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Items: 31


Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes.

Pandori WJ, Lima TS, Mallya S, Kao TH, Gov L, Lodoen MB.

PLoS Pathog. 2019 Aug 26;15(8):e1007923. doi: 10.1371/journal.ppat.1007923. eCollection 2019 Aug.


Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii.

Lima TS, Lodoen MB.

Front Cell Infect Microbiol. 2019 Apr 16;9:103. doi: 10.3389/fcimb.2019.00103. eCollection 2019. Review.


CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease.

Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA.

Glia. 2019 May;67(5):844-856. doi: 10.1002/glia.23575. Epub 2018 Dec 26.


Correction to "Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture".

Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP.

ACS Cent Sci. 2018 Nov 28;4(11):1593. doi: 10.1021/acscentsci.8b00752. Epub 2018 Oct 31.


A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion.

Coleman BI, Saha S, Sato S, Engelberg K, Ferguson DJP, Coppens I, Lodoen MB, Gubbels MJ.

MBio. 2018 Oct 2;9(5). pii: e01510-18. doi: 10.1128/mBio.01510-18.


Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture.

Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP.

ACS Cent Sci. 2018 Aug 22;4(8):982-995. doi: 10.1021/acscentsci.8b00218. Epub 2018 Jul 2. Erratum in: ACS Cent Sci. 2018 Nov 28;4(11):1593.


Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection.

Lima TS, Gov L, Lodoen MB.

MBio. 2018 Feb 13;9(1). pii: e02027-17. doi: 10.1128/mBio.02027-17.


Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility.

Cook JH, Ueno N, Lodoen MB.

J Biol Chem. 2018 Mar 2;293(9):3374-3385. doi: 10.1074/jbc.M117.793281. Epub 2018 Jan 2.


NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes during Toxoplasma gondii Infection.

Gov L, Schneider CA, Lima TS, Pandori W, Lodoen MB.

J Immunol. 2017 Oct 15;199(8):2855-2864. doi: 10.4049/jimmunol.1700245. Epub 2017 Sep 13.


CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic co-glycolic acid) microparticles and films.

Chen EY, Chu S, Gov L, Kim YK, Lodoen MB, Tenner AJ, Liu WF.

J Mater Chem B. 2017 Feb 28;5(8):1574-1584. doi: 10.1039/C6TB02269C. Epub 2017 Jan 10.


Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.

Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA.

Nat Microbiol. 2016 Feb 15;1:16001. doi: 10.1038/nmicrobiol.2016.1.


From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system.

Ueno N, Lodoen MB.

Curr Opin Microbiol. 2015 Aug;26:53-9. doi: 10.1016/j.mib.2015.05.006. Epub 2015 Jun 3. Review.


Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo.

Ueno N, Lodoen MB, Hickey GL, Robey EA, Coombes JL.

Immunol Cell Biol. 2015 May-Jun;93(5):508-13. doi: 10.1038/icb.2014.106. Epub 2014 Dec 23.


Toxoplasma gondii dissemination: a parasite's journey through the infected host.

Harker KS, Ueno N, Lodoen MB.

Parasite Immunol. 2015 Mar;37(3):141-9. doi: 10.1111/pim.12163. Review.


Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses.

Morgado P, Sudarshana DM, Gov L, Harker KS, Lam T, Casali P, Boyle JP, Lodoen MB.

Infect Immun. 2014 Oct;82(10):4047-55. doi: 10.1128/IAI.01615-14. Epub 2014 Jul 14.


GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response.

Shastri AJ, Marino ND, Franco M, Lodoen MB, Boothroyd JC.

Infect Immun. 2014 Jun;82(6):2595-605. doi: 10.1128/IAI.01339-13. Epub 2014 Apr 7.


Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium.

Harker KS, Jivan E, McWhorter FY, Liu WF, Lodoen MB.

MBio. 2014 Apr 1;5(2):e01111-13. doi: 10.1128/mBio.01111-13.


Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers.

Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB.

Cell Microbiol. 2014 Apr;16(4):580-95. doi: 10.1111/cmi.12239. Epub 2013 Dec 4.


Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.

Gov L, Karimzadeh A, Ueno N, Lodoen MB.

MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13.


Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress.

Harker KS, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen MB.

J Leukoc Biol. 2013 May;93(5):789-800. doi: 10.1189/jlb.1012517. Epub 2013 Mar 13.


Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.

Morgado P, Ong YC, Boothroyd JC, Lodoen MB.

Infect Immun. 2011 Nov;79(11):4401-12. doi: 10.1128/IAI.05562-11. Epub 2011 Sep 12.


Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.

Koshy AA, Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC.

Nat Methods. 2010 Apr;7(4):307-9. doi: 10.1038/nmeth.1438. Epub 2010 Mar 7.


4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion.

Ravindran S, Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC.

PLoS One. 2009 Dec 2;4(12):e8143. doi: 10.1371/journal.pone.0008143.


A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection.

Lodoen MB, Gerke C, Boothroyd JC.

Cell Microbiol. 2010 Jan;12(1):55-66. doi: 10.1111/j.1462-5822.2009.01378.x. Epub 2009 Sep 2.


Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM.

J Exp Med. 2009 Mar 16;206(3):515-23. doi: 10.1084/jem.20080954. Epub 2009 Mar 2.


Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease.

Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE.

J Virol. 2008 Mar;82(6):3021-30. Epub 2007 Dec 19.


NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system.

Walsh KB, Lodoen MB, Lanier LL, Lane TE.

Adv Exp Med Biol. 2006;581:369-72. No abstract available.


Natural killer cells as an initial defense against pathogens.

Lodoen MB, Lanier LL.

Curr Opin Immunol. 2006 Aug;18(4):391-8. Epub 2006 Jun 12. Review.


Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.

Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM.

Nat Genet. 2005 Jun;37(6):593-9. Epub 2005 May 15.


Viral modulation of NK cell immunity.

Lodoen MB, Lanier LL.

Nat Rev Microbiol. 2005 Jan;3(1):59-69. Review.


The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions.

Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL.

J Exp Med. 2004 Oct 18;200(8):1075-81. Epub 2004 Oct 11.

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