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Items: 1 to 50 of 558

1.

Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.

Li H, Natarajan A, Ezike J, Barrasa MI, Le Y, Feder ZA, Yang H, Ma C, Markoulaki S, Lodish HF.

Dev Cell. 2019 Apr 8;49(1):118-129.e7. doi: 10.1016/j.devcel.2019.01.026. Epub 2019 Feb 28.

PMID:
30827895
2.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.

J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.

PMID:
30366982
3.

Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment.

Li H, Lodish HF, Sieff CA.

Hematol Oncol Clin North Am. 2018 Aug;32(4):701-712. doi: 10.1016/j.hoc.2018.04.005. Epub 2018 Jun 5. Review.

PMID:
30047421
4.

SYK kinase mediates brown fat differentiation and activation.

Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF.

Nat Commun. 2017 Dec 13;8(1):2115. doi: 10.1038/s41467-017-02162-3.

5.

Fifty years of mentoring and advising.

Lodish HF.

Mol Biol Cell. 2017 Nov 1;28(22):2908-2910. doi: 10.1091/mbc.E17-07-0481.

6.

Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis.

Alvarez-Dominguez JR, Lodish HF.

Blood. 2017 Nov 2;130(18):1965-1975. doi: 10.1182/blood-2017-06-788695. Epub 2017 Sep 19. Review.

7.

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin.

Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HF.

Nat Commun. 2017 Sep 4;8(1):423. doi: 10.1038/s41467-017-00448-0.

8.

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.

Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10107-10112. doi: 10.1073/pnas.1711058114. Epub 2017 Sep 1.

9.

The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans.

Alvarez-Dominguez JR, Knoll M, Gromatzky AA, Lodish HF.

Cell Rep. 2017 Jun 20;19(12):2503-2514. doi: 10.1016/j.celrep.2017.05.082.

10.

Erythropoietin signaling regulates heme biosynthesis.

Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.

Elife. 2017 May 29;6. pii: e24767. doi: 10.7554/eLife.24767.

11.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3583. Dhesycka, Rhogerry [corrected to Deshycka, Rhogerry].

12.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
13.

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.

Doulatov S, Vo LT, Macari ER, Wahlster L, Kinney MA, Taylor AM, Barragan J, Gupta M, McGrath K, Lee HY, Humphries JM, DeVine A, Narla A, Alter BP, Beggs AH, Agarwal S, Ebert BL, Gazda HT, Lodish HF, Sieff CA, Schlaeger TM, Zon LI, Daley GQ.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645. doi: 10.1126/scitranslmed.aah5645.

14.

TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors.

Gao X, Lee HY, da Rocha EL, Zhang C, Lu YF, Li D, Feng Y, Ezike J, Elmes RR, Barrasa MI, Cahan P, Li H, Daley GQ, Lodish HF.

Blood. 2016 Dec 8;128(23):2637-2641. Epub 2016 Oct 24.

15.

A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.

Atianand MK, Hu W, Satpathy AT, Shen Y, Ricci EP, Alvarez-Dominguez JR, Bhatta A, Schattgen SA, McGowan JD, Blin J, Braun JE, Gandhi P, Moore MJ, Chang HY, Lodish HF, Caffrey DR, Fitzgerald KA.

Cell. 2016 Jun 16;165(7):1672-1685. doi: 10.1016/j.cell.2016.05.075.

16.

Efficient CRISPR-Cas9 mediated gene disruption in primary erythroid progenitor cells.

Li H, Shi J, Huang NJ, Pishesha N, Natarajan A, Eng JC, Lodish HF.

Haematologica. 2016 Jun;101(6):e216-9. doi: 10.3324/haematol.2015.135723. Epub 2016 Mar 11. No abstract available.

17.

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.

Patterson HC, Gerbeth C, Thiru P, Vögtle NF, Knoll M, Shahsafaei A, Samocha KE, Huang CX, Harden MM, Song R, Chen C, Kao J, Shi J, Salmon W, Shaul YD, Stokes MP, Silva JC, Bell GW, MacArthur DG, Ruland J, Meisinger C, Lodish HF.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5679-88. doi: 10.1073/pnas.1517932112. Epub 2015 Oct 5. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2094.

18.

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.

