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Acceleration of rare disease therapeutic development: a case study of AGIL-AADC.

Das S, Huang S, Lo AW.

Drug Discov Today. 2019 Jan 2. pii: S1359-6446(18)30340-4. doi: 10.1016/j.drudis.2018.12.006. [Epub ahead of print]


Renting health vs buying cures: how new financing tools can boost cancer therapy development.

Lo AW, Smith A.

Am J Manag Care. 2018 Dec;24(13 Spec No.):SP589-SP591. No abstract available.


The role of symptoms and insight in mediating cognition and functioning in first episode psychosis.

Lee EHM, Hui CLM, Chan KPK, Chan PY, Law EYL, Chong CSY, Chang WC, Chan SKW, Lee WK, Lo AWF, Pang EPF, Cheung EFC, Yiu MGC, Chung DWS, Ng RMK, Yeung WS, Lo WTL, Chen EYH.

Schizophr Res. 2018 Nov 15. pii: S0920-9964(18)30660-1. doi: 10.1016/j.schres.2018.11.009. [Epub ahead of print]


Corrigendum: Estimation of clinical trial success rates and related parameters.

Wong CH, Siah KW, Lo AW.

Biostatistics. 2018 Nov 14. doi: 10.1093/biostatistics/kxy072. [Epub ahead of print] No abstract available.


Discovery of New Genes Involved in Curli Production by a Uropathogenic Escherichia coli Strain from the Highly Virulent O45:K1:H7 Lineage.

Nhu NTK, Phan MD, Peters KM, Lo AW, Forde BM, Min Chong T, Yin WF, Chan KG, Chromek M, Brauner A, Chapman MR, Beatson SA, Schembri MA.

MBio. 2018 Aug 21;9(4). pii: e01462-18. doi: 10.1128/mBio.01462-18.


New Business Models to Accelerate Innovation in Pediatric Oncology Therapeutics: A Review.

Das S, Rousseau R, Adamson PC, Lo AW.

JAMA Oncol. 2018 Sep 1;4(9):1274-1280. doi: 10.1001/jamaoncol.2018.1739.


Molecular basis for the folding of β-helical autotransporter passenger domains.

Yuan X, Johnson MD, Zhang J, Lo AW, Schembri MA, Wijeyewickrema LC, Pike RN, Huysmans GHM, Henderson IR, Leyton DL.

Nat Commun. 2018 Apr 11;9(1):1395. doi: 10.1038/s41467-018-03593-2.


Is Smaller Better? A Proposal to Use Bacteria For Neuroscientific Modeling.

Ram A, Lo AW.

Front Comput Neurosci. 2018 Feb 23;12:7. doi: 10.3389/fncom.2018.00007. eCollection 2018.


Estimation of clinical trial success rates and related parameters.

Wong CH, Siah KW, Lo AW.

Biostatistics. 2018 Jan 31. doi: 10.1093/biostatistics/kxx069. [Epub ahead of print]


Just how good an investment is the biopharmaceutical sector?

Thakor RT, Anaya N, Zhang Y, Vilanilam C, Siah KW, Wong CH, Lo AW.

Nat Biotechnol. 2017 Dec;35(12):1149-1157. doi: 10.1038/nbt.4023. Epub 2017 Dec 8.


Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

Djoko KY, Achard MES, Phan MD, Lo AW, Miraula M, Prombhul S, Hancock SJ, Peters KM, Sidjabat HE, Harris PN, Mitić N, Walsh TR, Anderson GJ, Shafer WM, Paterson DL, Schenk G, McEwan AG, Schembri MA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02280-17. doi: 10.1128/AAC.02280-17. Print 2018 Feb.


Patient-centered clinical trials.

Chaudhuri SE, Ho MP, Irony T, Sheldon M, Lo AW.

Drug Discov Today. 2018 Feb;23(2):395-401. doi: 10.1016/j.drudis.2017.09.016. Epub 2017 Oct 4. Review.


Re-inventing drug development: A case study of the I-SPY 2 breast cancer clinical trials program.

