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Development of Novel Shortenings Structured by Ethylcellulose Oleogels.

Ye X, Li P, Lo YM, Fu H, Cao Y.

J Food Sci. 2019 Jun;84(6):1456-1464. doi: 10.1111/1750-3841.14615. Epub 2019 May 20.


Liver-derived cell-free nucleic acids in plasma: Biology and applications in liquid biopsies.

Jiang P, Chan KCA, Lo YMD.

J Hepatol. 2019 Apr 18. pii: S0168-8278(19)30258-2. doi: 10.1016/j.jhep.2019.04.003. [Epub ahead of print] Review.


Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling.

Cheng THT, Jiang P, Teoh JYC, Heung MMS, Tam JCW, Sun X, Lee WS, Ni M, Chan RCK, Ng CF, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2019 Apr 15. pii: clinchem.2018.301341. doi: 10.1373/clinchem.2018.301341. [Epub ahead of print]


Complementary roles of MRI and endoscopic examination in the early detection of nasopharyngeal carcinoma.

King AD, Woo JKS, Ai QY, Chan JSM, Lam WKJ, Tse IOL, Bhatia KS, Zee BCY, Hui EP, Ma BBY, Chiu RWK, Van Hasselt AC, Chan ATC, Lo YMD, Chan KCA.

Ann Oncol. 2019 Mar 26. pii: mdz106. doi: 10.1093/annonc/mdz106. [Epub ahead of print]


Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD.

Genome Res. 2019 Mar;29(3):418-427. doi: 10.1101/gr.242719.118.


Plasma Epstein-Barr virus DNA as an archetypal circulating tumour DNA marker.

Lam WKJ, Chan KCA, Lo YMD.

J Pathol. 2019 Apr;247(5):641-649. doi: 10.1002/path.5249. Epub 2019 Feb 25. Review.


Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.

Serpas L, Chan RWY, Jiang P, Ni M, Sun K, Rashidfarrokhi A, Soni C, Sisirak V, Lee WS, Cheng SH, Peng W, Chan KCA, Chiu RWK, Reizis B, Lo YMD.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):641-649. doi: 10.1073/pnas.1815031116. Epub 2018 Dec 28.


Enrichment of fetal and maternal long cell-free DNA fragments from maternal plasma following DNA repair.

Vong JSL, Jiang P, Cheng SH, Lee WS, Tsang JCH, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Prenat Diagn. 2019 Jan;39(2):88-99. doi: 10.1002/pd.5406. Epub 2019 Jan 10.


Enzymatic catalysis for sustainable production of high omega-3 triglyceride oil using imidazolium-based ionic liquids.

Fu H, Li M, Ni R, Lo YM.

Food Sci Nutr. 2018 Aug 6;6(8):2020-2027. doi: 10.1002/fsn3.733. eCollection 2018 Nov.


Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma.

Jiang P, Sun K, Tong YK, Cheng SH, Cheng THT, Heung MMS, Wong J, Wong VWS, Chan HLY, Chan KCA, Lo YMD, Chiu RWK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10925-E10933. doi: 10.1073/pnas.1814616115. Epub 2018 Oct 29.


Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells.

Leung CS, Yang KY, Li X, Chan VW, Ku M, Waldmann H, Hori S, Tsang JCH, Lo YMD, Lui KO.

Genome Med. 2018 Sep 20;10(1):71. doi: 10.1186/s13073-018-0581-y.


Analysis of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Cancer After Chemoradiation to Identify High-Risk Patients for Adjuvant Chemotherapy: A Randomized Controlled Trial.

Chan ATC, Hui EP, Ngan RKC, Tung SY, Cheng ACK, Ng WT, Lee VHF, Ma BBY, Cheng HC, Wong FCS, Loong HHF, Tong M, Poon DMC, Ahuja AT, King AD, Wang K, Mo F, Zee BCY, Chan KCA, Lo YMD.

