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Items: 1 to 50 of 151

1.

Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila.

Damulewicz M, Świątek M, Łoboda A, Dulak J, Bilska B, Przewłocki R, Pyza E.

Genes (Basel). 2018 Dec 21;10(1). pii: E6. doi: 10.3390/genes10010006.

2.

Kidney injury by cyclosporine A is aggravated in heme oxygenase-1 deficient mice and involves regulation of microRNAs.

Łoboda A, Mucha O, Podkalicka P, Sobczak M, Miksza-Cybulska A, Kaczara P, Jozkowicz A, Dulak J.

Acta Biochim Pol. 2018 Nov 27;65(4):613-620. doi: 10.18388/abp.2018_2658.

3.

Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy.

Ayers M, Nebozhyn M, Cristescu R, McClanahan TK, Perini R, Rubin E, Cheng JD, Kaufman DR, Loboda A.

Clin Cancer Res. 2018 Nov 15. doi: 10.1158/1078-0432.CCR-18-1316. [Epub ahead of print]

PMID:
30442684
4.

Characterization of murine CEACAM1 in vivo reveals low expression on CD8+ T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1.

McLeod RL, Angagaw MH, Baral TN, Liu L, Moniz RJ, Laskey J, Hsieh S, Lee M, Han JH, Issafras H, Javaid S, Loboda A, Sadekova S, O'Connor JA, Tse A, Punnonen J.

Oncotarget. 2018 Oct 2;9(77):34459-34470. doi: 10.18632/oncotarget.26108. eCollection 2018 Oct 2.

5.

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.

Cristescu R, Mogg R, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu XQ, Lu H, Nebozhyn M, Zhang C, Lunceford JK, Joe A, Cheng J, Webber AL, Ibrahim N, Plimack ER, Ott PA, Seiwert TY, Ribas A, McClanahan TK, Tomassini JE, Loboda A, Kaufman D.

Science. 2018 Oct 12;362(6411). pii: eaar3593. doi: 10.1126/science.aar3593.

6.

DYNAMICS OF CONTENT OF SOME MINERALS IN TEENAGERS WITH CARDIOVASCULAR SYSTEM PATHOLOGY AGAINST THE BACKGROUND OF CHRONIC TONSILLITIS ZMIANY ZAWARTOŚCI NIEKTÓRYCH SKŁADNIKÓW MINERALNYCH U MŁODZIEŻY Z CHOROBAMI UKŁADU SERCOWO-NACZYNIOWEGO JAKO PODŁOŻE ROZWOJU PRZEWLEKŁEGO ZAPALENIA MIGDAŁKÓW PODNIEBIENNYCH.

Smiyan OI, Loboda AM, Manko YA, Bynda TP, Popov SV, Petrashenko VO, Sichnenko PI, Romaniuk OK, Gorbas VA, Zagorodnii MP, Smiian-Horbunova KO, Kosarchuk VV, Ovsianko OL, Kolesnikova MV.

Wiad Lek. 2018;71(4):861-864.

PMID:
30099424
7.

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer.

Kim ST, Cristescu R, Bass AJ, Kim KM, Odegaard JI, Kim K, Liu XQ, Sher X, Jung H, Lee M, Lee S, Park SH, Park JO, Park YS, Lim HY, Lee H, Choi M, Talasaz A, Kang PS, Cheng J, Loboda A, Lee J, Kang WK.

Nat Med. 2018 Sep;24(9):1449-1458. doi: 10.1038/s41591-018-0101-z. Epub 2018 Jul 16.

PMID:
30013197
8.

Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system.

Mucha O, Podkalicka P, Czarnek M, Biela A, Mieczkowski M, Kachamakova-Trojanowska N, Stepniewski J, Jozkowicz A, Dulak J, Loboda A.

Acta Biochim Pol. 2018;65(2):277-286. doi: 10.18388/abp.2017_2542. Epub 2018 Apr 25.

9.

