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Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial.

Hull MA, Sprange K, Hepburn T, Tan W, Shafayat A, Rees CJ, Clifford G, Logan RF, Loadman PM, Williams EA, Whitham D, Montgomery AA; seAFOod Collaborative Group.

Lancet. 2018 Dec 15;392(10164):2583-2594. doi: 10.1016/S0140-6736(18)31775-6. Epub 2018 Nov 19.


A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota.

Watson H, Mitra S, Croden FC, Taylor M, Wood HM, Perry SL, Spencer JA, Quirke P, Toogood GJ, Lawton CL, Dye L, Loadman PM, Hull MA.

Gut. 2018 Nov;67(11):1974-1983. doi: 10.1136/gutjnl-2017-314968. Epub 2017 Sep 26.


A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival.

Mohanty S, Chen Z, Li K, Morais GR, Klockow J, Yerneni K, Pisani L, Chin FT, Mitra S, Cheshier S, Chang E, Gambhir SS, Rao J, Loadman PM, Falconer RA, Daldrup-Link HE.

Mol Cancer Ther. 2017 Sep;16(9):1909-1921. doi: 10.1158/1535-7163.MCT-17-0022. Epub 2017 Jun 28.


Drug delivery in a tumour cord model: a computational simulation.

Hubbard ME, Jove M, Loadman PM, Phillips RM, Twelves CJ, Smye SW.

R Soc Open Sci. 2017 May 24;4(5):170014. doi: 10.1098/rsos.170014. eCollection 2017 May.


Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs.

Jain M, Harburn JJ, Gill JH, Loadman PM, Falconer RA, Mooney CA, Cobb SL, Berry DJ.

J Med Chem. 2017 May 25;60(10):4496-4502. doi: 10.1021/acs.jmedchem.6b01472. Epub 2017 May 10.


A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples.

Volpato M, Spencer JA, Race AD, Munarini A, Belluzzi A, Cockbain AJ, Hull MA, Loadman PM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jun 15;1055-1056:125-134. doi: 10.1016/j.jchromb.2017.04.030. Epub 2017 Apr 24.


Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases.

Watson H, Cockbain AJ, Spencer J, Race A, Volpato M, Loadman PM, Toogood GJ, Hull MA.

Prostaglandins Leukot Essent Fatty Acids. 2016 Dec;115:60-66. doi: 10.1016/j.plefa.2016.10.003. Epub 2016 Oct 7.


Long-Term Plasticity in Reflex Excitability Induced by Five Weeks of Arm and Leg Cycling Training after Stroke.

Klarner T, Barss TS, Sun Y, Kaupp C, Loadman PM, Zehr EP.

Brain Sci. 2016 Nov 3;6(4). pii: E54.


Neuromechanical interactions between the limbs during human locomotion: an evolutionary perspective with translation to rehabilitation.

Zehr EP, Barss TS, Dragert K, Frigon A, Vasudevan EV, Haridas C, Hundza S, Kaupp C, Klarner T, Klimstra M, Komiyama T, Loadman PM, Mezzarane RA, Nakajima T, Pearcey GE, Sun Y.

Exp Brain Res. 2016 Nov;234(11):3059-3081. Epub 2016 Jul 15. Review.


Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment.

Elkashef SM, Allison SJ, Sadiq M, Basheer HA, Ribeiro Morais G, Loadman PM, Pors K, Falconer RA.

Sci Rep. 2016 Sep 9;6:33026. doi: 10.1038/srep33026.


An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity.

Elkashef SM, Sutherland M, Patterson LH, Loadman PM, Falconer RA.

Analyst. 2016 Oct 21;141(20):5849-5856. Epub 2016 Aug 12.


Exploiting Interlimb Arm and Leg Connections for Walking Rehabilitation: A Training Intervention in Stroke.

Klarner T, Barss TS, Sun Y, Kaupp C, Loadman PM, Zehr EP.

Neural Plast. 2016;2016:1517968. doi: 10.1155/2016/1517968. Epub 2016 Jun 23.


Proteases in cancer drug delivery.

Vandooren J, Opdenakker G, Loadman PM, Edwards DR.

Adv Drug Deliv Rev. 2016 Feb 1;97:144-55. doi: 10.1016/j.addr.2015.12.020. Epub 2016 Jan 3. Review.


Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota.

Piazzi G, D'Argenio G, Prossomariti A, Lembo V, Mazzone G, Candela M, Biagi E, Brigidi P, Vitaglione P, Fogliano V, D'Angelo L, Fazio C, Munarini A, Belluzzi A, Ceccarelli C, Chieco P, Balbi T, Loadman PM, Hull MA, Romano M, Bazzoli F, Ricciardiello L.

