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Items: 1 to 50 of 104

1.

Mechanisms of soft and hard electrophile toxicities.

LoPachin RM, Geohagen BC, Nordstroem LU.

Toxicology. 2019 Apr 15;418:62-69. doi: 10.1016/j.tox.2019.02.005. Epub 2019 Feb 28. Review.

PMID:
30826385
2.

Phloretin cytoprotection and toxicity.

Geohagen BC, Korsharskyy B, Vydyanatha A, Nordstroem L, LoPachin RM.

Chem Biol Interact. 2018 Dec 25;296:117-123. doi: 10.1016/j.cbi.2018.09.020. Epub 2018 Oct 1.

PMID:
30287234
3.

Enolate-Forming Compounds as a Novel Approach to Cytoprotection.

LoPachin RM, Geohagen BC, Nordstrøm LU, Gavin T.

Chem Res Toxicol. 2016 Dec 19;29(12):2096-2107. Epub 2016 Dec 6. Review.

PMID:
27989140
4.

Joint toxic effects of the type-2 alkene electrophiles.

Zhang L, Geohagen BC, Gavin T, LoPachin RM.

Chem Biol Interact. 2016 Jul 25;254:198-206. doi: 10.1016/j.cbi.2016.06.014. Epub 2016 Jun 8.

5.

Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity.

Geohagen BC, Vydyanathan A, Kosharskyy B, Shaparin N, Gavin T, LoPachin RM.

J Pharmacol Exp Ther. 2016 Jun;357(3):476-86. doi: 10.1124/jpet.115.231001. Epub 2016 Mar 30.

6.

Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation.

LoPachin RM, Gavin T.

Free Radic Res. 2016;50(2):195-205. doi: 10.3109/10715762.2015.1094184. Epub 2015 Nov 11. Review.

7.

Protein adduct formation initiates acrolein-induced endothelial cell toxicity.

LoPachin RM, Gavin T.

Toxicol Sci. 2015 Mar;144(1):2-3. doi: 10.1093/toxsci/kfu314. No abstract available.

8.

2-Acetylcyclopentanone, an enolate-forming 1,3-dicarbonyl compound, is cytoprotective in warm ischemia-reperfusion injury of rat liver.

Kosharskyy B, Vydyanathan A, Zhang L, Shaparin N, Geohagen BC, Bivin W, Liu Q, Gavin T, LoPachin RM.

J Pharmacol Exp Ther. 2015 Apr;353(1):150-8. doi: 10.1124/jpet.114.221622. Epub 2015 Feb 6.

9.

Toxic neuropathies: Mechanistic insights based on a chemical perspective.

LoPachin RM, Gavin T.

Neurosci Lett. 2015 Jun 2;596:78-83. doi: 10.1016/j.neulet.2014.08.054. Epub 2014 Sep 16. Review.

10.

Molecular mechanisms of aldehyde toxicity: a chemical perspective.

LoPachin RM, Gavin T.

Chem Res Toxicol. 2014 Jul 21;27(7):1081-91. doi: 10.1021/tx5001046. Epub 2014 Jun 17. Review.

11.

Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.

Zhang L, Gavin T, Geohagen BC, Liu Q, Downey KJ, LoPachin RM.

J Pharmacol Exp Ther. 2013 Aug;346(2):259-69. doi: 10.1124/jpet.113.205435. Epub 2013 Jun 12.

12.

Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells.

Martyniuk CJ, Feswick A, Fang B, Koomen JM, Barber DS, Gavin T, Lopachin RM.

Toxicol Lett. 2013 Jun 7;219(3):279-87. doi: 10.1016/j.toxlet.2013.03.031. Epub 2013 Apr 6.

13.

Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry.

LoPachin RM, Gavin T.

Environ Health Perspect. 2012 Dec;120(12):1650-7. doi: 10.1289/ehp.1205432. Epub 2012 Oct 11. Review.

14.

Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by α,β-unsaturated carbonyl derivatives.

