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Coordinate regulation of virulence and metabolic genes by the transcription factor HbhR in Mycobacterium marinum.

Raze D, Segers J, Mille C, Slupek S, Lecher S, Coutte L, Antoine R, Ducrocq L, Rouanet C, Appelmelk BJ, Locht C.

Mol Microbiol. 2019 Oct 6. doi: 10.1111/mmi.14400. [Epub ahead of print]


In Vivo Methods to Study Protein-Protein Interactions as Key Players in Mycobacterium Tuberculosis Virulence.

Veyron-Churlet R, Locht C.

Pathogens. 2019 Oct 1;8(4). pii: E173. doi: 10.3390/pathogens8040173. Review.


Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born to mothers who received Tdap during pregnancy: a randomised trial.

Wanlapakorn N, Maertens K, Vongpunsawad S, Peunpa J, Tran TMP, Hens N, Van Damme P, Thiriard A, Raze D, Locht C, Poovorawan Y, Leuridan E.

Clin Infect Dis. 2019 Aug 16. pii: ciz778. doi: 10.1093/cid/ciz778. [Epub ahead of print]


Identification of Mycobacterium tuberculosis Infection in Infants and Children With Partial Discrimination Between Active Disease and Asymptomatic Infection.

Dreesman A, Dirix V, Smits K, Corbière V, Van Praet A, Debulpaep S, De Schutter I, Felderhof MK, Malfroot A, Singh M, Locht C, Mouchet F, Mascart F.

Front Pediatr. 2019 Jul 25;7:311. doi: 10.3389/fped.2019.00311. eCollection 2019.


Proportions of interferon-γ-producing ascites lymphocytes in response to mycobacterial antigens: A help for early diagnosis of peritoneal tuberculosis in a low TB incidence country.

Henrard S, Corbière V, Schandené L, Ducarme M, Van Praet A, Petit E, Singh M, Locht C, Dirix V, Mascart F.

PLoS One. 2019 Apr 4;14(4):e0214333. doi: 10.1371/journal.pone.0214333. eCollection 2019.


Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis.

Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P.

ACS Nano. 2019 Apr 23;13(4):3992-4007. doi: 10.1021/acsnano.8b07902. Epub 2019 Mar 8.


The Role of Mucosal Immunity in Pertussis.

Solans L, Locht C.

Front Immunol. 2019 Jan 14;9:3068. doi: 10.3389/fimmu.2018.03068. eCollection 2018. Review.


Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases.

Cauchi S, Locht C.

Front Immunol. 2018 Dec 7;9:2872. doi: 10.3389/fimmu.2018.02872. eCollection 2018. Review.


HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans.

Aerts L, Selis E, Corbière V, Smits K, Van Praet A, Dauby N, Petit E, Singh M, Locht C, Dirix V, Mascart F.

J Immunol. 2019 Jan 15;202(2):421-427. doi: 10.4049/jimmunol.1800840. Epub 2018 Dec 17.


Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.

Raze D, Verwaerde C, Deloison G, Werkmeister E, Coupin B, Loyens M, Brodin P, Rouanet C, Locht C.

Front Microbiol. 2018 Sep 24;9:2258. doi: 10.3389/fmicb.2018.02258. eCollection 2018.


Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS.

Lesne E, Coutte L, Solans L, Slupek S, Debrie AS, Dhennin V, Froguel P, Hot D, Locht C, Antoine R, Jacob-Dubuisson F.

PLoS One. 2018 Oct 11;13(10):e0204861. doi: 10.1371/journal.pone.0204861. eCollection 2018.


IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine.

Solans L, Debrie AS, Borkner L, Aguiló N, Thiriard A, Coutte L, Uranga S, Trottein F, Martín C, Mills KHG, Locht C.

Mucosal Immunol. 2018 Nov;11(6):1753-1762. doi: 10.1038/s41385-018-0073-9. Epub 2018 Aug 16.


In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission.

Naninck T, Coutte L, Mayet C, Contreras V, Locht C, Le Grand R, Chapon C.

Sci Rep. 2018 Aug 16;8(1):12297. doi: 10.1038/s41598-018-30896-7.


Tuberculin skin test reaction is related to memory, but not naive CD4+ T cell responses to mycobacterial stimuli in BCG-vaccinated young adults.

Kowalewicz-Kulbat M, Szpakowski P, Locht C, Biet F, Kaplonek P, Krawczyk KT, Pestel J, Rudnicka W.

Vaccine. 2018 Jul 16;36(30):4566-4577. doi: 10.1016/j.vaccine.2018.05.068. Epub 2018 Jun 19.


Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria.

Veyron-Churlet R, Dupres V, Saliou JM, Lafont F, Raze D, Locht C.

Int J Mol Sci. 2018 Jun 5;19(6). pii: E1673. doi: 10.3390/ijms19061673.


Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis.

Amman F, D'Halluin A, Antoine R, Huot L, Bibova I, Keidel K, Slupek S, Bouquet P, Coutte L, Caboche S, Locht C, Vecerek B, Hot D.

