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Items: 1 to 50 of 274

1.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

Duclos F, Abell LM, Harden DG, Pike K, Nowak K, Locke GA, Duke GJ, Liu X, Fernando G, Shaw SA, Vokits BP, Wurtz NR, Viet A, Valente MN, Stachura S, Sleph P, Khan JA, Gao J, Dongre AR, Zhao L, Wexler RR, Gordon DA, Kick EK.

Medchemcomm. 2017 Oct 26;8(11):2093-2099. doi: 10.1039/c7md00268h. eCollection 2017 Nov 1.

PMID:
30108726
2.

Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome.

Almazar AE, Chang JY, Larson JJ, Atkinson EJ, Locke GR, Talley NJ, Saito YA.

J Clin Gastroenterol. 2018 Jun 16. doi: 10.1097/MCG.0000000000001065. [Epub ahead of print]

PMID:
29912753
3.

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.

Lan Y, Zhang D, Xu C, Hance KW, Marelli B, Qi J, Yu H, Qin G, Sircar A, Hernández VM, Jenkins MH, Fontana RE, Deshpande A, Locke G, Sabzevari H, Radvanyi L, Lo KM.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaan5488. doi: 10.1126/scitranslmed.aan5488.

PMID:
29343622
4.

Cubane Cross-Coupling and Cubane-Porphyrin Arrays.

Bernhard SSR, Locke GM, Plunkett S, Meindl A, Flanagan KJ, Senge MO.

Chemistry. 2018 Jan 24;24(5):1026-1030. doi: 10.1002/chem.201704344. Epub 2017 Nov 14.

PMID:
29048763
5.

High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus.

Mathur G, Yadav K, Ford B, Schafer IJ, Basavaraju SV, Knust B, Shieh WJ, Hill S, Locke GD, Quinlisk P, Brown S, Gibbons A, Cannon D, Kuehnert M, Nichol ST, Rollin PE, Ströher U, Miller R.

Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12707. Epub 2017 May 24.

PMID:
28423464
6.

Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.

Saito YA, Locke GR, Almazar AE, Bouras EP, Howden CW, Lacy BE, DiBaise JK, Prather CM, Abraham BP, El-Serag HB, Moayyedi P, Herrick LM, Szarka LA, Camilleri M, Hamilton FA, Schleck CD, Tilkes KE, Zinsmeister AR, Talley NJ.

Am J Gastroenterol. 2017 Jun;112(6):903-909. doi: 10.1038/ajg.2017.52. Epub 2017 Mar 14.

PMID:
28291238
7.

Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6.

Johnson BG, Ren S, Karaca G, Gomez IG, Fligny C, Smith B, Ergun A, Locke G, Gao B, Hayes S, MacDonnell S, Duffield JS.

J Am Soc Nephrol. 2017 Jun;28(6):1769-1782. doi: 10.1681/ASN.2016080826. Epub 2017 Jan 27.

8.

The incidence rate and characteristics of clinically diagnosed defecatory disorders in the community.

Noelting J, Eaton JE, Choung RS, Zinsmeister AR, Locke GR 3rd, Bharucha AE.

Neurogastroenterol Motil. 2016 Nov;28(11):1690-1697. doi: 10.1111/nmo.12868. Epub 2016 Jun 2.

9.

Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk.

Raslau D, Herrick LM, Locke GR, Schleck CD, Zinsmeister AR, Almazar A, Talley NJ, Saito YA.

Neurogastroenterol Motil. 2016 Oct;28(10):1518-24. doi: 10.1111/nmo.12849. Epub 2016 May 18.

PMID:
27193962
10.

Outcomes of Ultrasound-Guided Trigger Point Injection for Abdominal Wall Pain.

Alnahhas MF, Oxentenko SC, Locke GR 3rd, Hansel S, Schleck CD, Zinsmeister AR, Farrugia G, Grover M.

Dig Dis Sci. 2016 Feb;61(2):572-7. doi: 10.1007/s10620-015-3857-8. Epub 2015 Aug 30.

PMID:
26320087
11.

Non-enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders.

Paula H, Grover M, Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2015 Nov;27(11):1580-6. doi: 10.1111/nmo.12655. Epub 2015 Aug 24.

12.

Retained Capsule Endoscopy in a Large Tertiary Care Academic Practice and Radiologic Predictors of Retention.

