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Items: 1 to 50 of 151

1.

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.

Liberti MV, Allen AE, Ramesh V, Dai Z, Singleton KR, Guo Z, Liu JO, Wood KC, Locasale JW.

J Biol Chem. 2019 Nov 20. pii: jbc.RA119.010903. doi: 10.1074/jbc.RA119.010903. [Epub ahead of print]

2.

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.

Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q.

Nat Commun. 2019 Nov 15;10(1):5177. doi: 10.1038/s41467-019-13168-4.

3.

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.

Tabilas C, Wang J, Liu X, Locasale JW, Smith NL, Rudd BD.

J Immunol. 2019 Nov 15;203(10):2571-2576. doi: 10.4049/jimmunol.1900426. Epub 2019 Oct 9.

PMID:
31597706
4.

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.

Guo Z, Cheng Z, Wang J, Liu W, Peng H, Wang Y, Rao AVS, Li RJ, Ying X, Korangath P, Liberti MV, Li Y, Xie Y, Hong SY, Schiene-Fischer C, Fischer G, Locasale JW, Sukumar S, Zhu H, Liu JO.

Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17158-17162. doi: 10.1002/anie.201905578. Epub 2019 Oct 31.

PMID:
31591797
5.

Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.

Nat Immunol. 2019 Nov;20(11):1555. doi: 10.1038/s41590-019-0517-8.

PMID:
31551573
6.

Methionine metabolism in health and cancer: a nexus of diet and precision medicine.

Sanderson SM, Gao X, Dai Z, Locasale JW.

Nat Rev Cancer. 2019 Nov;19(11):625-637. doi: 10.1038/s41568-019-0187-8. Epub 2019 Sep 12. Review.

PMID:
31515518
7.

Metabolic landscape of the tumor microenvironment at single cell resolution.

Xiao Z, Dai Z, Locasale JW.

Nat Commun. 2019 Aug 21;10(1):3763. doi: 10.1038/s41467-019-11738-0.

8.

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.

Nat Immunol. 2019 Sep;20(9):1186-1195. doi: 10.1038/s41590-019-0453-7. Epub 2019 Aug 5. Erratum in: Nat Immunol. 2019 Sep 24;:.

PMID:
31384058
9.

Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW.

Nature. 2019 Aug;572(7769):397-401. doi: 10.1038/s41586-019-1437-3. Epub 2019 Jul 31.

PMID:
31367041
10.

Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.

Sanderson SM, Mikhael PG, Ramesh V, Dai Z, Locasale JW.

Sci Adv. 2019 Jun 26;5(6):eaav7769. doi: 10.1126/sciadv.aav7769. eCollection 2019 Jun.

11.

Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.

Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP.

Cell Rep. 2019 Jun 18;27(12):3587-3601.e4. doi: 10.1016/j.celrep.2019.05.066.

12.

Acetate Metabolism in Physiology, Cancer, and Beyond.

Bose S, Ramesh V, Locasale JW.

Trends Cell Biol. 2019 Sep;29(9):695-703. doi: 10.1016/j.tcb.2019.05.005. Epub 2019 May 31. Review.

PMID:
31160120
13.

T cell stemness and dysfunction in tumors are triggered by a common mechanism.

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP.

Science. 2019 Mar 29;363(6434). pii: eaau0135. doi: 10.1126/science.aau0135.

PMID:
30923193
14.

Antigen receptor control of methionine metabolism in T cells.

Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA.

Elife. 2019 Mar 27;8. pii: e44210. doi: 10.7554/eLife.44210.

15.

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.

Gao X, Locasale JW, Reid MA.

Cancer Cell. 2019 Mar 18;35(3):339-341. doi: 10.1016/j.ccell.2019.02.014.

PMID:
30889375
16.

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.

Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR.

Nature. 2019 Apr;568(7751):254-258. doi: 10.1038/s41586-019-1005-x. Epub 2019 Mar 6.

17.

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.

Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M.

