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Items: 10


Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae.

Locke MN, Thorner J.

Cell Cycle. 2019 May;18(10):1084-1094. doi: 10.1080/15384101.2019.1616999. Epub 2019 May 15.


Rab5 GTPases are required for optimal TORC2 function.

Locke MN, Thorner J.

J Cell Biol. 2019 Mar 4;218(3):961-976. doi: 10.1083/jcb.201807154. Epub 2018 Dec 21.


The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Martinez Marshall MN, Locke MN, Thorner J.

Biomolecules. 2017 Sep 5;7(3). pii: E66. doi: 10.3390/biom7030066. Review.


A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites.

Reed BJ, Locke MN, Gardner RG.

J Biol Chem. 2015 Aug 14;290(33):20601-12. doi: 10.1074/jbc.M115.650952. Epub 2015 Jul 6.


DNA damage: walking the edge.

Locke MN, Rape M.

Nat Chem Biol. 2014 Apr;10(4):243-4. doi: 10.1038/nchembio.1483. No abstract available.


A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability.

Richardson LA, Reed BJ, Charette JM, Freed EF, Fredrickson EK, Locke MN, Baserga SJ, Gardner RG.

Cell Rep. 2012 Aug 30;2(2):372-85. doi: 10.1016/j.celrep.2012.07.009. Epub 2012 Aug 16.


Comparing enhancer action in cis and in trans.

Bateman JR, Johnson JE, Locke MN.

Genetics. 2012 Aug;191(4):1143-55. doi: 10.1534/genetics.112.140954. Epub 2012 May 29.


Exposed hydrophobicity is a key determinant of nuclear quality control degradation.

Fredrickson EK, Rosenbaum JC, Locke MN, Milac TI, Gardner RG.

Mol Biol Cell. 2011 Jul 1;22(13):2384-95. doi: 10.1091/mbc.E11-03-0256. Epub 2011 May 5.


A yeast model for polyalanine-expansion aggregation and toxicity.

Konopka CA, Locke MN, Gallagher PS, Pham N, Hart MP, Walker CJ, Gitler AD, Gardner RG.

Mol Biol Cell. 2011 Jun 15;22(12):1971-84. doi: 10.1091/mbc.E11-01-0037. Epub 2011 Apr 20.


Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.

Rosenbaum JC, Fredrickson EK, Oeser ML, Garrett-Engele CM, Locke MN, Richardson LA, Nelson ZW, Hetrick ED, Milac TI, Gottschling DE, Gardner RG.

Mol Cell. 2011 Jan 7;41(1):93-106. doi: 10.1016/j.molcel.2010.12.004.

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