Heme Oxygenase-1 Influences Satellite Cells and Progression of Duchenne Muscular Dystrophy in Mice.

Pietraszek-Gremplewicz K, Kozakowska M, Bronisz-Budzynska I, Ciesla M, Mucha O, Podkalicka P, Madej M, Glowniak U, Szade K, Stepniewski J, Jez M, Andrysiak K, Bukowska-Strakova K, Kaminska A, Kostera-Pruszczyk A, Jozkowicz A, Loboda A, Dulak J.

Antioxid Redox Signal. 2018 Jul 10;29(2):128-148. doi: 10.1089/ars.2017.7435. Epub 2018 May 23.

PMID:
29669436
10.

Heme oxygenase inhibition in cancers: possible tools and targets.

Podkalicka P, Mucha O, Józkowicz A, Dulak J, Łoboda A.

Contemp Oncol (Pozn). 2018 Mar;22(1A):23-32. doi: 10.5114/wo.2018.73879. Epub 2018 Mar 5. Review.

11.

Lack of Heme Oxygenase-1 Induces Inflammatory Reaction and Proliferation of Muscle Satellite Cells after Cardiotoxin-Induced Skeletal Muscle Injury.

Kozakowska M, Pietraszek-Gremplewicz K, Ciesla M, Seczynska M, Bronisz-Budzynska I, Podkalicka P, Bukowska-Strakova K, Loboda A, Jozkowicz A, Dulak J.

Am J Pathol. 2018 Feb;188(2):491-506. doi: 10.1016/j.ajpath.2017.10.017. Epub 2017 Nov 21.

PMID:
29169990
12.

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.

Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Puré E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI.

Cancer Cell. 2017 Nov 13;32(5):654-668.e5. doi: 10.1016/j.ccell.2017.10.005.

13.

Phase I/II trial of vorinostat combined with temozolomide and radiation therapy for newly diagnosed glioblastoma: results of Alliance N0874/ABTC 02.

Galanis E, Anderson SK, Miller CR, Sarkaria JN, Jaeckle K, Buckner JC, Ligon KL, Ballman KV, Moore DF Jr, Nebozhyn M, Loboda A, Schiff D, Ahluwalia MS, Lee EQ, Gerstner ER, Lesser GJ, Prados M, Grossman SA, Cerhan J, Giannini C, Wen PY; Alliance for Clinical Trials in Oncology and ABTC.

Neuro Oncol. 2018 Mar 27;20(4):546-556. doi: 10.1093/neuonc/nox161.

PMID:
29016887
14.

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M.

Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023.

15.

Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.

Loboda A, Stachurska A, Sobczak M, Podkalicka P, Mucha O, Jozkowicz A, Dulak J.

Toxicology. 2017 Aug 15;389:42-52. doi: 10.1016/j.tox.2017.07.004. Epub 2017 Jul 12.

PMID:
28710020
16.

Haeme oxygenase protects against UV light DNA damages in the retina in clock-dependent manner.

Damulewicz M, Loboda A, Jozkowicz A, Dulak J, Pyza E.

Sci Rep. 2017 Jul 12;7(1):5197. doi: 10.1038/s41598-017-05418-6.

17.

IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.

Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK.

J Clin Invest. 2017 Aug 1;127(8):2930-2940. doi: 10.1172/JCI91190. Epub 2017 Jun 26.

18.

Alterations in Tear Biochemistry Associated with Postanesthetic Chronic Dry Eye Syndrome.

Zernii EY, Golovastova MO, Baksheeva VE, Kabanova EI, Ishutina IE, Gancharova OS, Gusev AE, Savchenko MS, Loboda AP, Sotnikova LF, Zamyatnin AA Jr, Philippov PP, Senin II.

Biochemistry (Mosc). 2016 Dec;81(12):1549-1557. doi: 10.1134/S0006297916120166.

19.

MCPIP1 contributes to clear cell renal cell carcinomas development.

