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Diagnostic yield of genetic tests in epilepsy: A meta-analysis and cost-effectiveness study.

Sánchez Fernández I, Loddenkemper T, Gaínza-Lein M, Sheidley BR, Poduri A.

Neurology. 2019 Jan 4. pii: 10.1212/WNL.0000000000006850. doi: 10.1212/WNL.0000000000006850. [Epub ahead of print]


Automating Interictal Spike Detection: Revisiting A Simple Threshold Rule.

Palepu A, Premanathan S, Azhar F, Vendrame M, Loddenkemper T, Reinsberger C, Kreiman G, Parkerson KA, Sarma S, Anderson WS.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:299-302. doi: 10.1109/EMBC.2018.8512244.


Status epilepticus prevention, ambulatory monitoring, early seizure detection and prediction in at-risk patients.

Amengual-Gual M, Ulate-Campos A, Loddenkemper T.

Seizure. 2018 Sep 18. pii: S1059-1311(18)30405-9. doi: 10.1016/j.seizure.2018.09.013. [Epub ahead of print] Review.


Circadian rhythm and epilepsy.

Khan S, Nobili L, Khatami R, Loddenkemper T, Cajochen C, Dijk DJ, Eriksson SH.

Lancet Neurol. 2018 Dec;17(12):1098-1108. doi: 10.1016/S1474-4422(18)30335-1. Epub 2018 Oct 23. Review. Erratum in: Lancet Neurol. 2018 Nov 19;:.


Chronotherapeutic implications of cyclic seizure patterns.

Sánchez Fernández I, Loddenkemper T.

Nat Rev Neurol. 2018 Dec;14(12):696-697. doi: 10.1038/s41582-018-0094-8. No abstract available.


KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM.

Ann Neurol. 2018 Nov;84(5):766-780. doi: 10.1002/ana.25351. Epub 2018 Nov 8.


Caring electronically for young outpatients who have epilepsy.

Oppenheimer J, Leviton A, Chiujdea M, Antonetty A, Ojo OW, Garcia S, Weas S, Fleegler EW, Chan E, Loddenkemper T.

Epilepsy Behav. 2018 Sep 6. pii: S1525-5050(18)30324-X. doi: 10.1016/j.yebeh.2018.06.018. [Epub ahead of print] Review.


Estimating the cost of admissions related to convulsive status epilepticus in the United States of America.

Sánchez Fernández I, Loddenkemper T.

Seizure. 2018 Oct;61:186-198. doi: 10.1016/j.seizure.2018.08.015. Epub 2018 Aug 19.


Long-term outcomes of status epilepticus: A critical assessment.

Sculier C, Gaínza-Lein M, Sánchez Fernández I, Loddenkemper T.

Epilepsia. 2018 Oct;59 Suppl 2:155-169. doi: 10.1111/epi.14515. Epub 2018 Aug 26.


Neuroimaging of Early Life Epilepsy.

Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT.

Pediatrics. 2018 Sep;142(3). pii: e20180672. doi: 10.1542/peds.2018-0672. Epub 2018 Aug 8.


Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers.

Vasquez A, Gaínza-Lein M, Sánchez Fernández I, Abend NS, Anderson A, Brenton JN, Carpenter JL, Chapman K, Clark J, Gaillard WD, Glauser T, Goldstein J, Goodkin HP, Lai YC, Loddenkemper T, McDonough TL, Mikati MA, Nayak A, Payne E, Riviello J, Tchapyjnikov D, Topjian AA, Wainwright MS, Tasker RC; Pediatric Status Epilepticus Research Group (pSERG).

Pediatr Neurol. 2018 Sep;86:33-41. doi: 10.1016/j.pediatrneurol.2018.06.004. Epub 2018 Jul 11.


Timing in the treatment of status epilepticus: From basics to the clinic.

Gaínza-Lein M, Fernández IS, Ulate-Campos A, Loddenkemper T, Ostendorf AP.

Seizure. 2018 Jun 1. pii: S1059-1311(18)30235-8. doi: 10.1016/j.seizure.2018.05.021. [Epub ahead of print] Review.


Machine Learning for Outcome Prediction in Electroencephalograph (EEG)-Monitored Children in the Intensive Care Unit.

Sánchez Fernández I, Sansevere AJ, Gaínza-Lein M, Kapur K, Loddenkemper T.

