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Three fluoropyrimidine-based regimens in routine clinical practice after nab-paclitaxel plus gemcitabine for metastatic pancreatic cancer: An AGEO multicenter study.

Pointet AL, Tougeron D, Pernot S, Pozet A, Béchade D, Trouilloud I, Lourenco N, Hautefeuille V, Locher C, Williet N, Desrame J, Artru P, Soularue E, Le Roy B, Taieb J.

Clin Res Hepatol Gastroenterol. 2019 Oct 10. pii: S2210-7401(19)30193-7. doi: 10.1016/j.clinre.2019.08.009. [Epub ahead of print]


Folfirinox versus gemcitabine/nab-paclitaxel as first-line therapy in patients with metastatic pancreatic cancer: a comparative propensity score study.

Williet N, Saint A, Pointet AL, Tougeron D, Pernot S, Pozet A, Bechade D, Trouilloud I, Lourenco N, Hautefeuille V, Locher C, Desrame J, Artru P, Thirot Bidault A, Le Roy B, Pezet D, Phelip JM, Taieb J.

Therap Adv Gastroenterol. 2019 Sep 25;12:1756284819878660. doi: 10.1177/1756284819878660. eCollection 2019.


Withholding the Introduction of Anti-Epidermal Growth Factor Receptor: Impact on Outcomes in RAS Wild-Type Metastatic Colorectal Tumors: A Multicenter AGEO Study (the WAIT or ACT Study).

Palmieri LJ, Mineur L, Tougeron D, Rousseau B, Granger V, Gornet JM, Smith D, Lievre A, Galais MP, Doat S, Pernot S, Bignon-Bretagne AL, Metges JP, Baba-Hamed N, Michel P, Obled S, Vitellius C, Bouche O, Saban-Roche L, Buecher B, des Guetz G, Locher C, Trouilloud I, Goujon G, Dior M, Manfredi S, Soularue E, Phelip JM, Henriques J, Vernery D, Coriat R.

Oncologist. 2019 Oct 2. pii: theoncologist.2019-0328. doi: 10.1634/theoncologist.2019-0328. [Epub ahead of print]


The Other Side of the Coin: Nocebo Effects and Psychotherapy.

Locher C, Koechlin H, Gaab J, Gerger H.

Front Psychiatry. 2019 Aug 8;10:555. doi: 10.3389/fpsyt.2019.00555. eCollection 2019.


Evaluation of two nutritional scores' association with systemic treatment toxicity and survival in metastatic colorectal cancer: an AGEO prospective multicentre study.

Gallois C, Artru P, Lièvre A, Auclin E, Lecomte T, Locher C, Marthey L, Zaimi Y, Faroux R, Pernot S, Barret M, Taieb J.

Eur J Cancer. 2019 Sep;119:35-43. doi: 10.1016/j.ejca.2019.07.011. Epub 2019 Aug 12.


Endogenous cortisol and conditioned placebo effects on pain - A randomized trial.

Gaab J, Bürgin D, Locher C, Werner C, Urech S, Bratschi C, Garcia LB, Hauke M, Bitter S, Bohny M, Bentz D.

J Psychosom Res. 2019 Aug;123:109739. doi: 10.1016/j.jpsychores.2019.109739. Epub 2019 Jun 13.


Open-label placebo clinical trials: is it the rationale, the interaction or the pill?

Blease CR, Bernstein MH, Locher C.

BMJ Evid Based Med. 2019 Jun 26. pii: bmjebm-2019-111209. doi: 10.1136/bmjebm-2019-111209. [Epub ahead of print]


[Second- or third-line treatment with erlotinib in EGFR wild-type non-small cell lung cancer: Real-life data].

Debieuvre D, Moreau L, Coudert M, Locher C, Asselain B, Coëtmeur D, Dayen C, Goupil F, Martin F, Brun P, De Faverges G, Hauss PA, Gally S, Ben Hadj Yahia B, Grivaux M.