Lee HY, Gao X, Barrasa MI, Li H, Elmes RR, Peters LL, Lodish HF.

Nature. 2015 Jun 25;522(7557):474-7. doi: 10.1038/nature14326. Epub 2015 May 11.

19.

De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development.

Alvarez-Dominguez JR, Bai Z, Xu D, Yuan B, Lo KA, Yoon MJ, Lim YC, Knoll M, Slavov N, Chen S, Peng C, Lodish HF, Sun L.

Cell Metab. 2015 May 5;21(5):764-776. doi: 10.1016/j.cmet.2015.04.003. Epub 2015 Apr 23. Erratum in: Cell Metab. 2015 Jun 2;21(6):918.

20.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH.

Sci Signal. 2015 Apr 14;8(372):ra34. doi: 10.1126/scisignal.aaa5903.

21.

Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.

Ludwig LS, Cho H, Wakabayashi A, Eng JC, Ulirsch JC, Fleming MD, Lodish HF, Sankaran VG.

Am J Hematol. 2015 May;90(5):386-91. doi: 10.1002/ajh.23952. Epub 2015 Feb 5.

22.

Accommodating family life: mentoring future female faculty members.

Lodish HF.

Trends Cell Biol. 2015 Mar;25(3):109-11. doi: 10.1016/j.tcb.2014.12.007. Epub 2015 Jan 15.

PMID:
25601644
23.

Long non-coding RNAs as regulators of the endocrine system.

Knoll M, Lodish HF, Sun L.

Nat Rev Endocrinol. 2015 Mar;11(3):151-60. doi: 10.1038/nrendo.2014.229. Epub 2015 Jan 6. Review.

24.

Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation.

Hu W, Yuan B, Lodish HF.

Dev Cell. 2014 Sep 29;30(6):660-72. doi: 10.1016/j.devcel.2014.07.008. Epub 2014 Sep 11.

25.

TMEM14C is required for erythroid mitochondrial heme metabolism.

Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH.

J Clin Invest. 2014 Oct;124(10):4294-304. doi: 10.1172/JCI76979. Epub 2014 Aug 26.

26.

Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation.

Hattangadi SM, Martinez-Morilla S, Patterson HC, Shi J, Burke K, Avila-Figueroa A, Venkatesan S, Wang J, Paulsen K, Görlich D, Murata-Hori M, Lodish HF.

Blood. 2014 Sep 18;124(12):1931-40.

27.

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10131-6. doi: 10.1073/pnas.1409861111. Epub 2014 Jun 30.

28.

Altered translation of GATA1 in Diamond-Blackfan anemia.

Ludwig LS, Gazda HT, Eng JC, Eichhorn SW, Thiru P, Ghazvinian R, George TI, Gotlib JR, Beggs AH, Sieff CA, Lodish HF, Lander ES, Sankaran VG.

Nat Med. 2014 Jul;20(7):748-53. doi: 10.1038/nm.3557. Epub 2014 Jun 22.

29.

Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis.

Cheng AW, Shi J, Wong P, Luo KL, Trepman P, Wang ET, Choi H, Burge CB, Lodish HF.

Blood. 2014 Jul 24;124(4):598-610. doi: 10.1182/blood-2013-12-542209. Epub 2014 May 28.

30.

Long noncoding RNAs during normal and malignant hematopoiesis.

Alvarez-Dominguez JR, Hu W, Gromatzky AA, Lodish HF.

Int J Hematol. 2014;99(5):531-41. doi: 10.1007/s12185-014-1552-8. Epub 2014 Mar 9. Review.

31.

Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis.

Chen C, Lodish HF.

Exp Hematol. 2014 Jun;42(6):464-76.e5. doi: 10.1016/j.exphem.2014.03.001. Epub 2014 Mar 7.

32.

Transcriptional divergence and conservation of human and mouse erythropoiesis.

Pishesha N, Thiru P, Shi J, Eng JC, Sankaran VG, Lodish HF.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4103-8. doi: 10.1073/pnas.1401598111. Epub 2014 Mar 3.

33.

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL.

Nat Struct Mol Biol. 2014 Feb;21(2):198-206. doi: 10.1038/nsmb.2764. Epub 2014 Jan 26.

34.

Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation.

Alvarez-Dominguez JR, Hu W, Yuan B, Shi J, Park SS, Gromatzky AA, van Oudenaarden A, Lodish HF.

Blood. 2014 Jan 23;123(4):570-81. doi: 10.1182/blood-2013-10-530683. Epub 2013 Nov 7.

35.

Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance.

Lo KA, Labadorf A, Kennedy NJ, Han MS, Yap YS, Matthews B, Xin X, Sun L, Davis RJ, Lodish HF, Fraenkel E.

Cell Rep. 2013 Oct 17;5(1):259-70. doi: 10.1016/j.celrep.2013.08.039. Epub 2013 Oct 3.

36.

MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.

Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H, Kotani A.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13410-5. doi: 10.1073/pnas.1220710110. Epub 2013 Jul 26.

37.

ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.

Zhang L, Prak L, Rayon-Estrada V, Thiru P, Flygare J, Lim B, Lodish HF.

Nature. 2013 Jul 4;499(7456):92-6. doi: 10.1038/nature12215. Epub 2013 Jun 9.

38.

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.

Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9776-81. doi: 10.1073/pnas.1307478110. Epub 2013 May 29.

39.

Snx3 regulates recycling of the transferrin receptor and iron assimilation.

Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH.

Cell Metab. 2013 Mar 5;17(3):343-52. doi: 10.1016/j.cmet.2013.01.013. Epub 2013 Feb 14.

40.

Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells.

Chou S, Flygare J, Lodish HF.

Exp Hematol. 2013 May;41(5):479-490.e4. doi: 10.1016/j.exphem.2013.02.003. Epub 2013 Feb 13.

41.

Long noncoding RNAs regulate adipogenesis.

Sun L, Goff LA, Trapnell C, Alexander R, Lo KA, Hacisuleyman E, Sauvageau M, Tazon-Vega B, Kelley DR, Hendrickson DG, Yuan B, Kellis M, Lodish HF, Rinn JL.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3387-92. doi: 10.1073/pnas.1222643110. Epub 2013 Feb 11.

42.

Regulation of mammalian cell differentiation by long non-coding RNAs.

Hu W, Alvarez-Dominguez JR, Lodish HF.

EMBO Rep. 2012 Nov 6;13(11):971-83. doi: 10.1038/embor.2012.145. Epub 2012 Oct 16. Review.

43.

Translational control of protein synthesis: the early years.

Lodish HF.

J Biol Chem. 2012 Oct 19;287(43):36528-35. doi: 10.1074/jbc.X112.420356. Epub 2012 Sep 17. Review.

44.

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.

Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF.

Genes Dev. 2012 Sep 15;26(18):2075-87. doi: 10.1101/gad.197020.112. Epub 2012 Aug 28.

45.

Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism.

Liu Q, Yuan B, Lo KA, Patterson HC, Sun Y, Lodish HF.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14568-73. doi: 10.1073/pnas.1211611109. Epub 2012 Aug 16.

46.

Sickle cell microRNAs inhibit the malaria parasite.

Duraisingh MT, Lodish HF.

Cell Host Microbe. 2012 Aug 16;12(2):127-8. doi: 10.1016/j.chom.2012.08.001.

47.

MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA.

Bousquet M, Nguyen D, Chen C, Shields L, Lodish HF.

Haematologica. 2012 Nov;97(11):1713-21. doi: 10.3324/haematol.2011.061515. Epub 2012 Jun 11.

48.

MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.

Zhang L, Sankaran VG, Lodish HF.

Leukemia. 2012 Nov;26(11):2310-6. doi: 10.1038/leu.2012.137. Epub 2012 May 23. Review.

49.

Mammalian erythroblast enucleation requires PI3K-dependent cell polarization.

Wang J, Ramirez T, Ji P, Jayapal SR, Lodish HF, Murata-Hori M.

J Cell Sci. 2012 Jan 15;125(Pt 2):340-9. doi: 10.1242/jcs.088286. Epub 2012 Feb 13.

50.

Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation.

Ji P, Lodish HF.

Biochem Biophys Res Commun. 2012 Jan 27;417(4):1188-92. doi: 10.1016/j.bbrc.2011.12.105. Epub 2011 Dec 27.

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