J Child Neurol. 2018 Jul;33(8):546-553. doi: 10.1177/0883073818773230. Epub 2018 May 13.


Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus.

Arya R, Peariso K, Gaínza-Lein M, Harvey J, Bergin A, Brenton JN, Burrows BT, Glauser T, Goodkin HP, Lai YC, Mikati MA, Fernández IS, Tchapyjnikov D, Wilfong AA, Williams K, Loddenkemper T; pediatric Status Epilepticus Research Group (pSERG).

Epilepsy Res. 2018 Aug;144:1-6. doi: 10.1016/j.eplepsyres.2018.04.012. Epub 2018 Apr 27.


Towards acute pediatric status epilepticus intervention teams: Do we need "Seizure Codes"?

Stredny CM, Abend NS, Loddenkemper T.

Seizure. 2018 May;58:133-140. doi: 10.1016/j.seizure.2018.04.011. Epub 2018 Apr 13. Review.


Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus.

Goldenholz DM, Rakesh K, Kapur K, Gaínza-Lein M, Hodgeman R, Moss R, Theodore WH, Loddenkemper T.

Epilepsia. 2018 May;59(5):e73-e77. doi: 10.1111/epi.14076. Epub 2018 Apr 23.


Factors associated with treatment delays in pediatric refractory convulsive status epilepticus.

Sánchez Fernández I, Gaínza-Lein M, Abend NS, Anderson AE, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Helseth AR, Jackson MC, Kapur K, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello JJ Jr, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T; Pediatric Status Epilepticus Research Group (pSERG).

Neurology. 2018 May 8;90(19):e1692-e1701. doi: 10.1212/WNL.0000000000005488. Epub 2018 Apr 11.


Common data elements for epilepsy mobile health systems.

Goldenholz DM, Moss R, Jost DA, Crone NE, Krauss G, Picard R, Caborni C, Cavazos JE, Hixson J, Loddenkemper T, Salazar TD, Lubbers L, Harte-Hargrove LC, Whittemore V, Duun-Henriksen J, Dolan E, Kasturia N, Oberemk M, Cook MJ, Lehmkuhle M, Sperling MR, Shafer PO.

Epilepsia. 2018 May;59(5):1020-1026. doi: 10.1111/epi.14066. Epub 2018 Mar 31.


Can a collaborative healthcare network improve the care of people with epilepsy?

Shamim EA, Mane K, Loddenkemper T, Leviton A.

Epilepsy Behav. 2018 May;82:189-193. doi: 10.1016/j.yebeh.2018.02.018. Epub 2018 Mar 21. Review.


Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms.

Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M.

PLoS One. 2018 Mar 8;13(3):e0193599. doi: 10.1371/journal.pone.0193599. eCollection 2018.


Patterns of epileptic seizure occurrence.

Amengual-Gual M, Sánchez Fernández I, Loddenkemper T.

Brain Res. 2019 Jan 15;1703:3-12. doi: 10.1016/j.brainres.2018.02.032. Epub 2018 Feb 23. Review.


New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives.

Gaspard N, Hirsch LJ, Sculier C, Loddenkemper T, van Baalen A, Lancrenon J, Emmery M, Specchio N, Farias-Moeller R, Wong N, Nabbout R.

Epilepsia. 2018 Apr;59(4):745-752. doi: 10.1111/epi.14022. Epub 2018 Feb 24. Review.


Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy.

Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT.

JAMA Pediatr. 2018 Apr 1;172(4):352-360. doi: 10.1001/jamapediatrics.2017.5211.


Conscious control of breathing: A key to prevention of sudden unexpected death in epilepsy?

Loddenkemper T.

Ann Neurol. 2018 Mar;83(3):449-450. doi: 10.1002/ana.25177. Epub 2018 Mar 10. No abstract available.


Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions.

Hirsch LJ, Gaspard N, van Baalen A, Nabbout R, Demeret S, Loddenkemper T, Navarro V, Specchio N, Lagae L, Rossetti AO, Hocker S, Gofton TE, Abend NS, Gilmore EJ, Hahn C, Khosravani H, Rosenow F, Trinka E.

Epilepsia. 2018 Apr;59(4):739-744. doi: 10.1111/epi.14016. Epub 2018 Feb 5. Review.


New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes.