J Clin Oncol. 2018 Jul 10:JCO2018777847. doi: 10.1200/JCO.2018.77.7847. [Epub ahead of print]


Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice.

Zhu S, Huang M, Feng G, Miao Y, Wu H, Zeng M, Lo YM.

Food Sci Nutr. 2018 Apr 16;6(4):1023-1031. doi: 10.1002/fsn3.639. eCollection 2018 Jun.


Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers with or without Liver Metastases.

Gai W, Ji L, Lam WKJ, Sun K, Jiang P, Chan AWH, Wong J, Lai PBS, Ng SSM, Ma BBY, Wong GLH, Wong VWS, Chan HLY, Chiu RWK, Lo YMD, Chan KCA.

Clin Chem. 2018 Aug;64(8):1239-1249. doi: 10.1373/clinchem.2018.290304. Epub 2018 Jun 14.


Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma.

Lam WKJ, Jiang P, Chan KCA, Cheng SH, Zhang H, Peng W, Tse OYO, Tong YK, Gai W, Zee BCY, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5115-E5124. doi: 10.1073/pnas.1804184115. Epub 2018 May 14.


Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing.

Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5106-E5114. doi: 10.1073/pnas.1804134115. Epub 2018 May 14.


Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).

Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC.

J Clin Oncol. 2018 May 10;36(14):1412-1418. doi: 10.1200/JCO.2017.77.0388. Epub 2018 Mar 27.


Prospective evaluation of plasma Epstein-Barr virus DNA clearance and fluorodeoxyglucose positron emission scan in assessing early response to chemotherapy in patients with advanced or recurrent nasopharyngeal carcinoma.

Ma B, Hui EP, King A, Leung SF, Kam MK, Mo F, Li L, Wang K, Loong H, Wong A, Chan CM, Chan KCA, Wong SCC, Lo YMD, Chan AT.

Br J Cancer. 2018 Apr;118(8):1051-1055. doi: 10.1038/s41416-018-0026-9. Epub 2018 Mar 20.


Ambient Temperature and Screening for Nasopharyngeal Cancer.

Chan KCA, Chu SWI, Lo YMD.

N Engl J Med. 2018 Mar 8;378(10):962-963. doi: 10.1056/NEJMc1800433. No abstract available.


Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring.

Sun K, Lun FMF, Leung TY, Chiu RWK, Lo YMD, Sun H.

Prenat Diagn. 2018 Feb;38(3):196-203. doi: 10.1002/pd.5214. Epub 2018 Jan 31.


DNase1 Does Not Appear to Play a Major Role in the Fragmentation of Plasma DNA in a Knockout Mouse Model.

Cheng THT, Lui KO, Peng XL, Cheng SH, Jiang P, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2018 Feb;64(2):406-408. doi: 10.1373/clinchem.2017.280446. Epub 2017 Nov 2. No abstract available. Erratum in: Clin Chem. 2018 May;64(5):869.


Effects of P25 TiO2 Nanoparticles on the Free Radical-Scavenging Ability of Antioxidants upon Their Exposure to Simulated Sunlight.

Li M, Chong Y, Fu PP, Xia Q, Croley TR, Lo YM, Yin JJ.

J Agric Food Chem. 2017 Nov 15;65(45):9893-9901. doi: 10.1021/acs.jafc.7b03407. Epub 2017 Nov 7.


Embracing the setting sun: provision of palliative care via a collaborative model between hospital and community for patients with intellectual disabilities.

Li CW, Wong YC, Lo YM, Sham MK, Cheng HW, Lai T, Lau WK, Chan KY.

Ann Palliat Med. 2018 Jul;7(3):365-367. doi: 10.21037/apm.2017.08.03. Epub 2017 Aug 26. No abstract available.


Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics.

Tsang JCH, Vong JSL, Ji L, Poon LCY, Jiang P, Lui KO, Ni YB, To KF, Cheng YKY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7786-E7795. doi: 10.1073/pnas.1710470114. Epub 2017 Aug 22.


