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Items: 27


Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area.

Lockie SH, Stark R, Spanswick DC, Andrews ZB.

J Neuroendocrinol. 2019 Jul;31(7):e12696. doi: 10.1111/jne.12696. Epub 2019 Mar 6.


Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons.

Lockie SH, Stark R, Mequinion M, Ch'ng S, Kong D, Spanswick DC, Lawrence AJ, Andrews ZB.

Endocrinology. 2018 Nov 1;159(11):3605-3614. doi: 10.1210/en.2018-00536.


Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction.

Reichenbach A, Stark R, Mequinion M, Lockie SH, Lemus MB, Mynatt RL, Luquet S, Andrews ZB.

FASEB J. 2018 Jun 22:fj201800634R. doi: 10.1096/fj.201800634R. [Epub ahead of print]


Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice.

Reichenbach A, Mequinion M, Bayliss JA, Lockie SH, Lemus MB, Mynatt RL, Stark R, Andrews ZB.

Endocrinology. 2018 Jun 1;159(6):2473-2483. doi: 10.1210/en.2018-00131.


AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

Reichenbach A, Stark R, Mequinion M, Denis RRG, Goularte JF, Clarke RE, Lockie SH, Lemus MB, Kowalski GM, Bruce CR, Huang C, Schittenhelm RB, Mynatt RL, Oldfield BJ, Watt MJ, Luquet S, Andrews ZB.

Cell Rep. 2018 Feb 13;22(7):1745-1759. doi: 10.1016/j.celrep.2018.01.067.


Food Seeking in a Risky Environment: A Method for Evaluating Risk and Reward Value in Food Seeking and Consumption in Mice.

Lockie SH, McAuley CV, Rawlinson S, Guiney N, Andrews ZB.

Front Neurosci. 2017 Jan 30;11:24. doi: 10.3389/fnins.2017.00024. eCollection 2017.


Des-Acyl Ghrelin and Ghrelin O-Acyltransferase Regulate Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Response to Acute Stress.

Stark R, Santos VV, Geenen B, Cabral A, Dinan T, Bayliss JA, Lockie SH, Reichenbach A, Lemus MB, Perello M, Spencer SJ, Kozicz T, Andrews ZB.

Endocrinology. 2016 Oct;157(10):3946-3957. Epub 2016 Aug 4.


Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice.

Lockie SH, Stefanidis A, Tschöp MH, Oldfield BJ.

Mol Cell Endocrinol. 2015 Dec 5;417:10-9. doi: 10.1016/j.mce.2015.09.003. Epub 2015 Sep 7.


Diet-induced obesity causes ghrelin resistance in reward processing tasks.

Lockie SH, Dinan T, Lawrence AJ, Spencer SJ, Andrews ZB.

Psychoneuroendocrinology. 2015 Dec;62:114-20. doi: 10.1016/j.psyneuen.2015.08.004. Epub 2015 Aug 11.


A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice.

Lemus MB, Bayliss JA, Lockie SH, Santos VV, Reichenbach A, Stark R, Andrews ZB.

Endocrinology. 2015 May;156(5):1701-13. doi: 10.1210/en.2014-1961. Epub 2015 Mar 5.


Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice.

Stark R, Reichenbach A, Lockie SH, Pracht C, Wu Q, Tups A, Andrews ZB.

Endocrinology. 2015 Mar;156(3):858-68. doi: 10.1210/en.2014-1733. Epub 2014 Dec 23.


Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.

Briggs DI, Lockie SH, Benzler J, Wu Q, Stark R, Reichenbach A, Hoy AJ, Lemus MB, Coleman HA, Parkington HC, Tups A, Andrews ZB.

Endocrinology. 2014 Jul;155(7):2411-22. doi: 10.1210/en.2013-1861. Epub 2014 Apr 17.


The temporal pattern of cfos activation in hypothalamic, cortical, and brainstem nuclei in response to fasting and refeeding in male mice.

Wu Q, Lemus MB, Stark R, Bayliss JA, Reichenbach A, Lockie SH, Andrews ZB.

Endocrinology. 2014 Mar;155(3):840-53. doi: 10.1210/en.2013-1831. Epub 2014 Jan 9.


The hormonal signature of energy deficit: Increasing the value of food reward.

Lockie SH, Andrews ZB.

Mol Metab. 2013 Aug 19;2(4):329-36. doi: 10.1016/j.molmet.2013.08.003. Review.


Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.


Brown adipose tissue thermogenesis in the resistance to and reversal of obesity: A potential new mechanism contributing to the metabolic benefits of proglucagon-derived peptides.

Lockie SH, Stefanidis A, Oldfield BJ, Perez-Tilve D.

Adipocyte. 2013 Oct 1;2(4):196-200. doi: 10.4161/adip.25417. Epub 2013 Jun 17. Review.


Glucagon-like peptide-1 receptor in the brain: role in neuroendocrine control of energy metabolism and treatment target for obesity.

Lockie SH.

J Neuroendocrinol. 2013 Jul;25(7):597-604. doi: 10.1111/jne.12039. Review.


Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner.

Briggs DI, Lockie SH, Wu Q, Lemus MB, Stark R, Andrews ZB.

Endocrinology. 2013 Feb;154(2):709-17. doi: 10.1210/en.2012-1421. Epub 2013 Jan 10.


Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.

Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D.

Diabetes. 2012 Nov;61(11):2753-62. doi: 10.2337/db11-1556. Epub 2012 Aug 28.


Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice.

Tsoli M, Moore M, Burg D, Painter A, Taylor R, Lockie SH, Turner N, Warren A, Cooney G, Oldfield B, Clarke S, Robertson G.

Cancer Res. 2012 Sep 1;72(17):4372-82. doi: 10.1158/0008-5472.CAN-11-3536. Epub 2012 Jun 19.


Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice.

Verty AN, Lockie SH, Stefanidis A, Oldfield BJ.

Int J Obes (Lond). 2013 Feb;37(2):279-87. doi: 10.1038/ijo.2012.35. Epub 2012 Apr 3.


Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model.

Kampe J, Stefanidis A, Lockie SH, Brown WA, Dixon JB, Odoi A, Spencer SJ, Raven J, Oldfield BJ.

Int J Obes (Lond). 2012 Nov;36(11):1403-11. doi: 10.1038/ijo.2012.25. Epub 2012 Mar 27.


CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice.

Lockie SH, Czyzyk TA, Chaudhary N, Perez-Tilve D, Woods SC, Oldfield BJ, Statnick MA, Tschöp MH.

Endocrinology. 2011 Oct;152(10):3661-7. doi: 10.1210/en.2011-1220. Epub 2011 Aug 2.


Ghrelin-induced adiposity is independent of orexigenic effects.

Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschöp M, Pfluger P.

FASEB J. 2011 Aug;25(8):2814-22. doi: 10.1096/fj.11-183632. Epub 2011 May 4.


A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13.


The endocannabinoid system: role in glucose and energy metabolism.

Nogueiras R, Diaz-Arteaga A, Lockie SH, Velásquez DA, Tschop J, López M, Cadwell CC, Diéguez C, Tschöp MH.

Pharmacol Res. 2009 Aug;60(2):93-8. doi: 10.1016/j.phrs.2009.04.004. Epub 2009 Apr 14. Review.


Coupled with uncouplers: the curious case of lifespan.

Lockie SH, Müller TD, Tschöp MH.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E619-20. doi: 10.1152/ajpendo.00060.2009. Epub 2009 Feb 10. No abstract available.

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