Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 247


Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers.

Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O.

Chem Biol Interact. 2020 Mar 1;319:109007. doi: 10.1016/j.cbi.2020.109007. Epub 2020 Feb 20.


Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase.

Biberoglu K, Tacal O, Schopfer LM, Lockridge O.

Molecules. 2020 Jan 25;25(3). pii: E533. doi: 10.3390/molecules25030533.


Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution.

Lockridge O, Verdier L, Schopfer LM.

Chem Biol Interact. 2019 Sep 25;311:108788. doi: 10.1016/j.cbi.2019.108788. Epub 2019 Aug 8.


Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad.

Grigorenko BL, Novichkova DA, Lushchekina SV, Zueva IV, Schopfer LM, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P.

Chem Biol Interact. 2019 Jun 1;306:138-146. doi: 10.1016/j.cbi.2019.04.019. Epub 2019 Apr 19.


Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon.

Schopfer LM, Lockridge O.

Chem Res Toxicol. 2019 Apr 15;32(4):762-772. doi: 10.1021/acs.chemrestox.9b00001. Epub 2019 Mar 7.


Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography.

Schopfer LM, Lockridge O, David E, Hinrichs SH.

PLoS One. 2019 Jan 9;14(1):e0209795. doi: 10.1371/journal.pone.0209795. eCollection 2019.


Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.

Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13270-13275. doi: 10.1073/pnas.1817009115. Epub 2018 Dec 11.


Purification of recombinant human butyrylcholinesterase on Hupresin®.

Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Dec 1;1102-1103:109-115. doi: 10.1016/j.jchromb.2018.10.026. Epub 2018 Oct 25.


Identification of Carboxylesterase, Butyrylcholinesterase, Acetylcholinesterase, Paraoxonase, and Albumin Pseudoesterase in Guinea Pig Plasma through Nondenaturing Gel Electrophoresis.

Napon G, Dafferner AJ, Saxena A, Lockridge O.

Comp Med. 2018 Oct 1;68(5):367-374. doi: 10.30802/AALAS-CM-18-000047. Epub 2018 Oct 2.


Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity.

Schopfer LM, Lockridge O.

J Biol Chem. 2018 Aug 31;293(35):13566-13577. doi: 10.1074/jbc.RA118.004172. Epub 2018 Jul 13.


Characterization of butyrylcholinesterase from porcine milk.

Saxena A, Belinskaya T, Schopfer LM, Lockridge O.

Arch Biochem Biophys. 2018 Aug 15;652:38-49. doi: 10.1016/ Epub 2018 Jun 15.


Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment.

Onder S, Schopfer LM, Tacal O, Blake TA, Johnson RC, Lockridge O.

Chem Res Toxicol. 2018 Jun 18;31(6):520-530. doi: 10.1021/acs.chemrestox.8b00083. Epub 2018 Jun 6.


Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents.

Lushchekina SV, Schopfer LM, Grigorenko BL, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P.

Front Pharmacol. 2018 Mar 13;9:211. doi: 10.3389/fphar.2018.00211. eCollection 2018.


Delipidation of Plasma Has Minimal Effects on Human Butyrylcholinesterase.

Onder S, Tacal O, Lockridge O.

Front Pharmacol. 2018 Feb 15;9:117. doi: 10.3389/fphar.2018.00117. eCollection 2018.


Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure.

Onder S, Schopfer LM, Cashman JR, Tacal O, Johnson RC, Blake TA, Lockridge O.

Anal Chem. 2018 Jan 2;90(1):974-979. doi: 10.1021/acs.analchem.7b04160. Epub 2017 Dec 13.


Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids.

Onder S, Dafferner AJ, Schopfer LM, Xiao G, Yerramalla U, Tacal O, Blake TA, Johnson RC, Lockridge O.

Chem Res Toxicol. 2017 Dec 18;30(12):2218-2228. doi: 10.1021/acs.chemrestox.7b00288. Epub 2017 Nov 28.


Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide.

Onder S, David E, Tacal O, Schopfer LM, Lockridge O.

