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Items: 1 to 50 of 212

1.

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.

2.

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S.

Nat Commun. 2018 Mar 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.

3.

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins.

Moreno E, Canet J, Gracia E, Lluís C, Mallol J, Canela EI, Cortés A, Casadó V.

Front Pharmacol. 2018 Feb 15;9:106. doi: 10.3389/fphar.2018.00106. eCollection 2018.

4.

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, McCormick PJ, Franco R.

BMC Biol. 2018 Feb 28;16(1):24. doi: 10.1186/s12915-018-0491-x.

5.

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M.

Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19.

6.

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

Moreno E, Quiroz C, Rea W, Cai NS, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, Ferré S.

J Neurosci. 2017 Feb 1;37(5):1176-1186. doi: 10.1523/JNEUROSCI.2442-16.2016. Epub 2016 Dec 22.

7.

Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease.

Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Franco R.

Mol Neurobiol. 2017 Aug;54(6):4537-4550. doi: 10.1007/s12035-016-9995-y. Epub 2016 Jul 1.

PMID:
27370794
8.

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

Navarro G, Aguinaga D, Angelats E, Medrano M, Moreno E, Mallol J, Cortés A, Canela EI, Casadó V, McCormick PJ, Lluís C, Ferré S.

J Biol Chem. 2016 Jun 17;291(25):13048-62. doi: 10.1074/jbc.M116.715144. Epub 2016 Apr 25.

9.

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ, Franco R.

BMC Biol. 2016 Apr 5;14:26. doi: 10.1186/s12915-016-0247-4.

10.

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.

Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Lluís C, Franco R, McCormick PJ, Climent N.

J Leukoc Biol. 2016 Feb;99(2):349-59. doi: 10.1189/jlb.3A1214-580RR. Epub 2015 Aug 26.

PMID:
26310829
11.

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.

Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, de La Torre R, Gasperini P, Navarro G, Howell LA, Pardo L, Lluís C, Canela EI, McCormick PJ, Maldonado R, Robledo P.

PLoS Biol. 2015 Jul 9;13(7):e1002194. doi: 10.1371/journal.pbio.1002194. eCollection 2015 Jul.

12.

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.

Bonaventura J, Navarro G, Casadó-Anguera V, Azdad K, Rea W, Moreno E, Brugarolas M, Mallol J, Canela EI, Lluís C, Cortés A, Volkow ND, Schiffmann SN, Ferré S, Casadó V.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3609-18. doi: 10.1073/pnas.1507704112. Epub 2015 Jun 22.

13.

Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer.

Ferré S, Bonaventura J, Tomasi D, Navarro G, Moreno E, Cortés A, Lluís C, Casadó V, Volkow ND.

Neuropharmacology. 2016 May;104:154-60. doi: 10.1016/j.neuropharm.2015.05.028. Epub 2015 Jun 4. Review.

14.

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

Molero A, Vendrell M, Bonaventura J, Zachmann J, López L, Pardo L, Lluis C, Cortés A, Albericio F, Casadó V, Royo M.

Eur J Med Chem. 2015 Jun 5;97:173-80. doi: 10.1016/j.ejmech.2015.04.052. Epub 2015 Apr 28.

15.

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.

Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS, Aguinaga D, Howell LA, Hausch F, Cortés A, Mallol J, Casadó V, Lluís C, Canela EI, Ferré S, McCormick PJ.

J Neurosci. 2015 Apr 29;35(17):6639-53. doi: 10.1523/JNEUROSCI.4364-14.2015.

16.

Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers.

Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V, Mikhaylova M, Kreutz MR, Lluís C, Canela EI, McCormick PJ, Ferré S.

Chem Biol. 2014 Nov 20;21(11):1546-56. doi: 10.1016/j.chembiol.2014.10.004.

17.

Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.

Farré D, Muñoz A, Moreno E, Reyes-Resina I, Canet-Pons J, Dopeso-Reyes IG, Rico AJ, Lluís C, Mallol J, Navarro G, Canela EI, Cortés A, Labandeira-García JL, Casadó V, Lanciego JL, Franco R.

Mol Neurobiol. 2015 Dec;52(3):1408-1420. doi: 10.1007/s12035-014-8936-x. Epub 2014 Oct 26.

PMID:
25344317
18.

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.

Guitart X, Navarro G, Moreno E, Yano H, Cai NS, Sánchez-Soto M, Kumar-Barodia S, Naidu YT, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Ferré S.

