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Items: 18


Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates.

Trebosc V, Gartenmann S, Tötzl M, Lucchini V, Schellhorn B, Pieren M, Lociuro S, Gitzinger M, Tigges M, Bumann D, Kemmer C.

mBio. 2019 Jul 16;10(4). pii: e01083-19. doi: 10.1128/mBio.01083-19.


A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism.

Trebosc V, Gartenmann S, Royet K, Manfredi P, Tötzl M, Schellhorn B, Pieren M, Tigges M, Lociuro S, Sennhenn PC, Gitzinger M, Bumann D, Kemmer C.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7263-7271. Print 2016 Dec.


Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.

Pavlović D, Mutak S, Andreotti D, Biondi S, Cardullo F, Paio A, Piga E, Donati D, Lociuro S.

ACS Med Chem Lett. 2014 Aug 15;5(10):1133-7. doi: 10.1021/ml500279k. eCollection 2014 Oct 9.


A microdose study of ¹⁴C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung.

Lappin G, Boyce MJ, Matzow T, Lociuro S, Seymour M, Warrington SJ.

Eur J Clin Pharmacol. 2013 Sep;69(9):1673-82. doi: 10.1007/s00228-013-1528-2. Epub 2013 Jun 6.


4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.

Fajdetić A, Cipcić Paljetak H, Lazarevski G, Hutinec A, Alihodzić S, Derek M, Stimac V, Andreotti D, Sunjić V, Berge JM, Mutak S, Dumić M, Lociuro S, Holmes DJ, Marsić N, Eraković Haber V, Spaventi R.

Bioorg Med Chem. 2010 Sep 1;18(17):6559-68. doi: 10.1016/j.bmc.2010.06.049. Epub 2010 Jun 22.


In vitro bactericidal activity of iclaprim in human plasma.

Laue H, Valensise T, Seguin A, Lociuro S, Islam K, Hawser S.

Antimicrob Agents Chemother. 2009 Oct;53(10):4542-4. doi: 10.1128/AAC.00766-09. Epub 2009 Aug 3.


Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.

Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. doi: 10.1107/S0907444909013936. Epub 2009 Jul 10.


Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.

Entenza JM, Haldimann A, Giddey M, Lociuro S, Hawser S, Moreillon P.

Antimicrob Agents Chemother. 2009 Sep;53(9):3635-41. doi: 10.1128/AAC.00325-09. Epub 2009 Jun 29.


Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.

Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE.

J Antimicrob Chemother. 2009 Apr;63(4):687-98. doi: 10.1093/jac/dkp024. Epub 2009 Feb 11.


Antistreptococcal activity of AR-709 compared to that of other agents.

Smith K, Ednie LM, Appelbaum PC, Hawser S, Lociuro S.

Antimicrob Agents Chemother. 2008 Jun;52(6):2279-82. doi: 10.1128/AAC.01620-07. Epub 2008 Mar 24.


In vitro activity of the novel diaminopyrimidine, iclaprim, in combination with folate inhibitors and other antimicrobials with different mechanisms of action.

Laue H, Weiss L, Bernardi A, Hawser S, Lociuro S, Islam K.

J Antimicrob Chemother. 2007 Dec;60(6):1391-4. Epub 2007 Oct 25.


Effect of human plasma on the antimicrobial activity of iclaprim in vitro.

Laue H, Valensise T, Seguin A, Hawser S, Lociuro S, Islam K.

J Antimicrob Chemother. 2007 Dec;60(6):1388-90. Epub 2007 Oct 19.


A novel ketolide class: Synthesis and antibacterial activity of a lead compound.

Andreotti D, Bientinesi I, Biondi S, Donati D, Erbetti I, Lociuro S, Marchioro C, Pozzan A, Ratti E, Terreni S.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5265-9. Epub 2007 Feb 9.


Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles.

DeMarco SJ, Henze H, Lederer A, Moehle K, Mukherjee R, Romagnoli B, Robinson JA, Brianza F, Gombert FO, Lociuro S, Ludin C, Vrijbloed JW, Zumbrunn J, Obrecht JP, Obrecht D, Brondani V, Hamy F, Klimkait T.

Bioorg Med Chem. 2006 Dec 15;14(24):8396-404. Epub 2006 Sep 28.


Dihydrofolate reductase inhibitors as antibacterial agents.

Hawser S, Lociuro S, Islam K.

Biochem Pharmacol. 2006 Mar 30;71(7):941-8. Epub 2005 Dec 13. Review.


Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A).

Lociuro S, Tavecchia P, Marzorati E, Landini P, Goldstein BP, Denaro M, Ciabatti R.

J Antibiot (Tokyo). 1997 Apr;50(4):344-9.


Antibiotics MDL 62,879 and kirromycin bind to distinct and independent sites of elongation factor Tu (EF-Tu).

Landini P, Soffientini A, Monti F, Lociuro S, Marzorati E, Islam K.

Biochemistry. 1996 Dec 3;35(48):15288-94.


Revised structure of the antibiotic GE 2270A.

Tavecchia P, Gentili P, Kurz M, Sottani C, Bonfichi R, Lociuro S, Selva E.

J Antibiot (Tokyo). 1994 Dec;47(12):1564-7. No abstract available.

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