Rev Mal Respir. 2019 Jun;36(6):649-663. doi: 10.1016/j.rmr.2019.03.010. Epub 2019 Jun 14. French.


Circulating free tumor-derived DNA to detect EGFR mutations in patients with advanced NSCLC: French subset analysis of the ASSESS study.

Denis MG, Lafourcade MP, Le Garff G, Dayen C, Falchero L, Thomas P, Locher C, Oliviero G, Licour M, Reck M, Normanno N, Molinier O.

J Thorac Dis. 2019 Apr;11(4):1370-1378. doi: 10.21037/jtd.2019.03.95.


Health-Related Quality of Life Impact from Adding Bevacizumab to Cisplatin-Pemetrexed in Malignant Pleural Mesothelioma in the MAPS IFCT-GFPC-0701 Phase III Trial.

Eberst G, Anota A, Scherpereel A, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Léna H, Rivière F, Monnet I, Gounant V, Janicot H, Gervais R, Locher C, Charton E, Morin F, Zalcman G, Westeel V; French Cooperative Thoracic Intergroup (IFCT).

Clin Cancer Res. 2019 Oct 1;25(19):5759-5765. doi: 10.1158/1078-0432.CCR-18-2860. Epub 2019 Jun 7.


Effects of sildenafil on maximum walking time in patients with arterial claudication: The ARTERIOFIL study.

Omarjee L, Le Pabic E, Custaud MA, Fontaine C, Locher C, Renault A, Jaquinandi V, Azzola V, Barbeau-Terrier C, Laporte I, Ripoche M, Onillon Y, Chretien JM, Daniel V, Chao de la Barca JM, Homedan C, Reynier P, Abraham P, Mahé G.

Vascul Pharmacol. 2019 Jul - Aug;118-119:106563. doi: 10.1016/j.vph.2019.05.003. Epub 2019 May 30.


Psychotherapy: A World of Meanings.

Locher C, Meier S, Gaab J.

Front Psychol. 2019 Mar 22;10:460. doi: 10.3389/fpsyg.2019.00460. eCollection 2019. Review.


Long-Term Effects of Psychological Interventions to Improve Adherence to Antiretroviral Treatment in HIV-Infected Persons: A Systematic Review and Meta-Analysis.

Locher C, Messerli M, Gaab J, Gerger H.

AIDS Patient Care STDS. 2019 Mar;33(3):131-144. doi: 10.1089/apc.2018.0164.


Evidence of slight improvement in five-year survival in non-small-cell lung cancer over the last 10 years: Results of the French KBP-CPHG real-world studies.

Debieuvre D, Locher C, Asselain B, Dayen C, Molinier O, Falchero L, Dujon C, Delclaux B, Grivaux M.

Bull Cancer. 2019 Apr;106(4):283-292. doi: 10.1016/j.bulcan.2019.01.010. Epub 2019 Feb 23.


Effects and Components of Placebos with a Psychological Treatment Rationale - Three Randomized-Controlled Studies.

Gaab J, Kossowsky J, Ehlert U, Locher C.

Sci Rep. 2019 Feb 5;9(1):1421. doi: 10.1038/s41598-018-37945-1.


Open-label placebo response - Does optimism matter? A secondary-analysis of a randomized controlled trial.

Locher C, Frey Nascimento A, Kossowsky J, Meyer A, Gaab J.

J Psychosom Res. 2019 Jan;116:25-30. doi: 10.1016/j.jpsychores.2018.11.009. Epub 2018 Nov 14.


When a Placebo Is Not a Placebo: Problems and Solutions to the Gold Standard in Psychotherapy Research.

Locher C, Gaab J, Blease C.

Front Psychol. 2018 Nov 26;9:2317. doi: 10.3389/fpsyg.2018.02317. eCollection 2018. No abstract available.


Increased incidence of Campylobacter enteritis and their quinolone resistance between 2010 and 2015: Results of a French national observatory conducted in 21 general hospitals (CHG).

