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Items: 1 to 50 of 54

1.

Immature murine hippocampal neurones do not develop long-term structural changes after a single isoflurane exposure.

Tong D, Godale CM, Kadakia FK, Gu Z, Danzer CSK, Alghamdi A, Zhao P, Loepke AW, Danzer SC.

Br J Anaesth. 2019 Dec;123(6):818-826. doi: 10.1016/j.bja.2019.08.019. Epub 2019 Sep 28.

PMID:
31570162
2.

Defining the Vulnerability Window of Anesthesia-Induced Neuroapoptosis in Developing Dentate Gyrus Granule Cells - A Transgenic Approach Utilizing POMC-EGFP Mice.

Wei K, Chen P, Shen FY, Zhang Y, Liu YH, Wang ZR, Loepke AW, Wang YW, Deng M.

Neuroscience. 2019 Sep 1;415:59-69. doi: 10.1016/j.neuroscience.2019.07.009. Epub 2019 Jul 10.

PMID:
31301366
3.

Anesthesia and the developing brain: A way forward for laboratory and clinical research.

Disma N, O'Leary JD, Loepke AW, Brambrink AM, Becke K, Clausen NG, De Graaff JC, Liu F, Hansen TG, McCann ME, Salorio CF, Soriano S, Sun LS, Szmuk P, Warner DO, Vutskits L, Davidson AJ.

Paediatr Anaesth. 2018 Sep;28(9):758-763. doi: 10.1111/pan.13455. Epub 2018 Aug 16. Review.

PMID:
30117228
4.
5.

Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.

Miller JW, Balyan R, Dong M, Mahmoud M, Lam JE, Pratap JN, Paquin JR, Li BL, Spaeth JP, Vinks A, Loepke AW.

Br J Anaesth. 2018 May;120(5):1056-1065. doi: 10.1016/j.bja.2018.01.035. Epub 2018 Mar 13.

6.

Comparison of Intranasal Dexmedetomidine and Oral Pentobarbital Sedation for Transthoracic Echocardiography in Infants and Toddlers: A Prospective, Randomized, Double-Blind Trial.

Miller JW, Ding L, Gunter JB, Lam JE, Lin EP, Paquin JR, Li BL, Spaeth JP, Kreeger RN, Divanovic A, Mahmoud M, Loepke AW.

Anesth Analg. 2018 Jun;126(6):2009-2016. doi: 10.1213/ANE.0000000000002791.

PMID:
29369091
7.

Alternative technique or mitigating strategy for sevoflurane-induced neurodegeneration: a randomized controlled dose-escalation study of dexmedetomidine in neonatal rats.

Lee JR, Lin EP, Hofacer RD, Upton B, Lee SY, Ewing L, Joseph B, Loepke AW.

Br J Anaesth. 2017 Sep 1;119(3):492-505. doi: 10.1093/bja/aex219.

8.

Sedation methods for transthoracic echocardiography in children with Trisomy 21-a retrospective study.

Miller J, Ding L, Spaeth J, Lam J, Paquin J, Lin E, Divanovic A, Li BL, Baskar S, Loepke AW.

Paediatr Anaesth. 2017 May;27(5):531-539. doi: 10.1111/pan.13120. Epub 2017 Feb 8.

PMID:
28181351
9.

Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies.

Lin EP, Lee JR, Lee CS, Deng M, Loepke AW.

Neurotoxicol Teratol. 2017 Mar - Apr;60:117-128. doi: 10.1016/j.ntt.2016.10.008. Epub 2016 Oct 26. Review.

PMID:
27793659
10.

Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity.

Jiang Y, Tong D, Hofacer RD, Loepke AW, Lian Q, Danzer SC.

Anesthesiology. 2016 Dec;125(6):1159-1170.

11.

Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.

Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX.

J Neurosurg Anesthesiol. 2016 Oct;28(4):384-388. doi: 10.1097/ANA.0000000000000351.

12.
13.

Dosing and efficacy of intranasal dexmedetomidine sedation for pediatric transthoracic echocardiography: a retrospective study.

Miller JW, Divanovic AA, Hossain MM, Mahmoud MA, Loepke AW.

Can J Anaesth. 2016 Jul;63(7):834-41. doi: 10.1007/s12630-016-0617-y. Epub 2016 Feb 16.

PMID:
26883963
14.

What lessons for clinical practice can be learned from systematic reviews of animal studies? The case of anesthetic neurotoxicity.

Loepke AW, Vutskits L.

Paediatr Anaesth. 2016 Jan;26(1):4-5. doi: 10.1111/pan.12826. No abstract available.

