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Items: 1 to 50 of 148

1.

Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed.

Midgley-Smith SL, Dimude JU, Taylor T, Forrester NM, Upton AL, Lloyd RG, Rudolph CJ.

Nucleic Acids Res. 2018 Sep 6;46(15):7701-7715. doi: 10.1093/nar/gky566.

2.

Spontaneous pneumothorax in a patient with pneumocystis pneumonia.

Lloyd RG, Aitchison F, Hagan G.

BMJ Case Rep. 2017 Mar 6;2017. pii: bcr2017219754. doi: 10.1136/bcr-2017-219754. No abstract available.

3.

Inhibiting translation elongation can aid genome duplication in Escherichia coli.

Myka KK, Hawkins M, Syeda AH, Gupta MK, Meharg C, Dillingham MS, Savery NJ, Lloyd RG, McGlynn P.

Nucleic Acids Res. 2017 Mar 17;45(5):2571-2584. doi: 10.1093/nar/gkw1254.

4.

The Balance between Recombination Enzymes and Accessory Replicative Helicases in Facilitating Genome Duplication.

Syeda AH, Atkinson J, Lloyd RG, McGlynn P.

Genes (Basel). 2016 Jul 29;7(8). pii: E42. doi: 10.3390/genes7080042.

5.

25 years on and no end in sight: a perspective on the role of RecG protein.

Lloyd RG, Rudolph CJ.

Curr Genet. 2016 Nov;62(4):827-840. Epub 2016 Apr 2.

6.

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus.

Upton AL, Grove JI, Mahdi AA, Briggs GS, Milner DS, Rudolph CJ, Lloyd RG.

Nucleic Acids Res. 2014 May;42(9):5702-14. doi: 10.1093/nar/gku228. Epub 2014 Apr 1.

7.

Avoiding chromosome pathology when replication forks collide.

Rudolph CJ, Upton AL, Stockum A, Nieduszynski CA, Lloyd RG.

Nature. 2013 Aug 29;500(7464):608-11. doi: 10.1038/nature12312. Epub 2013 Jul 28.

8.

Protein-DNA complexes are the primary sources of replication fork pausing in Escherichia coli.

Gupta MK, Guy CP, Yeeles JT, Atkinson J, Bell H, Lloyd RG, Marians KJ, McGlynn P.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7252-7. doi: 10.1073/pnas.1303890110. Epub 2013 Apr 15.

9.

Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase.

Mahdi AA, Briggs GS, Lloyd RG.

Mol Microbiol. 2012 Nov;86(3):675-91. doi: 10.1111/mmi.12010. Epub 2012 Sep 7.

10.

On the viability of Escherichia coli cells lacking DNA topoisomerase I.

Stockum A, Lloyd RG, Rudolph CJ.

BMC Microbiol. 2012 Feb 28;12:26. doi: 10.1186/1471-2180-12-26.

11.

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication.

Atkinson J, Gupta MK, Rudolph CJ, Bell H, Lloyd RG, McGlynn P.

Nucleic Acids Res. 2011 Feb;39(3):949-57. doi: 10.1093/nar/gkq889. Epub 2010 Oct 4.

12.

RecG protein and single-strand DNA exonucleases avoid cell lethality associated with PriA helicase activity in Escherichia coli.

Rudolph CJ, Mahdi AA, Upton AL, Lloyd RG.

Genetics. 2010 Oct;186(2):473-92. doi: 10.1534/genetics.110.120691. Epub 2010 Jul 20.

13.

The RdgC protein employs a novel mechanism involving a finger domain to bind to circular DNA.

Briggs GS, Yu J, Mahdi AA, Lloyd RG.

Nucleic Acids Res. 2010 Oct;38(19):6433-46. doi: 10.1093/nar/gkq509. Epub 2010 Jun 4.

14.

Promoting and avoiding recombination: contrasting activities of the Escherichia coli RuvABC Holliday junction resolvase and RecG DNA translocase.