Jafarpour S, Hodgeman RM, De Marchi Capeletto C, de Lima MTA, Kapur K, Tasker RC, Loddenkemper T.

Pediatr Neurol. 2018 Mar;80:61-69. doi: 10.1016/j.pediatrneurol.2017.11.016. Epub 2017 Dec 1.


Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.

Gaínza-Lein M, Sánchez Fernández I, Jackson M, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Kapur K, Mikati MA, Peariso K, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T; Pediatric Status Epilepticus Research Group.

JAMA Neurol. 2018 Apr 1;75(4):410-418. doi: 10.1001/jamaneurol.2017.4382.


Should patients with complex febrile seizure be admitted for further management?

Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA.

Am J Emerg Med. 2018 Aug;36(8):1386-1390. doi: 10.1016/j.ajem.2017.12.059. Epub 2017 Dec 28.


The Need for Antiepileptic Drug Chronotherapy to Treat Selected Childhood Epilepsy Syndromes and Avert the Harmful Consequences of Drug Resistance.

Manganaro S, Loddenkemper T, Rotenberg A.

J Cent Nerv Syst Dis. 2017 Dec 20;9:1179573516685883. doi: 10.1177/1179573516685883. eCollection 2017. Review.


Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases.

Ulate-Campos A, Tsuboyama M, Loddenkemper T.

Children (Basel). 2017 Dec 25;5(1). pii: E3. doi: 10.3390/children5010003.


Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism.

Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, St Hilaire MA, Phillips AJK, Loddenkemper T, Kothare SV, McConnell K, Braga-Kenyon P, Ahearn W, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW.

Autism Res. 2018 Feb;11(2):391-403. doi: 10.1002/aur.1899. Epub 2017 Dec 1.


Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit.

Sánchez Fernández I, Sansevere AJ, Gaínza-Lein M, Buraniqi E, Tasker RC, Loddenkemper T.

Seizure. 2018 Jan;54:19-26. doi: 10.1016/j.seizure.2017.11.013. Epub 2017 Nov 21.


Response to clobazam in continuous spike-wave during sleep.

Vega C, Sánchez Fernández I, Peters J, Thome-Souza MS, Jackson M, Takeoka M, Wilkening GN, Pearl PL, Chapman K, Loddenkemper T.

Dev Med Child Neurol. 2018 Mar;60(3):283-289. doi: 10.1111/dmcn.13607. Epub 2017 Nov 23.


The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium.

Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sánchez Fernández I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG; Pediatric Epilepsy Research Consortium.

Epilepsia. 2017 Dec;58(12):2098-2103. doi: 10.1111/epi.13937. Epub 2017 Nov 3.


Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism.

Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, Hilaire MAS, Phillips AJ, Loddenkemper T, Kothare SV, McConnell K, Ahearn W, Braga-Kenyon P, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW.

Sci Rep. 2017 Oct 27;7(1):14228. doi: 10.1038/s41598-017-14611-6.


Rescue Medications in Epilepsy Patients: A Family Perspective.

Gaínza-Lein M, Benjamin R, Stredny C, McGurl M, Kapur K, Loddenkemper T.

Seizure. 2017 Nov;52:188-194. doi: 10.1016/j.seizure.2017.10.007. Epub 2017 Oct 13.


Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors.

Onorati F, Regalia G, Caborni C, Migliorini M, Bender D, Poh MZ, Frazier C, Kovitch Thropp E, Mynatt ED, Bidwell J, Mai R, LaFrance WC Jr, Blum AS, Friedman D, Loddenkemper T, Mohammadpour-Touserkani F, Reinsberger C, Tognetti S, Picard RW.

Epilepsia. 2017 Nov;58(11):1870-1879. doi: 10.1111/epi.13899. Epub 2017 Oct 4.


Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus.

Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD.

Pediatr Neurol. 2017 Oct;75:73-79. doi: 10.1016/j.pediatrneurol.2017.06.011. Epub 2017 Jun 27.


Novel clinical manifestations in patients with KCNA2 mutations.

Sachdev M, Gaínza-Lein M, Tchapyjnikov D, Jiang YH, Loddenkemper T, Mikati MA.

Seizure. 2017 Oct;51:74-76. doi: 10.1016/j.seizure.2017.07.018. Epub 2017 Aug 5.


Early-Life Epilepsies and the Emerging Role of Genetic Testing.

Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S.