Trompette M, Le Guilloux L, Souply L, Denis B, Tsouria A, Garrec H, Quentin V, Vaucel J, Locher C, Barjonet G, Marthelet P, Causse X, Poisson D, Nahon S, Joubrel-Guyot C, Grasset D, Pouedras P, Renou C, Toyer AL, Boruchowicz A, Cattoen C, Heluwaert F, Bland S, Faroux R, Desroys V, Paupard T, Verhaeghe A, Correro MO, Pujol C, Picon M, Gallou J, Kaassi M, Touroult-Jupin P, Arotcarena R, Villeneuve L, Payen JL, Libier L, Charpignon C, Rahma M, Manuardi AG, Jeanne A, Lahmek P, Condat B, Macaigne G.

Clin Res Hepatol Gastroenterol. 2019 Jun;43(3):338-345. doi: 10.1016/j.clinre.2018.10.015. Epub 2018 Dec 7.


Tacrolimus Concentrations Measured in Excreted Bile in Liver Transplant Recipients: The STABILE Study.

Rayar M, Tron C, Locher C, Chebaro A, Beaurepaire JM, Blondeau M, Cusumano C, Bardou-Jacquet E, Houssel-Debry P, Camus C, Petitcollin A, Verdier MC, Lakéhal M, Desfourneaux V, Sulpice L, Meunier B, Bellissant E, Boudjema K, Lemaitre F.

Clin Ther. 2018 Dec;40(12):2088-2098. doi: 10.1016/j.clinthera.2018.10.015. Epub 2018 Nov 19.


Impact of an Educational Intervention on Ankle-Brachial Index Performance Among Medical Students and Fidelity Assessment at Six Months.

Omarjee L, Donnou C, Chaudru S, Locher C, Paul E, Charasson M, Mauger C, Jaquinandi V, Stivalet O, Mahe G.

Ann Vasc Surg. 2019 Apr;56:246-253. doi: 10.1016/j.avsg.2018.07.044. Epub 2018 Sep 29.


Oral vinorelbine-based concomitant chemoradiotherapy in unresectable stage III non-small cell lung cancer: a systematic review.

Lesueur P, Martel-Laffay I, Escande A, Kissel M, Locher C, Gervais R, Schott R, Vergnenegre A, Chouaid C.

Expert Rev Anticancer Ther. 2018 Nov;18(11):1159-1165. doi: 10.1080/14737140.2018.1518714. Epub 2018 Sep 17.


Impact of a comprehensive geriatric assessment to manage elderly patients with locally advanced non-small-cell lung cancers: An open phase II study using concurrent cisplatin-oral vinorelbine and radiotherapy (GFPC 08-06).

Locher C, Pourel N, Le Caer H, Berard H, Auliac JB, Monnet I, Descourt R, Vergnenègre A, Lafay IM, Greillier L, Chouaïd C.

Lung Cancer. 2018 Jul;121:25-29. doi: 10.1016/j.lungcan.2018.04.017. Epub 2018 Apr 22.


How to address the placebo response in the prescription SSRIs and SNRIs in children and adolescents.

Koechlin H, Kossowsky J, Gaab J, Locher C.

Expert Opin Drug Saf. 2018 Jun;17(6):537-540. doi: 10.1080/14740338.2018.1475558. Epub 2018 May 21.


Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer.

Aparicio T, Bouché O, Francois E, Retornaz F, Barbier E, Taieb J, Kirscher S, Etienne PL, Faroux R, Khemissa Akouz F, El Hajbi F, Locher C, Rinaldi Y, Lecomte T, Lavau-Denes S, Baconnier M, Oden-Gangloff A, Genet D, Bedenne L, Paillaud E; for PRODIGE 20 investigators.

Eur J Cancer. 2018 Jul;97:16-24. doi: 10.1016/j.ejca.2018.03.030. Epub 2018 May 16.


