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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C.

Eur J Med Chem. 2019 May 25;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. [Epub ahead of print]


Correction: Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women Without Celiac Disease: A Prospective Cohort Study.

Liu PH, Lebwohl B, Burke KE, Ivey KL, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H.

Am J Gastroenterol. 2019 May;114(5):837. doi: 10.14309/ajg.0000000000000211. No abstract available.


Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals Five Distinct Subtypes of Colorectal Adenocarcinomas.

Fennell L, Dumenil T, Wockner L, Hartel G, Nones K, Bond C, Borowsky J, Liu C, McKeone D, Bowdler L, Montgomery G, Klein K, Hoffmann I, Patch AM, Kazakoff S, Pearson J, Waddell N, Wirapati P, Lochhead P, Imamura Y, Ogino S, Shao R, Tejpar S, Leggett B, Whitehall V.

Cell Mol Gastroenterol Hepatol. 2019 Apr 5. pii: S2352-345X(19)30041-4. doi: 10.1016/j.jcmgh.2019.04.002. [Epub ahead of print]


Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis.

Liu PH, Burke KE, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H.

Clin Gastroenterol Hepatol. 2018 Dec 6. pii: S1542-3565(18)31334-X. doi: 10.1016/j.cgh.2018.11.057. [Epub ahead of print]


Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study.

Liu PH, Lebwohl B, Burke KE, Ivey KL, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H.

Am J Gastroenterol. 2019 Jan;114(1):127-134. doi: 10.1038/s41395-018-0267-5.


Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study.

Burke KE, Ananthakrishnan AN, Lochhead P, Liu PH, Olen O, Ludvigsson JF, Richter JM, Tworoger SS, Chan AT, Khalili H.

Gastroenterology. 2018 Dec;155(6):1764-1775.e2. doi: 10.1053/j.gastro.2018.08.029. Epub 2018 Aug 23.


The role of diet in the aetiopathogenesis of inflammatory bowel disease.

Khalili H, Chan SSM, Lochhead P, Ananthakrishnan AN, Hart AR, Chan AT.

Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):525-535. doi: 10.1038/s41575-018-0022-9. Review.


IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.

Simon TG, Van Der Sloot KWJ, Chin SB, Joshi AD, Lochhead P, Ananthakrishnan AN, Xavier R, Chung RT, Khalili H.

Inflamm Bowel Dis. 2018 Sep 15;24(10):2247-2257. doi: 10.1093/ibd/izy128.


Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation.

Moninuola OO, Milligan W, Lochhead P, Khalili H.

Aliment Pharmacol Ther. 2018 Jun;47(11):1428-1439. doi: 10.1111/apt.14606. Epub 2018 Apr 5. Review.


Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report.

Cushing KC, Mino-Kenudson M, Garber J, Lochhead P, Khalili H.

Am J Gastroenterol. 2018 Apr;113(4):632-633. doi: 10.1038/ajg.2018.7. No abstract available.


Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women.

Burke KE, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H.

J Crohns Colitis. 2018 Apr 27;12(5):559-567. doi: 10.1093/ecco-jcc/jjy005.


Stability of the human faecal microbiome in a cohort of adult men.

Mehta RS, Abu-Ali GS, Drew DA, Lloyd-Price J, Subramanian A, Lochhead P, Joshi AD, Ivey KL, Khalili H, Brown GT, DuLong C, Song M, Nguyen LH, Mallick H, Rimm EB, Izard J, Huttenhower C, Chan AT.

Nat Microbiol. 2018 Mar;3(3):347-355. doi: 10.1038/s41564-017-0096-0. Epub 2018 Jan 15.


Molecular Predictors of Gastric Neoplastic Progression.

Lochhead P, El-Omar EM.

Cancer Cell. 2018 Jan 8;33(1):9-11. doi: 10.1016/j.ccell.2017.12.006.


No Significant Association Between Proton Pump Inhibitor Use and Risk of Stroke After Adjustment for Lifestyle Factors and Indication.