PMID:
26644299
15.

Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia.

Backeljauw B, Holland SK, Altaye M, Loepke AW.

Pediatrics. 2015 Jul;136(1):e1-12. doi: 10.1542/peds.2014-3526. Epub 2015 Jun 8.

16.

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.

Osterop SF, Virtanen MA, Loepke JR, Joseph B, Loepke AW, Vutskits L.

Int J Dev Neurosci. 2015 Oct;45:19-28. doi: 10.1016/j.ijdevneu.2015.04.002. Epub 2015 Apr 18.

PMID:
25899661
17.

Is this your (paediatric patient's) brain on (anaesthetic) drugs?: The search for a potential neurological phenotype of anaesthesia-related neurotoxicity in humans.

Loepke AW, Hansen TG.

Eur J Anaesthesiol. 2015 May;32(5):298-300. doi: 10.1097/EJA.0000000000000148. No abstract available.

PMID:
25840346
18.

Clinical research into anesthetic neurotoxicity: does anesthesia cause neurological abnormalities in humans?

Lei SY, Hache M, Loepke AW.

J Neurosurg Anesthesiol. 2014 Oct;26(4):349-57. doi: 10.1097/ANA.0000000000000117. Review.

PMID:
25144503
19.

A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia.

Lin EP, Miles L, Hughes EA, McCann JC, Vorhees CV, McAuliffe JJ, Loepke AW.

Anesth Analg. 2014 Nov;119(5):1158-73. doi: 10.1213/ANE.0000000000000262.

PMID:
24878681
20.

Patient and procedural characteristics for successful and failed immediate tracheal extubation in the operating room following cardiac surgery in infancy.

Miller JW, Vu D, Chai PJ, Kreutzer J, Hossain MM, Jacobs JP, Loepke AW.

Paediatr Anaesth. 2014 Aug;24(8):830-9. doi: 10.1111/pan.12413. Epub 2014 May 12.

PMID:
24814869
21.

Anesthetic neurotoxicity.

Lin EP, Soriano SG, Loepke AW.

Anesthesiol Clin. 2014 Mar;32(1):133-55. doi: 10.1016/j.anclin.2013.10.003. Epub 2013 Dec 8. Review.

PMID:
24491654
22.

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions.

Deng M, Hofacer RD, Jiang C, Joseph B, Hughes EA, Jia B, Danzer SC, Loepke AW.

Br J Anaesth. 2014 Sep;113(3):443-51. doi: 10.1093/bja/aet469. Epub 2014 Jan 14.

23.

In response.

Istaphanous GK, Loepke AW.

Anesth Analg. 2013 Oct;117(4):1023-4. No abstract available.

PMID:
24187695
24.

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.

25.

Cell age-specific vulnerability of neurons to anesthetic toxicity.

Hofacer RD, Deng M, Ward CG, Joseph B, Hughes EA, Jiang C, Danzer SC, Loepke AW.

Ann Neurol. 2013 Jun;73(6):695-704. doi: 10.1002/ana.23892. Epub 2013 Jun 5.

26.

Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex.

Istaphanous GK, Ward CG, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW.

Anesth Analg. 2013 Apr;116(4):845-54. doi: 10.1213/ANE.0b013e318281e988. Epub 2013 Mar 4.

PMID:
23460572
27.

Single surgical procedure with general anaesthesia early in life is associated with subsequent impaired language development and cognitive function.

Loepke AW.

Evid Based Med. 2013 Aug;18(4):e39. doi: 10.1136/eb-2012-101084. Epub 2012 Dec 4. No abstract available.

PMID:
23213117
28.

Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls.

Mintz CD, Wagner M, Loepke AW.

J Neurosurg Anesthesiol. 2012 Oct;24(4):362-7. doi: 10.1097/ANA.0b013e31826a0495. Review.

29.

Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis.

Murphy BL, Hofacer RD, Faulkner CN, Loepke AW, Danzer SC.

Epilepsia. 2012 May;53(5):908-21. doi: 10.1111/j.1528-1167.2012.03463.x.

30.

Anesthetics and sedatives: toxic or protective for the developing brain?

Ward CG, Loepke AW.

Pharmacol Res. 2012 Mar;65(3):271-4. doi: 10.1016/j.phrs.2011.10.001. Epub 2011 Oct 14.

PMID:
22024740
31.

Contributions of mature granule cells to structural plasticity in temporal lobe epilepsy.

Santos VR, de Castro OW, Pun RY, Hester MS, Murphy BL, Loepke AW, Garcia-Cairasco N, Danzer SC.