Bevacizumab+chemotherapy versus chemotherapy alone in elderly patients with untreated metastatic colorectal cancer: a randomized phase II trial-PRODIGE 20 study results.

Aparicio T, Bouché O, Taieb J, Maillard E, Kirscher S, Etienne PL, Faroux R, Khemissa Akouz F, El Hajbi F, Locher C, Rinaldi Y, Lecomte T, Lavau-Denes S, Baconnier M, Oden-Gangloff A, Genet D, Paillaud E, Retornaz F, François E, Bedenne L; for PRODIGE 20 Investigators.

Ann Oncol. 2018 Nov 1;29(11):2270. doi: 10.1093/annonc/mdx808. No abstract available.


Placebo and Psychotherapy: Differences, Similarities, and Implications.

Gaab J, Locher C, Blease C.

Int Rev Neurobiol. 2018;138:241-255. doi: 10.1016/bs.irn.2018.01.013. Epub 2018 Feb 23. Review.


Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Muntel J, Madduri AVR, Velarde J, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN.

MBio. 2018 Mar 6;9(2). pii: e02333-17. doi: 10.1128/mBio.02333-17.


Prognostic role of a comprehensive geriatric assessment on the management of elderly patients with advanced non-small cell lung cancer (NSCLC): a pooled analysis of two prospective phase II trials by the GFPC Group.

Le Caer H, Borget I, Corre R, Locher C, Raynaud C, Decroisette C, Berard H, Audigier-Valette C, Dujon C, Auliac JB, Crequit J, Monnet I, Vergnenegre A, Chouaid C.

J Thorac Dis. 2017 Oct;9(10):3747-3754. doi: 10.21037/jtd.2017.09.51.


Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.

Wang T, Bemis G, Hanzelka B, Zuccola H, Wynn M, Moody CS, Green J, Locher C, Liu A, Gao H, Xu Y, Wang S, Wang J, Bennani YL, Thomson JA, Müh U.

ACS Med Chem Lett. 2017 Nov 28;8(12):1224-1229. doi: 10.1021/acsmedchemlett.7b00239. eCollection 2017 Dec 14.


Employing open/hidden administration in psychotherapy research: A randomized-controlled trial of expressive writing.

Tondorf T, Kaufmann LK, Degel A, Locher C, Birkhäuer J, Gerger H, Ehlert U, Gaab J.

PLoS One. 2017 Nov 27;12(11):e0187400. doi: 10.1371/journal.pone.0187400. eCollection 2017.


Small bowel adenocarcinoma: French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO).

Locher C, Batumona B, Afchain P, Carrère N, Samalin E, Cellier C, Aparicio T, Becouarn Y, Bedenne L, Michel P, Parc Y, Pocard M, Chibaudel B, Bouché O; Thésaurus National de Cancérologie Digestive (TNCD).

Dig Liver Dis. 2018 Jan;50(1):15-19. doi: 10.1016/j.dld.2017.09.123. Epub 2017 Oct 6. Review.


[First treatment strategies in the 2 years following lung cancer diagnosis. ESCAP-2011-CPHG, a real-life study carried out in French general hospitals].

Grivaux M, Goupil F, Asselain B, Blanchon F, Collon T, Coëtmeur D, Dayen C, Locher C, Molinier O, Martin F, Debieuvre D.

Rev Mal Respir. 2017 Nov;34(9):991-999. doi: 10.1016/j.rmr.2017.10.001. Epub 2017 Oct 27. French.


Bevacizumab+chemotherapy versus chemotherapy alone in elderly patients with untreated metastatic colorectal cancer: a randomized phase II trial-PRODIGE 20 study results.

Aparicio T, Bouché O, Taieb J, Maillard E, Kirscher S, Etienne PL, Faroux R, Khemissa Akouz F, El Hajbi F, Locher C, Rinaldi Y, Lecomte T, Lavau-Denes S, Baconnier M, Oden-Gangloff A, Genet D, Paillaud E, Retornaz F, François E, Bedenne L; for PRODIGE 20 Investigators.