Ligeza J, Marona P, Gach N, Lipert B, Miekus K, Wilk W, Jaszczynski J, Stelmach A, Loboda A, Dulak J, Branicki W, Rys J, Jura J.

Angiogenesis. 2017 Aug;20(3):325-340. doi: 10.1007/s10456-017-9540-2. Epub 2017 Feb 14.

20.

Imaging Mass Cytometry.

Chang Q, Ornatsky OI, Siddiqui I, Loboda A, Baranov VI, Hedley DW.

Cytometry A. 2017 Feb;91(2):160-169. doi: 10.1002/cyto.a.23053. Epub 2017 Feb 3.

21.

Effect of heme oxygenase-1 on ochratoxin A-induced nephrotoxicity in mice.

Loboda A, Stachurska A, Podkalicka P, Sobczak M, Mucha O, Witalisz-Siepracka A, Jozkowicz A, Dulak J.

Int J Biochem Cell Biol. 2017 Mar;84:46-57. doi: 10.1016/j.biocel.2017.01.003. Epub 2017 Jan 9.

PMID:
28089712
22.

Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial.

Sclafani F, Kim TY, Cunningham D, Kim TW, Tabernero J, Schmoll HJ, Roh JK, Kim SY, Park YS, Guren TK, Hawkes E, Clarke SJ, Ferry D, Frodin JE, Ayers M, Nebozhyn M, Peckitt C, Loboda A, Watkins DJ.

Int J Cancer. 2017 Jan 15;140(2):431-439. doi: 10.1002/ijc.30453. Epub 2016 Oct 17.

23.

Limb ischemia and vessel regeneration: Is there a role for VEGF?

Jazwa A, Florczyk U, Grochot-Przeczek A, Krist B, Loboda A, Jozkowicz A, Dulak J.

Vascul Pharmacol. 2016 Nov;86:18-30. doi: 10.1016/j.vph.2016.09.003. Epub 2016 Sep 10. Review.

PMID:
27620809
24.

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation.

Loboda A, Sobczak M, Jozkowicz A, Dulak J.

Mediators Inflamm. 2016;2016:8319283. doi: 10.1155/2016/8319283. Epub 2016 Aug 17. Review.

25.

Interactions Between the Circadian Clock and Heme Oxygenase in the Retina of Drosophila melanogaster.

Damulewicz M, Loboda A, Jozkowicz A, Dulak J, Pyza E.

Mol Neurobiol. 2017 Sep;54(7):4953-4962. doi: 10.1007/s12035-016-0026-9. Epub 2016 Aug 13.

26.

[THE LEVEL OF LACTATE DEHYDROGENASE AS A MARKER OF RENAL DYSFUNCTION IN NEONATES WITH ASPHYXIA].

Loboda AM.

Lik Sprava. 2015 Oct-Dec;(7-8):89-95. Ukrainian.

PMID:
27491157
27.

Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma.

Ciesla M, Marona P, Kozakowska M, Jez M, Seczynska M, Loboda A, Bukowska-Strakova K, Szade A, Walawender M, Kusior M, Stepniewski J, Szade K, Krist B, Yagensky O, Urbanik A, Kazanowska B, Dulak J, Jozkowicz A.

Cancer Res. 2016 Oct 1;76(19):5707-5718. Epub 2016 Aug 3.

28.

Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.

Severyn B, Nguyen T, Altman MD, Li L, Nagashima K, Naumov GN, Sathyanarayanan S, Cook E, Morris E, Ferrer M, Arthur B, Benita Y, Watters J, Loboda A, Hermes J, Gilliland DG, Cleary MA, Carroll PM, Strack P, Tudor M, Andersen JN.

J Biomol Screen. 2016 Oct;21(9):989-97. doi: 10.1177/1087057116658646. Epub 2016 Jul 26.

PMID:
27461835
29.

A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC.

Schell MJ, Yang M, Teer JK, Lo FY, Madan A, Coppola D, Monteiro AN, Nebozhyn MV, Yue B, Loboda A, Bien-Willner GA, Greenawalt DM, Yeatman TJ.