Neuroscience. 2011 Dec 1;197:348-57. doi: 10.1016/j.neuroscience.2011.09.034. Epub 2011 Sep 19.

32.

Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice.

Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW.

Anesthesiology. 2011 Mar;114(3):578-87. doi: 10.1097/ALN.0b013e3182084a70.

PMID:
21293251
33.

Outcome for the extremely premature neonate: how far do we push the edge?

Boat AC, Sadhasivam S, Loepke AW, Kurth CD.

Paediatr Anaesth. 2011 Jul;21(7):765-70. doi: 10.1111/j.1460-9592.2010.03505.x. Epub 2011 Jan 10. Review.

PMID:
21219536
34.

Heterogeneous integration of adult-generated granule cells into the epileptic brain.

Murphy BL, Pun RY, Yin H, Faulkner CR, Loepke AW, Danzer SC.

J Neurosci. 2011 Jan 5;31(1):105-17. doi: 10.1523/JNEUROSCI.2728-10.2011.

35.

The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns.

Istaphanous GK, Ward CG, Loepke AW.

Best Pract Res Clin Anaesthesiol. 2010 Sep;24(3):433-49. Review.

PMID:
21033018
36.

Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function.

Stratmann G, Sall JW, May LD, Loepke AW, Lee MT.

Anesth Analg. 2010 Feb;110(2):431-7. Review.

PMID:
25508825
37.

Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function.

Stratmann G, Sall JW, May LD, Loepke AW, Lee MT.

Anesth Analg. 2010 Feb;110(2):431-7. Review.

PMID:
19917621
38.

Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine?

Loepke AW.

Pediatr Crit Care Med. 2010 Mar;11(2):217-26. doi: 10.1097/PCC.0b013e3181b80383. Review.

PMID:
19770789
39.

Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV.

Anesthesiology. 2009 Sep;111(3):533-46. doi: 10.1097/ALN.0b013e3181b060d3.

PMID:
19672176
40.

General anesthetics and the developing brain.

Istaphanous GK, Loepke AW.

Curr Opin Anaesthesiol. 2009 Jun;22(3):368-73. Review.

PMID:
19434780
41.

Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets.

Kurth CD, McCann JC, Wu J, Miles L, Loepke AW.

Anesth Analg. 2009 Apr;108(4):1268-77. doi: 10.1213/ane.0b013e318196ac8e.

PMID:
19299799
42.

Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.

Danzer SC, He X, Loepke AW, McNamara JO.

Hippocampus. 2010 Jan;20(1):113-24. doi: 10.1002/hipo.20589.

43.

The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory.

Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC.

Anesth Analg. 2009 Jan;108(1):90-104. doi: 10.1213/ane.0b013e31818cdb29.

PMID:
19095836
44.

An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function.

Loepke AW, Soriano SG.

Anesth Analg. 2008 Jun;106(6):1681-707. doi: 10.1213/ane.0b013e318167ad77. Review.

PMID:
18499597
45.

CON: The toxic effects of anesthetics in the developing brain: the clinical perspective.

Loepke AW, McGowan FX Jr, Soriano SG.

Anesth Analg. 2008 Jun;106(6):1664-9. doi: 10.1213/ane.0b013e3181733ef8. No abstract available.

PMID:
18499595
46.

Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia.

Nelson LA, McCann JC, Loepke AW, Wu J, Ben Dor B, Kurth CD.

J Biomed Opt. 2006 Nov-Dec;11(6):064022.

47.

The physiologic effects of isoflurane anesthesia in neonatal mice.

Loepke AW, McCann JC, Kurth CD, McAuliffe JJ.

Anesth Analg. 2006 Jan;102(1):75-80.

PMID:
16368807
48.

Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children.

Soriano SG, Loepke AW.

J Neurosurg Anesthesiol. 2005 Oct;17(4):207-9. No abstract available.

PMID:
16184066
49.

Injury pattern of the neonatal brain after hypothermic low-flow cardiopulmonary bypass in a piglet model.

Loepke AW, Golden JA, McCann JC, Kurth CD.

Anesth Analg. 2005 Aug;101(2):340-8, table of contents.

PMID:
16037141
50.

The plasma pharmacokinetics and cerebral spinal fluid penetration of intravenous topiramate in newborn pigs.

Galinkin JL, Kurth CD, Shi H, Priestley MA, Loepke AW, Adamson PC.

Biopharm Drug Dispos. 2004 Sep;25(6):265-71.

PMID:
15334626

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