Mol Pharmacol. 2014 Oct;86(4):417-29. doi: 10.1124/mol.114.093096. Epub 2014 Aug 5.

19.

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

J Biol Chem. 2014 Aug 8;289(32):21960-72. doi: 10.1074/jbc.M114.561761. Epub 2014 Jun 18.

20.

Moonlighting adenosine deaminase: a target protein for drug development.

Cortés A, Gracia E, Moreno E, Mallol J, Lluís C, Canela EI, Casadó V.

Med Res Rev. 2015 Jan;35(1):85-125. doi: 10.1002/med.21324. Epub 2014 Jun 16. Review.

PMID:
24933472
21.

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M, Medrano M, Mallol J, Cortés A, Casadó V, Lluís C, Ferré S, Ortiz J, Canela E, McCormick PJ.

J Neurosci. 2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014.

22.

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.

Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, Casadó V, Armentero MT, Franco R.

Exp Neurol. 2014 Mar;253:180-91. doi: 10.1016/j.expneurol.2013.12.021. Epub 2014 Jan 9.

PMID:
24412491
23.

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.

Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V, Franco R.

Neuropharmacology. 2014 Apr;79:90-100. doi: 10.1016/j.neuropharm.2013.10.036. Epub 2013 Nov 11.

PMID:
24230991
24.

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R, Sebastião AM.

Purinergic Signal. 2013 Sep;9(3):433-49. doi: 10.1007/s11302-013-9364-5. Epub 2013 May 10.

25.

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.

Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A, Casadó V, Lluís C, Ferre S, Franco R, Canela E, McCormick PJ.

PLoS One. 2013 Apr 18;8(4):e61245. doi: 10.1371/journal.pone.0061245. Print 2013.

26.

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine.

Gracia E, Moreno E, Cortés A, Lluís C, Mallol J, McCormick PJ, Canela EI, Casadó V.

Neuropharmacology. 2013 Aug;71:56-69. doi: 10.1016/j.neuropharm.2013.03.005. Epub 2013 Mar 22.

PMID:
23523559
27.

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology.

Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI, Ferré S.

Methods Mol Biol. 2013;964:95-105. doi: 10.1007/978-1-62703-251-3_7.

PMID:
23296780
28.

Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.

Orrú M, Guitart X, Karcz-Kubicha M, Solinas M, Justinova Z, Barodia SK, Zanoveli J, Cortes A, Lluis C, Casado V, Moeller FG, Ferré S.

Neuropharmacology. 2013 Apr;67:476-84. doi: 10.1016/j.neuropharm.2012.11.029. Epub 2012 Dec 19.

29.

Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals.

Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T, Lluis C, Mallol J, Franco R, Climent N, McCormick PJ.

PLoS One. 2012;7(12):e51287. doi: 10.1371/journal.pone.0051287. Epub 2012 Dec 11.

30.

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors.

Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI, McCormick PJ, Franco R, Fanelli F, Casadó V.

FASEB J. 2013 Mar;27(3):1048-61. doi: 10.1096/fj.12-212621. Epub 2012 Nov 27.

PMID:
23193172
31.

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F.

Gene. 2012 Oct 25;508(2):199-205. doi: 10.1016/j.gene.2012.07.074. Epub 2012 Aug 7.

PMID:
22892378
32.

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.

González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V, Lluís C, Ortiz J, Ferré S, Canela E, McCormick PJ.

PLoS Biol. 2012;10(6):e1001347. doi: 10.1371/journal.pbio.1001347. Epub 2012 Jun 19.

33.

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain.

Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL, Franco R, Lluis C, Canela EI, McCormick PJ.

J Biol Chem. 2012 Jun 15;287(25):20851-65. doi: 10.1074/jbc.M111.335273. Epub 2012 Apr 24.

34.

NCS-1 associates with adenosine A(2A) receptors and modulates receptor function.

Navarro G, Hradsky J, Lluís C, Casadó V, McCormick PJ, Kreutz MR, Mikhaylova M.

Front Mol Neurosci. 2012 Apr 18;5:53. doi: 10.3389/fnmol.2012.00053. eCollection 2012.

35.

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer.

Trincavelli ML, Daniele S, Orlandini E, Navarro G, Casadó V, Giacomelli C, Nencetti S, Nuti E, Macchia M, Huebner H, Gmeiner P, Rossello A, Lluís C, Martini C.

Cell Signal. 2012 Apr;24(4):951-60. doi: 10.1016/j.cellsig.2011.12.018. Epub 2011 Dec 30.

PMID:
22230688
36.