Martyniuk CJ, Fang B, Koomen JM, Gavin T, Zhang L, Barber DS, Lopachin RM.

Chem Res Toxicol. 2011 Dec 19;24(12):2302-11. doi: 10.1021/tx200437y. Epub 2011 Nov 29.

15.

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

Lopachin RM, Gavin T, Decaprio A, Barber DS.

Chem Res Toxicol. 2012 Feb 20;25(2):239-51. doi: 10.1021/tx2003257. Epub 2011 Nov 16. Review.

16.

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.

Zhang L, Gavin T, Barber DS, LoPachin RM.

Toxicol Lett. 2011 Aug 10;205(1):1-7. doi: 10.1016/j.toxlet.2011.04.011. Epub 2011 Apr 21.

17.

β-dicarbonyl enolates: a new class of neuroprotectants.

LoPachin RM, Gavin T, Geohagen BC, Zhang L, Casper D, Lekhraj R, Barber DS.

J Neurochem. 2011 Jan;116(1):132-43. doi: 10.1111/j.1471-4159.2010.07091.x. Epub 2010 Dec 2.

18.

Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons.

Zhang L, Gavin T, DeCaprio AP, LoPachin RM.

Toxicol Sci. 2010 Sep;117(1):180-9. doi: 10.1093/toxsci/kfq176. Epub 2010 Jun 16.

19.

Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.

LoPachin RM, Gavin T, Petersen DR, Barber DS.

Chem Res Toxicol. 2009 Sep;22(9):1499-508. doi: 10.1021/tx900147g. Review.

20.

Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.

DeCaprio AP, Kinney EA, LoPachin RM.

J Toxicol Environ Health A. 2009;72(14):861-9. doi: 10.1080/15287390902959508.

PMID:
19557614
21.

Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.

Lopachin RM, Geohagen BC, Gavin T.

Toxicol Sci. 2009 Jan;107(1):171-81. doi: 10.1093/toxsci/kfn226. Epub 2008 Nov 7.

22.

Acrylamide-induced nerve terminal damage: relevance to neurotoxic and neurodegenerative mechanisms.

Lopachin RM, Gavin T.

J Agric Food Chem. 2008 Aug 13;56(15):5994-6003. doi: 10.1021/jf703745t. Epub 2008 Jul 15. Review.

PMID:
18624437
23.

Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases.

Lopachin RM, Gavin T, Barber DS.

Neurotoxicology. 2008 Sep;29(5):871-82. doi: 10.1016/j.neuro.2008.04.016. Epub 2008 May 3. Review.

PMID:
18582500
24.

Response to "Paraquat: the red herring of Parkinson's disease research".

LoPachin RM, Gavin T.

Toxicol Sci. 2008 May;103(1):219-21; author reply 222-3. doi: 10.1093/toxsci/kfn028. Epub 2008 Feb 27. No abstract available.

PMID:
18308704
25.
26.

Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate.

Barber DS, Stevens S, LoPachin RM.

Toxicol Sci. 2007 Nov;100(1):156-67. Epub 2007 Aug 13.

PMID:
17698512
27.

Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters.

LoPachin RM, Gavin T, Geohagen BC, Das S.

Toxicol Sci. 2007 Aug;98(2):561-70. Epub 2007 May 22.

PMID:
17519395
28.

Structure-toxicity analysis of type-2 alkenes: in vitro neurotoxicity.

Lopachin RM, Barber DS, Geohagen BC, Gavin T, He D, Das S.

Toxicol Sci. 2007 Jan;95(1):136-46. Epub 2006 Oct 5.

PMID:
17023561
29.

Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.

LoPachin RM, Barber DS.

Toxicol Sci. 2006 Dec;94(2):240-55. Epub 2006 Jul 31. Review.

PMID:
16880199
30.
31.

Acrylamide inhibits dopamine uptake in rat striatal synaptic vesicles.

LoPachin RM, Barber DS, He D, Das S.

Toxicol Sci. 2006 Jan;89(1):224-34. Epub 2005 Oct 5.

PMID:
16207938
32.