Acute effects of Kinesio taping on pain, disability and back extensor muscle endurance in patients with low back pain caused by magnetic resonance imaging-confirmed lumbar disc degeneration.

Chang NJ, Chou W, Hsiao PC, Chang WD, Lo YM.

J Back Musculoskelet Rehabil. 2018 Feb 6;31(1):85-93. doi: 10.3233/BMR-169681.


Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD.

N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. Erratum in: N Engl J Med. 2018 Mar 8;378(10 ):973.


DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia.

Lam WKJ, Gai W, Sun K, Wong RSM, Chan RWY, Jiang P, Chan NPH, Hui WWI, Chan AWH, Szeto CC, Ng SC, Law MF, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 Oct;63(10):1614-1623. doi: 10.1373/clinchem.2017.272401. Epub 2017 Aug 7.


Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers.

Hudecova I, Jiang P, Davies J, Lo YMD, Kadir RA, Chiu RWK.

Blood. 2017 Jul 20;130(3):340-347. doi: 10.1182/blood-2016-12-755017. Epub 2017 May 10.


Single-Stranded DNA Library Preparation Preferentially Enriches Short Maternal DNA in Maternal Plasma.

Vong JSL, Tsang JCH, Jiang P, Lee WS, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 May;63(5):1031-1037. doi: 10.1373/clinchem.2016.268656. Epub 2017 Mar 9.


Genomewide bisulfite sequencing reveals the origin and time-dependent fragmentation of urinary cfDNA.

Cheng THT, Jiang P, Tam JCW, Sun X, Lee WS, Yu SCY, Teoh JYC, Chiu PKF, Ng CF, Chow KM, Szeto CC, Chan KCA, Chiu RWK, Lo YMD.

Clin Biochem. 2017 Jun;50(9):496-501. doi: 10.1016/j.clinbiochem.2017.02.017. Epub 2017 Feb 24.


COFFEE: control-free noninvasive fetal chromosomal examination using maternal plasma DNA.

Sun K, Chan KC, Hudecova I, Chiu RW, Lo YM, Jiang P.

Prenat Diagn. 2017 Apr;37(4):336-340. doi: 10.1002/pd.5016. Epub 2017 Feb 17.


Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study.

Jiang P, Tong YK, Sun K, Cheng SH, Leung TY, Chan KC, Chiu RW, Lo YM.

Clin Chem. 2017 Feb;63(2):606-608. doi: 10.1373/clinchem.2016.265702. Epub 2016 Dec 15. No abstract available.


Combined Count- and Size-Based Analysis of Maternal Plasma DNA for Noninvasive Prenatal Detection of Fetal Subchromosomal Aberrations Facilitates Elucidation of the Fetal and/or Maternal Origin of the Aberrations.

Yu SC, Jiang P, Chan KC, Faas BH, Choy KW, Leung WC, Leung TY, Lo YM, Chiu RW.

Clin Chem. 2017 Feb;63(2):495-502. doi: 10.1373/clinchem.2016.254813. Epub 2016 Dec 14.


Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases.

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YK, New MI, Kadir RA, Chan KC, Leung TY, Lo YM, Chiu RW.

Clin Chem. 2017 Feb;63(2):513-524. doi: 10.1373/clinchem.2016.268375. Epub 2016 Dec 8.


Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends.

Chan KC, Jiang P, Sun K, Cheng YK, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8159-E8168. Epub 2016 Oct 31.


Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches.

Wong FC, Sun K, Jiang P, Cheng YK, Chan KC, Leung TY, Chiu RW, Lo YM.

Clin Biochem. 2016 Dec;49(18):1379-1386. doi: 10.1016/j.clinbiochem.2016.09.009. Epub 2016 Sep 9.


Tracing the tissue of origin of plasma DNA-feasibility and implications.