Zhang J, Mahdi AA, Briggs GS, Lloyd RG.

Genetics. 2010 May;185(1):23-37. doi: 10.1534/genetics.110.114413. Epub 2010 Feb 15.

15.

Is RecG a general guardian of the bacterial genome?

Rudolph CJ, Upton AL, Briggs GS, Lloyd RG.

DNA Repair (Amst). 2010 Mar 2;9(3):210-23. doi: 10.1016/j.dnarep.2009.12.014. Epub 2010 Jan 25. Review.

PMID:
20093100
16.

Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.

Guy CP, Atkinson J, Gupta MK, Mahdi AA, Gwynn EJ, Rudolph CJ, Moon PB, van Knippenberg IC, Cadman CJ, Dillingham MS, Lloyd RG, McGlynn P.

Mol Cell. 2009 Nov 25;36(4):654-66. doi: 10.1016/j.molcel.2009.11.009.

17.

A soluble RecN homologue provides means for biochemical and genetic analysis of DNA double-strand break repair in Escherichia coli.

Grove JI, Wood SR, Briggs GS, Oldham NJ, Lloyd RG.

DNA Repair (Amst). 2009 Dec 3;8(12):1434-43. doi: 10.1016/j.dnarep.2009.09.015. Epub 2009 Oct 20.

PMID:
19846353
18.

Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase.

Rudolph CJ, Upton AL, Lloyd RG.

Mol Microbiol. 2009 Nov;74(4):940-55. doi: 10.1111/j.1365-2958.2009.06909.x. Epub 2009 Oct 8.

19.

Pathological replication in cells lacking RecG DNA translocase.

Rudolph CJ, Upton AL, Harris L, Lloyd RG.

Mol Microbiol. 2009 Aug;73(3):352-66. doi: 10.1111/j.1365-2958.2009.06773.x. Epub 2009 Jun 16.

20.

Maintaining replication fork integrity in UV-irradiated Escherichia coli cells.

Rudolph CJ, Upton AL, Lloyd RG.

DNA Repair (Amst). 2008 Sep 1;7(9):1589-602. doi: 10.1016/j.dnarep.2008.06.012. Epub 2008 Jul 26.

PMID:
18644471
21.

DNA double strand break repair and crossing over mediated by RuvABC resolvase and RecG translocase.

Grove JI, Harris L, Buckman C, Lloyd RG.

DNA Repair (Amst). 2008 Sep 1;7(9):1517-30. doi: 10.1016/j.dnarep.2008.05.010. Epub 2008 Jul 7.

PMID:
18606573
22.

Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in Escherichia coli: predominance of strand transfer.

Izhar L, Goldsmith M, Dahan R, Geacintov N, Lloyd RG, Livneh Z.

J Mol Biol. 2008 Sep 12;381(4):803-9. doi: 10.1016/j.jmb.2008.06.031. Epub 2008 Jun 18.

24.

Avoiding and resolving conflicts between DNA replication and transcription.

Rudolph CJ, Dhillon P, Moore T, Lloyd RG.

DNA Repair (Amst). 2007 Jul 1;6(7):981-93. Epub 2007 Mar 30. Review.

PMID:
17400034
25.

Replication fork stalling and cell cycle arrest in UV-irradiated Escherichia coli.

Rudolph CJ, Upton AL, Lloyd RG.

Genes Dev. 2007 Mar 15;21(6):668-81.

26.

Ring structure of the Escherichia coli DNA-binding protein RdgC associated with recombination and replication fork repair.

Briggs GS, McEwan PA, Yu J, Moore T, Emsley J, Lloyd RG.

J Biol Chem. 2007 Apr 27;282(17):12353-7. Epub 2007 Feb 16.

27.

RusA Holliday junction resolvase: DNA complex structure--insights into selectivity and specificity.

Macmaster R, Sedelnikova S, Baker PJ, Bolt EL, Lloyd RG, Rafferty JB.