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

Aymerich MS, López-Azcárate J, Bonaventura J, Navarro G, Fernández-Suárez D, Casadó V, Mayor F, Lluís C, Valencia M, Artieda J, Franco R.

ScientificWorldJournal. 2011;11:1995-2010. doi: 10.1100/2011/690858. Epub 2011 Oct 26.

37.

Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins.

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R, Sebastião AM.

J Neurosci. 2011 Nov 2;31(44):15629-39. doi: 10.1523/JNEUROSCI.2526-11.2011. Retraction in: J Neurosci. 2013 Jan 16;33(3):1292.

38.

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV.

Martinez-Navio JM, Climent N, Gallart T, Lluis C, Franco R.

Immunol Cell Biol. 2012 Jul;90(6):594-600. doi: 10.1038/icb.2011.81. Epub 2011 Sep 20.

PMID:
21931337
39.

Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain.

González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J, Lluís C, Franco R, McCormick PJ, Volkow ND, Rubinstein M, Floran B, Ferré S.

Mol Psychiatry. 2012 Jun;17(6):650-62. doi: 10.1038/mp.2011.93. Epub 2011 Aug 16.

40.

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function.

Ferré S, Quiroz C, Orru M, Guitart X, Navarro G, Cortés A, Casadó V, Canela EI, Lluis C, Franco R.

Front Neuroanat. 2011 Jun 17;5:36. doi: 10.3389/fnana.2011.00036. eCollection 2011.

41.

Production of functional recombinant G-protein coupled receptors for heteromerization studies.

Cavić M, Lluís C, Moreno E, Bakešová J, Canela EI, Navarro G.

J Neurosci Methods. 2011 Aug 15;199(2):258-64. doi: 10.1016/j.jneumeth.2011.05.021. Epub 2011 May 31.

PMID:
21658412
42.

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI, McCormick PJ, Lluis C, Franco R, Ribeiro JA, Sebastião AM, Ferré S.

J Neurosci. 2011 May 18;31(20):7412-23. doi: 10.1523/JNEUROSCI.0191-11.2011.

43.

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase.

Gracia E, Pérez-Capote K, Moreno E, Barkešová J, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI.

Biochem J. 2011 May 1;435(3):701-9. doi: 10.1042/BJ20101749.

PMID:
21306300
44.

Biotin ergopeptide probes for dopamine receptors.

Vendrell M, Molero A, González S, Pérez-Capote K, Lluis C, McCormick PJ, Franco R, Cortés A, Casadó V, Albericio F, Royo M.

J Med Chem. 2011 Feb 24;54(4):1080-90. doi: 10.1021/jm101566d. Epub 2011 Jan 31.

PMID:
21280602
45.

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists.

Orru M, Bakešová J, Brugarolas M, Quiroz C, Beaumont V, Goldberg SR, Lluís C, Cortés A, Franco R, Casadó V, Canela EI, Ferré S.

PLoS One. 2011 Jan 11;6(1):e16088. doi: 10.1371/journal.pone.0016088.

46.

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

Llach A, Molina CE, Prat-Vidal C, Fernandes J, Casadó V, Ciruela F, Lluís C, Franco R, Cinca J, Hove-Madsen L.

Eur Heart J. 2011 Mar;32(6):721-9. doi: 10.1093/eurheartj/ehq464. Epub 2010 Dec 22.

PMID:
21177700
47.

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.

Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R.

J Biol Chem. 2011 Feb 18;286(7):5846-54. doi: 10.1074/jbc.M110.161489. Epub 2010 Dec 20.

48.

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.

Martinez-Navio JM, Casanova V, Pacheco R, Naval-Macabuhay I, Climent N, Garcia F, Gatell JM, Mallol J, Gallart T, Lluis C, Franco R.

J Leukoc Biol. 2011 Jan;89(1):127-36. doi: 10.1189/jlb.1009696. Epub 2010 Oct 19.

PMID:
20959412
49.

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.

Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortés A, Casadó V, Canela EI, Ortiz J, Fuxe K, Lluís C, Ferré S, Franco R.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18676-81. doi: 10.1073/pnas.1008911107. Epub 2010 Oct 18.

50.

G protein-coupled receptor heteromers as new targets for drug development.

Ferré S, Navarro G, Casadó V, Cortés A, Mallol J, Canela EI, Lluís C, Franco R.

Prog Mol Biol Transl Sci. 2010;91:41-52. doi: 10.1016/S1877-1173(10)91002-8. Review.

PMID:
20691958

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