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Items: 1 to 50 of 126

1.

Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.

Penton D, Moser S, Wengi A, Czogalla J, Rosenbaek LL, Rigendinger F, Faresse N, Martins JR, Fenton RA, Loffing-Cueni D, Loffing J.

J Am Soc Nephrol. 2019 May;30(5):737-750. doi: 10.1681/ASN.2018050540. Epub 2019 Mar 22.

PMID:
30902838
2.

Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish.

Cianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss SCF, Doye V.

Sci Rep. 2019 Mar 18;9(1):4750. doi: 10.1038/s41598-019-41202-4.

3.

Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease.

Eckhard AH, Zhu M, O'Malley JT, Williams GH, Loffing J, Rauch SD, Nadol JB Jr, Liberman MC, Adams JC.

Acta Neuropathol. 2019 Feb;137(2):343-357. doi: 10.1007/s00401-018-1927-7. Epub 2018 Nov 2.

4.

The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice.

Craigie E, Menzies RI, Larsen CK, Jacquillet G, Carrel M, Wildman SS, Loffing J, Leipziger J, Shirley DG, Bailey MA, Unwin RJ.

Physiol Rep. 2018 Oct;6(20):e13899. doi: 10.14814/phy2.13899.

5.

Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC.

Tokonami N, Takata T, Beyeler J, Ehrbar I, Yoshifuji A, Christensen EI, Loffing J, Devuyst O, Olinger EG.

Kidney Int. 2018 Oct;94(4):701-715. doi: 10.1016/j.kint.2018.04.021. Epub 2018 Jul 12.

6.

Gitelman's Syndrome: characterization of a novel c.1181G>A point mutation and functional classification of the known mutations.

Ravarotto V, Loffing J, Loffing-Cueni D, Heidemeyer M, Pagnin E, Calò LA, Rossi GP.

Hypertens Res. 2018 Aug;41(8):578-588. doi: 10.1038/s41440-018-0061-1. Epub 2018 Jun 20.

PMID:
29925901
7.

C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.

Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez IA, Wengi A, Stone KL, Zhang J, Loffing J, Lifton RP, Yang CL, Ellison DH, Gamba G, Castañeda-Bueno M.

J Biol Chem. 2018 Aug 3;293(31):12209-12221. doi: 10.1074/jbc.RA118.003037. Epub 2018 Jun 19.

PMID:
29921588
8.

Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific γENaC Knockout.

Boscardin E, Perrier R, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Koesters R, Rossier BC, Hummler E.

J Am Soc Nephrol. 2018 Mar;29(3):977-990. doi: 10.1681/ASN.2017030345. Epub 2018 Jan 25.

9.

Dietary sodium induces a redistribution of the tubular metabolic workload.

Udwan K, Abed A, Roth I, Dizin E, Maillard M, Bettoni C, Loffing J, Wagner CA, Edwards A, Feraille E.

J Physiol. 2017 Nov 15;595(22):6905-6922. doi: 10.1113/JP274927. Epub 2017 Oct 15.

10.

Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule.

Sugano Y, Cianciolo Cosentino C, Loffing-Cueni D, Neuhauss SCF, Loffing J.

Pflugers Arch. 2017 Aug;469(7-8):859-867. doi: 10.1007/s00424-017-2009-8. Epub 2017 Jun 27.

PMID:
28656378
11.

Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.

Boscardin E, Perrier R, Sergi C, Maillard M, Loffing J, Loffing-Cueni D, Koesters R, Rossier BC, Hummler E.

Pflugers Arch. 2017 Oct;469(10):1387-1399. doi: 10.1007/s00424-017-1990-2. Epub 2017 May 31.

PMID:
28567665
12.

Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension.

Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, Shimosawa T, Loffing J, Zhang MZ, Marumo T, Fujita T.

Hypertension. 2017 Jul;70(1):111-118. doi: 10.1161/HYPERTENSIONAHA.116.08966. Epub 2017 May 30.

13.

Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization.

Nagarajan S, Vohra T, Loffing J, Faresse N.

Mol Cell Endocrinol. 2017 Jul 15;450:74-82. doi: 10.1016/j.mce.2017.04.020. Epub 2017 Apr 25.

PMID:
28454724
14.

Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia.

Tokonami N, Cheval L, Monnay I, Meurice G, Loffing J, Feraille E, Houillier P.

J Physiol. 2017 Apr 15;595(8):2535-2550. doi: 10.1113/JP273610. Epub 2017 Mar 23.

15.

Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3.

Ishizawa K, Xu N, Loffing J, Lifton RP, Fujita T, Uchida S, Shibata S.

Biochem Biophys Res Commun. 2016 Nov;480(4):745-751. doi: 10.1016/j.bbrc.2016.10.127. Epub 2016 Oct 29.

16.

The Mouse Isolated Perfused Kidney Technique.

Czogalla J, Schweda F, Loffing J.

J Vis Exp. 2016 Nov 17;(117). doi: 10.3791/54712.

17.

Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl- -dependent and independent mechanisms.

