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Items: 34


Assembly of a GPCR-G Protein Complex.

Du Y, Duc NM, Rasmussen SGF, Hilger D, Kubiak X, Wang L, Bohon J, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance MR, Lodowski DT, Kobilka BK, Chung KY.

Cell. 2019 May 16;177(5):1232-1242.e11. doi: 10.1016/j.cell.2019.04.022. Epub 2019 May 9.


Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY.

Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1.


Structure of the full-length TRPV2 channel by cryo-EM.

Huynh KW, Cohen MR, Jiang J, Samanta A, Lodowski DT, Zhou ZH, Moiseenkova-Bell VY.

Nat Commun. 2016 Mar 29;7:11130. doi: 10.1038/ncomms11130.


The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation.

Blankenship E, Vahedi-Faridi A, Lodowski DT.

Structure. 2015 Dec 1;23(12):2358-2364. doi: 10.1016/j.str.2015.09.015. Epub 2015 Oct 29.


A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.

Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S.

J Gen Physiol. 2015 Oct;146(4):323-40. doi: 10.1085/jgp.201511478.


Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange.

Lodowski DT, Miyagi M.

Methods Mol Biol. 2015;1271:123-32. doi: 10.1007/978-1-4939-2330-4_9.


Rhodopsin purification from dark-adapted bovine retina.

Blankenship E, Lodowski DT.

Methods Mol Biol. 2015;1271:21-38. doi: 10.1007/978-1-4939-2330-4_2.


Conformational flexibility in the catalytic triad revealed by the high-resolution crystal structure of Streptomyces erythraeus trypsin in an unliganded state.

Blankenship E, Vukoti K, Miyagi M, Lodowski DT.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):833-40. doi: 10.1107/S1399004713033658. Epub 2014 Feb 22.


Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Ernst OP, Lodowski DT, Elstner M, Hegemann P, Brown LS, Kandori H.

Chem Rev. 2014 Jan 8;114(1):126-63. doi: 10.1021/cr4003769. Epub 2013 Dec 23. Review. No abstract available.


Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.

Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K.

J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.


The significance of G protein-coupled receptor crystallography for drug discovery.

Salon JA, Lodowski DT, Palczewski K.

Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350. Review.


Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization.

Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.

J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.


Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.

Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA.

J Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.


Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange.

Lodowski DT, Palczewski K, Miyagi M.

Biochemistry. 2010 Nov 9;49(44):9425-7. doi: 10.1021/bi101502v. Epub 2010 Oct 15.


Structural characterization of the rod cGMP phosphodiesterase 6.

Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K.

J Mol Biol. 2010 Aug 20;401(3):363-73. doi: 10.1016/j.jmb.2010.06.044. Epub 2010 Jul 1.


Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases.

Becka S, Zhang P, Craig SE, Lodowski DT, Wang Z, Brady-Kalnay SM.

Cell Commun Adhes. 2010 Apr;17(2):34-47. doi: 10.3109/15419061.2010.487957.


A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu.

Burden-Gulley SM, Gates TJ, Burgoyne AM, Cutter JL, Lodowski DT, Robinson S, Sloan AE, Miller RH, Basilion JP, Brady-Kalnay SM.

Neoplasia. 2010 Apr;12(4):305-16.


Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregation.

Zhang P, Becka S, Craig SE, Lodowski DT, Brady-Kalnay SM, Wang Z.

Cell Commun Adhes. 2009 Dec;16(5-6):146-53. doi: 10.3109/15419061003653771.


Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J.

J Med Chem. 2010 Feb 25;53(4):1867-70. doi: 10.1021/jm9017515.


Importance of membrane structural integrity for RPE65 retinoid isomerization activity.

Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K.

J Biol Chem. 2010 Mar 26;285(13):9667-82. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.


Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.

Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.


Chemokine receptors and other G protein-coupled receptors.

Lodowski DT, Palczewski K.

Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d. Review.


Comparative analysis of GPCR crystal structures.

Lodowski DT, Angel TE, Palczewski K.

Photochem Photobiol. 2009 Mar-Apr;85(2):425-30. doi: 10.1111/j.1751-1097.2008.00516.x. Epub 2009 Jan 19. Review.


Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.

Park PS, Lodowski DT, Palczewski K.

Annu Rev Pharmacol Toxicol. 2008;48:107-41. Review.


Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462].

Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE.

J Struct Biol. 2007 Aug;159(2):253-60.


Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions.

Kiser PD, Lodowski DT, Palczewski K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):457-61. Epub 2007 May 5.


Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations.

Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K.

Vision Res. 2007 Jul;47(15):2055-66. Epub 2007 May 21.


Crystal packing analysis of Rhodopsin crystals.

Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE.

J Struct Biol. 2007 Jun;158(3):455-62. Epub 2007 Feb 9.


Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.

Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23.


Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals.

Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT.

J Struct Biol. 2006 Dec;156(3):497-504. Epub 2006 Jun 2.


The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ.

J Biol Chem. 2006 Jun 16;281(24):16785-93. Epub 2006 Apr 13.


The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.

Lodowski DT, Barnhill JF, Pyskadlo RM, Ghirlando R, Sterne-Marr R, Tesmer JJ.

Biochemistry. 2005 May 10;44(18):6958-70.


Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.

Lodowski DT, Barnhill JF, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ.

Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):936-9. Epub 2003 Apr 25.


Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.

Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ.

Science. 2003 May 23;300(5623):1256-62.

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