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Items: 1 to 20 of 58

1.

Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.

Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martínez-Sánchez A, Baumeister W, Stefan CJ, Fernández-Busnadiego R.

Dev Cell. 2019 Nov 18;51(4):476-487.e7. doi: 10.1016/j.devcel.2019.10.018.

2.

TORC2 controls endocytosis through plasma membrane tension.

Riggi M, Bourgoint C, Macchione M, Matile S, Loewith R, Roux A.

J Cell Biol. 2019 Jul 1;218(7):2265-2276. doi: 10.1083/jcb.201901096. Epub 2019 May 23.

PMID:
31123183
3.

TOR Signaling Is Going through a Phase.

Prouteau M, Loewith R.

Cell Metab. 2019 May 7;29(5):1019-1021. doi: 10.1016/j.cmet.2019.04.010.

PMID:
31067446
4.

Sphingolipids and membrane targets for therapeutics.

Loewith R, Riezman H, Winssinger N.

Curr Opin Chem Biol. 2019 Jun;50:19-28. doi: 10.1016/j.cbpa.2019.02.015. Epub 2019 Mar 18. Review.

PMID:
30897494
5.

Regulation of Cellular Metabolism through Phase Separation of Enzymes.

Prouteau M, Loewith R.

Biomolecules. 2018 Dec 3;8(4). pii: E160. doi: 10.3390/biom8040160. Review.

6.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.

Nat Cell Biol. 2018 Sep;20(9):1043-1051. doi: 10.1038/s41556-018-0150-z. Epub 2018 Aug 27.

7.

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.

8.

Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.

9.

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.

Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C.

Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.

10.

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.

Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R.

Nature. 2017 Oct 12;550(7675):265-269. doi: 10.1038/nature24021. Epub 2017 Oct 4.

11.

Tensing Up for Lipid Droplet Formation.

Roux A, Loewith R.

Dev Cell. 2017 Jun 19;41(6):571-572. doi: 10.1016/j.devcel.2017.06.001. Review.

12.

A pathway of targeted autophagy is induced by DNA damage in budding yeast.

Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1158-E1167. doi: 10.1073/pnas.1614364114. Epub 2017 Feb 2.

13.

Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.

Primo C, Ferri-Blázquez A, Loewith R, Yenush L.

J Biol Chem. 2017 Jan 13;292(2):563-574. doi: 10.1074/jbc.M116.746982. Epub 2016 Nov 28.

14.

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.

Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.

15.

TORC2 Structure and Function.

Gaubitz C, Prouteau M, Kusmider B, Loewith R.

Trends Biochem Sci. 2016 Jun;41(6):532-545. doi: 10.1016/j.tibs.2016.04.001. Epub 2016 May 5. Review.

PMID:
27161823
16.

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K.

Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.

17.

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R.

Mol Biol Cell. 2016 Jan 15;27(2):397-409. doi: 10.1091/mbc.E15-08-0594. Epub 2015 Nov 18.

18.

TOR Complexes and the Maintenance of Cellular Homeostasis.

Eltschinger S, Loewith R.

Trends Cell Biol. 2016 Feb;26(2):148-159. doi: 10.1016/j.tcb.2015.10.003. Epub 2015 Nov 4. Review.

PMID:
26546292
19.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R.

Mol Cell. 2015 Jun 18;58(6):977-88. doi: 10.1016/j.molcel.2015.04.031. Epub 2015 May 28.

20.

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R.

J Biol Chem. 2015 Jun 12;290(24):14963-78. doi: 10.1074/jbc.M114.627794. Epub 2015 Apr 16.

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