Al-Bawardy B, Locke G, Huprich JE, Fletcher JG, Fidler JL, Barlow JM, Becker B, Rajan E, Loftus EV Jr, Bruining DH, Hansel SL.

Inflamm Bowel Dis. 2015 Sep;21(9):2158-64. doi: 10.1097/MIB.0000000000000482.

PMID:
26284295
13.

A Biophysical Approach to Predicting Protein-DNA Binding Energetics.

Locke G, Morozov AV.

Genetics. 2015 Aug;200(4):1349-61. doi: 10.1534/genetics.115.178384. Epub 2015 Jun 16.

14.

Evidence Against Routine Testing of Patients With Functional Gastrointestinal Disorders for Celiac Disease: A Population-based Study.

Choung RS, Rubio-Tapia A, Lahr BD, Kyle RA, Camilleri MJ, Locke GR 3rd, Talley NJ, Murray JA.

Clin Gastroenterol Hepatol. 2015 Nov;13(11):1937-43. doi: 10.1016/j.cgh.2015.05.014. Epub 2015 May 16.

15.

Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study.

Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, Lacy BE, DiBaise JK, Prather CM, Abraham BP, El-Serag HB, Moayyedi P, Herrick LM, Szarka LA, Camilleri M, Hamilton FA, Schleck CD, Tilkes KE, Zinsmeister AR.

Gastroenterology. 2015 Aug;149(2):340-9.e2. doi: 10.1053/j.gastro.2015.04.020. Epub 2015 Apr 25.

16.

Dyspepsia in the community: value of a community-based mailed survey to identify potential participants for a randomized clinical trial.

Herrick LM, Locke GR 3rd, Schleck CD, Zinsmeister AR, Treder V, Talley NJ.

Scand J Gastroenterol. 2015 Aug;50(8):959-64. doi: 10.3109/00365521.2014.980317. Epub 2015 Mar 11.

17.

Effects of Birth Cohorts on the Irritable Bowel Syndrome Support Early-Life Risk Factors.

Brummond NR, Locke GR 3rd, Choung RS, Chang JY, Schleck CD, Zinsmeister AR, Talley NJ.

Dig Dis Sci. 2015 Jul;60(7):2112-8. doi: 10.1007/s10620-015-3565-4. Epub 2015 Feb 14.

PMID:
25680871
18.

Letter: role of GNβ3 polymorphisms in oesophageal adenocarcinoma and gastroesophageal reflux disease.

Brummond NR, Saito YA, Locke GR 3rd, Larson JJ, Atkinson EJ, Romero Y, Talley NJ.

Aliment Pharmacol Ther. 2015 Mar;41(6):600-1. doi: 10.1111/apt.13094. No abstract available.

19.

Family history of mental illness or alcohol abuse and the irritable bowel syndrome.

Knight JR, Locke GR 3rd, Zinsmeister AR, Schleck CD, Talley NJ.

J Psychosom Res. 2015 Mar;78(3):237-41. doi: 10.1016/j.jpsychores.2014.11.021. Epub 2014 Dec 3.

20.

Lack of familial aggregation in chronic constipation excluding irritable bowel syndrome: a population-based study.

Chang JY, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.

Dig Dis Sci. 2015 May;60(5):1358-65. doi: 10.1007/s10620-014-3475-x. Epub 2014 Dec 23.

21.

Prevalence and risk factors for dysphagia: a USA community study.

Cho SY, Choung RS, Saito YA, Schleck CD, Zinsmeister AR, Locke GR 3rd, Talley NJ.

Neurogastroenterol Motil. 2015 Feb;27(2):212-9. doi: 10.1111/nmo.12467. Epub 2014 Nov 6.

22.

Overdiagnosis of gastro-esophageal reflux disease and underdiagnosis of functional dyspepsia in a USA community.

Pleyer C, Bittner H, Locke GR 3rd, Choung RS, Zinsmeister AR, Schleck CD, Herrick LM, Talley NJ.

Neurogastroenterol Motil. 2014 Aug;26(8):1163-71. doi: 10.1111/nmo.12377. Epub 2014 Jun 11.

PMID:
24916517
23.

Screening for Barrett's esophagus: results from a population-based survey.