Front Pharmacol. 2017 Oct 10;8:713. doi: 10.3389/fphar.2017.00713. eCollection 2017.


Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure.

Dafferner AJ, Schopfer LM, Xiao G, Cashman JR, Yerramalla U, Johnson RC, Blake TA, Lockridge O.

Chem Res Toxicol. 2017 Oct 16;30(10):1897-1910. doi: 10.1021/acs.chemrestox.7b00209. Epub 2017 Sep 25.


The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment.

Schopfer LM, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O.

Molecules. 2017 Jun 29;22(7). pii: E1083. doi: 10.3390/molecules22071083.


Characterization of butyrylcholinesterase in bovine serum.

Dafferner AJ, Lushchekina S, Masson P, Xiao G, Schopfer LM, Lockridge O.

Chem Biol Interact. 2017 Mar 25;266:17-27. doi: 10.1016/j.cbi.2017.02.004. Epub 2017 Feb 8.


Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures.

Peng H, Blake TA, Johnson RC, Dafferner AJ, Brimijoin S, Lockridge O.

ACS Omega. 2016 Dec 31;1(6):1182-1191. doi: 10.1021/acsomega.6b00311. Epub 2016 Dec 13.


Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors.

Lockridge O, Norgren RB Jr, Johnson RC, Blake TA.

Chem Res Toxicol. 2016 Sep 19;29(9):1381-92. doi: 10.1021/acs.chemrestox.6b00228. Epub 2016 Aug 31. Review.


Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers.

Schopfer LM, Lockridge O.

Biochim Biophys Acta. 2016 Jun;1864(6):706-714. doi: 10.1016/j.bbapap.2016.03.003. Epub 2016 Mar 3.


Heat pretreatment eliminates spurious butyrylcholinesterase enhancement of endotoxin levels in the kinetic chromogenic assay.

Brawner A, Hinrichs SH, Larson MA, Lockridge O.

Chem Biol Interact. 2016 Apr 5;249:19-22. doi: 10.1016/j.cbi.2016.02.015. Epub 2016 Feb 23.


Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers.

Peng H, Schopfer LM, Lockridge O.

Chem Biol Interact. 2016 Nov 25;259(Pt B):63-69. doi: 10.1016/j.cbi.2016.02.007. Epub 2016 Feb 11.


Human butyrylcholinesterase polymorphism: Molecular modeling.

Lushchekina S, Delacour H, Lockridge O, Masson P.

Int J Risk Saf Med. 2015;27 Suppl 1:S80-1. doi: 10.3233/JRS-150699.


Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma.

Peng H, Brimijoin S, Hrabovska A, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O.

Chem Biol Interact. 2016 Jan 5;243:82-90. doi: 10.1016/j.cbi.2015.11.011. Epub 2015 Nov 14.


Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences.

Peng H, Brimijoin S, Hrabovska A, Targosova K, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O.

Chem Biol Interact. 2015 Oct 5;240:336-45. doi: 10.1016/j.cbi.2015.08.024. Epub 2015 Sep 3.


Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin.

Schopfer LM, Lockridge O, Brimijoin S.

Gen Comp Endocrinol. 2015 Dec 1;224:61-8. doi: 10.1016/j.ygcen.2015.05.017. Epub 2015 Jun 12.


Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses.

Lockridge O.

Pharmacol Ther. 2015 Apr;148:34-46. doi: 10.1016/j.pharmthera.2014.11.011. Epub 2014 Nov 20. Review.


Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium.

Delacour H, Lushchekina S, Mabboux I, Ceppa F, Masson P, Schopfer LM, Lockridge O.

Biochem Pharmacol. 2014 Dec 1;92(3):476-83. doi: 10.1016/j.bcp.2014.09.014. Epub 2014 Sep 28.


Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

Delacour H, Lushchekina S, Mabboux I, Bousquet A, Ceppa F, Schopfer LM, Lockridge O, Masson P.

PLoS One. 2014 Jul 23;9(7):e101552. doi: 10.1371/journal.pone.0101552. eCollection 2014.


