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Items: 1 to 50 of 80

1.

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

Sanderlin EJ, Marie M, Velcicky J, Loetscher P, Yang LV.

Eur J Pharmacol. 2019 Jun 5;852:218-230. doi: 10.1016/j.ejphar.2019.03.038. Epub 2019 Mar 28.

PMID:
30930250
2.

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Miltz W, Velcicky J, Dawson J, Littlewood-Evans A, Ludwig MG, Seuwen K, Feifel R, Oberhauser B, Meyer A, Gabriel D, Nash M, Loetscher P.

Bioorg Med Chem. 2017 Aug 15;25(16):4512-4525. doi: 10.1016/j.bmc.2017.06.050. Epub 2017 Jun 29.

PMID:
28689977
3.

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

Velcicky J, Miltz W, Oberhauser B, Orain D, Vaupel A, Weigand K, Dawson King J, Littlewood-Evans A, Nash M, Feifel R, Loetscher P.

J Med Chem. 2017 May 11;60(9):3672-3683. doi: 10.1021/acs.jmedchem.6b01703. Epub 2017 Apr 26.

PMID:
28445047
4.

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Lionakis MS, Albert ND, Swamydas M, Lee CR, Loetscher P, Kontoyiannis DP.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02365-16. doi: 10.1128/AAC.02365-16. Print 2017 Mar.

5.

CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.

Bignon A, Gaudin F, Hémon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K.

J Immunol. 2014 Feb 1;192(3):886-96. doi: 10.4049/jimmunol.1300123. Epub 2013 Dec 23.

6.

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.

Schoeler M, Loetscher PD, Rossaint R, Fahlenkamp AV, Eberhardt G, Rex S, Weis J, Coburn M.

BMC Neurol. 2012 Apr 11;12:20. doi: 10.1186/1471-2377-12-20.

7.

The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.

Herzog D, Loetscher P, van Hengel J, Knüsel S, Brakebusch C, Taylor V, Suter U, Relvas JB.

J Neurosci. 2011 Mar 30;31(13):5120-30. doi: 10.1523/JNEUROSCI.4807-10.2011.

8.

Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats.

Ryang YM, Fahlenkamp AV, Rossaint R, Wesp D, Loetscher PD, Beyer C, Coburn M.

Crit Care Med. 2011 Jun;39(6):1448-53. doi: 10.1097/CCM.0b013e31821209be.

PMID:
21336110
9.

Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury.

Roehl AB, Hein M, Loetscher PD, Rossaint J, Weis J, Rossaint R, Coburn M.

BMC Neurol. 2010 Oct 21;10:97. doi: 10.1186/1471-2377-10-97.

10.

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13063-8. doi: 10.1073/pnas.1002372107. Epub 2010 Jun 29.

11.

Effect of immunomodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis--a longitudinal MRI study.

Bendfeldt K, Egger H, Nichols TE, Loetscher P, Denier N, Kuster P, Traud S, Mueller-Lenke N, Naegelin Y, Gass A, Kappos L, Radue EW, Borgwardt SJ.

Brain Res. 2010 Apr 14;1325:174-82. doi: 10.1016/j.brainres.2010.02.035. Epub 2010 Feb 16.

PMID:
20167205
12.

Spatiotemporal distribution pattern of white matter lesion volumes and their association with regional grey matter volume reductions in relapsing-remitting multiple sclerosis.

Bendfeldt K, Blumhagen JO, Egger H, Loetscher P, Denier N, Kuster P, Traud S, Mueller-Lenke N, Naegelin Y, Gass A, Hirsch J, Kappos L, Nichols TE, Radue EW, Borgwardt SJ.

Hum Brain Mapp. 2010 Oct;31(10):1542-55. doi: 10.1002/hbm.20951.

PMID:
20108225
13.

Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury.

Loetscher PD, Rossaint J, Rossaint R, Weis J, Fries M, Fahlenkamp A, Ryang YM, Grottke O, Coburn M.

Crit Care. 2009;13(6):R206. doi: 10.1186/cc8214. Epub 2009 Dec 17.

14.

Microinjection of Cre recombinase protein into zygotes enables specific deletion of two eukaryotic selection cassettes and enhances the expression of a DsRed2 reporter gene in Ccr2/Ccr5 double-deficient mice.

Luckow B, Hänggli A, Maier H, Chilla S, Loewe RP, Dehmel S, Schlöndorff D, Loetscher P, Zerwes HG, Müller M.

Genesis. 2009 Aug;47(8):545-58. doi: 10.1002/dvg.20531.

PMID:
19517561
15.

The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

Ninichuk V, Khandoga AG, Segerer S, Loetscher P, Schlapbach A, Revesz L, Feifel R, Khandoga A, Krombach F, Nelson PJ, Schlöndorff D, Anders HJ.

Am J Pathol. 2007 Apr;170(4):1267-76.

16.

A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis.

Haringman JJ, Gerlag DM, Smeets TJ, Baeten D, van den Bosch F, Bresnihan B, Breedveld FC, Dinant HJ, Legay F, Gram H, Loetscher P, Schmouder R, Woodworth T, Tak PP.

Arthritis Rheum. 2006 Aug;54(8):2387-92.

17.

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

Revesz L, Bollbuck B, Buhl T, Eder J, Esser R, Feifel R, Heng R, Hiestand P, Jachez-Demange B, Loetscher P, Sparrer H, Schlapbach A, Waelchli R.

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4. Epub 2005 Sep 28.

PMID:
16198561
18.

Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor.

Gilli UO, Schneider MK, Loetscher P, Seebach JD.

