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A nuclear role for the DEAD-box protein Dbp5 in tRNA export.

Lari A, Arul Nambi Rajan A, Sandhu R, Reiter T, Montpetit R, Young BP, Loewen CJ, Montpetit B.

Elife. 2019 Aug 27;8. pii: e48410. doi: 10.7554/eLife.48410.


In Vivo Forward Genetic Screen to Identify Novel Neuroprotective Genes in Drosophila melanogaster.

Gevedon O, Bolus H, Lye SH, Schmitz K, Fuentes-González J, Hatchell K, Bley L, Pienaar J, Loewen C, Chtarbanova S.

J Vis Exp. 2019 Jul 11;(149). doi: 10.3791/59720.


Mechanisms of PTPσ-Mediated Presynaptic Differentiation.

Bomkamp C, Padmanabhan N, Karimi B, Ge Y, Chao JT, Loewen CJR, Siddiqui TJ, Craig AM.

Front Synaptic Neurosci. 2019 May 22;11:17. doi: 10.3389/fnsyn.2019.00017. eCollection 2019.


A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila.

Loewen C, Boekhoff-Falk G, Ganetzky B, Chtarbanova S.

G3 (Bethesda). 2018 Oct 3;8(10):3331-3346. doi: 10.1534/g3.118.200627.


Viral proteins as a potential driver of histone depletion in dinoflagellates.

Irwin NAT, Martin BJE, Young BP, Browne MJG, Flaus A, Loewen CJR, Keeling PJ, Howe LJ.

Nat Commun. 2018 Apr 18;9(1):1535. doi: 10.1038/s41467-018-03993-4.


Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome.

Loewen CA, Ganetzky B.

Genetics. 2018 Apr;208(4):1535-1552. doi: 10.1534/genetics.118.300818. Epub 2018 Mar 1.


Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes.

Hayes M, Choudhary V, Ojha N, Shin JJ, Han GS, Carman GM, Loewen CJ, Prinz WA, Levine T.

Microb Cell. 2017 Dec 28;5(2):88-103. doi: 10.15698/mic2018.02.614.


Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.

Olufs ZPG, Loewen CA, Ganetzky B, Wassarman DA, Perouansky M.

Sci Rep. 2018 Feb 5;8(1):2348. doi: 10.1038/s41598-018-20720-7.


Mobile ascending aortic mass presenting as acute myocardial infarction.

Muller Moran HR, Loewen C, Dutta V, Shah PJ.

Can J Anaesth. 2018 Jun;65(6):724-725. doi: 10.1007/s12630-018-1052-z. Epub 2018 Jan 11. No abstract available.


Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.

Mathew V, Tam AS, Milbury KL, Hofmann AK, Hughes CS, Morin GB, Loewen CJR, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):4027-4040. doi: 10.1083/jcb.201612018. Epub 2017 Oct 4.


Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae.

Lawrence MBD, Coutin N, Choi JK, Martin BJE, Irwin NAT, Young B, Loewen C, Howe LJ.

Genetics. 2017 Sep;207(1):347-355. doi: 10.1534/genetics.117.1132. Epub 2017 Jul 24.


Regional diversity reverses the negative impacts of an alien predator on local species-poor communities.

Loewen CJ, Vinebrooke RD.

Ecology. 2016 Oct;97(10):2740-2749. doi: 10.1002/ecy.1485.


Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets.

Shin JJ, Aftab Q, Austin P, McQueen JA, Poon T, Li SC, Young BP, Roskelley CD, Loewen CJ.

Dis Model Mech. 2016 Sep 1;9(9):1039-49. doi: 10.1242/dmm.023374. Epub 2016 Aug 12.


Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.

Comyn SA, Young BP, Loewen CJ, Mayor T.

PLoS Genet. 2016 Jul 22;12(7):e1006184. doi: 10.1371/journal.pgen.1006184. eCollection 2016 Jul.


Global reorganization of budding yeast chromosome conformation in different physiological conditions.