Lo YM, Lam WK.

Ann N Y Acad Sci. 2016 Jul;1376(1):14-7. doi: 10.1111/nyas.13163. Epub 2016 Aug 15.


FetalQuantSD: accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA.

Jiang P, Peng X, Su X, Sun K, Yu SCY, Chu WI, Leung TY, Sun H, Chiu RWK, Lo YMD, Chan KCA.

NPJ Genom Med. 2016 May 11;1:16013. doi: 10.1038/npjgenmed.2016.13. eCollection 2016.


The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics.

Jiang P, Lo YMD.

Trends Genet. 2016 Jun;32(6):360-371. doi: 10.1016/j.tig.2016.03.009. Epub 2016 Apr 26. Review.


Noninvasive prenatal testing complicated by maternal malignancy: new tools for a complex problem.


NPJ Genom Med. 2016 Jan 13;1:15002. doi: 10.1038/npjgenmed.2015.2. eCollection 2016. No abstract available.


Noninvasive Prenatal Diagnosis of Congenital Adrenal Hyperplasia.

Khattab A, Yuen T, Sun L, Yau M, Barhan A, Zaidi M, Lo YM, New MI.

Endocr Dev. 2016;30:37-41. doi: 10.1159/000439326. Epub 2015 Dec 10. Review.


Prenatal Diagnosis Innovation: Genome Sequencing of Maternal Plasma.

Wong FC, Lo YM.

Annu Rev Med. 2016;67:419-32. doi: 10.1146/annurev-med-091014-115715. Epub 2015 Oct 15. Review.


Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5503-12. doi: 10.1073/pnas.1508736112. Epub 2015 Sep 21.


Noninvasive prenatal testing by nanopore sequencing of maternal plasma DNA: feasibility assessment.

Cheng SH, Jiang P, Sun K, Cheng YK, Chan KC, Leung TY, Chiu RW, Lo YM.

Clin Chem. 2015 Oct;61(10):1305-6. doi: 10.1373/clinchem.2015.245076. Epub 2015 Aug 18. No abstract available.


The effect of pH on the rheology of mixed gels containing whey protein isolate and xanthan-curdlan hydrogel.

Shiroodi SG, Lo YM.

J Dairy Res. 2015 Nov;82(4):506-12. doi: 10.1017/S0022029915000370. Epub 2015 Aug 3.


Noninvasive Prenatal Screening for Genetic Diseases Using Massively Parallel Sequencing of Maternal Plasma DNA.

Chitty LS, Lo YM.

Cold Spring Harb Perspect Med. 2015 Jul 17;5(9):a023085. doi: 10.1101/cshperspect.a023085. Review.


Disruptive Innovation in Laboratory Medicine.

Rifai N, Topol E, Chan E, Lo YM, Wittwer CT.

Clin Chem. 2015 Sep;61(9):1129-32. doi: 10.1373/clinchem.2015.243667. Epub 2015 Jul 7. No abstract available.


Influence of Xanthan-Curdlan Hydrogel Complex on Freeze-Thaw Stability and Rheological Properties of Whey Protein Isolate Gel over Multiple Freeze-Thaw Cycle.

Shiroodi SG, Rasco BA, Lo YM.

J Food Sci. 2015 Jul;80(7):E1498-505. doi: 10.1111/1750-3841.12915. Epub 2015 May 25.


Size-dependent tuning of horseradish peroxidase bioreactivity by gold nanoparticles.

Wu H, Liu Y, Li M, Chong Y, Zeng M, Lo YM, Yin JJ.

Nanoscale. 2015 Mar 14;7(10):4505-13. doi: 10.1039/c4nr07056a.


Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Jiang P, Chan CW, Chan KC, Cheng SH, Wong J, Wong VW, Wong GL, Chan SL, Mok TS, Chan HL, Lai PB, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1317-25. doi: 10.1073/pnas.1500076112. Epub 2015 Feb 2.

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