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Items: 1 to 50 of 69

1.

CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer.

Bailey CG, Metierre C, Feng Y, Baidya K, Filippova GN, Loukinov DI, Lobanenkov VV, Semaan C, Rasko JE.

Int J Mol Sci. 2018 Nov 30;19(12). pii: E3832. doi: 10.3390/ijms19123832.

2.

Discovering a binary CTCF code with a little help from BORIS.

Lobanenkov VV, Zentner GE.

Nucleus. 2018 Jan 1;9(1):33-41. doi: 10.1080/19491034.2017.1394536. Epub 2017 Dec 5.

3.

Corrigendum: Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.

Rivero-Hinojosa S, Kang S, Lobanenkov VV, Zentner GE.

Sci Rep. 2017 Aug 4;7:46891. doi: 10.1038/srep46891.

4.

Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.

Rivero-Hinojosa S, Kang S, Lobanenkov VV, Zentner GE.

Sci Rep. 2017 Feb 1;7:41279. doi: 10.1038/srep41279. Erratum in: Sci Rep. 2017 Aug 04;7:46891.

5.

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions.

Pugacheva EM, Rivero-Hinojosa S, Espinoza CA, Méndez-Catalá CF, Kang S, Suzuki T, Kosaka-Suzuki N, Robinson S, Nagarajan V, Ye Z, Boukaba A, Rasko JE, Strunnikov AV, Loukinov D, Ren B, Lobanenkov VV.

Genome Biol. 2015 Aug 14;16:161. doi: 10.1186/s13059-015-0736-8.

6.

Chromatin architecture reorganization during stem cell differentiation.

Dixon JR, Jung I, Selvaraj S, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B.

Nature. 2015 Feb 19;518(7539):331-6. doi: 10.1038/nature14222.

7.

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

Kemp CJ, Moore JM, Moser R, Bernard B, Teater M, Smith LE, Rabaia NA, Gurley KE, Guinney J, Busch SE, Shaknovich R, Lobanenkov VV, Liggitt D, Shmulevich I, Melnick A, Filippova GN.

Cell Rep. 2014 May 22;7(4):1020-9. doi: 10.1016/j.celrep.2014.04.004. Epub 2014 May 1.

8.

A map of the cis-regulatory sequences in the mouse genome.

Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, Ren B.

Nature. 2012 Aug 2;488(7409):116-20. doi: 10.1038/nature11243.

9.

Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos.

Moore JM, Rabaia NA, Smith LE, Fagerlie S, Gurley K, Loukinov D, Disteche CM, Collins SJ, Kemp CJ, Lobanenkov VV, Filippova GN.

PLoS One. 2012;7(4):e34915. doi: 10.1371/journal.pone.0034915. Epub 2012 Apr 20.

10.

Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency.

Hawkins RD, Hon GC, Yang C, Antosiewicz-Bourget JE, Lee LK, Ngo QM, Klugman S, Ching KA, Edsall LE, Ye Z, Kuan S, Yu P, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Ren B.

Cell Res. 2011 Oct;21(10):1393-409. doi: 10.1038/cr.2011.146. Epub 2011 Aug 30.

11.

Histone modifications at human enhancers reflect global cell-type-specific gene expression.

Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B.

Nature. 2009 May 7;459(7243):108-12. doi: 10.1038/nature07829. Epub 2009 Mar 18.

12.

DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice.

Mkrtichyan M, Ghochikyan A, Loukinov D, Davtyan H, Ichim TE, Cribbs DH, Lobanenkov VV, Agadjanyan MG.

Gene Ther. 2008 Jan;15(1):61-4. Epub 2007 Nov 1.

13.

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome.

Kim TH, Abdullaev ZK, Smith AD, Ching KA, Loukinov DI, Green RD, Zhang MQ, Lobanenkov VV, Ren B.

Cell. 2007 Mar 23;128(6):1231-45.

14.

Interspecies comparative genomic hybridization (I-CGH): a new twist to study animal tumor models.

Jaikumar S, Zhuang Z, Mannan P, Vortmeyer AO, Furuta M, Dickerman R, Bedanova J, Lonser RR, Walbridge S, Weil RJ, Lobanenkov VV, Oldfield EH, Pack SD.

Cell Cycle. 2007 Apr 1;6(7):836-42. Epub 2007 Apr 25.

PMID:
17377495
15.

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.

Fitzpatrick GV, Pugacheva EM, Shin JY, Abdullaev Z, Yang Y, Khatod K, Lobanenkov VV, Higgins MJ.

Mol Cell Biol. 2007 Apr;27(7):2636-47. Epub 2007 Jan 22.

16.

A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.

Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, Dallosso AR, Klenova E, Loukinov D, Ohlsson R, Lobanenkov VV, Malik K.