Gupta M, Beebe TJ, Dunagan KT, Schleck CD, Zinsmeister AR, Talley NJ, Locke GR 3rd, Iyer PG.

Dig Dis Sci. 2014 Aug;59(8):1831-50. doi: 10.1007/s10620-014-3092-8. Epub 2014 Mar 21.

24.

Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome.

Beyder A, Mazzone A, Strege PR, Tester DJ, Saito YA, Bernard CE, Enders FT, Ek WE, Schmidt PT, Dlugosz A, Lindberg G, Karling P, Ohlsson B, Gazouli M, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Camilleri M, Locke GR, Talley NJ, D'Amato M, Ackerman MJ, Farrugia G.

Gastroenterology. 2014 Jun;146(7):1659-1668. doi: 10.1053/j.gastro.2014.02.054. Epub 2014 Mar 5.

25.

Interpersonal guilt and substance use in college students.

Locke GW, Shilkret R, Everett JE, Petry NM.

Subst Abus. 2015;36(1):113-8. doi: 10.1080/08897077.2014.885482. Epub 2015 Jan 22.

26.

The effects of ageing on the onset and disappearance of unexplained abdominal pain: a population-based study.

Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.

Aliment Pharmacol Ther. 2014 Jan;39(2):217-25. doi: 10.1111/apt.12557. Epub 2013 Dec 4.

27.

Endotherapy for and tailored approaches to treating GERD, and refractory GERD.

Locke GR 3rd, Horwhat J, Mashimo H, Savarino E, Zentilin P, Savarino V, Zerbib F, Armbruster SP, Wong RK, Moawad F.

Ann N Y Acad Sci. 2013 Oct;1300:166-186. doi: 10.1111/nyas.12240. Review.

PMID:
24117641
28.

Novel partial 5HT3 agonist pumosetrag reduces acid reflux events in uninvestigated GERD patients after a standard refluxogenic meal: a randomized, double-blind, placebo-controlled pharmacodynamic study.

Choung RS, Locke GR 3rd, Francis DD, Katzka D, Winkle PJ, Orr WC, Crowell MD, Devault K, Harmsen WS, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2014 Jan;26(1):13-20. doi: 10.1111/nmo.12214. Epub 2013 Sep 3.

PMID:
24001105
29.

Measurement of muon neutrino quasielastic scattering on a hydrocarbon target at Eν ~ 3.5 GeV.

Fiorentini GA, Schmitz DW, Rodrigues PA, Aliaga L, Altinok O, Baldin B, Baumbaugh A, Bodek A, Boehnlein D, Boyd S, Bradford R, Brooks WK, Budd H, Butkevich A, Martinez Caicedo DA, Castromonte CM, Christy ME, Chung H, Chvojka J, Clark M, da Motta H, Damiani DS, Danko I, Datta M, Day M, DeMaat R, Devan J, Draeger E, Dytman SA, Díaz GA, Eberly B, Edmondson DA, Felix J, Fields L, Fitzpatrick T, Gago AM, Gallagher H, George CA, Gielata JA, Gingu C, Gobbi B, Gran R, Grossman N, Hanson J, Harris DA, Heaton J, Higuera A, Howley IJ, Hurtado K, Jerkins M, Kafka T, Kaisen J, Kanter MO, Keppel CE, Kilmer J, Kordosky M, Krajeski AH, Kulagin SA, Le T, Lee H, Leister AG, Locke G, Maggi G, Maher E, Manly S, Mann WA, Marshall CM, McFarland KS, McGivern CL, McGowan AM, Mislivec A, Morfín JG, Mousseau J, Naples D, Nelson JK, Niculescu G, Niculescu I, Ochoa N, O'Connor CD, Olsen J, Osmanov B, Osta J, Palomino JL, Paolone V, Park J, Patrick CE, Perdue GN, Peña C, Rakotondravohitra L, Ransome RD, Ray H, Ren L, Rude C, Sassin KE, Schellman H, Schneider RM, Schulte EC, Simon C, Snider FD, Snyder MC, Sobczyk JT, Solano Salinas CJ, Tagg N, Tan W, Tice BG, Tzanakos G, Velásquez JP, Walding J, Walton T, Wolcott J, Wolthuis BA, Woodward N, Zavala G, Zeng HB, Zhang D, Zhu LY, Ziemer BP; MINERvA Collaboration.