RNA Biol. 2018;15(7):967-975. doi: 10.1080/15476286.2018.1462655. Epub 2018 May 18.


Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor.

Hovingh ES, Mariman R, Solans L, Hijdra D, Hamstra HJ, Jongerius I, van Gent M, Mooi F, Locht C, Pinelli E.

Emerg Microbes Infect. 2018 Mar 21;7(1):39. doi: 10.1038/s41426-018-0039-8.


Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family.

Lesne E, Dupré E, Lensink MF, Locht C, Antoine R, Jacob-Dubuisson F.

MBio. 2018 Feb 27;9(1). pii: e02052-17. doi: 10.1128/mBio.02052-17.


Diversion of complement-mediated killing by Bordetella.

Thiriard A, Raze D, Locht C.

Microbes Infect. 2018 Oct - Nov;20(9-10):512-520. doi: 10.1016/j.micinf.2018.02.002. Epub 2018 Feb 14. Review.


Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3.

Debrie AS, Coutte L, Raze D, Mooi F, Alexander F, Gorringe A, Mielcarek N, Locht C.

Vaccine. 2018 Mar 7;36(11):1345-1352. doi: 10.1016/j.vaccine.2018.02.017. Epub 2018 Feb 9.


Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women.

Wanlapakorn N, Maertens K, Chaithongwongwatthana S, Srimuan D, Suratannon N, Vongpunsawad S, Tran TMP, Hens N, Van Damme P, Locht C, Poovorawan Y, Leuridan E.

Vaccine. 2018 Mar 7;36(11):1453-1459. doi: 10.1016/j.vaccine.2018.01.059.


Will we have new pertussis vaccines?

Locht C.

Vaccine. 2018 Aug 28;36(36):5460-5469. doi: 10.1016/j.vaccine.2017.11.055. Epub 2017 Nov 24.


Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis.

Dreesman A, Corbière V, Dirix V, Smits K, Debulpaep S, De Schutter I, Libin M, Singh M, Malfroot A, Locht C, Mascart F.

Front Immunol. 2017 Sep 5;8:1059. doi: 10.3389/fimmu.2017.01059. eCollection 2017.


Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection.

Locht C, Papin JF, Lecher S, Debrie AS, Thalen M, Solovay K, Rubin K, Mielcarek N.

J Infect Dis. 2017 Jul 1;216(1):117-124. doi: 10.1093/infdis/jix254.


BCG and protection against inflammatory and auto-immune diseases.

Kowalewicz-Kulbat M, Locht C.

Expert Rev Vaccines. 2017 Jul;16(7):1-10. doi: 10.1080/14760584.2017.1333906. Epub 2017 May 30. Review.


Conformational Changes of an Interdomain Linker Mediate Mechanical Signal Transmission in Sensor Kinase BvgS.

Lesne E, Dupré E, Locht C, Antoine R, Jacob-Dubuisson F.

J Bacteriol. 2017 Aug 22;199(18). pii: e00114-17. doi: 10.1128/JB.00114-17. Print 2017 Sep 15.


Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis.

Rivera-Millot A, Lesne E, Solans L, Coutte L, Bertrand-Michel J, Froguel P, Dhennin V, Hot D, Locht C, Antoine R, Jacob-Dubuisson F.

PLoS One. 2017 May 11;12(5):e0176396. doi: 10.1371/journal.pone.0176396. eCollection 2017.


Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development".

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00071-17. doi: 10.1128/CVI.00071-17. Print 2017 May. No abstract available.


Live pertussis vaccines: will they protect against carriage and spread of pertussis?

Locht C.

Clin Microbiol Infect. 2016 Dec 1;22 Suppl 5:S96-S102. doi: 10.1016/j.cmi.2016.05.029. Epub 2016 Oct 27. Review.


Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Déprez B, Willand N, Baulard AR.

Science. 2017 Mar 17;355(6330):1206-1211. doi: 10.1126/science.aag1006. Epub 2017 Mar 16.


Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis.

Zimmermann N, Thormann V, Hu B, Köhler AB, Imai-Matsushima A, Locht C, Arnett E, Schlesinger LS, Zoller T, Schürmann M, Kaufmann SH, Wardemann H.

EMBO Mol Med. 2016 Nov 2;8(11):1325-1339. doi: 10.15252/emmm.201606330. Print 2016 Nov.


Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development.

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2016 Nov 4;23(11):842-850. Print 2016 Nov. Erratum in: Clin Vaccine Immunol. 2017 May 5;24(5):.


The multifaceted RisA regulon of Bordetella pertussis.

Coutte L, Huot L, Antoine R, Slupek S, Merkel TJ, Chen Q, Stibitz S, Hot D, Locht C.

Sci Rep. 2016 Sep 13;6:32774. doi: 10.1038/srep32774.


[Tuberculosis, a story still relevant].

Locht C.

Med Sci (Paris). 2016 Jun-Jul;32(6-7):535-6. doi: 10.1051/medsci/20163206001. Epub 2016 Jul 12. French. No abstract available.


STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.

Queval CJ, Song OR, Deboosère N, Delorme V, Debrie AS, Iantomasi R, Veyron-Churlet R, Jouny S, Redhage K, Deloison G, Baulard A, Chamaillard M, Locht C, Brodin P.

