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Items: 1 to 50 of 148

1.

Structure and function of a lignostilbene-α,β-dioxygenase orthologue from Pseudomonas brassicacearum.

Loewen PC, Switala J, Wells JP, Huang F, Zara AT, Allingham JS, Loewen MC.

BMC Biochem. 2018 Aug 16;19(1):8. doi: 10.1186/s12858-018-0098-4.

2.

KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin.

Loewen PC, De Silva PM, Donald LJ, Switala J, Villanueva J, Fita I, Kumar A.

ACS Omega. 2018 Apr 30;3(4):4213-4219. doi: 10.1021/acsomega.8b00356. Epub 2018 Apr 16.

3.

Insights on the Mechanism of Action of INH-C10 as an Antitubercular Prodrug.

Vila-Viçosa D, Victor BL, Ramos J, Machado D, Viveiros M, Switala J, Loewen PC, Leitão R, Martins F, Machuqueiro M.

Mol Pharm. 2017 Dec 4;14(12):4597-4605. doi: 10.1021/acs.molpharmaceut.7b00719. Epub 2017 Nov 13.

PMID:
29091448
4.

The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.

Machuqueiro M, Victor B, Switala J, Villanueva J, Rovira C, Fita I, Loewen PC.

Biochemistry. 2017 May 2;56(17):2271-2281. doi: 10.1021/acs.biochem.6b01276. Epub 2017 Apr 20.

PMID:
28409923
5.

Multi-omics approach to study global changes in a triclosan-resistant mutant strain of Acinetobacter baumannii ATCC 17978.

Fernando DM, Chong P, Singh M, Spicer V, Unger M, Loewen PC, Westmacott G, Kumar A.

Int J Antimicrob Agents. 2017 Jan;49(1):74-80. doi: 10.1016/j.ijantimicag.2016.10.014. Epub 2016 Dec 2.

PMID:
27939676
6.

Pseudomonas brassicacearum strain DF41 kills Caenorhabditis elegans through biofilm-dependent and biofilm-independent mechanisms.

Nandi M, Berry C, Brassinga AK, Belmonte MF, Fernando WG, Loewen PC, de Kievit TR.

Appl Environ Microbiol. 2016 Dec;82(23):6889-6898. Epub 2016 Sep 16.

7.

Complete Genome Sequence of a Rhodococcus Species Isolated from the Winter Skate Leucoraja ocellata.

Wiens J, Ho R, Fernando D, Kumar A, Loewen PC, Brassinga AK, Anderson WG.

Genome Announc. 2016 Sep 1;4(5). pii: e00918-16. doi: 10.1128/genomeA.00918-16.

8.

Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions.

Behrens W, Schweinitzer T, McMurry JL, Loewen PC, Buettner FF, Menz S, Josenhans C.

Sci Rep. 2016 Apr 5;6:23582. doi: 10.1038/srep23582.

9.

KatG and KatE confer Acinetobacter resistance to hydrogen peroxide but sensitize bacteria to killing by phagocytic respiratory burst.

Sun D, Crowell SA, Harding CM, De Silva PM, Harrison A, Fernando DM, Mason KM, Santana E, Loewen PC, Kumar A, Liu Y.

Life Sci. 2016 Mar 1;148:31-40. doi: 10.1016/j.lfs.2016.02.015. Epub 2016 Feb 6.

10.

Identification of Interactions between Abscisic Acid and Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase.

Galka MM, Rajagopalan N, Buhrow LM, Nelson KM, Switala J, Cutler AJ, Palmer DR, Loewen PC, Abrams SR, Loewen MC.

PLoS One. 2015 Jul 21;10(7):e0133033. doi: 10.1371/journal.pone.0133033. eCollection 2015.

11.

Pyrrolnitrin and Hydrogen Cyanide Production by Pseudomonas chlororaphis Strain PA23 Exhibits Nematicidal and Repellent Activity against Caenorhabditis elegans.

Nandi M, Selin C, Brassinga AK, Belmonte MF, Fernando WG, Loewen PC, de Kievit TR.