Nat Commun. 2016 Jun 15;7:11743. doi: 10.1038/ncomms11743.

30.

High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.

Guertin AD, O'Neil J, Stoeck A, Reddy JA, Cristescu R, Haines BB, Hinton MC, Dorton R, Bloomfield A, Nelson M, Vetzel M, Lejnine S, Nebozhyn M, Zhang T, Loboda A, Picard KL, Schmidt EV, Dussault I, Leamon CP.

Mol Cancer Ther. 2016 Aug;15(8):1998-2008. doi: 10.1158/1535-7163.MCT-15-0950. Epub 2016 Jun 2.

31.

Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T.

Mol Neurodegener. 2016 May 23;11(1):42. No abstract available.

32.

Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T.

Mol Neurodegener. 2016 Apr 26;11:31. doi: 10.1186/s13024-016-0095-2. Erratum in: Mol Neurodegener. 2016;11(1):42.

33.

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism.

Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J.

Cell Mol Life Sci. 2016 Sep;73(17):3221-47. doi: 10.1007/s00018-016-2223-0. Epub 2016 Apr 21. Review.

34.

GAM: a web-service for integrated transcriptional and metabolic network analysis.

Sergushichev AA, Loboda AA, Jha AK, Vincent EE, Driggers EM, Jones RG, Pearce EJ, Artyomov MN.

Nucleic Acids Res. 2016 Jul 8;44(W1):W194-200. doi: 10.1093/nar/gkw266. Epub 2016 Apr 20.

35.

Influence of osteoclasts and osteoprotegerin on the mode of calcific degeneration of aortic valves.

Lis GJ, Czubek U, Jasek-Gajda E, Łoboda A, Dulak J, Nessler J, Kapelak B, Sadowski J, Litwin JA.

Pol Arch Med Wewn. 2016;126(3):149-58. doi: 10.20452/pamw.3326. Epub 2016 Mar 22.

36.

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies.

O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, Bloecher A, Shumway SD.

Mol Cancer Ther. 2016 Jun;15(6):1155-62. doi: 10.1158/1535-7163.MCT-15-0843. Epub 2016 Mar 16.

37.

An accessible pharmacodynamic transcriptional biomarker for notch target engagement.

Tanis KQ, Podtelezhnikov AA, Blackman SC, Hing J, Railkar RA, Lunceford J, Klappenbach JA, Wei B, Harman A, Camargo LM, Shah S, Finney EM, Hardwick JS, Loboda A, Watters J, Bergstrom DA, Demuth T, Herman GA, Strack PR, Iannone R.

Clin Pharmacol Ther. 2016 Apr;99(4):370-80. doi: 10.1002/cpt.335. Epub 2016 Feb 17.

PMID:
26765077
38.

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination.

Fourati S, Cristescu R, Loboda A, Talla A, Filali A, Railkar R, Schaeffer AK, Favre D, Gagnon D, Peretz Y, Wang IM, Beals CR, Casimiro DR, Carayannopoulos LN, Sékaly RP.

Nat Commun. 2016 Jan 8;7:10369. doi: 10.1038/ncomms10369.

39.

Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.

Muise ES, Podtelezhnikov AA, Pickarski M, Loboda A, Tan Y, Hu G, Thomspon JR, Duong le T.

J Bone Miner Res. 2016 Apr;31(4):839-51. doi: 10.1002/jbmr.2752. Epub 2016 Jan 8.

40.

Letter by Loboda et al Regarding Article, "Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis": IL-8 Is Not Present in Murine Genome Hence it Cannot Be Responsible for the Bach1 Effect on Angiogenesis in Mice.

Loboda A, Florczyk U, Jazwa A, Grochot-Przeczek A, Nowak W, Jozkowicz A, Dulak J.

Circ Res. 2015 Oct 9;117(9):e75-6. doi: 10.1161/CIRCRESAHA.115.307450. No abstract available.

PMID:
26450896
41.

A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome.