Phys Rev Lett. 2013 Jul 12;111(2):022502. Epub 2013 Jul 11.

PMID:
23889389
30.

Measurement of muon antineutrino quasielastic scattering on a hydrocarbon target at Eν ~ 3.5 GeV.

Fields L, Chvojka J, Aliaga L, Altinok O, Baldin B, Baumbaugh A, Bodek A, Boehnlein D, Boyd S, Bradford R, Brooks WK, Budd H, Butkevich A, Martinez Caicedo DA, Castromonte CM, Christy ME, Chung H, Clark M, da Motta H, Damiani DS, Danko I, Datta M, Day M, DeMaat R, Devan J, Draeger E, Dytman SA, Díaz GA, Eberly B, Edmondson DA, Felix J, Fitzpatrick T, Fiorentini GA, Gago AM, Gallagher H, George CA, Gielata JA, Gingu C, Gobbi B, Gran R, Grossman N, Hanson J, Harris DA, Heaton J, Higuera A, Howley IJ, Hurtado K, Jerkins M, Kafka T, Kaisen J, Kanter MO, Keppel CE, Kilmer J, Kordosky M, Krajeski AH, Kulagin SA, Le T, Lee H, Leister AG, Locke G, Maggi G, Maher E, Manly S, Mann WA, Marshall CM, McFarland KS, McGivern CL, McGowan AM, Mislivec A, Morfín JG, Mousseau J, Naples D, Nelson JK, Niculescu G, Niculescu I, Ochoa N, O'Connor CD, Olsen J, Osmanov B, Osta J, Palomino JL, Paolone V, Park J, Patrick CE, Perdue GN, Peña C, Rakotondravohitra L, Ransome RD, Ray H, Ren L, Rodrigues PA, Rude C, Sassin KE, Schellman H, Schmitz DW, Schneider RM, Schulte EC, Simon C, Snider FD, Snyder MC, Sobczyk JT, Solano Salinas CJ, Tagg N, Tan W, Tice BG, Tzanakos G, Velásquez JP, Walding J, Walton T, Wolcott J, Wolthuis BA, Woodward N, Zavala G, Zeng HB, Zhang D, Zhu LY, Ziemer BP; MINERvA Collaboration.

Phys Rev Lett. 2013 Jul 12;111(2):022501. Epub 2013 Jul 11.

PMID:
23889388
31.

Reply: To PMID 23261065.

Bharucha AE, Locke GR, Pemberton JH.

Gastroenterology. 2013 Aug;145(2):488. doi: 10.1053/j.gastro.2013.06.035. Epub 2013 Jun 26. No abstract available.

PMID:
23810349
32.

Global remodeling of nucleosome positions in C. elegans.

Locke G, Haberman D, Johnson SM, Morozov AV.

BMC Genomics. 2013 Apr 26;14:284. doi: 10.1186/1471-2164-14-284.

33.

Metabolic syndrome as a risk factor for Barrett esophagus: a population-based case-control study.

Leggett CL, Nelsen EM, Tian J, Schleck CB, Zinsmeister AR, Dunagan KT, Locke GR 3rd, Wang KK, Talley NJ, Iyer PG.

Mayo Clin Proc. 2013 Feb;88(2):157-65. doi: 10.1016/j.mayocp.2012.09.017.

34.

Associations between medication use and functional gastrointestinal disorders: a population-based study.

Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2013 May;25(5):413-9, e298. doi: 10.1111/nmo.12082. Epub 2013 Jan 29.

35.

American Gastroenterological Association technical review on constipation.

Bharucha AE, Pemberton JH, Locke GR 3rd.

Gastroenterology. 2013 Jan;144(1):218-38. doi: 10.1053/j.gastro.2012.10.028. Review. No abstract available.

36.

Interpersonal guilt in college student pathological gamblers.

Locke GW, Shilkret R, Everett JE, Petry NM.

Am J Drug Alcohol Abuse. 2013 Jan;39(1):28-32. doi: 10.3109/00952990.2012.694520. Epub 2012 Jul 2.

37.

Review article: current treatment options and management of functional dyspepsia.

Lacy BE, Talley NJ, Locke GR 3rd, Bouras EP, DiBaise JK, El-Serag HB, Abraham BP, Howden CW, Moayyedi P, Prather C.