Sci Rep. 2016 Jul 7;6:29297. doi: 10.1038/srep29297.


Added Value of Long-Term Cytokine Release Assays to Detect Mycobacterium tuberculosis Infection in HIV-Infected Subjects in Uganda.

Dirix V, Schepers K, Massinga-Loembe M, Worodria W, Colebunders R, Singh M, Locht C, Kestens L, Mascart F; TB-IRIS study group.

J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):344-52. doi: 10.1097/QAI.0000000000000980.


LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.

Deboosère N, Iantomasi R, Queval CJ, Song OR, Deloison G, Jouny S, Debrie AS, Chamaillard M, Nigou J, Cohen-Gonsaud M, Locht C, Brodin P, Veyron-Churlet R.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12619. Epub 2016 Jul 11.


Pertussis: Where did we go wrong and what can we do about it?

Locht C.

J Infect. 2016 Jul 5;72 Suppl:S34-40. doi: 10.1016/j.jinf.2016.04.020. Epub 2016 May 6.


Pertussis: acellular, whole-cell, new vaccines, what to choose?

Locht C.

Expert Rev Vaccines. 2016 Jun;15(6):671-3. doi: 10.1586/14760584.2016.1161511. Epub 2016 Mar 21. No abstract available.


Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella.

Lesne E, Krammer EM, Dupre E, Locht C, Lensink MF, Antoine R, Jacob-Dubuisson F.

MBio. 2016 Mar 1;7(2):e02089. doi: 10.1128/mBio.02089-15.


Reciprocal interference of maternal and infant immunization in protection against pertussis.

Feunou PF, Mielcarek N, Locht C.

Vaccine. 2016 Feb 17;34(8):1062-9. doi: 10.1016/j.vaccine.2016.01.011. Epub 2016 Jan 15.


In search of acceptable alternatives to the murine histamine sensitisation test (HIST): what is possible and practical?

Wagner L, Isbrucker R, Locht C, Arciniega J, Costanzo A, McFarland R, Oh H, Hoonakker M, Descamps J, Andersen SR, Gupta RK, Markey K, Chapsal JM, Lidster K, Casey W, Allen D.

Pharmeur Bio Sci Notes. 2016;2016:151-170.


Signal transduction by BvgS sensor kinase. Binding of modulator nicotinate affects the conformation and dynamics of the entire periplasmic moiety.

Dupré E, Lesne E, Guérin J, Lensink MF, Verger A, de Ruyck J, Brysbaert G, Vezin H, Locht C, Antoine R, Jacob-Dubuisson F.

J Biol Chem. 2015 Oct 30;290(44):26473. doi: 10.1074/jbc.A115.655720. No abstract available.


Integrating knowledge of Mycobacterium tuberculosis pathogenesis for the design of better vaccines.

Mascart F, Locht C.

Expert Rev Vaccines. 2015;14(12):1573-85. doi: 10.1586/14760584.2015.1102638. Epub 2015 Oct 30. Review.


Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults.

Szpakowski P, Biet F, Locht C, Paszkiewicz M, Rudnicka W, Druszczyńska M, Allain F, Fol M, Pestel J, Kowalewicz-Kulbat M.

J Immunol Res. 2015;2015:359153. doi: 10.1155/2015/359153. Epub 2015 Aug 3.



Dupré E, Lesne E, Guérin J, Lensink MF, Verger A, de Ruyck J, Brysbaert G, Vezin H, Locht C, Antoine R, Jacob-Dubuisson F.

J Biol Chem. 2015 Sep 18;290(38):23307-19. doi: 10.1074/jbc.M115.655720. Epub 2015 Jul 22. Erratum in: J Biol Chem. 2015 Oct 30;290(44):26473.


Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC.

Guérin J, Saint N, Baud C, Meli AC, Etienne E, Locht C, Vezin H, Jacob-Dubuisson F.

Mol Microbiol. 2015 Oct;98(3):490-501. doi: 10.1111/mmi.13137. Epub 2015 Aug 14.


Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine.

Fedele G, Sanseverino I, D'Agostino K, Schiavoni I, Locht C, Horenstein AL, Malavasi F, Ausiello CM.

J Leukoc Biol. 2015 Oct;98(4):631-9. doi: 10.1189/jlb.3A0315-101R. Epub 2015 Jun 18.


Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube.

Wyndham-Thomas C, Dirix V, Schepers K, Martin C, Hildebrand M, Goffard JC, Domont F, Libin M, Loyens M, Locht C, Van Vooren JP, Mascart F.

BMC Infect Dis. 2015 Feb 14;15:59. doi: 10.1186/s12879-015-0796-0.


Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS.

Dupré E, Herrou J, Lensink MF, Wintjens R, Vagin A, Lebedev A, Crosson S, Villeret V, Locht C, Antoine R, Jacob-Dubuisson F.

PLoS Pathog. 2015 Mar 4;11(3):e1004700. doi: 10.1371/journal.ppat.1004700. eCollection 2015 Mar.

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