Penton D, Czogalla J, Wengi A, Himmerkus N, Loffing-Cueni D, Carrel M, Rajaram RD, Staub O, Bleich M, Schweda F, Loffing J.

J Physiol. 2016 Nov 1;594(21):6319-6331. doi: 10.1113/JP272504. Epub 2016 Sep 11.

18.

TRPV4 is associated with central rather than nephrogenic osmoregulation.

Janas S, Seghers F, Schakman O, Alsady M, Deen P, Vriens J, Tissir F, Nilius B, Loffing J, Gailly P, Devuyst O.

Pflugers Arch. 2016 Sep;468(9):1595-607. doi: 10.1007/s00424-016-1850-5. Epub 2016 Jun 30.

PMID:
27364478
19.

The Authors Reply.

Segerer S, Sugano Y, Lindenmeyer MT, Auberger I, Ziegler U, Cohen CD, Neuhauss SCF, Loffing J.

Kidney Int. 2016 May;89(5):1161-1162. doi: 10.1016/j.kint.2015.10.020. No abstract available.

PMID:
27083290
20.

Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.

Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23.

21.

The mineralocorticoid receptor (MR) regulates ENaC but not NCC in mice with random MR deletion.

Czogalla J, Vohra T, Penton D, Kirschmann M, Craigie E, Loffing J.

Pflugers Arch. 2016 May;468(5):849-58. doi: 10.1007/s00424-016-1798-5. Epub 2016 Feb 22.

PMID:
26898302
22.

Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Canonica J, Sergi C, Maillard M, Klusonova P, Odermatt A, Koesters R, Loffing-Cueni D, Loffing J, Rossier B, Frateschi S, Hummler E.

Pflugers Arch. 2016 May;468(5):895-908. doi: 10.1007/s00424-015-1785-2. Epub 2016 Jan 14.

23.

Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.

Perrier R, Boscardin E, Malsure S, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Sørensen MV, Koesters R, Rossier BC, Frateschi S, Hummler E.

J Am Soc Nephrol. 2016 Aug;27(8):2309-18. doi: 10.1681/ASN.2015020154. Epub 2015 Dec 23.

24.

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.

de Groot T, Sinke AP, Kortenoeven ML, Alsady M, Baumgarten R, Devuyst O, Loffing J, Wetzels JF, Deen PM.

J Am Soc Nephrol. 2016 Jul;27(7):2082-91. doi: 10.1681/ASN.2015070796. Epub 2015 Nov 16.

25.

An Integrated View of Potassium Homeostasis.

Hoorn EJ, Loffing J, Ellison DH.

N Engl J Med. 2015 Oct 29;373(18):1786. doi: 10.1056/NEJMc1509656. No abstract available.

26.

Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.

Di Chiara M, Glaudemans B, Loffing-Cueni D, Odermatt A, Al-Hasani H, Devuyst O, Faresse N, Loffing J.

Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F779-90. doi: 10.1152/ajprenal.00139.2015. Epub 2015 Sep 2.

27.

The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier.

Sugano Y, Lindenmeyer MT, Auberger I, Ziegler U, Segerer S, Cohen CD, Neuhauss SC, Loffing J.

Kidney Int. 2015 Nov;88(5):1047-56. doi: 10.1038/ki.2015.197. Epub 2015 Jul 8.

PMID:
26154927
28.

ENaC activity in collecting ducts modulates NCC in cirrhotic mice.

Mordasini D, Loffing-Cueni D, Loffing J, Beatrice R, Maillard MP, Hummler E, Burnier M, Escher G, Vogt B.

Pflugers Arch. 2015 Dec;467(12):2529-39. doi: 10.1007/s00424-015-1711-7. Epub 2015 Jun 10.

29.

Deletion of both Rab-GTPase-activating proteins TBC14KO and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport. Diabetes 2015;64:746-759.

Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H.

Diabetes. 2015 Apr;64(4):1492. doi: 10.2337/db15-er04. No abstract available.

30.

Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia.

Alves DS, Thulin G, Loffing J, Kashgarian M, Caplan MJ.

J Am Soc Nephrol. 2015 Nov;26(11):2765-76. doi: 10.1681/ASN.2013101040. Epub 2015 Mar 18.

31.

Dietary potassium and the renal control of salt balance and blood pressure.

Penton D, Czogalla J, Loffing J.

Pflugers Arch. 2015 Mar;467(3):513-30. doi: 10.1007/s00424-014-1673-1. Epub 2015 Jan 6. Review.

PMID:
25559844
32.

“Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport [corrected].

Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H.

Diabetes. 2015 Mar;64(3):746-59. doi: 10.2337/db14-0368. Epub 2014 Sep 23. Erratum in: Diabetes. 2015 Apr;64(4):1492.

33.

Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction?

Demoulin N, Aydin S, Cosyns JP, Dahan K, Cornet G, Auberger I, Loffing J, Devuyst O.

Nephrol Dial Transplant. 2014 Sep;29 Suppl 4:iv117-20. doi: 10.1093/ndt/gfu075.

34.

Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency.

Todkar A, Picard N, Loffing-Cueni D, Sorensen MV, Mihailova M, Nesterov V, Makhanova N, Korbmacher C, Wagner CA, Loffing J.