Nguyen LH, Lochhead P, Joshi AD, Cao Y, Ma W, Khalili H, Rimm EB, Rexrode KM, Chan AT.

Gastroenterology. 2018 Apr;154(5):1290-1297.e1. doi: 10.1053/j.gastro.2017.12.006. Epub 2017 Dec 19.


Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study.

Ananthakrishnan AN, Khalili H, Song M, Higuchi LM, Lochhead P, Richter JM, Chan AT.

Inflamm Bowel Dis. 2017 Nov;23(11):1898-1904. doi: 10.1097/MIB.0000000000001236.


Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis.

Walsh E, Chah YW, Chin SM, Lochhead P, Yajnik V, Denmark V, Garber JJ, Khalili H.

Inflamm Bowel Dis. 2017 Nov;23(11):2035-2041. doi: 10.1097/MIB.0000000000001214.


Systematic review with meta-analysis: breastfeeding and the risk of Crohn's disease and ulcerative colitis.

Xu L, Lochhead P, Ko Y, Claggett B, Leong RW, Ananthakrishnan AN.

Aliment Pharmacol Ther. 2017 Nov;46(9):780-789. doi: 10.1111/apt.14291. Epub 2017 Sep 11. Review.


Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.

Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S.

Gastroenterology. 2017 Dec;153(6):1517-1530.e14. doi: 10.1053/j.gastro.2017.08.045. Epub 2017 Sep 1.


Association Between Proton Pump Inhibitor Use and Cognitive Function in Women.

Lochhead P, Hagan K, Joshi AD, Khalili H, Nguyen LH, Grodstein F, Chan AT.

Gastroenterology. 2017 Oct;153(4):971-979.e4. doi: 10.1053/j.gastro.2017.06.061. Epub 2017 Jul 18.


Dietary Iron and Heme Iron Consumption, Genetic Susceptibility, and Risk of Crohn's Disease and Ulcerative Colitis.

Khalili H, de Silva PS, Ananthakrishnan AN, Lochhead P, Joshi A, Garber JJ, Richter JR, Sauk J, Chan AT.

Inflamm Bowel Dis. 2017 Jul;23(7):1088-1095. doi: 10.1097/MIB.0000000000001161. Review.


Long-term use of antibiotics and risk of colorectal adenoma.

Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, Nguyen LH, Izard J, Fuchs CS, Garrett WS, Huttenhower C, Ogino S, Giovannucci EL, Chan AT.

Gut. 2018 Apr;67(4):672-678. doi: 10.1136/gutjnl-2016-313413. Epub 2017 Apr 4.


A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers.

Drew DA, Nishihara R, Lochhead P, Kuchiba A, Qian ZR, Mima K, Nosho K, Wu K, Wang M, Giovannucci E, Fuchs CS, Chan AT, Ogino S.

Am J Gastroenterol. 2017 Mar;112(3):493-501. doi: 10.1038/ajg.2016.589. Epub 2017 Jan 24.


Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Van Der Sloot KW, Joshi AD, Bellavance DR, Gilpin KK, Stewart KO, Lochhead P, Garber JJ, Giallourakis C, Yajnik V, Ananthakrishnan AN, Alizadeh BZ, Xavier RJ, Khalili H.

Inflamm Bowel Dis. 2017 Jan;23(1):82-88. doi: 10.1097/MIB.0000000000000978.


Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes.

Cao Y, Nishihara R, Qian ZR, Song M, Mima K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Morikawa T, Zhang X, Wu K, Wang M, Garrett WS, Giovannucci EL, Fuchs CS, Chan AT, Ogino S.

Gastroenterology. 2016 Nov;151(5):879-892.e4. doi: 10.1053/j.gastro.2016.07.030. Epub 2016 Jul 27.


A New, Atypical Case of Cobalamin F Disorder Diagnosed by Whole Exome Sequencing.

Deciphering Developmental Disorders Study Group, Constantinou P, D'Alessandro M, Lochhead P, Samant S, Bisset WM, Hauptfleisch C, Dean J.