Gamma-Diketone central neuropathy: quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract.

Lopachin RM, Jortner BS, Reid ML, Monir A.

Neurotoxicology. 2005 Dec;26(6):1021-30. Epub 2005 Jun 17.

PMID:
15964632
33.

Protein adduct formation as a molecular mechanism in neurotoxicity.

Lopachin RM, Decaprio AP.

Toxicol Sci. 2005 Aug;86(2):214-25. Epub 2005 May 18. Review.

PMID:
15901921
34.

2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve.

LoPachin RM, He D, Reid ML.

Neurotoxicology. 2005 Mar;26(2):229-40.

PMID:
15713344
35.

Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes.

Barber DS, LoPachin RM.

Toxicol Appl Pharmacol. 2004 Dec 1;201(2):120-36.

PMID:
15541752
36.

gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction.

LoPachin RM, DeCaprio AP.

Toxicol Appl Pharmacol. 2004 Aug 15;199(1):20-34. Review.

PMID:
15289087
37.

Acrylamide toxicities and food safety: Session IV summary and research needs.

LoPachin RM, Canady RA.

Neurotoxicology. 2004 Jun;25(4):507-9. No abstract available.

PMID:
15264346
38.

2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions.

LoPachin RM, He D, Reid ML, Opanashuk LA.

Toxicol Appl Pharmacol. 2004 Jul 1;198(1):61-73.

PMID:
15207649
39.

The changing view of acrylamide neurotoxicity.

LoPachin RM.

Neurotoxicology. 2004 Jun;25(4):617-30. Review.

PMID:
15183015
40.

In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release.

LoPachin RM, Schwarcz AI, Gaughan CL, Mansukhani S, Das S.

Neurotoxicology. 2004 Mar;25(3):349-63.

PMID:
15019298
41.

Application of proteomics to the study of molecular mechanisms in neurotoxicology.

LoPachin RM, Jones RC, Patterson TA, Slikker W Jr, Barber DS.

Neurotoxicology. 2003 Dec;24(6):761-75. Review.

PMID:
14637371
42.

gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots.

LoPachin RM, Jortner BS, Reid ML, Das S.

Toxicol Appl Pharmacol. 2003 Nov 15;193(1):29-46.

PMID:
14613714
43.

Acrylamide axonopathy revisited.

LoPachin RM, Balaban CD, Ross JF.

Toxicol Appl Pharmacol. 2003 May 1;188(3):135-53. Review.

PMID:
12729714
44.

Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in forebrain.

Lehning EJ, Balaban CD, Ross JF, LoPachin RM.

Neurotoxicology. 2003 Jan;24(1):125-36.

PMID:
12564388
45.

Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord.

Lehning EJ, Balaban CD, Ross JF, LoPachin RM.

Neurotoxicology. 2003 Jan;24(1):109-23.

PMID:
12564387
46.

Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum.

Lehning EJ, Balaban CD, Ross JF, Reid MA, LoPachin RM.

Neurotoxicology. 2002 Sep;23(3):397-414.

PMID:
12387366
47.

The role of fast axonal transport in acrylamide pathophysiology: mechanism or epiphenomenon?

LoPachin RM.

Neurotoxicology. 2002 Jul;23(2):253-7; discussion 265-70. Review. No abstract available.

PMID:
12224765
48.

Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.

LoPachin RM, Ross JF, Reid ML, Das S, Mansukhani S, Lehning EJ.

Neurotoxicology. 2002 May;23(1):95-110.

PMID:
12164553
49.

Nerve terminals as the primary site of acrylamide action: a hypothesis.

LoPachin RM, Ross JF, Lehning EJ.

Neurotoxicology. 2002 May;23(1):43-59. Review.

PMID:
12164547
50.

Determination of acrylamide and glycidamide in rat plasma by reversed-phase high performance liquid chromatography.

Barber DS, Hunt J, LoPachin RM, Ehrich M.

J Chromatogr B Biomed Sci Appl. 2001 Jul 15;758(2):289-93.

PMID:
11486839

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