Int J Cancer. 2014 Nov 1;135(9):2004-13. doi: 10.1002/ijc.28853. Epub 2014 Mar 28.


Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity.

Gill JH, Loadman PM, Shnyder SD, Cooper P, Atkinson JM, Ribeiro Morais G, Patterson LH, Falconer RA.

Mol Pharm. 2014 Apr 7;11(4):1294-300. doi: 10.1021/mp400760b. Epub 2014 Mar 27.


Mathematical and computational models of drug transport in tumours.

Groh CM, Hubbard ME, Jones PF, Loadman PM, Periasamy N, Sleeman BD, Smye SW, Twelves CJ, Phillips RM.

J R Soc Interface. 2014 Mar 12;11(94):20131173. doi: 10.1098/rsif.2013.1173. Print 2014 May 6.


Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid.

Cockbain AJ, Volpato M, Race AD, Munarini A, Fazio C, Belluzzi A, Loadman PM, Toogood GJ, Hull MA.

Gut. 2014 Nov;63(11):1760-8. doi: 10.1136/gutjnl-2013-306445. Epub 2014 Jan 27.


Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy.

Ansari C, Tikhomirov GA, Hong SH, Falconer RA, Loadman PM, Gill JH, Castaneda R, Hazard FK, Tong L, Lenkov OD, Felsher DW, Rao J, Daldrup-Link HE.

Small. 2014 Feb 12;10(3):566-75, 417. doi: 10.1002/smll.201301456. Epub 2013 Aug 27.


Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration.

Al-Saraireh YM, Sutherland M, Springett BR, Freiberger F, Ribeiro Morais G, Loadman PM, Errington RJ, Smith PJ, Fukuda M, Gerardy-Schahn R, Patterson LH, Shnyder SD, Falconer RA.

PLoS One. 2013 Aug 9;8(8):e73366. doi: 10.1371/journal.pone.0073366. eCollection 2013.


Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K.

J Med Chem. 2013 Aug 8;56(15):6273-7. doi: 10.1021/jm4000209. Epub 2013 Jul 26.


Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass.

Kant P, Perry SL, Dexter SP, Race AD, Loadman PM, Hull MA.

Obesity (Silver Spring). 2014 Jan;22(1):202-10. doi: 10.1002/oby.20493.


Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.

Travica S, Pors K, Loadman PM, Shnyder SD, Johansson I, Alandas MN, Sheldrake HM, Mkrtchian S, Patterson LH, Ingelman-Sundberg M.

Clin Cancer Res. 2013 Jun 1;19(11):2952-61. doi: 10.1158/1078-0432.CCR-13-0238. Epub 2013 Apr 15.


Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.

Cosentino L, Redondo-Horcajo M, Zhao Y, Santos AR, Chowdury KF, Vinader V, Abdallah QM, Abdel-Rahman H, Fournier-Dit-Chabert J, Shnyder SD, Loadman PM, Fang WS, Díaz JF, Barasoain I, Burns PA, Pors K.

J Med Chem. 2012 Dec 27;55(24):11062-6. doi: 10.1021/jm301151t. Epub 2012 Dec 7.


Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

Fournier-Dit-Chabert J, Vinader V, Santos AR, Redondo-Horcajo M, Dreneau A, Basak R, Cosentino L, Marston G, Abdel-Rahman H, Loadman PM, Shnyder SD, Díaz JF, Barasoain I, Falconer RA, Pors K.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7693-6. doi: 10.1016/j.bmcl.2012.09.104. Epub 2012 Oct 10.


Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH.

Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1.


FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms.

Tomlinson DC, Baxter EW, Loadman PM, Hull MA, Knowles MA.

PLoS One. 2012;7(6):e38972. doi: 10.1371/journal.pone.0038972. Epub 2012 Jun 12.


Neural control of rhythmic arm cycling after stroke.

Zehr EP, Loadman PM, Hundza SR.

J Neurophysiol. 2012 Aug 1;108(3):891-905. doi: 10.1152/jn.01152.2011. Epub 2012 May 9.


The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.

Hawcroft G, Volpato M, Marston G, Ingram N, Perry SL, Cockbain AJ, Race AD, Munarini A, Belluzzi A, Loadman PM, Coletta PL, Hull MA.

Br J Pharmacol. 2012 Jul;166(5):1724-37. doi: 10.1111/j.1476-5381.2012.01882.x.


Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.

Pors K, Loadman PM, Shnyder SD, Sutherland M, Sheldrake HM, Guino M, Kiakos K, Hartley JA, Searcey M, Patterson LH.

Chem Commun (Camb). 2011 Nov 28;47(44):12062-4. doi: 10.1039/c1cc15638a. Epub 2011 Oct 14.


