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Tissue signals imprint ILC2 identity with anticipatory function.

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM.

Nat Immunol. 2018 Sep 10. doi: 10.1038/s41590-018-0201-4. [Epub ahead of print]


Innate Lymphoid Cells: 10 Years On.

Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H.

Cell. 2018 Aug 23;174(5):1054-1066. doi: 10.1016/j.cell.2018.07.017. Review.


Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.


Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J.

Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016.


Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD.

Nature. 2018 Jul 16. doi: 10.1038/s41586-018-0370-1. [Epub ahead of print]


Chitins and chitinase activity in airway diseases.

Van Dyken SJ, Locksley RM.

J Allergy Clin Immunol. 2018 Aug;142(2):364-369. doi: 10.1016/j.jaci.2018.06.017. Epub 2018 Jun 28.


Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD.

Nature. 2018 Jul;559(7712):109-113. doi: 10.1038/s41586-018-0257-1. Epub 2018 Jun 27. Erratum in: Nature. 2018 Jul 16;:.


Why Innate Lymphoid Cells?

Kotas ME, Locksley RM.

Immunity. 2018 Jun 19;48(6):1081-1090. doi: 10.1016/j.immuni.2018.06.002. Review.


A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM.

Cell. 2018 Jul 12;174(2):271-284.e14. doi: 10.1016/j.cell.2018.05.014. Epub 2018 Jun 7.


Pulmonary neuroendocrine cells amplify allergic asthma responses.

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X.

Science. 2018 Jun 8;360(6393). pii: eaan8546. doi: 10.1126/science.aan8546. Epub 2018 Mar 29.


Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A.

Cell. 2017 Dec 14;171(7):1707. doi: 10.1016/j.cell.2017.12.003. No abstract available.


MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM.

J Exp Med. 2017 Dec 4;214(12):3627-3643. doi: 10.1084/jem.20170545. Epub 2017 Nov 9.


The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.

Savage AK, Liang HE, Locksley RM.

J Immunol. 2017 Sep 1;199(5):1912-1922. doi: 10.4049/jimmunol.1700155. Epub 2017 Jul 26.


Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.

Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR.

Cell Stem Cell. 2017 Jul 6;21(1):120-134.e7. doi: 10.1016/j.stem.2017.03.024. Epub 2017 May 11.


Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM.

Cell. 2017 Apr 20;169(3):497-509.e13. doi: 10.1016/j.cell.2017.03.044.


Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM.

J Exp Med. 2017 Jan;214(1):27-37. doi: 10.1084/jem.20161274. Epub 2016 Dec 23.


Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL.

PLoS One. 2016 Dec 15;11(12):e0167693. doi: 10.1371/journal.pone.0167693. eCollection 2016.


A tissue checkpoint regulates type 2 immunity.

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM.

Nat Immunol. 2016 Dec;17(12):1381-1387. doi: 10.1038/ni.3582. Epub 2016 Oct 17.


Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.

Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD.

JCI Insight. 2016 Jul 7;1(10). pii: e85395.


Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A.

Cell. 2016 Aug 11;166(4):841-854. doi: 10.1016/j.cell.2016.06.040. Epub 2016 Jul 21. Erratum in: Cell. 2017 Dec 14;171(7):1707.


Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.

Gordon ED, Locksley RM, Fahy JV.

Am J Respir Crit Care Med. 2016 May 1;193(9):935-6. doi: 10.1164/rccm.201512-2534ED. No abstract available.


Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.

von Moltke J, Ji M, Liang HE, Locksley RM.

Nature. 2016 Jan 14;529(7585):221-5. doi: 10.1038/nature16161. Epub 2015 Dec 14.


Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.

Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM.

Mucosal Immunol. 2016 Jan;9(1):275-86. doi: 10.1038/mi.2015.59. Epub 2015 Jul 1.


Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM.

Immunity. 2015 Jul 21;43(1):161-74. doi: 10.1016/j.immuni.2015.05.019. Epub 2015 Jun 16.


Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.

Molofsky AB, Savage AK, Locksley RM.

Immunity. 2015 Jun 16;42(6):1005-19. doi: 10.1016/j.immuni.2015.06.006. Review.


New blood: Creative funding of disease-specific research.

Seaman WE, Locksley RM, Welsh MJ.

Sci Transl Med. 2015 May 20;7(288):288ed5. doi: 10.1126/scitranslmed.aaa9513. No abstract available.


IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.

Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM.

J Exp Med. 2015 Apr 6;212(4):513-24. doi: 10.1084/jem.20141671. Epub 2015 Mar 16.


A novel model for IFN-γ-mediated autoinflammatory syndromes.

Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM.

J Immunol. 2015 Mar 1;194(5):2358-68. doi: 10.4049/jimmunol.1401992. Epub 2015 Jan 30.


Activated type 2 innate lymphoid cells regulate beige fat biogenesis.

Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A.

Cell. 2015 Jan 15;160(1-2):74-87. doi: 10.1016/j.cell.2014.12.011. Epub 2014 Dec 24.


Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.

Bando JK, Liang HE, Locksley RM.

Nat Immunol. 2015 Feb;16(2):153-60. doi: 10.1038/ni.3057. Epub 2014 Dec 15.


I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.

von Moltke J, Locksley RM.

Curr Opin Immunol. 2014 Dec;31:58-65. doi: 10.1016/j.coi.2014.09.009. Epub 2014 Oct 13. Review.


Allergic inflammation--innately homeostatic.

Cheng LE, Locksley RM.

Cold Spring Harb Perspect Biol. 2014 Nov 20;7(3):a016352. doi: 10.1101/cshperspect.a016352. Review.


Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA.

Blood. 2014 Dec 4;124(24):3572-6. doi: 10.1182/blood-2014-07-587493. Epub 2014 Oct 16.


Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A.

Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.


Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.

Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD.

J Exp Med. 2014 Jun 30;211(7):1281-8. doi: 10.1084/jem.20132336. Epub 2014 Jun 2.


Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.

O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP.

Infect Immun. 2014 Aug;82(8):3199-205. doi: 10.1128/IAI.01990-14. Epub 2014 May 19.


Asthma and the flu: a tricky two-step.

Locksley RM, Fahy JV.

Immunol Cell Biol. 2014 May-Jun;92(5):389-91. doi: 10.1038/icb.2014.24. Epub 2014 Apr 1. No abstract available.


Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.

Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM.

Immunity. 2014 Mar 20;40(3):414-24. doi: 10.1016/j.immuni.2014.02.003. Epub 2014 Mar 13.


Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

Hams E, Locksley RM, McKenzie AN, Fallon PG.

J Immunol. 2013 Dec 1;191(11):5349-53. doi: 10.4049/jimmunol.1301176. Epub 2013 Oct 28.


Type 2 innate lymphoid cells control eosinophil homeostasis.

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM.

Nature. 2013 Oct 10;502(7470):245-8. doi: 10.1038/nature12526. Epub 2013 Sep 15.


Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.

Bando JK, Nussbaum JC, Liang HE, Locksley RM.

J Leukoc Biol. 2013 Nov;94(5):877-84. doi: 10.1189/jlb.0213084. Epub 2013 Aug 7.


Eosinophils secrete IL-4 to facilitate liver regeneration.

Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9914-9. doi: 10.1073/pnas.1304046110. Epub 2013 May 28.


Traumatic brain injury induces macrophage subsets in the brain.

Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE.

Eur J Immunol. 2013 Aug;43(8):2010-22. doi: 10.1002/eji.201243084. Epub 2013 Jun 5.


Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A.

Cell. 2013 Apr 11;153(2):376-88. doi: 10.1016/j.cell.2013.02.053.


Raggin' on T-bet.

Locksley RM.

Cell Metab. 2013 Apr 2;17(4):473-4. doi: 10.1016/j.cmet.2013.03.012.


Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM.

J Exp Med. 2013 Mar 11;210(3):535-49. doi: 10.1084/jem.20121964. Epub 2013 Feb 18.


Innate lymphoid cells--a proposal for uniform nomenclature.

Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E.

Nat Rev Immunol. 2013 Feb;13(2):145-9. doi: 10.1038/nri3365. Review.


Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.

Van Dyken SJ, Locksley RM.

Annu Rev Immunol. 2013;31:317-43. doi: 10.1146/annurev-immunol-032712-095906. Epub 2013 Jan 3. Review.


Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM.

Immunity. 2013 Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 Jan 3.


Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.

Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF.

J Leukoc Biol. 2012 Nov;92(5):999-1009. doi: 10.1189/jlb.0512242. Epub 2012 Aug 31.

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