Hum Mol Genet. 2007 Feb 1;16(3):343-54. Epub 2007 Jan 8.

PMID:
17210670
17.

Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.

Ghochikyan A, Mkrtichyan M, Loukinov D, Mamikonyan G, Pack SD, Movsesyan N, Ichim TE, Cribbs DH, Lobanenkov VV, Agadjanyan MG.

J Immunol. 2007 Jan 1;178(1):566-73.

18.

Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant.

Loukinov D, Ghochikyan A, Mkrtichyan M, Ichim TE, Lobanenkov VV, Cribbs DH, Agadjanyan MG.

J Cell Biochem. 2006 Aug 1;98(5):1037-43.

PMID:
16741971
19.

Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization.

Pugacheva EM, Kwon YW, Hukriede NA, Pack S, Flanagan PT, Ahn JC, Park JA, Choi KS, Kim KW, Loukinov D, Dawid IB, Lobanenkov VV.

Gene. 2006 Jun 21;375:26-36. Epub 2006 May 2.

PMID:
16647825
20.

Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker.

Yoon B, Herman H, Hu B, Park YJ, Lindroth A, Bell A, West AG, Chang Y, Stablewski A, Piel JC, Loukinov DI, Lobanenkov VV, Soloway PD.

Mol Cell Biol. 2005 Dec;25(24):11184-90.

21.

Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.

Hong JA, Kang Y, Abdullaev Z, Flanagan PT, Pack SD, Fischette MR, Adnani MT, Loukinov DI, Vatolin S, Risinger JI, Custer M, Chen GA, Zhao M, Nguyen DM, Barrett JC, Lobanenkov VV, Schrump DS.

Cancer Res. 2005 Sep 1;65(17):7763-74.

22.

Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes.

Vatolin S, Abdullaev Z, Pack SD, Flanagan PT, Custer M, Loukinov DI, Pugacheva E, Hong JA, Morse H 3rd, Schrump DS, Risinger JI, Barrett JC, Lobanenkov VV.

Cancer Res. 2005 Sep 1;65(17):7751-62.

23.

Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation.

Pugacheva EM, Tiwari VK, Abdullaev Z, Vostrov AA, Flanagan PT, Quitschke WW, Loukinov DI, Ohlsson R, Lobanenkov VV.

Hum Mol Genet. 2005 Apr 1;14(7):953-65. Epub 2005 Feb 24.

PMID:
15731119
24.

Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.

Garrett FE, Emelyanov AV, Sepulveda MA, Flanagan P, Volpi S, Li F, Loukinov D, Eckhardt LA, Lobanenkov VV, Birshtein BK.

Mol Cell Biol. 2005 Feb;25(4):1511-25.

25.

CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells.

Qi CF, Martensson A, Mattioli M, Dalla-Favera R, Lobanenkov VV, Morse HC 3rd.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):633-8. Epub 2003 Jan 10.

26.

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer.

Klenova EM, Morse HC 3rd, Ohlsson R, Lobanenkov VV.

Semin Cancer Biol. 2002 Oct;12(5):399-414. Review.

PMID:
12191639
27.

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.

Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C, Vostrov AA, Cui H, Niemitz EL, Rasko JE, Docquier FM, Kistler M, Breen JJ, Zhuang Z, Quitschke WW, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse HC 3rd, Lobanenkov VV.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11.

28.

Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.

Filippova GN, Qi CF, Ulmer JE, Moore JM, Ward MD, Hu YJ, Loukinov DI, Pugacheva EM, Klenova EM, Grundy PE, Feinberg AP, Cleton-Jansen AM, Moerland EW, Cornelisse CJ, Suzuki H, Komiya A, Lindblom A, Dorion-Bonnet F, Neiman PE, Morse HC 3rd, Collins SJ, Lobanenkov VV.

Cancer Res. 2002 Jan 1;62(1):48-52.

29.

Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF.

Rasko JE, Klenova EM, Leon J, Filippova GN, Loukinov DI, Vatolin S, Robinson AF, Hu YJ, Ulmer J, Ward MD, Pugacheva EM, Neiman PE, Morse HC 3rd, Collins SJ, Lobanenkov VV.

Cancer Res. 2001 Aug 15;61(16):6002-7.

30.

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus.

Filippova GN, Thienes CP, Penn BH, Cho DH, Hu YJ, Moore JM, Klesert TR, Lobanenkov VV, Tapscott SJ.

Nat Genet. 2001 Aug;28(4):335-43.

PMID:
11479593
31.

Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.

Cui H, Niemitz EL, Ravenel JD, Onyango P, Brandenburg SA, Lobanenkov VV, Feinberg AP.

