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Items: 1 to 50 of 57

1.

TORC2 controls endocytosis through plasma membrane tension.

Riggi M, Bourgoint C, Macchione M, Matile S, Loewith R, Roux A.

J Cell Biol. 2019 Jul 1;218(7):2265-2276. doi: 10.1083/jcb.201901096. Epub 2019 May 23.

PMID:
31123183
2.

TOR Signaling Is Going through a Phase.

Prouteau M, Loewith R.

Cell Metab. 2019 May 7;29(5):1019-1021. doi: 10.1016/j.cmet.2019.04.010.

PMID:
31067446
3.

Sphingolipids and membrane targets for therapeutics.

Loewith R, Riezman H, Winssinger N.

Curr Opin Chem Biol. 2019 Jun;50:19-28. doi: 10.1016/j.cbpa.2019.02.015. Epub 2019 Mar 18. Review.

PMID:
30897494
4.

Regulation of Cellular Metabolism through Phase Separation of Enzymes.

Prouteau M, Loewith R.

Biomolecules. 2018 Dec 3;8(4). pii: E160. doi: 10.3390/biom8040160. Review.

5.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.

Nat Cell Biol. 2018 Sep;20(9):1043-1051. doi: 10.1038/s41556-018-0150-z. Epub 2018 Aug 27.

6.

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.

7.

Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.

8.

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.

Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C.

Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.

9.

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R.

Nature. 2017 Oct 12;550(7675):265-269. doi: 10.1038/nature24021. Epub 2017 Oct 4.

10.

Tensing Up for Lipid Droplet Formation.

Roux A, Loewith R.

Dev Cell. 2017 Jun 19;41(6):571-572. doi: 10.1016/j.devcel.2017.06.001. Review.

11.

A pathway of targeted autophagy is induced by DNA damage in budding yeast.

Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1158-E1167. doi: 10.1073/pnas.1614364114. Epub 2017 Feb 2.

12.

Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.

Primo C, Ferri-Blázquez A, Loewith R, Yenush L.

J Biol Chem. 2017 Jan 13;292(2):563-574. doi: 10.1074/jbc.M116.746982. Epub 2016 Nov 28.

13.

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.

Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.

14.

TORC2 Structure and Function.

Gaubitz C, Prouteau M, Kusmider B, Loewith R.

Trends Biochem Sci. 2016 Jun;41(6):532-545. doi: 10.1016/j.tibs.2016.04.001. Epub 2016 May 5. Review.

PMID:
27161823
15.

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K.

Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.

16.

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R.

Mol Biol Cell. 2016 Jan 15;27(2):397-409. doi: 10.1091/mbc.E15-08-0594. Epub 2015 Nov 18.

17.

TOR Complexes and the Maintenance of Cellular Homeostasis.

Eltschinger S, Loewith R.

Trends Cell Biol. 2016 Feb;26(2):148-159. doi: 10.1016/j.tcb.2015.10.003. Epub 2015 Nov 4. Review.

PMID:
26546292
18.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R.

Mol Cell. 2015 Jun 18;58(6):977-88. doi: 10.1016/j.molcel.2015.04.031. Epub 2015 May 28.

19.

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R.

J Biol Chem. 2015 Jun 12;290(24):14963-78. doi: 10.1074/jbc.M114.627794. Epub 2015 Apr 16.

20.

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.

da Silveira Dos Santos AX, Riezman I, Aguilera-Romero MA, David F, Piccolis M, Loewith R, Schaad O, Riezman H.

Mol Biol Cell. 2014 Oct 15;25(20):3234-46. doi: 10.1091/mbc.E14-03-0851. Epub 2014 Aug 20.

21.

Roles for PI(3,5)P2 in nutrient sensing through TORC1.

Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS.

Mol Biol Cell. 2014 Apr;25(7):1171-85. doi: 10.1091/mbc.E14-01-0021. Epub 2014 Jan 29.

22.

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K.

PLoS Genet. 2014 Jan;10(1):e1004010. doi: 10.1371/journal.pgen.1004010. Epub 2014 Jan 23.

23.

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM.

Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.

24.

Growth control: function follows form.

Loewith R.

Curr Biol. 2013 Jul 22;23(14):R607-9. doi: 10.1016/j.cub.2013.05.048.

25.

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway.

Chen J, Young SM, Allen C, Waller A, Ursu O, Strouse JJ, Yao T, Golden JE, Peterson BR, Foutz TD, Chavez SE, Perez D, Evangelisti AM, Garcia MJ, Bologa CG, Carter MB, Salas VM, Oprea TI, Edwards BS, Panchaud N, De Virgilio C, Seeber A, Loewith R, Manzanilla E, Werner-Washburne M, Aubé J, Sklar LA.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 25].

26.

Amino acid signaling in high definition.

Gaubitz C, Loewith R.

Structure. 2012 Dec 5;20(12):1993-4. doi: 10.1016/j.str.2012.11.006.

27.

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R.

