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Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure.

Rahman SA, Wright KP Jr, Lockley SW, Czeisler CA, Gronfier C.

Sci Rep. 2019 Dec 23;9(1):19720. doi: 10.1038/s41598-019-54806-7.


Light Me up? Why, When, and How Much Light We Need.

Vetter C, Phillips AJK, Silva A, Lockley SW, Glickman G.

J Biol Rhythms. 2019 Dec;34(6):573-575. doi: 10.1177/0748730419892111. Epub 2019 Dec 8. No abstract available.


Associations between shift work characteristics, shift work schedules, sleep and burnout in North American police officers: a cross-sectional study.

Peterson SA, Wolkow AP, Lockley SW, O'Brien CS, Qadri S, Sullivan JP, Czeisler CA, Rajaratnam SMW, Barger LK.

BMJ Open. 2019 Dec 1;9(11):e030302. doi: 10.1136/bmjopen-2019-030302.


Using a Single Daytime Performance Test to Identify Most Individuals at High-Risk for Performance Impairment during Extended Wake.

St Hilaire MA, Kristal BS, Rahman SA, Sullivan JP, Quackenbush J, Duffy JF, Barger LK, Gooley JJ, Czeisler CA, Lockley SW.

Sci Rep. 2019 Nov 13;9(1):16681. doi: 10.1038/s41598-019-52930-y.


Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio.

Grant LK, Gooley JJ, St Hilaire MA, Rajaratnam SMW, Brainard GC, Czeisler CA, Lockley SW, Rahman SA.

Sleep. 2020 Feb 13;43(2). pii: zsz227. doi: 10.1093/sleep/zsz227.


The role of sleep hygiene in the risk of Shift Work Disorder in nurses.

Booker LA, Barnes M, Alvaro P, Collins A, Chai-Coetzer CL, McMahon M, Lockley SW, Rajaratnam SMW, Howard ME, Sletten TL.

Sleep. 2020 Feb 13;43(2). pii: zsz228. doi: 10.1093/sleep/zsz228.


Classifying attentional vulnerability to total sleep deprivation using baseline features of Psychomotor Vigilance Test performance.

Chua EC, Sullivan JP, Duffy JF, Klerman EB, Lockley SW, Kristal BS, Czeisler CA, Gooley JJ.

Sci Rep. 2019 Aug 20;9(1):12102. doi: 10.1038/s41598-019-48280-4.


Endogenous Circadian Regulation of Female Reproductive Hormones.

Rahman SA, Grant LK, Gooley JJ, Rajaratnam SMW, Czeisler CA, Lockley SW.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6049-6059. doi: 10.1210/jc.2019-00803.


Application of a Limit-Cycle Oscillator Model for Prediction of Circadian Phase in Rotating Night Shift Workers.

Stone JE, Aubert XL, Maass H, Phillips AJK, Magee M, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL.

Sci Rep. 2019 Jul 30;9(1):11032. doi: 10.1038/s41598-019-47290-6.


Generalizability of A Neural Network Model for Circadian Phase Prediction in Real-World Conditions.

Stone JE, Phillips AJK, Ftouni S, Magee M, Howard M, Lockley SW, Sletten TL, Anderson C, Rajaratnam SMW, Postnova S.

Sci Rep. 2019 Jul 29;9(1):11001. doi: 10.1038/s41598-019-47311-4.


How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments.

Spitschan M, Stefani O, Blattner P, Gronfier C, Lockley SW, Lucas RJ.

Clocks Sleep. 2019 Jul 1;1(3):280-289. doi: 10.3390/clockssleep1030024. Epub 2019 Jun 26.


Exploring the associations between shift work disorder, depression, anxiety and sick leave taken amongst nurses.

Booker LA, Sletten TL, Alvaro PK, Barnes M, Collins A, Chai-Coetzer CL, Naqvi A, McMahon M, Lockley SW, Rajaratnam SMW, Howard ME.