Dultz E, Tjong H, Weider E, Herzog M, Young B, Brune C, Müllner D, Loewen C, Alber F, Weis K.

J Cell Biol. 2016 Feb 1;212(3):321-34. doi: 10.1083/jcb.201507069. Epub 2016 Jan 25.


A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila.

Katzenberger RJ, Loewen CA, Bockstruck RT, Woods MA, Ganetzky B, Wassarman DA.

J Vis Exp. 2015 Jun 30;(100):e52905. doi: 10.3791/52905. Erratum in: J Vis Exp. 2015;(101):e5744. Ganetky, Barry [corrected to Ganetzky, Barry].


Net effects of multiple stressors in freshwater ecosystems: a meta-analysis.

Jackson MC, Loewen CJ, Vinebrooke RD, Chimimba CT.

Glob Chang Biol. 2016 Jan;22(1):180-9. doi: 10.1111/gcb.13028. Epub 2015 Oct 23. Review.


A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition.

Ho KL, Ma L, Cheung S, Manhas S, Fang N, Wang K, Young B, Loewen C, Mayor T, Measday V.

PLoS Genet. 2015 Mar 30;11(3):e1005109. doi: 10.1371/journal.pgen.1005109. eCollection 2015 Mar.


A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.

Lahiri S, Chao JT, Tavassoli S, Wong AK, Choudhary V, Young BP, Loewen CJ, Prinz WA.

PLoS Biol. 2014 Oct 14;12(10):e1001969. doi: 10.1371/journal.pbio.1001969. eCollection 2014 Oct.


Polarization of the endoplasmic reticulum by ER-septin tethering.

Chao JT, Wong AK, Tavassoli S, Young BP, Chruscicki A, Fang NN, Howe LJ, Mayor T, Foster LJ, Loewen CJ.

Cell. 2014 Jul 31;158(3):620-32. doi: 10.1016/j.cell.2014.06.033.


Barriers to uniformity within the endoplasmic reticulum.

Wong AK, Chao JT, Loewen CJ.

Curr Opin Cell Biol. 2014 Aug;29:31-8. doi: 10.1016/ Epub 2014 Apr 14. Review.


An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.

Riekhof WR, Wu WI, Jones JL, Nikrad M, Chan MM, Loewen CJ, Voelker DR.

J Biol Chem. 2014 Feb 28;289(9):5809-19. doi: 10.1074/jbc.M113.518217. Epub 2013 Dec 23.


Balony: a software package for analysis of data generated by synthetic genetic array experiments.

Young BP, Loewen CJ.

BMC Bioinformatics. 2013 Dec 4;14:354. doi: 10.1186/1471-2105-14-354.


A Drosophila model of closed head traumatic brain injury.

Katzenberger RJ, Loewen CA, Wassarman DR, Petersen AJ, Ganetzky B, Wassarman DA.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4152-9. doi: 10.1073/pnas.1316895110. Epub 2013 Oct 14.


Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis.

Tavassoli S, Chao JT, Young BP, Cox RC, Prinz WA, de Kroon AI, Loewen CJ.

EMBO Rep. 2013 May;14(5):434-40. doi: 10.1038/embor.2013.36. Epub 2013 Mar 22.


The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division.

McQueen J, van Dyk D, Young B, Loewen C, Measday V.

Cell Cycle. 2012 Sep 15;11(18):3421-32. doi: 10.4161/cc.21731. Epub 2012 Aug 23.


ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.

Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA.

J Cell Sci. 2012 Oct 15;125(Pt 20):4791-9. doi: 10.1242/jcs.105635. Epub 2012 Jul 13.


Regulation of lipid metabolism: a tale of two yeasts.

Raychaudhuri S, Young BP, Espenshade PJ, Loewen C Jr.

Curr Opin Cell Biol. 2012 Aug;24(4):502-8. Epub 2012 Jun 11. Review.


Lipids as conductors in the orchestra of life.

Loewen CJ.

F1000 Biol Rep. 2012;4:4. doi: 10.3410/B4-4. Epub 2012 Feb 1.


