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Items: 1 to 50 of 181

1.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Singhania A, Graham CM, Gabryšová L, Moreira-Teixeira L, Stavropoulos E, Pitt JM, Chakravarty P, Warnatsch A, Branchett WJ, Conejero L, Lin JW, Davidson S, Wilson MS, Bancroft G, Langhorne J, Frickel E, Sesay AK, Priestnall SL, Herbert E, Ioannou M, Wang Q, Humphreys IR, Dodd J, Openshaw PJM, Mayer-Barber KD, Jankovic D, Sher A, Lloyd CM, Baldwin N, Chaussabel D, Papayannopoulos V, Wack A, Banchereau JF, Pascual VM, O'Garra A.

Nat Commun. 2019 Jun 28;10(1):2887. doi: 10.1038/s41467-019-10601-6.

2.

Curated Collections for Clinician Educators: Five Key Papers on Graduated Responsibility in Residency Education.

Schnapp BH, Caretta-Weyer HA, Cortez E, Heinrich SA, Kraut AS, Lloyd CM, Silvester C, Sorge RM, Wain A, Gottlieb M.

Cureus. 2019 Apr 4;11(4):e4383. doi: 10.7759/cureus.4383.

3.

Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness".

Patel DF, Gaggar A, Blalock JE, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaaw0462. doi: 10.1126/scitranslmed.aaw0462.

PMID:
31217333
4.

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.

Turnbull AR, Pyle CJ, Patel DF, Jackson PL, Hilliard TN, Regamey N, Tan HL, Brown S, Thursfield R, Short C, Mc Fie M, Alton EWFW, Gaggar A, Blalock JE, Lloyd CM, Bush A, Davies JC, Snelgrove RJ.

J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30769-6. doi: 10.1016/j.jcf.2019.05.017. [Epub ahead of print]

5.

Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.

Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM.

Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638.

6.

Pulmonary type2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids.

Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

Eur Respir J. 2019 Jun 4. pii: 1801809. doi: 10.1183/13993003.01809-2018. [Epub ahead of print]

PMID:
31164437
7.

The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis.

Allden SJ, Ogger PP, Ghai P, McErlean P, Hewitt R, Toshner R, Walker SA, Saunders P, Kingston S, Molyneaux PL, Maher TM, Lloyd CM, Byrne AJ.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):209-219. doi: 10.1164/rccm.201809-1775OC.

8.

Regulatory cytokine function in the respiratory tract.

Branchett WJ, Lloyd CM.

Mucosal Immunol. 2019 May;12(3):589-600. doi: 10.1038/s41385-019-0158-0. Epub 2019 Mar 15. Review.

9.

Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds.

Hahn JM, Combs KA, Lloyd CM, McFarland KL, Boyce ST, Supp DM.

PLoS One. 2019 Mar 5;14(3):e0213325. doi: 10.1371/journal.pone.0213325. eCollection 2019.

10.

Airway macrophages as the guardians of tissue repair in the lung.

Puttur F, Gregory LG, Lloyd CM.

Immunol Cell Biol. 2019 Mar;97(3):246-257. doi: 10.1111/imcb.12235. Epub 2019 Feb 15. Review.

PMID:
30768869
11.

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo.

Davies ER, Denney L, Wandel M, Lloyd CM, Davies DE, Haitchi HM.

J Allergy Clin Immunol. 2019 Jun;143(6):2281-2284.e3. doi: 10.1016/j.jaci.2019.01.026. Epub 2019 Feb 2. No abstract available.

12.

Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze.

Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ, Lloyd CM, Bush A, Marsland BJ, Saglani S.

J Allergy Clin Immunol. 2019 Apr;143(4):1607-1610.e3. doi: 10.1016/j.jaci.2018.12.985. Epub 2018 Dec 21. No abstract available.

13.

The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Zhang Y, Willis-Owen SAG, Spiegel S, Lloyd CM, Moffatt MF, Cookson WOCM.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):478-488. doi: 10.1164/rccm.201803-0438OC.