J Sleep Res. 2019 May 29:e12872. doi: 10.1111/jsr.12872. [Epub ahead of print]


Shift Work, Chronotype, and Melatonin Rhythm in Nurses.

Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE, Willett WC, Schernhammer ES.

Cancer Epidemiol Biomarkers Prev. 2019 Jul;28(7):1177-1186. doi: 10.1158/1055-9965.EPI-18-1018. Epub 2019 May 29.


High sensitivity and interindividual variability in the response of the human circadian system to evening light.

Phillips AJK, Vidafar P, Burns AC, McGlashan EM, Anderson C, Rajaratnam SMW, Lockley SW, Cain SW.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12019-12024. doi: 10.1073/pnas.1901824116. Epub 2019 May 28.


Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder.

Murray JM, Phillips AJK, Magee M, Sletten TL, Gordon C, Lovato N, Bei B, Bartlett DJ, Kennaway DJ, Lack LC, Grunstein RR, Lockley SW, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group.

Sleep Med. 2019 Jun;58:93-101. doi: 10.1016/j.sleep.2019.03.009. Epub 2019 Mar 23.


Associations between sleep disturbances, mental health outcomes and burnout in firefighters, and the mediating role of sleep during overnight work: A cross-sectional study.

Wolkow AP, Barger LK, O'Brien CS, Sullivan JP, Qadri S, Lockley SW, Czeisler CA, Rajaratnam SMW.

J Sleep Res. 2019 Dec;28(6):e12869. doi: 10.1111/jsr.12869. Epub 2019 May 26.


Effects on resident work hours, sleep duration, and work experience in a randomized order safety trial evaluating resident-physician schedules (ROSTERS).

Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA; ROSTERS Study Group.

Sleep. 2019 Aug 1;42(8). pii: zsz110. doi: 10.1093/sleep/zsz110.


Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.

Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R.

Sci Rep. 2019 Mar 29;9(1):5350. doi: 10.1038/s41598-019-41712-1.


Design and recruitment of the randomized order safety trial evaluating resident-physician schedules (ROSTERS) study.

Blackwell T, Kriesel DR, Vittinghoff E, O'Brien CS, Sullivan JP, Viyaran NC, Rahman SA, Lockley SW, Barger LK, Halbower AC, Poynter SE, Wright KP Jr, Yu PL, Zee PC, Landrigan CP, Czeisler CA, Stone KL; ROSTERS Study Group.

Contemp Clin Trials. 2019 May;80:22-33. doi: 10.1016/j.cct.2019.03.005. Epub 2019 Mar 15.


Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors.

Mulhall MD, Sletten TL, Magee M, Stone JE, Ganesan S, Collins A, Anderson C, Lockley SW, Howard ME, Rajaratnam SMW.

Sleep. 2019 Jun 11;42(6). pii: zsz074. doi: 10.1093/sleep/zsz074.


The Impact of Shift Work on Sleep, Alertness and Performance in Healthcare Workers.

Ganesan S, Magee M, Stone JE, Mulhall MD, Collins A, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL.

Sci Rep. 2019 Mar 15;9(1):4635. doi: 10.1038/s41598-019-40914-x.


Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.

Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C.

Sci Rep. 2019 Mar 14;9(1):4428. doi: 10.1038/s41598-019-40353-8.


Brief (<4 hr) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts.

St Hilaire MA, Anderson C, Anwar J, Sullivan JP, Cade BE, Flynn-Evans EE, Czeisler CA, Lockley SW; Harvard Work Hours Health and Safety Group.

Sleep. 2019 May 1;42(5). pii: zsz041. doi: 10.1093/sleep/zsz041.


Light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-image-forming photoreception.

Vandewalle G, van Ackeren MJ, Daneault V, Hull JT, Albouy G, Lepore F, Doyon J, Czeisler CA, Dumont M, Carrier J, Lockley SW, Collignon O.

Sci Rep. 2018 Nov 16;8(1):16968. doi: 10.1038/s41598-018-35400-9.


Randomized trial of polychromatic blue-enriched light for circadian phase shifting, melatonin suppression, and alerting responses.