Nat Commun. 2019 Feb 18;10(1):809. doi: 10.1038/s41467-019-08759-0.

18.

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.

Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ.

Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043.

19.

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.

Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL Jr, Hoehn KL, Rathmell JC, Bullock TNJ.

Sci Immunol. 2019 Jan 25;4(31). pii: eaap9520. doi: 10.1126/sciimmunol.aap9520.

20.

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L.

J Immunol. 2019 Feb 15;202(4):1265-1286. doi: 10.4049/jimmunol.1800002. Epub 2019 Jan 18.

21.

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.

Hart PC, Chiyoda T, Liu X, Weigert M, Curtis M, Chiang CY, Loth R, Lastra R, McGregor SM, Locasale JW, Lengyel E, Romero IL.

Mol Cancer Res. 2019 Apr;17(4):870-881. doi: 10.1158/1541-7786.MCR-18-0409. Epub 2019 Jan 17.

PMID:
30655321
22.

Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.

Ma H, Yu S, Liu X, Zhang Y, Fakadej T, Liu Z, Yin C, Shen W, Locasale JW, Taylor JM, Qian L, Liu J.

Circulation. 2019 Apr 2;139(14):1725-1740. doi: 10.1161/CIRCULATIONAHA.118.037803.

PMID:
30636447
23.

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.

Immunity. 2019 Jan 15;50(1):64-76.e4. doi: 10.1016/j.immuni.2018.11.017. Epub 2019 Jan 8.

PMID:
30635240
24.

IDH3α regulates one-carbon metabolism in glioblastoma.

May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH.

Sci Adv. 2019 Jan 2;5(1):eaat0456. doi: 10.1126/sciadv.aat0456. eCollection 2019 Jan.

25.

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.

Reid MA, Allen AE, Liu S, Liberti MV, Liu P, Liu X, Dai Z, Gao X, Wang Q, Liu Y, Lai L, Locasale JW.

Nat Commun. 2018 Dec 21;9(1):5442. doi: 10.1038/s41467-018-07868-6.

26.

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.

Lu M, Sanderson SM, Zessin A, Ashcraft KA, Jones LW, Dewhirst MW, Locasale JW, Hsu DS.

Cancer Metab. 2018 Nov 15;6:14. doi: 10.1186/s40170-018-0190-7. eCollection 2018.

27.

Revisiting the Warburg Effect: Some Tumors Hold Their Breath.

Sanderson SM, Locasale JW.

Cell Metab. 2018 Nov 6;28(5):669-670. doi: 10.1016/j.cmet.2018.10.011.

28.

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC.

Cell. 2018 Dec 13;175(7):1780-1795.e19. doi: 10.1016/j.cell.2018.10.001. Epub 2018 Nov 1.

PMID:
30392958
29.

Thermodynamic constraints on the regulation of metabolic fluxes.

Dai Z, Locasale JW.

J Biol Chem. 2018 Dec 21;293(51):19725-19739. doi: 10.1074/jbc.RA118.004372. Epub 2018 Oct 25.

PMID:
30361440
30.

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.

Stone OA, El-Brolosy M, Wilhelm K, Liu X, Romão AM, Grillo E, Lai JKH, Günther S, Jeratsch S, Kuenne C, Lee IC, Braun T, Santoro MM, Locasale JW, Potente M, Stainier DYR.

Nat Commun. 2018 Oct 9;9(1):4077. doi: 10.1038/s41467-018-06406-8.

31.

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.

Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW.

Cell. 2018 Oct 4;175(2):502-513.e13. doi: 10.1016/j.cell.2018.08.040. Epub 2018 Sep 20.

32.

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E.

Cell Metab. 2019 Jan 8;29(1):141-155.e9. doi: 10.1016/j.cmet.2018.08.007. Epub 2018 Aug 30.

PMID:
30174305
33.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 Jun 7;70(5):984. doi: 10.1016/j.molcel.2018.05.035. Epub 2018 Jun 7. No abstract available.