Das S, Lo AW.

Contemp Clin Trials. 2017 Nov;62:168-174. doi: 10.1016/j.cct.2017.09.002. Epub 2017 Sep 9.


A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.

Furlong EJ, Lo AW, Kurth F, Premkumar L, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA, Martin JL.

Nat Commun. 2017 Jul 19;8:16065. doi: 10.1038/ncomms16065.


Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury.

Lam PK, Wang KKW, Lo AWI, Tong CSW, Ching DWC, Wong K, Yang Z, Kong T, Lo KKY, Choy RKW, Lai PBS, Wong GKC, Poon WS.

Sci Rep. 2017 Jul 10;7(1):5017. doi: 10.1038/s41598-017-01772-7.


Discussion: New directions for the FDA in the 21st century.

Lo AW.

Biostatistics. 2017 Jul 1;18(3):404-407. doi: 10.1093/biostatistics/kxx019. No abstract available.


Topical Application of Mesenchymal Stromal Cells Ameliorated Liver Parenchyma Damage After Ischemia-Reperfusion Injury in an Animal Model.

Lam PK, Chong CCN, Lo AWI, Chan AWH, Tong CSW, Chin DWC, Wong KHK, Choy RKW, Fung AK, Wang YX, To KF, Lai PBS.

Transplant Direct. 2017 May 11;3(6):e160. doi: 10.1097/TXD.0000000000000675. eCollection 2017 Jun.


'Omic' Approaches to Study Uropathogenic Escherichia coli Virulence.

Lo AW, Moriel DG, Phan MD, Schulz BL, Kidd TJ, Beatson SA, Schembri MA.

Trends Microbiol. 2017 Sep;25(9):729-740. doi: 10.1016/j.tim.2017.04.006. Epub 2017 May 24. Review.


Novel genes associated with enhanced motility of Escherichia coli ST131.

Kakkanat A, Phan MD, Lo AW, Beatson SA, Schembri MA.

PLoS One. 2017 May 10;12(5):e0176290. doi: 10.1371/journal.pone.0176290. eCollection 2017.


Accelerating biomedical innovation: a case study of the SPARK program at Stanford University, School of Medicine.

Kim ES, Omura PMC, Lo AW.

Drug Discov Today. 2017 Jul;22(7):1064-1068. doi: 10.1016/j.drudis.2017.03.015. Epub 2017 Apr 26. Review.


Use of Bayesian Decision Analysis to Minimize Harm in Patient-Centered Randomized Clinical Trials in Oncology.

Montazerhodjat V, Chaudhuri SE, Sargent DJ, Lo AW.

JAMA Oncol. 2017 Sep 14;3(9):e170123. doi: 10.1001/jamaoncol.2017.0123. Epub 2017 Sep 14.


Prognostic significance of tumor-infiltrating immune cells and PD-L1 expression in esophageal squamous cell carcinoma.

Jiang Y, Lo AWI, Wong A, Chen W, Wang Y, Lin L, Xu J.

Oncotarget. 2017 May 2;8(18):30175-30189. doi: 10.18632/oncotarget.15621.


Leiomyosarcoma of the portal vein: a case report and review of the literature.

Chiu WHK, Lo AW, Lee JK.

BJR Case Rep. 2016 Dec 23;3(2):20160125. doi: 10.1259/bjrcr.20160125. eCollection 2017.


A Novel Protective Vaccine Antigen from the Core Escherichia coli Genome.

Moriel DG, Tan L, Goh KG, Phan MD, Ipe DS, Lo AW, Peters KM, Ulett GC, Beatson SA, Schembri MA.

mSphere. 2016 Nov 23;1(6). pii: e00326-16. eCollection 2016 Nov-Dec.


Dual-Tracer PET/CT Using 18F-FDG and 11C-Acetate in Gastric Adenocarcinoma With Liver Metastasis.

Vardhanabhuti V, Lo AW, Lee EY, Law SY.

Clin Nucl Med. 2016 Nov;41(11):864-865.


