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Items: 1 to 50 of 120

1.

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.

Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW.

Cell. 2018 Sep 17. pii: S0092-8674(18)31101-2. doi: 10.1016/j.cell.2018.08.040. [Epub ahead of print]

PMID:
30245009
2.

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E.

Cell Metab. 2018 Aug 28. pii: S1550-4131(18)30508-4. doi: 10.1016/j.cmet.2018.08.007. [Epub ahead of print]

PMID:
30174305
3.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 Jun 7;70(5):984. doi: 10.1016/j.molcel.2018.05.035. Epub 2018 Jun 7. No abstract available.

4.

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.

Bechard ME, Word AE, Tran AV, Liu X, Locasale JW, McDonald OG.

Oncogene. 2018 Sep;37(38):5248-5256. doi: 10.1038/s41388-018-0346-5. Epub 2018 May 30.

PMID:
29849117
5.

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H.

Nat Commun. 2018 May 29;9(1):2095. doi: 10.1038/s41467-018-04392-5.

6.

EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 May 17;70(4):663-678.e6. doi: 10.1016/j.molcel.2018.04.011. Erratum in: Mol Cell. 2018 Jun 7;70(5):984.

PMID:
29775581
7.

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.

Dai Z, Mentch SJ, Gao X, Nichenametla SN, Locasale JW.

Nat Commun. 2018 May 16;9(1):1955. doi: 10.1038/s41467-018-04426-y.

8.

Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.

Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD.

J Biol Chem. 2018 Jul 6;293(27):10630-10645. doi: 10.1074/jbc.RA118.002187. Epub 2018 May 16.

PMID:
29769314
9.

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.

Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE.

Nat Cell Biol. 2018 May;20(5):597-609. doi: 10.1038/s41556-018-0083-6. Epub 2018 Apr 16.

PMID:
29662176
10.

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.

Gao X, Lee K, Reid MA, Sanderson SM, Qiu C, Li S, Liu J, Locasale JW.

Cell Rep. 2018 Mar 27;22(13):3507-3520. doi: 10.1016/j.celrep.2018.03.017.

11.

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.

Allen AE, Locasale JW.

Cancer Cell. 2018 Mar 12;33(3):337-339. doi: 10.1016/j.ccell.2018.02.008.

PMID:
29533776
12.

Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.

Zhao F, Xiao C, Evans KS, Theivanthiran T, DeVito N, Holtzhausen A, Liu J, Liu X, Boczkowski D, Nair S, Locasale JW, Hanks BA.

Immunity. 2018 Jan 16;48(1):147-160.e7. doi: 10.1016/j.immuni.2017.12.004.

PMID:
29343435
13.

Differential response to exercise in claudin-low breast cancer.

Glass OK, Bowie M, Fuller J, Darr D, Usary J, Boss K, Choudhury KR, Liu X, Zhang Z, Locasale JW, Williams C, Dewhirst MW, Jones LW, Seewaldt V.

Oncotarget. 2017 Sep 19;8(60):100989-101004. doi: 10.18632/oncotarget.21054. eCollection 2017 Nov 24.

14.

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.

Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, Sproesser K, Herlyn M, Adams DJ, Locasale JW, Cichowski K, Mukherjee S, Wood KC.

Cell Rep. 2017 Dec 5;21(10):2796-2812. doi: 10.1016/j.celrep.2017.11.022.

15.

FOXO protects against age-progressive axonal degeneration.

Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12701. Epub 2017 Nov 26.

16.

A Missing Link to Vitamin B12 Metabolism.

Reid MA, Paik J, Locasale JW.

Cell. 2017 Nov 2;171(4):736-737. doi: 10.1016/j.cell.2017.10.030.

PMID:
29100069
17.

The impact of cellular metabolism on chromatin dynamics and epigenetics.

Reid MA, Dai Z, Locasale JW.

Nat Cell Biol. 2017 Nov;19(11):1298-1306. doi: 10.1038/ncb3629. Epub 2017 Oct 23. Review.

PMID:
29058720
18.

Molecular features that predict the response to antimetabolite chemotherapies.

Mehrmohamadi M, Jeong SH, Locasale JW.

Cancer Metab. 2017 Oct 3;5:8. doi: 10.1186/s40170-017-0170-3. eCollection 2017.

19.

Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.

Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X.

EMBO J. 2017 Nov 2;36(21):3175-3193. doi: 10.15252/embj.201796708. Epub 2017 Oct 11.

PMID:
29021282
20.

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.

Hershberger KA, Abraham DM, Martin AS, Mao L, Liu J, Gu H, Locasale JW, Hirschey MD.

J Biol Chem. 2017 Dec 1;292(48):19767-19781. doi: 10.1074/jbc.M117.809897. Epub 2017 Oct 2.

PMID:
28972174
21.

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW.

Cell Metab. 2017 Oct 3;26(4):648-659.e8. doi: 10.1016/j.cmet.2017.08.017. Epub 2017 Sep 14.

PMID:
28918937
22.

Biochemistry: A toxin that fuels metabolism.

Liu X, Locasale JW.

Nature. 2017 Aug 31;548(7669):533-534. doi: 10.1038/nature23541. Epub 2017 Aug 16. No abstract available.

PMID:
28813408
23.

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.

Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD.

JCI Insight. 2017 Jul 20;2(14). pii: 93885. doi: 10.1172/jci.insight.93885. [Epub ahead of print]

24.

RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards.

Salerno S Jr, Mehrmohamadi M, Liberti MV, Wan M, Wells MT, Booth JG, Locasale JW.