Transplantation. 2005 May 27;79(10):1324-31.

PMID:
15912099
19.

A skin-selective homing mechanism for human immune surveillance T cells.

Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B.

J Exp Med. 2004 May 3;199(9):1265-75.

20.

Chemokines: multiple levels of leukocyte migration control.

Moser B, Wolf M, Walz A, Loetscher P.

Trends Immunol. 2004 Feb;25(2):75-84. Review.

PMID:
15102366
21.

Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes.

Bardi G, Niggli V, Loetscher P.

FEBS Lett. 2003 May 8;542(1-3):79-83.

22.

Structure-function relationship between the human chemokine receptor CXCR3 and its ligands.

Clark-Lewis I, Mattioli I, Gong JH, Loetscher P.

J Biol Chem. 2003 Jan 3;278(1):289-95. Epub 2002 Nov 1.

23.

Homing chemokines in rheumatoid arthritis.

Loetscher P, Moser B.

Arthritis Res. 2002;4(4):233-6. Epub 2002 Jan 31. Review.

24.

CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses.

Moser B, Schaerli P, Loetscher P.

Trends Immunol. 2002 May;23(5):250-4. Review. No abstract available.

PMID:
12102746
25.

Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries.

Houimel M, Loetscher P, Baggiolini M, Mazzucchelli L.

Eur J Immunol. 2001 Dec;31(12):3535-45.

26.

The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC.

Bardi G, Lipp M, Baggiolini M, Loetscher P.

Eur J Immunol. 2001 Nov;31(11):3291-7.

27.

Cutting edge: induction of follicular homing precedes effector Th cell development.

Schaerli P, Loetscher P, Moser B.

J Immunol. 2001 Dec 1;167(11):6082-6.

28.

Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo.

Robson RL, McLoughlin RM, Witowski J, Loetscher P, Wilkinson TS, Jones SA, Topley N.

J Immunol. 2001 Jul 15;167(2):1028-38.

29.

Agonistic and antagonistic activities of chemokines.

Loetscher P, Clark-Lewis I.

J Leukoc Biol. 2001 Jun;69(6):881-4. Review.

PMID:
11404371
30.

Lymphocyte traffic control by chemokines.

Moser B, Loetscher P.

Nat Immunol. 2001 Feb;2(2):123-8. Review.

PMID:
11175804
31.

Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.

Delgado MB, Clark-Lewis I, Loetscher P, Langen H, Thelen M, Baggiolini M, Wolf M.

Eur J Immunol. 2001 Mar;31(3):699-707.

32.

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes.

Wehrli N, Legler DF, Finke D, Toellner KM, Loetscher P, Baggiolini M, MacLennan IC, Acha-Orbea H.

Eur J Immunol. 2001 Feb;31(2):609-16.

33.

The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.

Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I.

J Biol Chem. 2001 Feb 2;276(5):2986-91. Epub 2000 Nov 10.

34.

CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.

Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B.

J Exp Med. 2000 Dec 4;192(11):1553-62.

35.

Chemokines in inflammation and immunity.

Baggiolini M, Loetscher P.

Immunol Today. 2000 Sep;21(9):418-20.

PMID:
10953090
36.
37.

Chemokines and their receptors in lymphocyte traffic and HIV infection.

Loetscher P, Moser B, Baggiolini M.

Adv Immunol. 2000;74:127-80. Review. No abstract available.

PMID:
10605606
38.

Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression.

Li FK, Davenport A, Robson RL, Loetscher P, Rothlein R, Williams JD, Topley N.

Kidney Int. 1998 Dec;54(6):2170-83.

39.

Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization.

Loetscher M, Loetscher P, Brass N, Meese E, Moser B.

Eur J Immunol. 1998 Nov;28(11):3696-705.

40.

Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes.

Seitz M, Zwicker M, Loetscher P.

Arthritis Rheum. 1998 Nov;41(11):2032-8.

PMID:
9811059
41.

Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains.

Bermejo M, Martín-Serrano J, Oberlin E, Pedraza MA, Serrano A, Santiago B, Caruz A, Loetscher P, Baggiolini M, Arenzana-Seisdedos F, Alcami J.

Eur J Immunol. 1998 Oct;28(10):3192-204.

42.

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation.

Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, Qin S, Lanzavecchia A.

Eur J Immunol. 1998 Sep;28(9):2760-9.

43.

N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities.

Loetscher P, Gong JH, Dewald B, Baggiolini M, Clark-Lewis I.

J Biol Chem. 1998 Aug 28;273(35):22279-83.

44.

HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.

Pardigol A, Forssmann U, Zucht HD, Loetscher P, Schulz-Knappe P, Baggiolini M, Forssmann WG, Mägert HJ.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6308-13.

45.

Lymphocyte responses to chemokines.

Moser B, Loetscher M, Piali L, Loetscher P.

Int Rev Immunol. 1998;16(3-4):323-44. Review.

PMID:
9505194
46.

CCR5 is characteristic of Th1 lymphocytes.

Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer JM.

Nature. 1998 Jan 22;391(6665):344-5. No abstract available.

PMID:
9450746
47.

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

Crump MP, Gong JH, Loetscher P, Rajarathnam K, Amara A, Arenzana-Seisdedos F, Virelizier JL, Baggiolini M, Sykes BD, Clark-Lewis I.

EMBO J. 1997 Dec 1;16(23):6996-7007.

48.

TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.

Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B.

Curr Biol. 1997 Sep 1;7(9):652-60.

49.

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA.

J Clin Invest. 1997 Sep 1;100(5):1137-43.

50.

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