Roesinger M, Gresko N, Todkar AP, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J.

Kidney Int. 2013 May;83(5):811-24. doi: 10.1038/ki.2013.14. Epub 2013 Feb 27.


Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.

Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O.

J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25.


Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.

Frebel H, Nindl V, Schuepbach RA, Braunschweiler T, Richter K, Vogel J, Wagner CA, Loffing-Cueni D, Kurrer M, Ludewig B, Oxenius A.

J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.


Aldosterone deficiency adversely affects pregnancy outcome in mice.

Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J, Wagner CA.

Pflugers Arch. 2012 Oct;464(4):331-43. Epub 2012 Sep 2.


OS058. Aldosterone deficiency adversely affects pregnancy outcome in mice.

Todkar A, Chiara MD, Loffing-Cueni D, Bettoni C, Mohaupt MG, Loffing J, Wagner C.

Pregnancy Hypertens. 2012 Jul;2(3):208. doi: 10.1016/j.preghy.2012.04.059. Epub 2012 Jun 13.


Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney.

Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J.

Histochem Cell Biol. 2012 Jul;138(1):101-12. doi: 10.1007/s00418-012-0944-1. Epub 2012 Mar 31.


Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line.

Gaeggeler HP, Guillod Y, Loffing-Cueni D, Loffing J, Rossier BC.

Kidney Int. 2011 Apr;79(8):843-52. doi: 10.1038/ki.2010.486. Epub 2010 Dec 22.


In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule.

Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier BC, Loffing J.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1473-85. doi: 10.1152/ajprenal.00437.2010. Epub 2010 Sep 22.


Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins.

Wagner CA, Loffing-Cueni D, Yan Q, Schulz N, Fakitsas P, Carrel M, Wang T, Verrey F, Geibel JP, Giebisch G, Hebert SC, Loffing J.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1373-80. doi: 10.1152/ajprenal.00613.2007. Epub 2008 Mar 5.


Replication of segment-specific and intercalated cells in the mouse renal collecting system.

Wehrli P, Loffing-Cueni D, Kaissling B, Loffing J.

Histochem Cell Biol. 2007 Apr;127(4):389-98. Epub 2006 Dec 22.


The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase.

Kovacikova J, Winter C, Loffing-Cueni D, Loffing J, Finberg KE, Lifton RP, Hummler E, Rossier B, Wagner CA.

Kidney Int. 2006 Nov;70(10):1706-16. Epub 2006 Sep 20.


Pendrin regulation in mouse kidney primarily is chloride-dependent.

Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D.

J Am Soc Nephrol. 2006 Aug;17(8):2153-63. Epub 2006 Jul 6.


Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system.

Loffing-Cueni D, Flores SY, Sauter D, Daidié D, Siegrist N, Meneton P, Staub O, Loffing J.

J Am Soc Nephrol. 2006 May;17(5):1264-74. Epub 2006 Mar 29.


Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.

Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O.

J Am Soc Nephrol. 2005 Aug;16(8):2279-87. Epub 2005 Jun 15.


Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line.

Gaeggeler HP, Gonzalez-Rodriguez E, Jaeger NF, Loffing-Cueni D, Norregaard R, Loffing J, Horisberger JD, Rossier BC.

J Am Soc Nephrol. 2005 Apr;16(4):878-91. Epub 2005 Mar 2.


Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.

Loffing J, Vallon V, Loffing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M, Hoenderop JG, Shull GE, Meneton P, Kaissling B.

J Am Soc Nephrol. 2004 Sep;15(9):2276-88.


Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells.

Bauch C, Forster N, Loffing-Cueni D, Summa V, Verrey F.

J Biol Chem. 2003 Jan 10;278(2):1316-22. Epub 2002 Nov 1.


Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron.

Loffing J, Loffing-Cueni D, Valderrabano V, Kläusli L, Hebert SC, Rossier BC, Hoenderop JG, Bindels RJ, Kaissling B.

Am J Physiol Renal Physiol. 2001 Dec;281(6):F1021-7.


Trafficking of GFP-tagged DeltaF508-CFTR to the plasma membrane in a polarized epithelial cell line.

Loffing-Cueni D, Loffing J, Shaw C, Taplin AM, Govindan M, Stanton CR, Stanton BA.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C1889-97.


Localization of organic cation transporters OCT1 and OCT2 in rat kidney.

Karbach U, Kricke J, Meyer-Wentrup F, Gorboulev V, Volk C, Loffing-Cueni D, Kaissling B, Bachmann S, Koepsell H.

Am J Physiol Renal Physiol. 2000 Oct;279(4):F679-87.


Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex.

Loffing J, Loffing-Cueni D, Macher A, Hebert SC, Olson B, Knepper MA, Rossier BC, Kaissling B.

Am J Physiol Renal Physiol. 2000 Apr;278(4):F530-9.


Luminal heterodimeric amino acid transporter defective in cystinuria.

Pfeiffer R, Loffing J, Rossier G, Bauch C, Meier C, Eggermann T, Loffing-Cueni D, Kühn LC, Verrey F.

Mol Biol Cell. 1999 Dec;10(12):4135-47.


Butyrate increases apical membrane CFTR but reduces chloride secretion in MDCK cells.

Moyer BD, Loffing-Cueni D, Loffing J, Reynolds D, Stanton BA.

Am J Physiol. 1999 Aug;277(2):F271-6. doi: 10.1152/ajprenal.1999.277.2.F271.


Molecular cloning and tissue expression of the insulin-like growth factor II prohormone in the bony fish Cottus scorpius.

Loffing-Cueni D, Schmid AC, Reinecke M.

Gen Comp Endocrinol. 1999 Jan;113(1):32-7.


Subunit stoichiometry of a core conduction element in a cloned epithelial amiloride-sensitive Na+ channel.

Berdiev BK, Karlson KH, Jovov B, Ripoll PJ, Morris R, Loffing-Cueni D, Halpin P, Stanton BA, Kleyman TR, Ismailov II.

Biophys J. 1998 Nov;75(5):2292-301.


IGF-I in the bony fish Cottus scorpius: cDNA, expression and differential localization in brain and islets.

Loffing-Cueni D, Schmid AC, Graf H, Reinecke M.

Mol Cell Endocrinol. 1998 Jun 25;141(1-2):187-94.


Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells.

Moyer BD, Loffing J, Schwiebert EM, Loffing-Cueni D, Halpin PA, Karlson KH, Ismailov II, Guggino WB, Langford GM, Stanton BA.

J Biol Chem. 1998 Aug 21;273(34):21759-68. Erratum in: J Biol Chem 1998 Oct 2;273(40):26256.


Localization, expression, and characterization of guanylin in the rat adrenal medulla.

Reinecke M, David I, Loffing-Cueni D, Ablinger P, Cetin Y, Kuhn M, Forssmann WG.

Histochem Cell Biol. 1996 Oct;106(4):367-74.


Thiazide treatment of rats provokes apoptosis in distal tubule cells.

Loffing J, Loffing-Cueni D, Hegyi I, Kaplan MR, Hebert SC, Le Hir M, Kaissling B.

Kidney Int. 1996 Oct;50(4):1180-90.

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