Hanifin JP, Lockley SW, Cecil K, West K, Jablonski M, Warfield B, James M, Ayers M, Byrne B, Gerner E, Pineda C, Rollag M, Brainard GC.

Physiol Behav. 2019 Jan 1;198:57-66. doi: 10.1016/j.physbeh.2018.10.004. Epub 2018 Oct 5.


Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder.

Watson LA, Phillips AJK, Hosken IT, McGlashan EM, Anderson C, Lack LC, Lockley SW, Rajaratnam SMW, Cain SW.

J Physiol. 2018 Dec;596(24):6249-6261. doi: 10.1113/JP275917. Epub 2018 Oct 25.


Cross-sectional analysis of sleep-promoting and wake-promoting drug use on health, fatigue-related error, and near-crashes in police officers.

Ogeil RP, Barger LK, Lockley SW, O'Brien CS, Sullivan JP, Qadri S, Lubman DI, Czeisler CA, Rajaratnam SMW.

BMJ Open. 2018 Sep 19;8(9):e022041. doi: 10.1136/bmjopen-2018-022041.


The wake maintenance zone shows task dependent changes in cognitive function following one night without sleep.

McMahon WR, Ftouni S, Drummond SPA, Maruff P, Lockley SW, Rajaratnam SMW, Anderson C.

Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy148.


Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.

Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group.

PLoS Med. 2018 Jun 18;15(6):e1002587. doi: 10.1371/journal.pmed.1002587. eCollection 2018 Jun.


Increased vulnerability to attentional failure during acute sleep deprivation in women depends on menstrual phase.

Vidafar P, Gooley JJ, Burns AC, Rajaratnam SMW, Rueger M, Van Reen E, Czeisler CA, Lockley SW, Cain SW.

Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy098.


Functional decoupling of melatonin suppression and circadian phase resetting in humans.

Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW.

J Physiol. 2018 Jun;596(11):2147-2157. doi: 10.1113/JP275501. Epub 2018 Apr 29.


Prediction of Cognitive Performance and Subjective Sleepiness Using a Model of Arousal Dynamics.

Postnova S, Lockley SW, Robinson PA.

J Biol Rhythms. 2018 Apr;33(2):203-218. doi: 10.1177/0748730418758454.


Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light: Clinical Characteristics.

Hull JT, Czeisler CA, Lockley SW.

Ophthalmology. 2018 Aug;125(8):1160-1171. doi: 10.1016/j.ophtha.2018.01.036. Epub 2018 Apr 4.


Temporal dynamics of circadian phase shifting response to consecutive night shifts in healthcare workers: role of light-dark exposure.

Stone JE, Sletten TL, Magee M, Ganesan S, Mulhall MD, Collins A, Howard M, Lockley SW, Rajaratnam SMW.

J Physiol. 2018 Jun;596(12):2381-2395. doi: 10.1113/JP275589. Epub 2018 Apr 6.


A unified model of melatonin, 6-sulfatoxymelatonin, and sleep dynamics.

Abeysuriya RG, Lockley SW, Robinson PA, Postnova S.

J Pineal Res. 2018 May;64(4):e12474. doi: 10.1111/jpi.12474. Epub 2018 Mar 8.


Relationship between melatonin and bone resorption rhythms in premenopausal women.

St Hilaire MA, Rahman SA, Gooley JJ, Witt-Enderby PA, Lockley SW.

J Bone Miner Metab. 2019 Jan;37(1):60-71. doi: 10.1007/s00774-017-0896-6. Epub 2018 Jan 9.


Self-reported Drowsiness and Safety Outcomes While Driving After an Extended Duration Work Shift in Trainee Physicians.

Anderson C, Ftouni S, Ronda JM, Rajaratnam SMW, Czeisler CA, Lockley SW.

Sleep. 2018 Feb 1;41(2). pii: zsx195. doi: 10.1093/sleep/zsx195.


Is 8:30 a.m. Still Too Early to Start School? A 10:00 a.m. School Start Time Improves Health and Performance of Students Aged 13-16.