Mol Syndromol. 2016 Feb;6(5):254-8. doi: 10.1159/000441134. Epub 2015 Oct 14.


Fecal Microbiome in Epidemiologic Studies-Letter.

Drew DA, Lochhead P, Abu-Ali G, Chan AT, Huttenhower C, Izard J.

Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):869. doi: 10.1158/1055-9965.EPI-16-0063. Epub 2016 Mar 9. No abstract available.


Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ, Gilmour L, Squires M, Gilley R, Foxton C, Newell DR, Wedge SR, Cook SJ.

Cell Cycle. 2016;15(4):506-18. doi: 10.1080/15384101.2015.1120915.


Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.

Ogino S, Nishihara R, VanderWeele TJ, Wang M, Nishi A, Lochhead P, Qian ZR, Zhang X, Wu K, Nan H, Yoshida K, Milner DA Jr, Chan AT, Field AE, Camargo CA Jr, Williams MA, Giovannucci EL.

Epidemiology. 2016 Jul;27(4):602-11. doi: 10.1097/EDE.0000000000000471.


Association Between Circulating Levels of C-Reactive Protein and Interleukin-6 and Risk of Inflammatory Bowel Disease.

Lochhead P, Khalili H, Ananthakrishnan AN, Richter JM, Chan AT.

Clin Gastroenterol Hepatol. 2016 Jun;14(6):818-824.e6. doi: 10.1016/j.cgh.2016.01.016. Epub 2016 Feb 1.


Statistical methods for studying disease subtype heterogeneity.

Wang M, Spiegelman D, Kuchiba A, Lochhead P, Kim S, Chan AT, Poole EM, Tamimi R, Tworoger SS, Giovannucci E, Rosner B, Ogino S.

Stat Med. 2016 Feb 28;35(5):782-800. doi: 10.1002/sim.6793. Epub 2015 Dec 1.


Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status.

Inamura K, Song M, Jung S, Nishihara R, Yamauchi M, Lochhead P, Qian ZR, Kim SA, Mima K, Sukawa Y, Masuda A, Imamura Y, Zhang X, Pollak MN, Mantzoros CS, Harris CC, Giovannucci E, Fuchs CS, Cho E, Chan AT, Wu K, Ogino S.

J Natl Cancer Inst. 2015 Nov 23;108(4). pii: djv363. doi: 10.1093/jnci/djv363. Print 2016 Apr.


Molecular pathological epidemiology gives clues to paradoxical findings.

Nishihara R, VanderWeele TJ, Shibuya K, Mittleman MA, Wang M, Field AE, Giovannucci E, Lochhead P, Ogino S.

Eur J Epidemiol. 2015 Oct;30(10):1129-35. doi: 10.1007/s10654-015-0088-4. Epub 2015 Oct 7.


Postdiagnostic intake of one-carbon nutrients and alcohol in relation to colorectal cancer survival.

Lochhead P, Nishihara R, Qian ZR, Mima K, Cao Y, Sukawa Y, Kim SA, Inamura K, Zhang X, Wu K, Giovannucci E, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S.

Am J Clin Nutr. 2015 Nov;102(5):1134-41. doi: 10.3945/ajcn.115.115162. Epub 2015 Sep 30.


Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M, Rowlinson RA, Baak LM, Gallo R, Balmanno K, Goodwin LM, Ward RA, Lochhead PA, Guichard S, Hudson K, Cook SJ.

Cell Mol Life Sci. 2016 Feb;73(4):883-900. doi: 10.1007/s00018-015-2032-x. Epub 2015 Sep 7.


DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.

Najas S, Arranz J, Lochhead PA, Ashford AL, Oxley D, Delabar JM, Cook SJ, Barallobre MJ, Arbonés ML.

EBioMedicine. 2015 Jan 17;2(2):120-34. doi: 10.1016/j.ebiom.2015.01.010. eCollection 2015.


Initial experience of direct-to-test endoscopic ultrasonography for suspected choledocholithiasis.

