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The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation.

Zhang Y, Willis-Owen SAG, Spiegel S, Lloyd CM, Moffatt MF, Cookson WOCM.

Am J Respir Crit Care Med. 2018 Oct 19. doi: 10.1164/rccm.201803-0438OC. [Epub ahead of print]


Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.

Uwadiae FI, Pyle CJ, Walker SA, Lloyd CM, Harker JA.

Allergy. 2018 Sep 16. doi: 10.1111/all.13602. [Epub ahead of print]


Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.


Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?  A description of the protocol for the Breathing Together study.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.

Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


Type 2 immunity: Expanding our view.

Lloyd CM, Snelgrove RJ.

Sci Immunol. 2018 Jul 6;3(25). pii: eaat1604. doi: 10.1126/sciimmunol.aat1604. Review.


Epigenetic Control of Interleukin-9 in Asthma.

Lloyd CM, Harker JA.

N Engl J Med. 2018 Jul 5;379(1):87-89. doi: 10.1056/NEJMcibr1803610. No abstract available.


Tasting type 2 inflammation in the airways.

Snelgrove RJ, Lloyd CM.

J Allergy Clin Immunol. 2018 Aug;142(2):403-404. doi: 10.1016/j.jaci.2018.06.009. Epub 2018 Jun 19. No abstract available.


The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent?

Snelgrove RJ, Patel DF, Patel T, Lloyd CM.

Clin Exp Allergy. 2018 Oct;48(10):1275-1285. doi: 10.1111/cea.13191. Epub 2018 Jul 11. Review.


Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.

Zhang Y, Poobalasingam T, Yates LL, Walker SA, Taylor MS, Chessum L, Harrison J, Tsaprouni L, Adcock IM, Lloyd CM, Cookson WO, Moffatt MF, Dean CH.

Dis Model Mech. 2018 Jan 29;11(1). pii: dmm031369. doi: 10.1242/dmm.031369.


Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. [Epub ahead of print]


Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection.

Peiró T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.

Thorax. 2018 Jun;73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010. Epub 2017 Oct 27.


Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection.

Denney L, Branchett W, Gregory LG, Oliver RA, Lloyd CM.

Mucosal Immunol. 2018 Mar;11(2):523-535. doi: 10.1038/mi.2017.77. Epub 2017 Oct 25.


After asthma: redefining airways diseases.

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A.

Lancet. 2018 Jan 27;391(10118):350-400. doi: 10.1016/S0140-6736(17)30879-6. Epub 2017 Sep 11. Review. No abstract available.


Lung Alveolar Repair: Not All Cells Are Equal.

Dean CH, Lloyd CM.

Trends Mol Med. 2017 Oct;23(10):871-873. doi: 10.1016/j.molmed.2017.08.009. Epub 2017 Sep 1.


An NLRP3, IL-1β, Neutrophil Axis in the Respiratory Tract Leaves You Breathless.

Snelgrove RJ, Lloyd CM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):253-254. doi: 10.1164/rccm.201703-0483ED. No abstract available.


Development of allergic immunity in early life.

Lloyd CM, Saglani S.

Immunol Rev. 2017 Jul;278(1):101-115. doi: 10.1111/imr.12562. Review.


Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes.

Boyce ST, Lloyd CM, Kleiner MC, Swope VB, Abdel-Malek Z, Supp DM.

Pigment Cell Melanoma Res. 2017 Jan;30(6):531-540. doi: 10.1111/pcmr.12609. Epub 2017 Oct 19.



Löser S, Lloyd CM, Gregory LG.

J Allergy Clin Immunol. 2017 Oct;140(4):1211-1212. doi: 10.1016/j.jaci.2017.01.048. Epub 2017 Jun 16. No abstract available.


State Emergency Department Opioid Guidelines: Current Status.

Broida RI, Gronowski T, Kalnow AF, Little AG, Lloyd CM.

West J Emerg Med. 2017 Apr;18(3):340-344. doi: 10.5811/westjem.2016.12.30854. Epub 2017 Mar 7.


Lung Homeostasis: Influence of Age, Microbes, and the Immune System.

Lloyd CM, Marsland BJ.

Immunity. 2017 Apr 18;46(4):549-561. doi: 10.1016/j.immuni.2017.04.005. Review.


The development of novel LTA4H modulators to selectively target LTB4 generation.

Low CM, Akthar S, Patel DF, Löser S, Wong CT, Jackson PL, Blalock JE, Hare SA, Lloyd CM, Snelgrove RJ.

Sci Rep. 2017 Mar 17;7:44449. doi: 10.1038/srep44449.


Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH.

Dis Model Mech. 2017 Apr 1;10(4):409-423. doi: 10.1242/dmm.028175. Epub 2017 Feb 24.


Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors.

Weiss G, Lai C, Fife ME, Grabiec AM, Tildy B, Snelgrove RJ, Xin G, Lloyd CM, Hussell T.

Mucosal Immunol. 2017 Jul;10(4):1021-1030. doi: 10.1038/mi.2016.104. Epub 2016 Dec 14.


A critical role for IRF5 in regulating allergic airway inflammation.

Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA.

Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19.


Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CM.

J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.


Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

Löser S, Gregory LG, Zhang Y, Schaefer K, Walker SA, Buckley J, Denney L, Dean CH, Cookson WOC, Moffatt MF, Lloyd CM.

J Allergy Clin Immunol. 2017 May;139(5):1496-1507.e3. doi: 10.1016/j.jaci.2016.07.033. Epub 2016 Sep 10.


Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

Byrne AJ, Maher TM, Lloyd CM.