Ann Oncol. 2018 Jan 1;29(1):133-138. doi: 10.1093/annonc/mdx529. Erratum in: Ann Oncol. 2018 Nov 1;29(11):2270.


Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate.

Palpacuer C, Duprez R, Huneau A, Locher C, Boussageon R, Laviolle B, Naudet F.

Addiction. 2018 Feb;113(2):220-237. doi: 10.1111/add.13974. Epub 2017 Sep 20.


Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents: A Systematic Review and Meta-analysis.

Locher C, Koechlin H, Zion SR, Werner C, Pine DS, Kirsch I, Kessler RC, Kossowsky J.

JAMA Psychiatry. 2017 Oct 1;74(10):1011-1020. doi: 10.1001/jamapsychiatry.2017.2432.


2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis.

Clark MP, Wang T, Perola E, Deininger DD, Zuccola HJ, Jones SM, Gao H, VanderVen BC, Russell DG, Shoen CM, Cynamon MH, Thomson JA, Locher CP.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):3987-3991. doi: 10.1016/j.bmcl.2017.07.067. Epub 2017 Jul 27.


Non-Small-Cell Lung Cancer (NSCLC) Harboring ALK Translocations: Clinical Characteristics and Management in a Real-Life Setting: a French Retrospective Analysis (GFPC 02-14 Study).

Auliac JB, Monnet I, Dubos-Arvis C, Chiappa AM, Baize N, Bota S, Vergnenegre A, Doubre H, Locher C, Bizieux A, Robinet G, Chouaid C.

Target Oncol. 2017 Dec;12(6):833-838. doi: 10.1007/s11523-017-0520-7.


Is the rationale more important than deception? A randomized controlled trial of open-label placebo analgesia.

Locher C, Frey Nascimento A, Kirsch I, Kossowsky J, Meyer A, Gaab J.

Pain. 2017 Dec;158(12):2320-2328. doi: 10.1097/j.pain.0000000000001012.


Differentiating enhancing multiple sclerosis lesions, glioblastoma, and lymphoma with dynamic texture parameters analysis (DTPA): A feasibility study.

Verma RK, Wiest R, Locher C, Heldner MR, Schucht P, Raabe A, Gralla J, Kamm CP, Slotboom J, Kellner-Weldon F.

Med Phys. 2017 Aug;44(8):4000-4008. doi: 10.1002/mp.12356. Epub 2017 Jun 30.


Over 90% of cases of Microscopic Colitis can be diagnosed by performing a short colonoscopy.

Macaigne G, Lahmek P, Locher C, Boivin JF, Lesgourgues B, Yver M, Costes L, Alsamad IA, Cucherousset J, Charpignon C, Guyot H, Lambaré B, Ghilain JM, Calès V, de Montigny-Lenhardt S, Bellaïche G, Pariente A, Nahon S; COLMI Group of the Association Nationale des Gastroentérologues des Hôpitaux (ANGH).

Clin Res Hepatol Gastroenterol. 2017 Jun;41(3):333-340. doi: 10.1016/j.clinre.2016.12.008. Epub 2017 Feb 16.


Accuracy of tablet splitting and liquid measurements: an examination of who, what and how.

Abu-Geras D, Hadziomerovic D, Leau A, Khan RN, Gudka S, Locher C, Razaghikashani M, Lim LY.

J Pharm Pharmacol. 2017 May;69(5):603-612. doi: 10.1111/jphp.12671. Epub 2016 Dec 28.


Geriatric factors analyses from FFCD 2001-02 phase III study of first-line chemotherapy for elderly metastatic colorectal cancer patients.