34.

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.

Bechard ME, Word AE, Tran AV, Liu X, Locasale JW, McDonald OG.

Oncogene. 2018 Sep;37(38):5248-5256. doi: 10.1038/s41388-018-0346-5. Epub 2018 May 30.

35.

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H.

Nat Commun. 2018 May 29;9(1):2095. doi: 10.1038/s41467-018-04392-5.

36.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 May 17;70(4):663-678.e6. doi: 10.1016/j.molcel.2018.04.011. Erratum in: Mol Cell. 2018 Jun 7;70(5):984. Title and abstract corrected.

37.

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.

Dai Z, Mentch SJ, Gao X, Nichenametla SN, Locasale JW.

Nat Commun. 2018 May 16;9(1):1955. doi: 10.1038/s41467-018-04426-y.

38.

Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.

Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD.

J Biol Chem. 2018 Jul 6;293(27):10630-10645. doi: 10.1074/jbc.RA118.002187. Epub 2018 May 16.

39.

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.

Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE.

Nat Cell Biol. 2018 May;20(5):597-609. doi: 10.1038/s41556-018-0083-6. Epub 2018 Apr 16.

40.

New concepts in feedback regulation of glucose metabolism.

Locasale JW.

Curr Opin Syst Biol. 2018 Apr;8:32-38. doi: 10.1016/j.coisb.2017.11.005. Epub 2017 Dec 5.

41.

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.

Gao X, Lee K, Reid MA, Sanderson SM, Qiu C, Li S, Liu J, Locasale JW.

Cell Rep. 2018 Mar 27;22(13):3507-3520. doi: 10.1016/j.celrep.2018.03.017.

42.

Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.

Allen AE, Locasale JW.

Cancer Cell. 2018 Mar 12;33(3):337-339. doi: 10.1016/j.ccell.2018.02.008.

43.

Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.

Zhao F, Xiao C, Evans KS, Theivanthiran T, DeVito N, Holtzhausen A, Liu J, Liu X, Boczkowski D, Nair S, Locasale JW, Hanks BA.

Immunity. 2018 Jan 16;48(1):147-160.e7. doi: 10.1016/j.immuni.2017.12.004.

44.

Differential response to exercise in claudin-low breast cancer.

Glass OK, Bowie M, Fuller J, Darr D, Usary J, Boss K, Choudhury KR, Liu X, Zhang Z, Locasale JW, Williams C, Dewhirst MW, Jones LW, Seewaldt V.

Oncotarget. 2017 Sep 19;8(60):100989-101004. doi: 10.18632/oncotarget.21054. eCollection 2017 Nov 24.

45.

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.

Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, Sproesser K, Herlyn M, Adams DJ, Locasale JW, Cichowski K, Mukherjee S, Wood KC.

Cell Rep. 2017 Dec 5;21(10):2796-2812. doi: 10.1016/j.celrep.2017.11.022.

46.

FOXO protects against age-progressive axonal degeneration.

Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12701. Epub 2017 Nov 26.

47.

A Missing Link to Vitamin B12 Metabolism.

Reid MA, Paik J, Locasale JW.

Cell. 2017 Nov 2;171(4):736-737. doi: 10.1016/j.cell.2017.10.030.

48.

The impact of cellular metabolism on chromatin dynamics and epigenetics.

Reid MA, Dai Z, Locasale JW.

Nat Cell Biol. 2017 Nov;19(11):1298-1306. doi: 10.1038/ncb3629. Epub 2017 Oct 23. Review.

49.

Molecular features that predict the response to antimetabolite chemotherapies.

Mehrmohamadi M, Jeong SH, Locasale JW.

Cancer Metab. 2017 Oct 3;5:8. doi: 10.1186/s40170-017-0170-3. eCollection 2017.

50.

Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.

Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X.

EMBO J. 2017 Nov 2;36(21):3175-3193. doi: 10.15252/embj.201796708. Epub 2017 Oct 11.

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