Nucleic Acids Res. 2006;34(19):5577-84. Epub 2006 Oct 5.

28.
29.

RNA polymerase modulators and DNA repair activities resolve conflicts between DNA replication and transcription.

Trautinger BW, Jaktaji RP, Rusakova E, Lloyd RG.

Mol Cell. 2005 Jul 22;19(2):247-58.

30.

RecN protein and transcription factor DksA combine to promote faithful recombinational repair of DNA double-strand breaks.

Meddows TR, Savory AP, Grove JI, Moore T, Lloyd RG.

Mol Microbiol. 2005 Jul;57(1):97-110.

31.

AFM studies on the role of the protein RdgC in bacterial DNA recombination.

Tessmer I, Moore T, Lloyd RG, Wilson A, Erie DA, Allen S, Tendler SJ.

J Mol Biol. 2005 Jul 8;350(2):254-62.

PMID:
15923011
32.

DNA binding by the substrate specificity (wedge) domain of RecG helicase suggests a role in processivity.

Briggs GS, Mahdi AA, Wen Q, Lloyd RG.

J Biol Chem. 2005 Apr 8;280(14):13921-7. Epub 2005 Feb 3.

33.

Conservation of RecG activity from pathogens to hyperthermophiles.

Wen Q, Mahdi AA, Briggs GS, Sharples GJ, Lloyd RG.

DNA Repair (Amst). 2005 Jan 2;4(1):23-31.

PMID:
15533834
34.

Interplay between DNA replication, recombination and repair based on the structure of RecG helicase.

Briggs GS, Mahdi AA, Weller GR, Wen Q, Lloyd RG.

Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):49-59. Review.

35.

RecG helicase promotes DNA double-strand break repair.

Meddows TR, Savory AP, Lloyd RG.

Mol Microbiol. 2004 Apr;52(1):119-32.

36.
37.

DNA binding by the meningococcal RdgC protein, associated with pilin antigenic variation.

Moore T, Sharples GJ, Lloyd RG.

J Bacteriol. 2004 Feb;186(3):870-4.

38.

The structure of Escherichia coli RusA endonuclease reveals a new Holliday junction DNA binding fold.

Rafferty JB, Bolt EL, Muranova TA, Sedelnikova SE, Leonard P, Pasquo A, Baker PJ, Rice DW, Sharples GJ, Lloyd RG.

Structure. 2003 Dec;11(12):1557-67.

39.

Crystallization of RusA Holliday junction resolvase from Escherichia coli.

Muranova TA, Sedelnikova SE, Leonard PM, Pasquo A, Bolt EL, Lloyd RG, Rafferty JB.

Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2262-4. Epub 2003 Nov 27.

PMID:
14646089
40.
41.
42.

A model for dsDNA translocation revealed by a structural motif common to RecG and Mfd proteins.

Mahdi AA, Briggs GS, Sharples GJ, Wen Q, Lloyd RG.

EMBO J. 2003 Feb 3;22(3):724-34.

43.
44.

The RuvABC resolvasome.

Dickman MJ, Ingleston SM, Sedelnikova SE, Rafferty JB, Lloyd RG, Grasby JA, Hornby DP.

Eur J Biochem. 2002 Nov;269(22):5492-501.

45.

Replicating past lesions in DNA.

McGlynn P, Lloyd RG.

Mol Cell. 2002 Oct;10(4):700-1.

46.

Recombinational repair and restart of damaged replication forks.

McGlynn P, Lloyd RG.

Nat Rev Mol Cell Biol. 2002 Nov;3(11):859-70. Review.

PMID:
12415303
47.
48.

Genome stability and the processing of damaged replication forks by RecG.

McGlynn P, Lloyd RG.

Trends Genet. 2002 Aug;18(8):413-9. Review.

PMID:
12142010
49.
50.

Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae.

Ingleston SM, Dickman MJ, Grasby JA, Hornby DP, Sharples GJ, Lloyd RG.

Eur J Biochem. 2002 Mar;269(5):1525-33.

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