JAMA Pediatr. 2017 Sep 1;171(9):863-871. doi: 10.1001/jamapediatrics.2017.1743.


Disparities in epilepsy surgery in the United States of America.

Sánchez Fernández I, Stephen C, Loddenkemper T.

J Neurol. 2017 Aug;264(8):1735-1745. doi: 10.1007/s00415-017-8560-6. Epub 2017 Jul 12.


Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit.

Buraniqi E, Sansevere AJ, Kapur K, Bergin AM, Pearl PL, Loddenkemper T.

J Child Neurol. 2017 Sep;32(10):880-885. doi: 10.1177/0883073817713918. Epub 2017 Jul 9.


Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy.

Jackson MC, Jafarpour S, Klehm J, Thome-Souza S, Coughlin F, Kapur K, Loddenkemper T.

Epilepsia. 2017 Sep;58(9):1575-1585. doi: 10.1111/epi.13836. Epub 2017 Jul 10.


Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis.

Sánchez Fernández I, Gaínza-Lein M, Loddenkemper T.

Epilepsia. 2017 Aug;58(8):1349-1359. doi: 10.1111/epi.13812. Epub 2017 Jun 16.


Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy.

Sansevere AJ, Avalone J, Strauss LD, Patel AA, Pinto A, Ramachandran M, Fernandez IS, Bergin AM, Kimia A, Pearl PL, Loddenkemper T.

J Child Neurol. 2017 Jul;32(8):774-788. doi: 10.1177/0883073817706028. Epub 2017 May 14. Review.


Use of EEG in critically ill children and neonates in the United States of America.

Gaínza-Lein M, Sánchez Fernández I, Loddenkemper T.

J Neurol. 2017 Jun;264(6):1165-1173. doi: 10.1007/s00415-017-8510-3. Epub 2017 May 13.


A Question Worth Asking.

Sánchez Fernández I, Loddenkemper T.

J Clin Neurophysiol. 2017 Jul;34(4):392. doi: 10.1097/WNP.0000000000000388. No abstract available.


Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection.

Sansevere AJ, Duncan ED, Libenson MH, Loddenkemper T, Pearl PL, Tasker RC.

J Clin Neurophysiol. 2017 Sep;34(5):421-426. doi: 10.1097/WNP.0000000000000379.


Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.

Wolff M, Johannesen KM, Hedrich UBS, Masnada S, Rubboli G, Gardella E, Lesca G, Ville D, Milh M, Villard L, Afenjar A, Chantot-Bastaraud S, Mignot C, Lardennois C, Nava C, Schwarz N, Gérard M, Perrin L, Doummar D, Auvin S, Miranda MJ, Hempel M, Brilstra E, Knoers N, Verbeek N, van Kempen M, Braun KP, Mancini G, Biskup S, Hörtnagel K, Döcker M, Bast T, Loddenkemper T, Wong-Kisiel L, Baumeister FM, Fazeli W, Striano P, Dilena R, Fontana E, Zara F, Kurlemann G, Klepper J, Thoene JG, Arndt DH, Deconinck N, Schmitt-Mechelke T, Maier O, Muhle H, Wical B, Finetti C, Brückner R, Pietz J, Golla G, Jillella D, Linnet KM, Charles P, Moog U, Õiglane-Shlik E, Mantovani JF, Park K, Deprez M, Lederer D, Mary S, Scalais E, Selim L, Van Coster R, Lagae L, Nikanorova M, Hjalgrim H, Korenke GC, Trivisano M, Specchio N, Ceulemans B, Dorn T, Helbig KL, Hardies K, Stamberger H, de Jonghe P, Weckhuysen S, Lemke JR, Krägeloh-Mann I, Helbig I, Kluger G, Lerche H, Møller RS.

Brain. 2017 May 1;140(5):1316-1336. doi: 10.1093/brain/awx054.


Increasing Ketamine Use for Refractory Status Epilepticus in US Pediatric Hospitals.

Keros S, Buraniqi E, Alex B, Antonetty A, Fialho H, Hafeez B, Jackson MC, Jawahar R, Kjelleren S, Stewart E, Morgan LA, Wainwright MS, Sogawa Y, Patel AD, Loddenkemper T, Grinspan ZM.

J Child Neurol. 2017 Jun;32(7):638-646. doi: 10.1177/0883073817698629. Epub 2017 Mar 28.


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