PLoS One. 2015 Apr 22;10(4):e0123184. doi: 10.1371/journal.pone.0123184. eCollection 2015.

12.
13.

Genome Sequence of a Tigecycline-Resistant Clinical Isolate of Acinetobacter baumannii Strain AB031 Obtained from a Bloodstream Infection.

Loewen PC, Alsaadi Y, Fernando D, Kumar A.

Genome Announc. 2014 Oct 16;2(5). pii: e01036-14. doi: 10.1128/genomeA.01036-14.

14.

Genome Sequence of an Extremely Drug-Resistant Clinical Isolate of Acinetobacter baumannii Strain AB030.

Loewen PC, Alsaadi Y, Fernando D, Kumar A.

Genome Announc. 2014 Oct 16;2(5). pii: e01035-14. doi: 10.1128/genomeA.01035-14.

15.

Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter baumannii ATCC 17978 that displays reduced susceptibility to multiple antibiotics.

Fernando DM, Xu W, Loewen PC, Zhanel GG, Kumar A.

Antimicrob Agents Chemother. 2014 Nov;58(11):6424-31. doi: 10.1128/AAC.03074-14. Epub 2014 Aug 18.

16.

Genome Sequence of Pseudomonas chlororaphis Strain PA23.

Loewen PC, Villenueva J, Fernando WG, de Kievit T.

Genome Announc. 2014 Jul 17;2(4). pii: e00689-14. doi: 10.1128/genomeA.00689-14.

17.

Identifying the elusive sites of tyrosyl radicals in cytochrome c peroxidase: implications for oxidation of substrates bound at a site remote from the heme.

Miner KD, Pfister TD, Hosseinzadeh P, Karaduman N, Donald LJ, Loewen PC, Lu Y, Ivancich A.

Biochemistry. 2014 Jun 17;53(23):3781-9. doi: 10.1021/bi500353p. Epub 2014 Jun 5.

18.

Genome Sequence of Pseudomonas brassicacearum DF41.

Loewen PC, Switala J, Fernando WG, de Kievit T.

Genome Announc. 2014 May 8;2(3). pii: e00390-14. doi: 10.1128/genomeA.00390-14.

19.

An ionizable active-site tryptophan imparts catalase activity to a peroxidase core.

Loewen PC, Carpena X, Vidossich P, Fita I, Rovira C.

J Am Chem Soc. 2014 May 21;136(20):7249-52. doi: 10.1021/ja502794e. Epub 2014 May 7.

PMID:
24785434
20.

Genome Sequence of Bacillus pumilus MTCC B6033.

Villanueva J, Switala J, Ivancich A, Loewen PC.

Genome Announc. 2014 Apr 17;2(2). pii: e00327-14. doi: 10.1128/genomeA.00327-14.

21.

Binding of the antitubercular pro-drug isoniazid in the heme access channel of catalase-peroxidase (KatG). A combined structural and metadynamics investigation.

Vidossich P, Loewen PC, Carpena X, Fiorin G, Fita I, Rovira C.

J Phys Chem B. 2014 Mar 20;118(11):2924-31. doi: 10.1021/jp4123425. Epub 2014 Mar 7.

PMID:
24568093
22.

Spectroscopic and kinetic investigation of the reactions of peroxyacetic acid with Burkholderia pseudomallei catalase-peroxidase, KatG.

Ivancich A, Donald LJ, Villanueva J, Wiseman B, Fita I, Loewen PC.

Biochemistry. 2013 Oct 15;52(41):7271-82. doi: 10.1021/bi400963j. Epub 2013 Oct 2.

PMID:
24044787
23.

Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.

Aparicio D, Pérez-Luque R, Carpena X, Díaz M, Ferrer JC, Loewen PC, Fita I.

J Biol Chem. 2013 Apr 26;288(17):11907-19. doi: 10.1074/jbc.M112.443846. Epub 2013 Mar 11.

24.

Structure of Pisum sativum Rubisco with bound ribulose 1,5-bisphosphate.