Aparicio T, Gargot D, Teillet L, Maillard E, Genet D, Cretin J, Locher C, Bouché O, Breysacher G, Seitz JF, Gasmi M, Stefani L, Ramdani M, Lecomte T, Auby D, Faroux R, Bachet JB, Lepère C, Khemissa F, Sobhani I, Boulat O, Mitry E, Jouve JL; FFCD 2001-02 investigators.

Eur J Cancer. 2017 Mar;74:98-108. doi: 10.1016/j.ejca.2016.09.029. Epub 2016 Nov 5.


Antibacterial activity and chemical characteristics of several Western Australian honeys compared to manuka honey and pasture honey.

Roshan N, Rippers T, Locher C, Hammer KA.

Arch Microbiol. 2017 Mar;199(2):347-355. doi: 10.1007/s00203-016-1308-3. Epub 2016 Oct 26.


Benefits of temporary portocaval shunt during orthotopic liver transplantation with vena cava preservation: A propensity score analysis.

Rayar M, Levi Sandri GB, Cusumano C, Locher C, Houssel-Debry P, Camus C, Lombard N, Desfourneaux V, Lakehal M, Meunier B, Sulpice L, Boudjema K.

Liver Transpl. 2017 Feb;23(2):174-183. doi: 10.1002/lt.24650. Epub 2016 Dec 30.


Perioperative chemotherapy with FOLFOX in resectable gastroesophageal adenocarcinoma in real life practice: An AGEO multicenter retrospective study.

Mary F, Zaanan A, Boige V, Artru P, Samalin E, Coriat R, Bachet JB, Boubaya M, Benallaoua M, Tougeron D, Afchain P, Locher C, Baumgaertner I, Lecaille C, des Guetz G, Aparicio T; AGEO (Association des Gastro-Entérologues Oncologues).

Dig Liver Dis. 2016 Dec;48(12):1498-1502. doi: 10.1016/j.dld.2016.07.022. Epub 2016 Aug 9.


Effect of a Perioperative Nutritional Supplementation with Oral Impact® in Patients undergoing Hepatic Surgery for Liver Cancer: A Prospective, Placebo-Controlled, Randomized, Double-Blind Study.

Seguin P, Locher C, Boudjema K, Hamon C, Mouchel C, Malledant Y, Bellissant E.

Nutr Cancer. 2016;68(3):464-72. doi: 10.1080/01635581.2016.1153670. Epub 2016 Mar 23.


Characterization of Enhancing MS Lesions by Dynamic Texture Parameter Analysis of Dynamic Susceptibility Perfusion Imaging.

Verma RK, Slotboom J, Locher C, Heldner MR, Weisstanner C, Abela E, Kellner-Weldon F, Zbinden M, Kamm CP, Wiest R.

Biomed Res Int. 2016;2016:9578139. doi: 10.1155/2016/9578139. Epub 2016 Jan 13.


Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT).

Lancet. 2016 Apr 2;387(10026):1405-1414. doi: 10.1016/S0140-6736(15)01238-6. Epub 2015 Dec 21. Erratum in: Lancet. 2016 Apr 2;387(10026):e24.


Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer.

Ladoire S, Penault-Llorca F, Senovilla L, Dalban C, Enot D, Locher C, Prada N, Poirier-Colame V, Chaba K, Arnould L, Ghiringhelli F, Fumoleau P, Spielmann M, Delaloge S, Poillot ML, Arveux P, Goubar A, Andre F, Zitvogel L, Kroemer G.

Autophagy. 2015;11(10):1878-90. doi: 10.1080/15548627.2015.1082022.


Safety and efficacy of palliative systemic chemotherapy combined with colorectal self-expandable metallic stents in advanced colorectal cancer: A multicenter study.

Cézé N, Charachon A, Locher C, Aparicio T, Mitry E, Barbieux JP, Landi B, Dorval E, Moussata D, Lecomte T.

Clin Res Hepatol Gastroenterol. 2016 Apr;40(2):230-8. doi: 10.1016/j.clinre.2015.09.004. Epub 2015 Oct 21.


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