Cancer Res. 2001 Jul 1;61(13):4947-50.

32.

Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF.

Klenova EM, Chernukhin IV, El-Kady A, Lee RE, Pugacheva EM, Loukinov DI, Goodwin GH, Delgado D, Filippova GN, León J, Morse HC 3rd, Neiman PE, Lobanenkov VV.

Mol Cell Biol. 2001 Mar;21(6):2221-34.

33.

Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF.

Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM.

J Biol Chem. 2000 Sep 22;275(38):29915-21.

34.

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive.

Kanduri C, Pant V, Loukinov D, Pugacheva E, Qi CF, Wolffe A, Ohlsson R, Lobanenkov VV.

Curr Biol. 2000 Jul 13;10(14):853-6.

35.

Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence.

Awad TA, Bigler J, Ulmer JE, Hu YJ, Moore JM, Lutz M, Neiman PE, Collins SJ, Renkawitz R, Lobanenkov VV, Filippova GN.

J Biol Chem. 1999 Sep 17;274(38):27092-8.

36.

Characterization of the chicken CTCF genomic locus, and initial study of the cell cycle-regulated promoter of the gene.

Klenova EM, Fagerlie S, Filippova GN, Kretzner L, Goodwin GH, Loring G, Neiman PE, Lobanenkov VV.

J Biol Chem. 1998 Oct 9;273(41):26571-9.

37.
38.

Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.

Burcin M, Arnold R, Lutz M, Kaiser B, Runge D, Lottspeich F, Filippova GN, Lobanenkov VV, Renkawitz R.

Mol Cell Biol. 1997 Mar;17(3):1281-8.

40.

Molecular pathogenesis of myc-initiated B-cell lymphomas in the bursa of Fabricius.

Neiman PE, Clurman BE, Lobanenkov VV.

Curr Top Microbiol Immunol. 1997;224:231-8. No abstract available.

PMID:
9308246
41.

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G, Neiman PE, Collins SJ, Lobanenkov VV.

Mol Cell Biol. 1996 Jun;16(6):2802-13.

42.

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.

Klenova EM, Nicolas RH, Paterson HF, Carne AF, Heath CM, Goodwin GH, Neiman PE, Lobanenkov VV.

Mol Cell Biol. 1993 Dec;13(12):7612-24.

43.

Isolation of a cDNA clone encoding the RNase-superfamily-related gene highly expressed in chicken bone marrow cells.

Klenova EM, Botezato I, Laudet V, Goodwin GH, Wallace JC, Lobanenkov VV.

Biochem Biophys Res Commun. 1992 May 29;185(1):231-9.

PMID:
1599460
44.

[Regulatory protein factor CTCF interacts with a segment of the chicken c-myc oncogene promotor, capable of changing to a noncanonical conformation].

Tevosian SG, Gromova ES, Adler VV, Lobanenkov VV.

Mol Biol (Mosk). 1991 Jul-Aug;25(4):1013-23. Russian.

PMID:
1795697
45.

[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777].

Adler VV, Kiseleva NP, Kistanova EN, Klenova EM, Lobanenkov VV, Polotskaia AV, Tevosian SG.

Mol Biol (Mosk). 1991 Mar-Apr;25(2):431-41. Russian.

PMID:
1679193
46.

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene.

Lobanenkov VV, Nicolas RH, Adler VV, Paterson H, Klenova EM, Polotskaja AV, Goodwin GH.

Oncogene. 1990 Dec;5(12):1743-53.

PMID:
2284094
47.

[Multiple DNA recognition sites by sequence-specific DNA-binding proteins in the region of replication initiation site located 5-end upstream to the chicken alpha-globin gene domain].

Kintsurashvili EG, Adler VV, Klenova EM, Lobanenkov VV, Razin SV.

Dokl Akad Nauk SSSR. 1990 Jan-Feb;310(1):227-8. Russian. No abstract available.

PMID:
2338045
48.

[Nuclear factor A5 from the rat liver that requires a metal for specific interaction in vitro with distal element of the tyrosine aminotransferase gene promoter].

Klenova EM, Polotskaia AV, Adler VV, Gorodetskiĭ SI, Gribanovskiĭ VA, Lobanenkov VV.

Mol Biol (Mosk). 1989 Sep-Oct;23(5):1416-27. Russian.

PMID:
2575211
49.

[Specific interaction of a nuclear protein factor from the CTF/NF-I family with 2 different promoter regions of the rat tyrosine aminotransferase gene].

Klenova EM, Adler VV, Gribanovskiĭ VA, Gorodetskiĭ SI, Bogdanova NN, Lobanenkov VV.

Mol Biol (Mosk). 1989 Sep-Oct;23(5):1400-15. Russian.

PMID:
2575210
50.

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