Concordance of immune checkpoints within tumor immune contexture and their prognostic significance in gastric cancer.

Dai C, Geng R, Wang C, Wong A, Qing M, Hu J, Sun Y, Lo AW, Li J.

Mol Oncol. 2016 Dec;10(10):1551-1558. doi: 10.1016/j.molonc.2016.09.004. Epub 2016 Sep 24.


Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine.

Stubenrauch C, Belousoff MJ, Hay ID, Shen HH, Lillington J, Tuck KL, Peters KM, Phan MD, Lo AW, Schembri MA, Strugnell RA, Waksman G, Lithgow T.

Nat Microbiol. 2016 May 16;1(7):16064. doi: 10.1038/nmicrobiol.2016.64.


Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma.

Lee VH, Lo AW, Leung CY, Shek WH, Kwong DL, Lam KO, Tong CC, Sze CK, Leung TW.

PLoS One. 2016 Jun 24;11(6):e0157969. doi: 10.1371/journal.pone.0157969. eCollection 2016.


Comprehensive analysis of type 1 fimbriae regulation in fimB-null strains from the multidrug resistant Escherichia coli ST131 clone.

Sarkar S, Roberts LW, Phan MD, Tan L, Lo AW, Peters KM, Paterson DL, Upton M, Ulett GC, Beatson SA, Totsika M, Schembri MA.

Mol Microbiol. 2016 Sep;101(6):1069-87. doi: 10.1111/mmi.13442. Epub 2016 Jul 15.


'Open-and-close' pituitary surgery in an acromegalic man presenting with excessive sweatiness.

Cheung KK, Chow FC, Lo AW.

BMJ Case Rep. 2016 Jun 9;2016. pii: bcr2016215183. doi: 10.1136/bcr-2016-215183.


Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein.

Moriel DG, Heras B, Paxman JJ, Lo AW, Tan L, Sullivan MJ, Dando SJ, Beatson SA, Ulett GC, Schembri MA.

MBio. 2016 Mar 15;7(2):e02046. doi: 10.1128/mBio.02046-15.


The aqueous extract of rhizome of Gastrodia elata Blume attenuates locomotor defect and inflammation after traumatic brain injury in rats.

Ng CF, Ko CH, Koon CM, Chin WC, Kwong HC, Lo AW, Wong HL, Fung KP, Lau CB, Lam PK, Poon WS, Leung PC.

J Ethnopharmacol. 2016 Jun 5;185:87-95. doi: 10.1016/j.jep.2016.03.018. Epub 2016 Mar 12.


Buying cures versus renting health: Financing health care with consumer loans.

Montazerhodjat V, Weinstock DM, Lo AW.

Sci Transl Med. 2016 Feb 24;8(327):327ps6. doi: 10.1126/scitranslmed.aad6913. Review.


Natural history and outcome in Chinese patients with gastroenteropancreatic neuroendocrine tumours: - a 17-year retrospective analysis.

Chan DT, Luk AO, So WY, Kong AP, Chow FC, Ma RC, Lo AW.

BMC Endocr Disord. 2016 Feb 24;16:12. doi: 10.1186/s12902-016-0087-9.


Molecular Characterization of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli.

Nichols KB, Totsika M, Moriel DG, Lo AW, Yang J, Wurpel DJ, Rossiter AE, Strugnell RA, Henderson IR, Ulett GC, Beatson SA, Schembri MA.

J Bacteriol. 2016 Apr 28;198(10):1487-98. doi: 10.1128/JB.00791-15. Print 2016 May 15.


Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.

Moonens K, Gideonsson P, Subedi S, Bugaytsova J, Romaõ E, Mendez M, Nordén J, Fallah M, Rakhimova L, Shevtsova A, Lahmann M, Castaldo G, Brännström K, Coppens F, Lo AW, Ny T, Solnick JV, Vandenbussche G, Oscarson S, Hammarström L, Arnqvist A, Berg DE, Muyldermans S, Borén T, Remaut H.