Persistence of locomotor-related interlimb reflex networks during walking after stroke.

Zehr EP, Loadman PM.

Clin Neurophysiol. 2012 Apr;123(4):796-807. doi: 10.1016/j.clinph.2011.07.049. Epub 2011 Sep 23.


Use of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research.

Bateson H, Saleem S, Loadman PM, Sutton CW.

J Pharmacol Toxicol Methods. 2011 Nov-Dec;64(3):197-206. doi: 10.1016/j.vascn.2011.04.003. Epub 2011 Apr 22. Review.


Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Benelkebir H, Marie S, Hayden AL, Lyle J, Loadman PM, Crabb SJ, Packham G, Ganesan A.

Bioorg Med Chem. 2011 Jun 15;19(12):3650-8. doi: 10.1016/j.bmc.2011.02.024. Epub 2011 Feb 17.


Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.

Atkinson JM, Falconer RA, Edwards DR, Pennington CJ, Siller CS, Shnyder SD, Bibby MC, Patterson LH, Loadman PM, Gill JH.

Cancer Res. 2010 Sep 1;70(17):6902-12. doi: 10.1158/0008-5472.CAN-10-1440. Epub 2010 Jul 27.


Context-dependent modulation of cutaneous reflex amplitudes during forward and backward leg cycling.

Zehr EP, Hundza SR, Balter JE, Loadman PM.

Motor Control. 2009 Oct;13(4):368-86.


In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

Williams KJ, Albertella MR, Fitzpatrick B, Loadman PM, Shnyder SD, Chinje EC, Telfer BA, Dunk CR, Harris PA, Stratford IJ.

Mol Cancer Ther. 2009 Dec;8(12):3266-75. doi: 10.1158/1535-7163.MCT-09-0396.


Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections.

Djidja MC, Francese S, Loadman PM, Sutton CW, Scriven P, Claude E, Snel MF, Franck J, Salzet M, Clench MR.

Proteomics. 2009 May;9(10):2750-63. doi: 10.1002/pmic.200800624.


A mathematical model of doxorubicin penetration through multicellular layers.

Evans CJ, Phillips RM, Jones PF, Loadman PM, Sleeman BD, Twelves CJ, Smye SW.

J Theor Biol. 2009 Apr 21;257(4):598-608. doi: 10.1016/j.jtbi.2008.11.031. Epub 2009 Jan 4. Erratum in: J Theor Biol. 2011 Mar 21;273(1):235.


Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging.

Djidja MC, Carolan V, Loadman PM, Clench MR.

Rapid Commun Mass Spectrom. 2008 May;22(10):1615-8. doi: 10.1002/rcm.3503. No abstract available.


Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study.

Albertella MR, Loadman PM, Jones PH, Phillips RM, Rampling R, Burnet N, Alcock C, Anthoney A, Vjaters E, Dunk CR, Harris PA, Wong A, Lalani AS, Twelves CJ.

Clin Cancer Res. 2008 Feb 15;14(4):1096-104. doi: 10.1158/1078-0432.CCR-07-4020.


Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.

Wells G, Suggitt M, Coffils M, Baig MA, Howard PW, Loadman PM, Hartley JA, Jenkins TC, Thurston DE.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2147-51. doi: 10.1016/j.bmcl.2008.01.083. Epub 2008 Jan 30.


Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

Volpato M, Abou-Zeid N, Tanner RW, Glassbrook LT, Taylor J, Stratford I, Loadman PM, Jaffar M, Phillips RM.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3122-30.


Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

Atkinson JM, Pennington CJ, Martin SW, Anikin VA, Mearns AJ, Loadman PM, Edwards DR, Gill JH.

Eur J Cancer. 2007 Jul;43(11):1764-71. Epub 2007 Jun 27.


Neural regulation of rhythmic arm and leg movement is conserved across human locomotor tasks.

Zehr EP, Balter JE, Ferris DP, Hundza SR, Loadman PM, Stoloff RH.

J Physiol. 2007 Jul 1;582(Pt 1):209-27. Epub 2007 Apr 26.


The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study.

Steward WP, Middleton M, Benghiat A, Loadman PM, Hayward C, Waller S, Ford S, Halbert G, Patterson LH, Talbot D.

Ann Oncol. 2007 Jun;18(6):1098-103. Epub 2007 Apr 17.


Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).

Burger AM, Loadman PM, Thurston DE, Schultz R, Fiebig HH, Bibby MC.

J Chemother. 2007 Feb;19(1):66-78.


Rhythmic arm cycling produces a non-specific signal that suppresses Soleus H-reflex amplitude in stationary legs.

Loadman PM, Zehr EP.

Exp Brain Res. 2007 May;179(2):199-208. Epub 2006 Nov 22.


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