Aliment Pharmacol Ther. 2012 Jul;36(1):3-15. doi: 10.1111/j.1365-2036.2012.05128.x. Epub 2012 May 16. Review.

38.

Challenges and lessons learned in conducting comparative-effectiveness trials.

Herrick LM, Locke GR 3rd, Zinsmeister AR, Talley NJ.

Am J Gastroenterol. 2012 May;107(5):644-9. doi: 10.1038/ajg.2011.475.

39.

Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.

Wang A, Dorso C, Kopcho L, Locke G, Langish R, Harstad E, Shipkova P, Marcinkeviciene J, Hamann L, Kirby MS.

BMC Pharmacol. 2012 Apr 4;12:2. doi: 10.1186/1471-2210-12-2.

40.

Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.

Talley NJ, Locke GR 3rd, Herrick LM, Silvernail VM, Prather CM, Lacy BE, DiBaise JK, Howden CW, Brenner DM, Bouras EP, El-Serag HB, Abraham BP, Moayyedi P, Zinsmeister AR.

Contemp Clin Trials. 2012 May;33(3):523-33. doi: 10.1016/j.cct.2012.02.002. Epub 2012 Feb 10.

41.

Prevalence of hidden gastroparesis in the community: the gastroparesis "iceberg".

Rey E, Choung RS, Schleck CD, Zinsmeister AR, Talley NJ, Locke GR 3rd.

J Neurogastroenterol Motil. 2012 Jan;18(1):34-42. doi: 10.5056/jnm.2012.18.1.34. Epub 2012 Jan 16.

42.

Factors associated with persistent and nonpersistent chronic constipation, over 20 years.

Choung RS, Locke GR 3rd, Rey E, Schleck CD, Baum C, Zinsmeister AR, Talley NJ.

Clin Gastroenterol Hepatol. 2012 May;10(5):494-500. doi: 10.1016/j.cgh.2011.12.041. Epub 2012 Jan 28.

43.

Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?

Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2012 Mar;24(3):229-34, e106. doi: 10.1111/j.1365-2982.2011.01845.x. Epub 2011 Dec 12.

44.

Population screening for barrett esophagus: a prospective randomized pilot study.

Chang JY, Talley NJ, Locke GR 3rd, Katzka DA, Schleck CD, Zinsmeister AR, Dunagan KT, Wu TT, Wang KK, Prasad GA.

Mayo Clin Proc. 2011 Dec;86(12):1174-80. doi: 10.4065/mcp.2011.0396.

45.

Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population.

Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ.

Am J Gastroenterol. 2012 Jan;107(1):82-8. doi: 10.1038/ajg.2011.310. Epub 2011 Nov 15.

46.

Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males.

Choung RS, Locke GR 3rd, Lee RM, Schleck CD, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2012 Jan;24(1):20-6, e1. doi: 10.1111/j.1365-2982.2011.01791.x. Epub 2011 Sep 27.

47.

Statistical mechanics of nucleosome ordering by chromatin-structure-induced two-body interactions.

Chereji RV, Tolkunov D, Locke G, Morozov AV.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 May;83(5 Pt 1):050903. Epub 2011 May 13.

48.

Epidemiology and natural history of intestinal metaplasia of the gastroesophageal junction and Barrett's esophagus: a population-based study.

Jung KW, Talley NJ, Romero Y, Katzka DA, Schleck CD, Zinsmeister AR, Dunagan KT, Lutzke LS, Wu TT, Wang KK, Frederickson M, Geno DM, Locke GR, Prasad GA.

Am J Gastroenterol. 2011 Aug;106(8):1447-55; quiz 1456. doi: 10.1038/ajg.2011.130. Epub 2011 Apr 12.

49.

Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture.

Choung RS, Ruff KC, Malhotra A, Herrick L, Locke GR 3rd, Harmsen WS, Zinsmeister AR, Talley NJ, Saito YA.

Aliment Pharmacol Ther. 2011 May;33(9):1059-67. doi: 10.1111/j.1365-2036.2011.04625.x. Epub 2011 Mar 13.

50.

Epidemiology of IBS.

Choung RS, Locke GR 3rd.

Gastroenterol Clin North Am. 2011 Mar;40(1):1-10. doi: 10.1016/j.gtc.2010.12.006. Review.

PMID:
21333897

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