Cell Host Microbe. 2016 Jan 13;19(1):55-66. doi: 10.1016/j.chom.2015.12.004.


Price, value, and the cost of cancer drugs.

Fojo T, Lo AW.

Lancet Oncol. 2016 Jan;17(1):3-5. doi: 10.1016/S1470-2045(15)00564-1. Epub 2015 Dec 23. No abstract available.


Financing drug discovery via dynamic leverage.

Montazerhodjat V, Frishkopf JJ, Lo AW.

Drug Discov Today. 2016 Mar;21(3):410-4. doi: 10.1016/j.drudis.2015.12.004. Epub 2015 Dec 18.


The role of H4 flagella in Escherichia coli ST131 virulence.

Kakkanat A, Totsika M, Schaale K, Duell BL, Lo AW, Phan MD, Moriel DG, Beatson SA, Sweet MJ, Ulett GC, Schembri MA.

Sci Rep. 2015 Nov 9;5:16149. doi: 10.1038/srep16149.


Health, Wealth, and the 21st Century Cures Act.

Lo AW, Philipson TJ, von Eschenbach AC.

JAMA Oncol. 2016 Jan;2(1):17-8. doi: 10.1001/jamaoncol.2015.4221. No abstract available.


Opinion: A new approach to financial regulation.

Levin SA, Lo AW.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12543-4. doi: 10.1073/pnas.1518385112. No abstract available.


Blocking the 'MIDAS' touch of Enterococcus faecalis.

Schembri MA, Lo AW, Ulett GC.

Ann Transl Med. 2015 May;3(Suppl 1):S3. doi: 10.3978/j.issn.2305-5839.2015.03.32. No abstract available.


Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958.

Phan MD, Peters KM, Sarkar S, Forde BM, Lo AW, Stanton-Cook M, Roberts LW, Upton M, Beatson SA, Schembri MA.

J Antimicrob Chemother. 2015 Jul;70(7):1969-72. doi: 10.1093/jac/dkv066. Epub 2015 Mar 18.


Financing translation: analysis of the NCATS rare-diseases portfolio.

Fagnan DE, Yang NN, McKew JC, Lo AW.

Sci Transl Med. 2015 Feb 25;7(276):276ps3. doi: 10.1126/scitranslmed.aaa2360. Review.


The origin of risk aversion.

Zhang R, Brennan TJ, Lo AW.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17777-82. doi: 10.1073/pnas.1406755111. Epub 2014 Dec 1.


Dealing with femtorisks in international relations.

Frank AB, Collins MG, Levin SA, Lo AW, Ramo J, Dieckmann U, Kremenyuk V, Kryazhimskiy A, Linnerooth-Bayer J, Ramalingam B, Roy JS, Saari DG, Thurner S, von Winterfeldt D.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17356-62. doi: 10.1073/pnas.1400229111. Epub 2014 Nov 17.


Group selection as behavioral adaptation to systematic risk.

Zhang R, Brennan TJ, Lo AW.

PLoS One. 2014 Oct 29;9(10):e110848. doi: 10.1371/journal.pone.0110848. eCollection 2014.


Inflammatory myofibroblastic tumours of the urinary bladder: multi-centre 18-year experience.

Teoh JY, Chan NH, Mak SM, Lo AW, Leung CY, Hui Y, Law IC, Fan CW, Cheung FK, Chan SW, Yiu MK, Man CW, So HS, Cheung HY, Hou SS, Ng CF.

Urol Int. 2015;94(1):31-6. doi: 10.1159/000358732. Epub 2014 Jul 18.


The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.

Lo AW, Moonens K, De Kerpel M, Brys L, Pardon E, Remaut H, De Greve H.

J Biol Chem. 2014 Sep 5;289(36):25374-81. doi: 10.1074/jbc.M114.566257. Epub 2014 Jul 22.


Parallel discovery of Alzheimer's therapeutics.

Lo AW, Ho C, Cummings J, Kosik KS.

Sci Transl Med. 2014 Jun 18;6(241):241cm5. doi: 10.1126/scitranslmed.3008228.


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