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Items: 28


PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells.

Sheng C, Mendler IH, Rieke S, Snyder P, Jentsch M, Friedrich D, Drossel B, Loewer A.

Cell Rep. 2019 Apr 2;27(1):48-58.e7. doi: 10.1016/j.celrep.2019.03.031.


Comparing Agent-Based Delivery of DNA and PNA Forced Intercalation (FIT) Probes for Multicolor mRNA Imaging.

Chamiolo J, Fang GM, Hövelmann F, Friedrich D, Knoll A, Loewer A, Seitz O.

Chembiochem. 2019 Feb 15;20(4):595-604. doi: 10.1002/cbic.201800526. Epub 2018 Dec 10.


Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

Strasen J, Sarma U, Jentsch M, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S, Loewer A.

Mol Syst Biol. 2018 Jan 25;14(1):e7733. doi: 10.15252/msb.20177733.


Recent progress and open challenges in modeling p53 dynamics in single cells.

Batchelor E, Loewer A.

Curr Opin Syst Biol. 2017 Jun;3:54-59. doi: 10.1016/j.coisb.2017.04.007. Epub 2017 Mar 25.


Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.

Mönke G, Cristiano E, Finzel A, Friedrich D, Herzel H, Falcke M, Loewer A.

Sci Rep. 2017 Apr 18;7:46571. doi: 10.1038/srep46571.


Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.

Finzel A, Grybowski A, Strasen J, Cristiano E, Loewer A.

Mol Biol Cell. 2016 Aug 1;27(15):2360-7. doi: 10.1091/mbc.E16-01-0032. Epub 2016 Jun 8.


Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.

Paek AL, Liu JC, Loewer A, Forrester WC, Lahav G.

Cell. 2016 Apr 21;165(3):631-42. doi: 10.1016/j.cell.2016.03.025. Epub 2016 Apr 7.


PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.

Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J.

Nat Neurosci. 2015 Jan;18(1):10-6. doi: 10.1038/nn.3894. Epub 2014 Dec 3.


Chlamydia infection depends on a functional MDM2-p53 axis.

González E, Rother M, Kerr MC, Al-Zeer MA, Abu-Lubad M, Kessler M, Brinkmann V, Loewer A, Meyer TF.

Nat Commun. 2014 Nov 13;5:5201. doi: 10.1038/ncomms6201.


Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.

Borcherds W, Theillet FX, Katzer A, Finzel A, Mishall KM, Powell AT, Wu H, Manieri W, Dieterich C, Selenko P, Loewer A, Daughdrill GW.

Nat Chem Biol. 2014 Dec;10(12):1000-2. doi: 10.1038/nchembio.1668. Epub 2014 Nov 2.


Differential protein occupancy profiling of the mRNA transcriptome.

Schueler M, Munschauer M, Gregersen LH, Finzel A, Loewer A, Chen W, Landthaler M, Dieterich C.

Genome Biol. 2014 Jan 13;15(1):R15. doi: 10.1186/gb-2014-15-1-r15.


The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.

Loewer A, Karanam K, Mock C, Lahav G.

BMC Biol. 2013 Nov 19;11:114. doi: 10.1186/1741-7007-11-114.


Circular RNAs are a large class of animal RNAs with regulatory potency.

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N.

Nature. 2013 Mar 21;495(7441):333-8. doi: 10.1038/nature11928. Epub 2013 Feb 27.


Dynamics of the DNA damage response: insights from live-cell imaging.

Karanam K, Loewer A, Lahav G.

Brief Funct Genomics. 2013 Mar;12(2):109-17. doi: 10.1093/bfgp/els059. Epub 2013 Jan 4. Review.


Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

Karanam K, Kafri R, Loewer A, Lahav G.

Mol Cell. 2012 Jul 27;47(2):320-9. doi: 10.1016/j.molcel.2012.05.052.


p53 dynamics control cell fate.

Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G.

Science. 2012 Jun 15;336(6087):1440-4. doi: 10.1126/science.1218351.


Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.

Orth JD, Loewer A, Lahav G, Mitchison TJ.

Mol Biol Cell. 2012 Feb;23(4):567-76. doi: 10.1091/mbc.E11-09-0781. Epub 2011 Dec 14.


We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.

Loewer A, Lahav G.

Curr Opin Genet Dev. 2011 Dec;21(6):753-8. doi: 10.1016/j.gde.2011.09.010. Epub 2011 Oct 15. Review.


Stimulus-dependent dynamics of p53 in single cells.

Batchelor E, Loewer A, Mock C, Lahav G.

Mol Syst Biol. 2011 May 10;7:488. doi: 10.1038/msb.2011.20.


A synthetic-natural hybrid oscillator in human cells.

Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17047-52. doi: 10.1073/pnas.1005615107. Epub 2010 Sep 13.


Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

Loewer A, Batchelor E, Gaglia G, Lahav G.

Cell. 2010 Jul 9;142(1):89-100. doi: 10.1016/j.cell.2010.05.031.


In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G.

Mol Cell Biol. 2010 Jul;30(13):3165-75. doi: 10.1128/MCB.00030-10. Epub 2010 Apr 26.


The ups and downs of p53: understanding protein dynamics in single cells.

Batchelor E, Loewer A, Lahav G.

Nat Rev Cancer. 2009 May;9(5):371-7. doi: 10.1038/nrc2604. Epub 2009 Apr 9. Review.


Distinct mechanisms act in concert to mediate cell cycle arrest.

Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):785-90. doi: 10.1073/pnas.0806196106. Epub 2009 Jan 12.


Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G.

Mol Cell. 2008 May 9;30(3):277-89. doi: 10.1016/j.molcel.2008.03.016.


Cellular conference call: external feedback affects cell-fate decisions.

Loewer A, Lahav G.

Cell. 2006 Mar 24;124(6):1128-30. Review.


Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.

Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R.

EMBO J. 2004 Oct 13;23(20):4082-95. Epub 2004 Sep 23.


Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.

Loewer A, Soba P, Beyreuther K, Paro R, Merdes G.

EMBO Rep. 2004 Apr;5(4):405-11.

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