Loewen PC, Didychuk AL, Switala J, Perez-Luque R, Fita I, Loewen MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):10-4. doi: 10.1107/S1744309112047549. Epub 2012 Dec 25.

25.

Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution.

Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1279-83. doi: 10.1107/S1744309112037736. Epub 2012 Oct 26.

26.

Chemical and biological characterization of sclerosin, an antifungal lipopeptide.

Berry CL, Brassinga AK, Donald LJ, Fernando WG, Loewen PC, de Kievit TR.

Can J Microbiol. 2012 Aug;58(8):1027-34. doi: 10.1139/w2012-079.

PMID:
22838838
27.

High conformational stability of secreted eukaryotic catalase-peroxidases: answers from first crystal structure and unfolding studies.

Zámocký M, García-Fernández Q, Gasselhuber B, Jakopitsch C, Furtmüller PG, Loewen PC, Fita I, Obinger C, Carpena X.

J Biol Chem. 2012 Sep 14;287(38):32254-62. doi: 10.1074/jbc.M112.384271. Epub 2012 Jul 20.

28.

Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli.

Jha V, Chelikani P, Carpena X, Fita I, Loewen PC.

Arch Biochem Biophys. 2012 Oct 1;526(1):54-9. doi: 10.1016/j.abb.2012.06.010. Epub 2012 Jul 20.

PMID:
22820098
29.

Thirty years of heme catalases structural biology.

Díaz A, Loewen PC, Fita I, Carpena X.

Arch Biochem Biophys. 2012 Sep 15;525(2):102-10. doi: 10.1016/j.abb.2011.12.011. Epub 2011 Dec 23. Review.

PMID:
22209752
30.

Identification of group I introns within the SSU rDNA gene in species of Ceratocystiopsis and related taxa.

Hafez M, Iranpour M, Mullineux ST, Sethuraman J, Wosnitza KM, Lehn P, Kroeker J, Loewen PC, Reid J, Hausner G.

Fungal Biol. 2012 Jan;116(1):98-111. doi: 10.1016/j.funbio.2011.10.005. Epub 2011 Nov 2.

PMID:
22208605
31.

Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli leads to side chain damage and main chain cleavage.

Jha V, Donald LJ, Loewen PC.

Arch Biochem Biophys. 2012 Sep 15;525(2):207-14. doi: 10.1016/j.abb.2011.11.022. Epub 2011 Dec 8.

PMID:
22172685
32.

Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli.

Jha V, Louis S, Chelikani P, Carpena X, Donald LJ, Fita I, Loewen PC.

Biochemistry. 2011 Mar 29;50(12):2101-10. doi: 10.1021/bi200027v. Epub 2011 Mar 3.

PMID:
21332158
33.

Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.

Wiseman B, Carpena X, Feliz M, Donald LJ, Pons M, Fita I, Loewen PC.

J Biol Chem. 2010 Aug 20;285(34):26662-73. doi: 10.1074/jbc.M110.139428. Epub 2010 Jun 15.

34.

The dynamic role of distal side residues in heme hydroperoxidase catalysis. Interplay between X-ray crystallography and ab initio MD simulations.

Vidossich P, Alfonso-Prieto M, Carpena X, Fita I, Loewen PC, Rovira C.

Arch Biochem Biophys. 2010 Aug 1;500(1):37-44. doi: 10.1016/j.abb.2010.04.021. Epub 2010 May 4. Review.

PMID:
20447375
36.

Mechanistic insight into the initiation step of the reaction of Burkholderia pseudomallei catalase-peroxidase with peroxyacetic acid.

Wiseman B, Colin J, Smith AT, Ivancich A, Loewen PC.

J Biol Inorg Chem. 2009 Jun;14(5):801-11. doi: 10.1007/s00775-009-0493-9. Epub 2009 Mar 17.

PMID:
19290552
37.

Urea as a protein destabilizing agent in electrospray ionisation.

Donald LJ, Collado VM, Galka JJ, O'Neil JD, Duckworth HW, Loewen PC, Standing KG.