Trends Mol Med. 2016 Apr;22(4):303-316. doi: 10.1016/j.molmed.2016.02.004. Epub 2016 Mar 12. Review.


Location, Location, Location: Localized Memory Cells Take Residence in the Allergic Lung.

Lloyd CM, Harker JA.

Immunity. 2016 Jan 19;44(1):13-15. doi: 10.1016/j.immuni.2015.12.012.


Prostacyclin as a Potential Novel Means to Manipulate Type 2 Innate Lymphoid Cell Function.

Saglani S, Lloyd CM.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):2-4. doi: 10.1164/rccm.201509-1773ED. No abstract available.


Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

Denney L, Byrne AJ, Shea TJ, Buckley JS, Pease JE, Herledan GM, Walker SA, Gregory LG, Lloyd CM.

Immunity. 2015 Nov 17;43(5):945-58. doi: 10.1016/j.immuni.2015.10.012.


Novel concepts in airway inflammation and remodelling in asthma.

Saglani S, Lloyd CM.

Eur Respir J. 2015 Dec;46(6):1796-804. doi: 10.1183/13993003.01196-2014. Epub 2015 Nov 5. Review.


Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.

Akthar S, Patel DF, Beale RC, Peiró T, Xu X, Gaggar A, Jackson PL, Blalock JE, Lloyd CM, Snelgrove RJ.

Nat Commun. 2015 Sep 24;6:8423. doi: 10.1038/ncomms9423.


Pulmonary macrophages: key players in the innate defence of the airways.

Byrne AJ, Mathie SA, Gregory LG, Lloyd CM.

Thorax. 2015 Dec;70(12):1189-96. doi: 10.1136/thoraxjnl-2015-207020. Epub 2015 Aug 18. Review.


Type 2 innate lymphoid cells in induced sputum from children with severe asthma.

Nagakumar P, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2016 Feb;137(2):624-626.e6. doi: 10.1016/j.jaci.2015.06.038. Epub 2015 Aug 12. No abstract available.


Special delivery: how macrophages get the message across.

Lloyd CM.

J Exp Med. 2015 May 4;212(5):598. doi: 10.1084/jem.2125insight1. No abstract available.


Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.


Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.

Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, Ullmann N, Grychtol R, Campbell G, Maglione M, Koo S, Fleming L, Gregory L, Snelgrove RJ, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.


Epithelial cytokines and pulmonary allergic inflammation.

Lloyd CM, Saglani S.

Curr Opin Immunol. 2015 Jun;34:52-8. doi: 10.1016/j.coi.2015.02.001. Epub 2015 Feb 20. Review.


Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.

Johnson JR, Folestad E, Rowley JE, Noll EM, Walker SA, Lloyd CM, Rankin SM, Pietras K, Eriksson U, Fuxe J.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L658-71. doi: 10.1152/ajplung.00286.2014. Epub 2015 Jan 30.


Chair's summary: Innate and adaptive immune responses in airway disease.

Lloyd CM.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S234-5. doi: 10.1513/AnnalsATS.201405-210AW. Review. No abstract available.


Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge.

Mathie SA, Dixon KL, Walker SA, Tyrrell V, Mondhe M, O'Donnell VB, Gregory LG, Lloyd CM.

Allergy. 2015 Jan;70(1):80-9. doi: 10.1111/all.12536. Epub 2014 Nov 28.


Implementing the foundations of learning project: considerations for preschool intervention research.

Lloyd CM, Morris PA, Portilla XA.

J Prev Interv Community. 2014;42(4):282-99. doi: 10.1080/10852352.2014.943641.


γδT cells regulate chronic airway inflammation and development of airway remodelling.

Murdoch JR, Gregory LG, Lloyd CM.

Clin Exp Allergy. 2014 Nov;44(11):1386-98. doi: 10.1111/cea.12395.


Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease.

Vasiliou JE, Lui S, Walker SA, Chohan V, Xystrakis E, Bush A, Hawrylowicz CM, Saglani S, Lloyd CM.

Allergy. 2014 Oct;69(10):1380-9. doi: 10.1111/all.12465. Epub 2014 Aug 4.


Lung microbiota promotes tolerance to allergens in neonates via PD-L1.

Gollwitzer ES, Saglani S, Trompette A, Yadava K, Sherburn R, McCoy KD, Nicod LP, Lloyd CM, Marsland BJ.

Nat Med. 2014 Jun;20(6):642-7. doi: 10.1038/nm.3568. Epub 2014 May 11.


Year in review 2013: basic science and epidemiology.

Cullinan P, Lloyd CM.

Thorax. 2014 Jun;69(6):505-7. doi: 10.1136/thoraxjnl-2014-205423. Epub 2014 Mar 28. No abstract available.


Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations.

Snelgrove RJ, Gregory LG, Peiró T, Akthar S, Campbell GA, Walker SA, Lloyd CM.

J Allergy Clin Immunol. 2014 Sep;134(3):583-592.e6. doi: 10.1016/j.jaci.2014.02.002. Epub 2014 Mar 15.


Eosinophils in the pathogenesis of paediatric severe asthma.

Saglani S, Lloyd CM.

Curr Opin Allergy Clin Immunol. 2014 Apr;14(2):143-8. doi: 10.1097/ACI.0000000000000045. Review.


A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

Campbell JD, Kell SA, Kozy HM, Lum JA, Sweetwood R, Chu M, Cunningham CR, Salamon H, Lloyd CM, Coffman RL, Hessel EM.

Thorax. 2014 Jun;69(6):565-573. doi: 10.1136/thoraxjnl-2013-204605. Epub 2014 Jan 24.

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