Schell MJ, Yang M, Missiaglia E, Delorenzi M, Soneson C, Yue B, Nebozhyn MV, Loboda A, Bloom G, Yeatman TJ.

Clin Cancer Res. 2016 Feb 1;22(3):734-45. doi: 10.1158/1078-0432.CCR-15-0143. Epub 2015 Oct 7.

42.

Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster.

Damulewicz M, Loboda A, Bukowska-Strakova K, Jozkowicz A, Dulak J, Pyza E.

Front Cell Neurosci. 2015 Sep 15;9:353. doi: 10.3389/fncel.2015.00353. eCollection 2015.

43.

A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer.

Sclafani F, Kim TY, Cunningham D, Kim TW, Tabernero J, Schmoll HJ, Roh JK, Kim SY, Park YS, Guren TK, Hawkes E, Clarke SJ, Ferry D, Frödin JE, Ayers M, Nebozhyn M, Peckitt C, Loboda A, Mauro DJ, Watkins DJ.

J Natl Cancer Inst. 2015 Sep 23;107(12):djv258. doi: 10.1093/jnci/djv258. Print 2015 Dec.

PMID:
26405092
44.

HO-1/CO system in tumor growth, angiogenesis and metabolism - Targeting HO-1 as an anti-tumor therapy.

Loboda A, Jozkowicz A, Dulak J.

Vascul Pharmacol. 2015 Nov;74:11-22. doi: 10.1016/j.vph.2015.09.004. Epub 2015 Sep 25. Review.

PMID:
26392237
45.

Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.

Geeleher P, Loboda A, Lenkala D, Wang F, LaCroix B, Karovic S, Wang J, Nebozhyn M, Chisamore M, Hardwick J, Maitland ML, Huang RS.

J Natl Cancer Inst. 2015 Aug 21;107(11). pii: djv247. doi: 10.1093/jnci/djv247. Print 2015 Nov.

46.

Carbon monoxide: pro- or anti-angiogenic agent? Comment on Ahmad et al. (Thromb Haemost 2015; 113: 329-337).

Loboda A, Jozkowicz A, Dulak J.

Thromb Haemost. 2015 Aug;114(2):432-3. doi: 10.1160/TH15-01-0082. Epub 2015 Apr 23. No abstract available.

PMID:
25904352
47.

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, Liu J, Yue YG, Wang J, Yu K, Ye XS, Do IG, Liu S, Gong L, Fu J, Jin JG, Choi MG, Sohn TS, Lee JH, Bae JM, Kim ST, Park SH, Sohn I, Jung SH, Tan P, Chen R, Hardwick J, Kang WK, Ayers M, Hongyue D, Reinhard C, Loboda A, Kim S, Aggarwal A.

Nat Med. 2015 May;21(5):449-56. doi: 10.1038/nm.3850. Epub 2015 Apr 20.

PMID:
25894828
48.

Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients.

MacIsaac KD, Baumgartner R, Kang J, Loboda A, Peterfy C, DiCarlo J, Riek J, Beals C.

PLoS One. 2014 Dec 12;9(12):e113937. doi: 10.1371/journal.pone.0113937. eCollection 2014.

49.

Comment on "role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells".

Loboda A, Jozkowicz A, Dulak J.

Toxicology. 2015 Feb 3;328:82-3. doi: 10.1016/j.tox.2014.12.002. Epub 2014 Dec 4. No abstract available.

PMID:
25483801
50.

Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing.

Wong SS, Kim KM, Ting JC, Yu K, Fu J, Liu S, Cristescu R, Nebozhyn M, Gong L, Yue YG, Wang J, Ronghua C, Loboda A, Hardwick J, Liu X, Dai H, Jin JG, Ye XS, Kang SY, Do IG, Park JO, Sohn TS, Reinhard C, Lee J, Kim S, Aggarwal A.

Nat Commun. 2014 Nov 19;5:5477. doi: 10.1038/ncomms6477.

PMID:
25407104

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