PLoS One. 2017 Jun 29;12(6):e0179530. doi: 10.1371/journal.pone.0179530. eCollection 2017.

25.

Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3558.

PMID:
28659639
26.

Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.

Garcia J, Bagwell J, Njaine B, Norman J, Levic DS, Wopat S, Miller SE, Liu X, Locasale JW, Stainier DYR, Bagnat M.

Curr Biol. 2017 Jul 10;27(13):1982-1989.e3. doi: 10.1016/j.cub.2017.05.035. Epub 2017 Jun 22.

27.

Metabolomics reveals intratumor heterogeneity - Implications for precision medicine.

Liu X, Locasale JW.

EBioMedicine. 2017 May;19:4-5. doi: 10.1016/j.ebiom.2017.04.030. Epub 2017 Apr 24. No abstract available.

28.

Glutamine Metabolism in Cancer: Understanding the Heterogeneity.

Cluntun AA, Lukey MJ, Cerione RA, Locasale JW.

Trends Cancer. 2017 Mar;3(3):169-180. doi: 10.1016/j.trecan.2017.01.005. Review.

29.

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.

Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suvà ML, Hwang TH, Locasale JW, Bao S, Rich JN.

Nat Neurosci. 2017 May;20(5):661-673. doi: 10.1038/nn.4537. Epub 2017 Mar 27.

30.

Metabolomics: A Primer.

Liu X, Locasale JW.

Trends Biochem Sci. 2017 Apr;42(4):274-284. doi: 10.1016/j.tibs.2017.01.004. Epub 2017 Feb 11. Review.

31.

Metabolic pattern formation in the tumor microenvironment.

Dai Z, Locasale JW.

Mol Syst Biol. 2017 Feb 9;13(2):915. doi: 10.15252/msb.20167518. No abstract available.

32.

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.

McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP.

Nat Genet. 2017 Mar;49(3):367-376. doi: 10.1038/ng.3753. Epub 2017 Jan 16.

33.

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW, Lai L.

Cell Chem Biol. 2017 Jan 19;24(1):55-65. doi: 10.1016/j.chembiol.2016.11.013. Epub 2016 Dec 29.

34.

Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.

Gao X, Locasale JW.

Cell Metab. 2016 Dec 13;24(6):777-779. doi: 10.1016/j.cmet.2016.11.012.

35.

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.

Mehrmohamadi M, Mentch LK, Clark AG, Locasale JW.

Nat Commun. 2016 Dec 14;7:13666. doi: 10.1038/ncomms13666.

36.

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.

Mattocks DA, Mentch SJ, Shneyder J, Ables GP, Sun D, Richie JP Jr, Locasale JW, Nichenametla SN.

Exp Gerontol. 2017 Feb;88:1-8. doi: 10.1016/j.exger.2016.12.003. Epub 2016 Dec 7.

37.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC.

Nat Immunol. 2016 Dec;17(12):1459-1466. doi: 10.1038/ni.3577. Epub 2016 Oct 3.

38.

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.

Liu X, Romero IL, Litchfield LM, Lengyel E, Locasale JW.

Cell Metab. 2016 Nov 8;24(5):728-739. doi: 10.1016/j.cmet.2016.09.005. Epub 2016 Oct 13.

39.

Understanding metabolism with flux analysis: From theory to application.

Dai Z, Locasale JW.

Metab Eng. 2017 Sep;43(Pt B):94-102. doi: 10.1016/j.ymben.2016.09.005. Epub 2016 Sep 22. Review.

40.

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H.

Immunity. 2016 Sep 20;45(3):540-554. doi: 10.1016/j.immuni.2016.08.017. Epub 2016 Sep 13.

41.

Metabolic interactions with cancer epigenetics.

Gao X, Reid MA, Kong M, Locasale JW.

Mol Aspects Med. 2017 Apr;54:50-57. doi: 10.1016/j.mam.2016.09.001. Epub 2016 Sep 9. Review.

42.

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.

Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M.

Nat Cell Biol. 2016 Oct;18(10):1090-101. doi: 10.1038/ncb3410. Epub 2016 Sep 12.

43.

A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.

Dai Z, Shestov AA, Lai L, Locasale JW.

Biophys J. 2016 Sep 6;111(5):1088-100. doi: 10.1016/j.bpj.2016.07.028.

44.

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.

Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M.

Genes Dev. 2016 Aug 15;30(16):1837-51. doi: 10.1101/gad.287235.116. Epub 2016 Sep 1.

45.

Metabolism: A new layer of glycolysis.

Liberti MV, Locasale JW.

Nat Chem Biol. 2016 Jul 19;12(8):577-8. doi: 10.1038/nchembio.2133. No abstract available.

PMID:
27434766
46.

Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.

Ser Z, Gao X, Johnson C, Mehrmohamadi M, Liu X, Li S, Locasale JW.

Cell Rep. 2016 Jun 14;15(11):2367-76. doi: 10.1016/j.celrep.2016.05.035. Epub 2016 Jun 2.

47.

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2016 Jun;18(6):645-656. doi: 10.1038/ncb3357. Epub 2016 May 23. Erratum in: Nat Cell Biol. 2017 Jun 29;19(7):873.

48.

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC.

Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008.

49.

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.

Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4320-5. doi: 10.1073/pnas.1519858113. Epub 2016 Apr 5.

50.

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP.

Cell Rep. 2016 Apr 12;15(2):323-35. doi: 10.1016/j.celrep.2016.03.026. Epub 2016 Mar 31.

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