Putting the pH into phosphatidic acid signaling.

Shin JJ, Loewen CJ.

BMC Biol. 2011 Dec 2;9:85. doi: 10.1186/1741-7007-9-85. Review.


High density array screening to identify the genetic requirements for transition metal tolerance in Saccharomyces cerevisiae.

Bleackley MR, Young BP, Loewen CJ, MacGillivray RT.

Metallomics. 2011 Feb;3(2):195-205. doi: 10.1039/c0mt00035c. Epub 2011 Jan 6.


The unfolded protein response protects from tau neurotoxicity in vivo.

Loewen CA, Feany MB.

PLoS One. 2010 Sep 29;5(9). pii: e13084. doi: 10.1371/journal.pone.0013084.


Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.

Young BP, Shin JJ, Orij R, Chao JT, Li SC, Guan XL, Khong A, Jan E, Wenk MR, Prinz WA, Smits GJ, Loewen CJ.

Science. 2010 Aug 27;329(5995):1085-8. doi: 10.1126/science.1191026.


Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB.

PLoS Genet. 2010 Jul 15;6(7):e1001026. doi: 10.1371/journal.pgen.1001026.


Critical determinants for chromatin binding by Saccharomyces cerevisiae Yng1 exist outside of the plant homeodomain finger.

Chruscicki A, Macdonald VE, Young BP, Loewen CJ, Howe LJ.

Genetics. 2010 Jun;185(2):469-77. doi: 10.1534/genetics.110.116285. Epub 2010 Mar 29.


Identification of protein complexes with quantitative proteomics in S. cerevisiae.

Chao JT, Foster LJ, Loewen CJ.

J Vis Exp. 2009 Mar 4;(25). pii: 1225. doi: 10.3791/1225.


A high-throughput method to globally study the organelle morphology in S. cerevisiae.

Tavassoli S, Chao JT, Loewen C.

J Vis Exp. 2009 Mar 2;(25). pii: 1224. doi: 10.3791/1224.


Inheritance of cortical ER in yeast is required for normal septin organization.

Loewen CJ, Young BP, Tavassoli S, Levine TP.

J Cell Biol. 2007 Nov 5;179(3):467-83.


C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.

Loewen CA, Lee SM, Shin YK, Reist NE.

Mol Biol Cell. 2006 Dec;17(12):5211-26. Epub 2006 Sep 20.


Inter-organelle membrane contact sites: through a glass, darkly.

Levine T, Loewen C.

Curr Opin Cell Biol. 2006 Aug;18(4):371-8. Epub 2006 Jun 27. Review.


Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.

Loewen CJ, Gaspar ML, Jesch SA, Delon C, Ktistakis NT, Henry SA, Levine TP.

Science. 2004 Jun 11;304(5677):1644-7.


Role of subunit assembly in autosomal dominant retinitis pigmentosa linked to mutations in peripherin 2.

Molday RS, Molday LL, Loewen CJ.

Novartis Found Symp. 2004;255:95-112; discussion 113-6, 177-8. Review.


The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.

Loewen CJ, Moritz OL, Tam BM, Papermaster DS, Molday RS.

Mol Biol Cell. 2003 Aug;14(8):3400-13. Epub 2003 May 3.


Cholesterol homeostasis: not until the SCAP lady INSIGs.

Loewen CJ, Levine TP.

Curr Biol. 2002 Nov 19;12(22):R779-81. Review.


The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

Mackler JM, Drummond JA, Loewen CA, Robinson IM, Reist NE.

Nature. 2002 Jul 18;418(6895):340-4. Epub 2002 Jul 7.


Drosophila synaptotagmin I null mutants survive to early adulthood.

Loewen CA, Mackler JM, Reist NE.

Genesis. 2001 Sep;31(1):30-6.


Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.

Loewen CJ, Moritz OL, Molday RS.

J Biol Chem. 2001 Jun 22;276(25):22388-96. Epub 2001 Apr 10.

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