Kelley P, Lockley SW, Kelley J, Evans MDR.

Front Hum Neurosci. 2017 Dec 8;11:588. doi: 10.3389/fnhum.2017.00588. eCollection 2017.


Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism.

Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, St Hilaire MA, Phillips AJK, Loddenkemper T, Kothare SV, McConnell K, Braga-Kenyon P, Ahearn W, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW.

Autism Res. 2018 Feb;11(2):391-403. doi: 10.1002/aur.1899. Epub 2017 Dec 1.


Law-based arguments and messages to advocate for later school start time policies in the United States.

Lee CJ, Nolan DM, Lockley SW, Pattison B.

Sleep Health. 2017 Dec;3(6):486-497. doi: 10.1016/j.sleh.2017.09.003. Epub 2017 Oct 17. Review.


Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism.

Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, Hilaire MAS, Phillips AJ, Loddenkemper T, Kothare SV, McConnell K, Ahearn W, Braga-Kenyon P, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW.

Sci Rep. 2017 Oct 27;7(1):14228. doi: 10.1038/s41598-017-14611-6.


Circadian Phase and Phase Angle Disorders in Primary Insomnia.

Flynn-Evans EE, Shekleton JA, Miller B, Epstein LJ, Kirsch D, Brogna LA, Burke LM, Bremer E, Murray JM, Gehrman P, Rajaratnam SMW, Lockley SW.

Sleep. 2017 Dec 1;40(12). doi: 10.1093/sleep/zsx163.


Randomised controlled trial of the efficacy of a blue-enriched light intervention to improve alertness and performance in night shift workers.

Sletten TL, Ftouni S, Nicholas CL, Magee M, Grunstein RR, Ferguson S, Kennaway DJ, O'Brien D, Lockley SW, Rajaratnam SMW.

Occup Environ Med. 2017 Nov;74(11):792-801. doi: 10.1136/oemed-2016-103818. Epub 2017 Jun 19.


Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing.

Phillips AJK, Clerx WM, O'Brien CS, Sano A, Barger LK, Picard RW, Lockley SW, Klerman EB, Czeisler CA.

Sci Rep. 2017 Jun 12;7(1):3216. doi: 10.1038/s41598-017-03171-4.


The effects of spectral tuning of evening ambient light on melatonin suppression, alertness and sleep.

Rahman SA, St Hilaire MA, Lockley SW.

Physiol Behav. 2017 Aug 1;177:221-229. doi: 10.1016/j.physbeh.2017.05.002. Epub 2017 May 1.


Circadian phase resetting by a single short-duration light exposure.

Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB.

JCI Insight. 2017 Apr 6;2(7):e89494. doi: 10.1172/jci.insight.89494.


Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder.

Murray JM, Sletten TL, Magee M, Gordon C, Lovato N, Bartlett DJ, Kennaway DJ, Lack LC, Grunstein RR, Lockley SW, Rajaratnam SM; Delayed Sleep on Melatonin (DelSoM) Study Group.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw002.


Modeling Neurocognitive Decline and Recovery During Repeated Cycles of Extended Sleep and Chronic Sleep Deficiency.

St Hilaire MA, RĂ¼ger M, Fratelli F, Hull JT, Phillips AJ, Lockley SW.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw009.


Randomized, Prospective Study of the Impact of a Sleep Health Program on Firefighter Injury and Disability.

Sullivan JP, O'Brien CS, Barger LK, Rajaratnam SM, Czeisler CA, Lockley SW; Harvard Work Hours, Health and Safety Group.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw001.


Corrigendum: Ocular exposure to blue-enriched light has an asymmetric influence on neural activity and spatial attention.

Newman DP, Lockley SW, Loughnane GM, Martins AC, Abe R, Zoratti MT, Kelly SP, O'Neill MH, Rajaratnam SM, O'Connell RG, Bellgrove MA.

Sci Rep. 2017 Mar 23;7:44958. doi: 10.1038/srep44958. No abstract available.

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