Lochhead P, Phull P.

Scott Med J. 2015 May;60(2):85-9. doi: 10.1177/0036933015572276. Epub 2015 Feb 10.


Screening and surveillance for Barrett esophagus.

Lochhead P, Chan AT.

JAMA Intern Med. 2015 Feb;175(2):159-60. doi: 10.1001/jamainternmed.2014.6983. No abstract available.


Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis.

Inamura K, Yamauchi M, Nishihara R, Lochhead P, Qian ZR, Kuchiba A, Kim SA, Mima K, Sukawa Y, Jung S, Zhang X, Wu K, Cho E, Chan AT, Meyerhardt JA, Harris CC, Fuchs CS, Ogino S.

J Natl Cancer Inst. 2014 Sep 4;106(9). pii: dju195. doi: 10.1093/jnci/dju195. Print 2014 Sep.



Lochhead P, Meyerhardt JA, Fuchs CS, Ogino S.

J Natl Cancer Inst. 2014 Aug 11;106(8). pii: dju181. doi: 10.1093/jnci/dju181. Print 2014 Aug. No abstract available.


SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.

Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S, Qian ZR.

Ann Surg Oncol. 2014 Dec;21(13):4164-73. doi: 10.1245/s10434-014-3888-y. Epub 2014 Jul 15.


Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions.

Lochhead P, Chan AT, Giovannucci E, Fuchs CS, Wu K, Nishihara R, O'Brien M, Ogino S.

Am J Gastroenterol. 2014 Aug;109(8):1205-14. doi: 10.1038/ajg.2014.153. Epub 2014 Jun 17. Review.


Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.

Lochhead P, Chan AT, Nishihara R, Fuchs CS, Beck AH, Giovannucci E, Ogino S.

Mod Pathol. 2015 Jan;28(1):14-29. doi: 10.1038/modpathol.2014.81. Epub 2014 Jun 13. Review.


Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S.

Mol Cancer. 2014 May 31;13:135. doi: 10.1186/1476-4598-13-135.


A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA.

Biochem J. 2014 Jan 1;457(1):43-56. doi: 10.1042/BJ20130461.


The ductal origin of structural and functional heterogeneity between pancreatic islets.

Merkwitz C, Blaschuk OW, Schulz A, Lochhead P, Meister J, Ehrlich A, Ricken AM.

Prog Histochem Cytochem. 2013 Oct;48(3):103-40. doi: 10.1016/j.proghi.2013.09.001. Epub 2013 Oct 4. Review.


Long-term colorectal-cancer incidence and mortality after lower endoscopy.

Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BA, Fuchs CS, Giovannucci E, Ogino S, Chan AT.

N Engl J Med. 2013 Sep 19;369(12):1095-105. doi: 10.1056/NEJMoa1301969.


Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.

Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS.

Cell Host Microbe. 2013 Aug 14;14(2):207-15. doi: 10.1016/j.chom.2013.07.007.


Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.

Lochhead P, Kuchiba A, Imamura Y, Liao X, Yamauchi M, Nishihara R, Qian ZR, Morikawa T, Shen J, Meyerhardt JA, Fuchs CS, Ogino S.

J Natl Cancer Inst. 2013 Aug 7;105(15):1151-6. doi: 10.1093/jnci/djt173. Epub 2013 Jul 22.


Aspirin use and risk of colorectal cancer according to BRAF mutation status.

Nishihara R, Lochhead P, Kuchiba A, Jung S, Yamauchi M, Liao X, Imamura Y, Qian ZR, Morikawa T, Wang M, Spiegelman D, Cho E, Giovannucci E, Fuchs CS, Chan AT, Ogino S.

JAMA. 2013 Jun 26;309(24):2563-71. doi: 10.1001/jama.2013.6599.


Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.

Ogino S, Lochhead P, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT.

Oncogene. 2014 Jun 5;33(23):2949-55. doi: 10.1038/onc.2013.244. Epub 2013 Jun 24. Review.

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