Rapid Commun Mass Spectrom. 2009 Mar;23(6):788-92. doi: 10.1002/rcm.3941.

PMID:
19219845
38.

Electronic state of the molecular oxygen released by catalase.

Alfonso-Prieto M, Vidossich P, Rodríguez-Fortea A, Carpena X, Fita I, Loewen PC, Rovira C.

J Phys Chem A. 2008 Dec 18;112(50):12842-8. doi: 10.1021/jp801512h.

PMID:
18816030
39.

Intramolecular electron transfer versus substrate oxidation in lactoperoxidase: investigation of radical intermediates by stopped-flow absorption spectrophotometry and (9-285 GHz) electron paramagnetic resonance spectroscopy.

Fielding AJ, Singh R, Boscolo B, Loewen PC, Ghibaudi EM, Ivancich A.

Biochemistry. 2008 Sep 16;47(37):9781-92. doi: 10.1021/bi801032k. Epub 2008 Aug 20.

PMID:
18712881
40.

Comparative study of catalase-peroxidases (KatGs).

Singh R, Wiseman B, Deemagarn T, Jha V, Switala J, Loewen PC.

Arch Biochem Biophys. 2008 Mar 15;471(2):207-14. doi: 10.1016/j.abb.2007.12.008. Epub 2007 Dec 23.

PMID:
18178143
41.

RhaU of Rhizobium leguminosarum is a rhamnose mutarotase.

Richardson JS, Carpena X, Switala J, Perez-Luque R, Donald LJ, Loewen PC, Oresnik IJ.

J Bacteriol. 2008 Apr;190(8):2903-10. Epub 2007 Dec 21.

42.
43.

Versatility of the electronic structure of compound I in catalase-peroxidases.

Vidossich P, Alfonso-Prieto M, Carpena X, Loewen PC, Fita I, Rovira C.

J Am Chem Soc. 2007 Nov 7;129(44):13436-46. Epub 2007 Oct 10.

PMID:
17927173
44.

Evaluation of mercury toxicity as a predictor of mercury bioavailability.

Golding GR, Kelly CA, Sparling R, Loewen PC, Barkay T.

Environ Sci Technol. 2007 Aug 15;41(16):5685-92.

PMID:
17874774
45.

The structures and electronic configuration of compound I intermediates of Helicobacter pylori and Penicillium vitale catalases determined by X-ray crystallography and QM/MM density functional theory calculations.

Alfonso-Prieto M, Borovik A, Carpena X, Murshudov G, Melik-Adamyan W, Fita I, Rovira C, Loewen PC.

J Am Chem Soc. 2007 Apr 11;129(14):4193-205. Epub 2007 Mar 15.

PMID:
17358056
46.
47.

Two alternative substrate paths for compound I formation and reduction in catalase-peroxidase KatG from Burkholderia pseudomallei.

Deemagarn T, Wiseman B, Carpena X, Ivancich A, Fita I, Loewen PC.

Proteins. 2007 Jan 1;66(1):219-28.

PMID:
17063492
48.

Method for estimating the isotopic distributions of metabolically labeled proteins by MALDI-TOFMS: application to NMR samples.

Choudhary K, Spicer VL, Donald LJ, Duckworth HW, Ens W, Loewen PC, Standing KG.

Anal Chem. 2006 Aug 1;78(15):5419-23.

PMID:
16878877
49.

Isolation of salt-sensitive mutants of Sinorhizobium meliloti strain Rm1021.

Miller-Williams M, Loewen PC, Oresnik IJ.

Microbiology. 2006 Jul;152(Pt 7):2049-59.

PMID:
16804180
50.

Roles for Arg426 and Trp111 in the modulation of NADH oxidase activity of the catalase-peroxidase KatG from Burkholderia pseudomallei inferred from pH-induced structural changes.

Carpena X, Wiseman B, Deemagarn T, Herguedas B, Ivancich A, Singh R, Loewen PC, Fita I.

Biochemistry. 2006 Apr 25;45(16):5171-9.

PMID:
16618106

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