Polyproline promotes tetramerization of recombinant human butyrylcholinesterase.

Larson MA, Lockridge O, Hinrichs SH.

Biochem J. 2014 Sep 1;462(2):329-35. doi: 10.1042/BJ20140421.


Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome.

Schopfer LM, Masson P, Lamourette P, Simon S, Lockridge O.

Anal Biochem. 2014 Sep 15;461:17-26. doi: 10.1016/j.ab.2014.05.021. Epub 2014 Jun 2.


PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin.

Jiang W, Dubrovskii YA, Podolskaya EP, Murashko EA, Babakov V, Nachon F, Masson P, Schopfer LM, Lockridge O.

Chem Res Toxicol. 2013 Dec 16;26(12):1917-25. doi: 10.1021/tx400352h. Epub 2013 Nov 14.


Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase.

Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O.

Anal Biochem. 2013 Aug 15;439(2):132-41. doi: 10.1016/j.ab.2013.04.018. Epub 2013 Apr 25.


Protein tyrosine adduct in humans self-poisoned by chlorpyrifos.

Li B, Eyer P, Eddleston M, Jiang W, Schopfer LM, Lockridge O.

Toxicol Appl Pharmacol. 2013 Jun 15;269(3):215-25. doi: 10.1016/j.taap.2013.03.021. Epub 2013 Apr 6.


Polyclonal antibody to soman-tyrosine.

Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW, Cashman J, Williams GR, Lockridge O.

Chem Res Toxicol. 2013 Apr 15;26(4):584-92. doi: 10.1021/tx400027n. Epub 2013 Mar 21.


Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis.

Larson MA, Ding SJ, Slater SR, Hanway A, Bartling AM, Fey PD, Lockridge O, Francesconi SC, Hinrichs SH.

Proteomics Clin Appl. 2013 Jun;7(5-6):416-23. doi: 10.1002/prca.201200092. Epub 2013 May 10.


Human serum albumin-based design of a diflunisal prodrug.

Yang F, Ma ZY, Zhang Y, Li GQ, Li M, Qin JK, Lockridge O, Liang H.

Eur J Pharm Biopharm. 2013 Aug;84(3):549-54. doi: 10.1016/j.ejpb.2013.01.013. Epub 2013 Feb 14.


Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor.

Liyasova MS, Schopfer LM, Kodani S, Lantz SR, Casida JE, Lockridge O.

Chem Res Toxicol. 2013 Mar 18;26(3):422-31. doi: 10.1021/tx300501n. Epub 2013 Mar 1.


Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase.

Biberoglu K, Schopfer LM, Saxena A, Tacal O, Lockridge O.

Biochim Biophys Acta. 2013 Apr;1834(4):745-53. doi: 10.1016/j.bbapap.2013.01.009. Epub 2013 Jan 23.


Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond.

Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O.

Toxicol Sci. 2013 Apr;132(2):390-8. doi: 10.1093/toxsci/kft011. Epub 2013 Jan 23.


Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry.

Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M.

Chem Res Toxicol. 2013 Feb 18;26(2):280-9. doi: 10.1021/tx3004505. Epub 2013 Feb 5.


Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products.

Tacal O, Li B, Lockridge O, Schopfer LM.

Photochem Photobiol. 2013 Mar-Apr;89(2):336-48. doi: 10.1111/php.12016. Epub 2012 Dec 17.


Detectable organophosphorus pesticide exposure in the blood of Nebraska and Iowa residents measured by mass spectrometry of butyrylcholinesterase adducts.

Jiang W, Lockridge O.

Chem Biol Interact. 2013 Mar 25;203(1):91-5. doi: 10.1016/j.cbi.2012.09.002. Epub 2012 Sep 16.


Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase.

Liyasova MS, Schopfer LM, Lockridge O.

Chem Biol Interact. 2013 Mar 25;203(1):103-7. doi: 10.1016/j.cbi.2012.07.006. Epub 2012 Aug 8.

Supplemental Content

Loading ...
Support Center