Nat Cell Biol. 2012 Apr 15;14(5):542-7. doi: 10.1038/ncb2480.

PMID:
22504275
28.

Chemical biology approaches to membrane homeostasis and function.

Takahashi-Umebayashi M, Pineau L, Hannich T, Zumbuehl A, Doval DA, Matile S, Heinis C, Turcatti G, Loewith R, Roux A, Reymond L, Johnsson K, Riezman H.

Chimia (Aarau). 2011;65(11):849-52. doi: 10.2533/chimia.2011.849. Review.

29.

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA.

ACS Chem Biol. 2012 Apr 20;7(4):715-22. doi: 10.1021/cb200452r. Epub 2012 Feb 1.

30.

Target of rapamycin (TOR) in nutrient signaling and growth control.

Loewith R, Hall MN.

Genetics. 2011 Dec;189(4):1177-201. doi: 10.1534/genetics.111.133363. Review.

31.

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

Kawai S, Urban J, Piccolis M, Panchaud N, De Virgilio C, Loewith R.

Eukaryot Cell. 2011 Oct;10(10):1367-9. doi: 10.1128/EC.05157-11. Epub 2011 Aug 12.

32.

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.

Huber A, French SL, Tekotte H, Yerlikaya S, Stahl M, Perepelkina MP, Tyers M, Rougemont J, Beyer AL, Loewith R.

EMBO J. 2011 Jul 5;30(15):3052-64. doi: 10.1038/emboj.2011.221.

33.

A brief history of TOR.

Loewith R.

Biochem Soc Trans. 2011 Apr;39(2):437-42. doi: 10.1042/BST0390437. Review.

PMID:
21428915
34.

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.

Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, Colman-Lerner A, Nolan GP, Nesvizhskii AI, Peter M, Loewith R, von Mering C, Aebersold R.

Sci Signal. 2010 Dec 21;3(153):rs4. doi: 10.1126/scisignal.2001182.

35.

The Vam6 GEF controls TORC1 by activating the EGO complex.

Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C.

Mol Cell. 2009 Sep 11;35(5):563-73. doi: 10.1016/j.molcel.2009.06.033.

36.

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.

Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R.

Genes Dev. 2009 Aug 15;23(16):1929-43. doi: 10.1101/gad.532109.

37.

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.

Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D.

Mol Cell. 2009 Mar 27;33(6):704-16. doi: 10.1016/j.molcel.2009.01.034.

38.

Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.

Guan XL, Souza CM, Pichler H, Dewhurst G, Schaad O, Kajiwara K, Wakabayashi H, Ivanova T, Castillon GA, Piccolis M, Abe F, Loewith R, Funato K, Wenk MR, Riezman H.

Mol Biol Cell. 2009 Apr;20(7):2083-95. doi: 10.1091/mbc.E08-11-1126. Epub 2009 Feb 18.

39.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.

40.

Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.

Hosiner D, Lempiäinen H, Reiter W, Urban J, Loewith R, Ammerer G, Schweyen R, Shore D, Schüller C.

Mol Biol Cell. 2009 Feb;20(3):1048-57. doi: 10.1091/mbc.E08-04-0438. Epub 2008 Dec 10.

41.

Caffeine extends yeast lifespan by targeting TORC1.

Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C.

Mol Microbiol. 2008 Jul;69(1):277-85. doi: 10.1111/j.1365-2958.2008.06292.x. Epub 2008 May 26.

42.

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, Broach JR, De Virgilio C, Hall MN, Loewith R.

Mol Cell. 2007 Jun 8;26(5):663-74.

43.

Cell growth control: little eukaryotes make big contributions.

De Virgilio C, Loewith R.

Oncogene. 2006 Oct 16;25(48):6392-415. Review.

PMID:
17041625
44.

Mutual antagonism of target of rapamycin and calcineurin signaling.

Mulet JM, Martin DE, Loewith R, Hall MN.

J Biol Chem. 2006 Nov 3;281(44):33000-7. Epub 2006 Sep 7.

45.

The TOR signalling network from yeast to man.

De Virgilio C, Loewith R.

Int J Biochem Cell Biol. 2006;38(9):1476-81. Epub 2006 Mar 9. Review.

PMID:
16647875
46.

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM.

Cell. 2006 May 19;125(4):733-47. Epub 2006 Apr 27.

47.

TOR signaling in growth and metabolism.

Wullschleger S, Loewith R, Hall MN.

Cell. 2006 Feb 10;124(3):471-84. Review.

48.

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.

Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y.

Mol Cell Biol. 2005 Aug;25(16):7239-48.

49.

Molecular organization of target of rapamycin complex 2.

Wullschleger S, Loewith R, Oppliger W, Hall MN.

J Biol Chem. 2005 Sep 2;280(35):30697-704. Epub 2005 Jul 7.

50.

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN.

Nat Cell Biol. 2004 Nov;6(11):1122-8. Epub 2004 Oct 3.

PMID:
15467718

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