J Am Soc Nephrol. 2015 Feb;26(2):425-38. doi: 10.1681/ASN.2013111156. Epub 2014 Jul 28.

35.

Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.

Terker AS, Yang CL, McCormick JA, Meermeier NP, Rogers SL, Grossmann S, Trompf K, Delpire E, Loffing J, Ellison DH.

Hypertension. 2014 Jul;64(1):178-84. doi: 10.1161/HYPERTENSIONAHA.114.03335. Epub 2014 May 5.

36.

Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.

Olden M, Corre T, Hayward C, Toniolo D, Ulivi S, Gasparini P, Pistis G, Hwang SJ, Bergmann S, Campbell H, Cocca M, Gandin I, Girotto G, Glaudemans B, Hastie ND, Loffing J, Polasek O, Rampoldi L, Rudan I, Sala C, Traglia M, Vollenweider P, Vuckovic D, Youhanna S, Weber J, Wright AF, Kutalik Z, Bochud M, Fox CS, Devuyst O.

J Am Soc Nephrol. 2014 Aug;25(8):1869-82. doi: 10.1681/ASN.2013070781. Epub 2014 Feb 27.

37.

Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.

Sinke AP, Kortenoeven ML, de Groot T, Baumgarten R, Devuyst O, Wetzels JF, Loffing J, Deen PM.

Am J Physiol Renal Physiol. 2014 Mar 1;306(5):F525-33. doi: 10.1152/ajprenal.00617.2013. Epub 2013 Dec 18.

38.

The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.

Moes AD, van der Lubbe N, Zietse R, Loffing J, Hoorn EJ.

Pflugers Arch. 2014 Jan;466(1):107-18. doi: 10.1007/s00424-013-1407-9. Epub 2013 Dec 6. Review.

PMID:
24310820
39.

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.

Picard N, Trompf K, Yang CL, Miller RL, Carrel M, Loffing-Cueni D, Fenton RA, Ellison DH, Loffing J.

J Am Soc Nephrol. 2014 Mar;25(3):511-22. doi: 10.1681/ASN.2012121202. Epub 2013 Nov 14.

40.

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.

Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M, Citterio L, Demaretz S, Trevisani F, Ristagno G, Glaudemans B, Laghmani K, Dell'Antonio G; SKIPOGH team, Loffing J, Rastaldi MP, Manunta P, Devuyst O, Rampoldi L.

Nat Med. 2013 Dec;19(12):1655-60. doi: 10.1038/nm.3384. Epub 2013 Nov 3.

41.

Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.

Pouly D, Debonneville A, Ruffieux-Daidié D, Maillard M, Abriel H, Loffing J, Staub O.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F21-30. doi: 10.1152/ajprenal.00012.2013. Epub 2013 Apr 3.

42.

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice.

Sorensen MV, Grossmann S, Roesinger M, Gresko N, Todkar AP, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J.

Kidney Int. 2013 May;83(5):811-24. doi: 10.1038/ki.2013.14. Epub 2013 Feb 27.

43.

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.

Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O.

J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25.

44.

Parvalbumin: calcium and magnesium buffering in the distal nephron.

Olinger E, Schwaller B, Loffing J, Gailly P, Devuyst O.

Nephrol Dial Transplant. 2012 Nov;27(11):3988-94. doi: 10.1093/ndt/gfs457. Review.

45.

Low-dose oral sirolimus and the risk of menstrual-cycle disturbances and ovarian cysts: analysis of the randomized controlled SUISSE ADPKD trial.

Braun M, Young J, Reiner CS, Poster D, Krauer F, Kistler AD, Kristanto P, Wang X, Liu Y, Loffing J, Andreisek G, von Eckardstein A, Senn O, Wüthrich RP, Serra AL.

PLoS One. 2012;7(10):e45868. doi: 10.1371/journal.pone.0045868. Epub 2012 Oct 10.

46.

Aldosterone deficiency adversely affects pregnancy outcome in mice.

Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J, Wagner CA.

Pflugers Arch. 2012 Oct;464(4):331-43. Epub 2012 Sep 2.

47.

Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1289-99. doi: 10.1152/ajprenal.00247.2012. Epub 2012 Aug 29.

48.

A primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport.

Markadieu N, San-Cristobal P, Nair AV, Verkaart S, Lenssen E, Tudpor K, van Zeeland F, Loffing J, Bindels RJ, Hoenderop JG.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F886-92. doi: 10.1152/ajprenal.00114.2012. Epub 2012 Jul 3.

49.

OS058. Aldosterone deficiency adversely affects pregnancy outcome in mice.

Todkar A, Chiara MD, Loffing-Cueni D, Bettoni C, Mohaupt MG, Loffing J, Wagner C.

Pregnancy Hypertens. 2012 Jul;2(3):208. doi: 10.1016/j.preghy.2012.04.059. Epub 2012 Jun 13.

PMID:
26105272
50.

Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney.

Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J.

Histochem Cell Biol. 2012 Jul;138(1):101-12. doi: 10.1007/s00418-012-0944-1. Epub 2012 Mar 31.

PMID:
22466139

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