14.

Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.

Uwadiae FI, Pyle CJ, Walker SA, Lloyd CM, Harker JA.

Allergy. 2019 Apr;74(4):650-662. doi: 10.1111/all.13602. Epub 2018 Nov 12.

15.

Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.

16.

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?  A description of the protocol for the Breathing Together study.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.

Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018.

17.

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.

18.

Type 2 immunity: Expanding our view.

Lloyd CM, Snelgrove RJ.

Sci Immunol. 2018 Jul 6;3(25). pii: eaat1604. doi: 10.1126/sciimmunol.aat1604. Review.

19.

Epigenetic Control of Interleukin-9 in Asthma.

Lloyd CM, Harker JA.

N Engl J Med. 2018 Jul 5;379(1):87-89. doi: 10.1056/NEJMcibr1803610. No abstract available.

20.

Tasting type 2 inflammation in the airways.

Snelgrove RJ, Lloyd CM.

J Allergy Clin Immunol. 2018 Aug;142(2):403-404. doi: 10.1016/j.jaci.2018.06.009. Epub 2018 Jun 19. No abstract available.

21.

The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent?

Snelgrove RJ, Patel DF, Patel T, Lloyd CM.

Clin Exp Allergy. 2018 Oct;48(10):1275-1285. doi: 10.1111/cea.13191. Epub 2018 Jul 11. Review.

22.

Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.

Zhang Y, Poobalasingam T, Yates LL, Walker SA, Taylor MS, Chessum L, Harrison J, Tsaprouni L, Adcock IM, Lloyd CM, Cookson WO, Moffatt MF, Dean CH.

Dis Model Mech. 2018 Jan 29;11(1). pii: dmm031369. doi: 10.1242/dmm.031369.

23.

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.

24.

Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection.

Peiró T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.

Thorax. 2018 Jun;73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010. Epub 2017 Oct 27.

25.

Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection.

Denney L, Branchett W, Gregory LG, Oliver RA, Lloyd CM.

Mucosal Immunol. 2018 Mar;11(2):523-535. doi: 10.1038/mi.2017.77. Epub 2017 Oct 25.

26.

After asthma: redefining airways diseases.

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A.

Lancet. 2018 Jan 27;391(10118):350-400. doi: 10.1016/S0140-6736(17)30879-6. Epub 2017 Sep 11. Review. No abstract available.

27.

Lung Alveolar Repair: Not All Cells Are Equal.

Dean CH, Lloyd CM.

Trends Mol Med. 2017 Oct;23(10):871-873. doi: 10.1016/j.molmed.2017.08.009. Epub 2017 Sep 1.

28.

An NLRP3, IL-1β, Neutrophil Axis in the Respiratory Tract Leaves You Breathless.

Snelgrove RJ, Lloyd CM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):253-254. doi: 10.1164/rccm.201703-0483ED. No abstract available.

29.

Development of allergic immunity in early life.

Lloyd CM, Saglani S.

Immunol Rev. 2017 Jul;278(1):101-115. doi: 10.1111/imr.12562. Review.

30.

Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes.

Boyce ST, Lloyd CM, Kleiner MC, Swope VB, Abdel-Malek Z, Supp DM.

Pigment Cell Melanoma Res. 2017 Jan;30(6):531-540. doi: 10.1111/pcmr.12609. Epub 2017 Oct 19.

PMID:
28640957
31.

Reply.

Löser S, Lloyd CM, Gregory LG.

J Allergy Clin Immunol. 2017 Oct;140(4):1211-1212. doi: 10.1016/j.jaci.2017.01.048. Epub 2017 Jun 16. No abstract available.

PMID:
28624350
32.

State Emergency Department Opioid Guidelines: Current Status.

Broida RI, Gronowski T, Kalnow AF, Little AG, Lloyd CM.

West J Emerg Med. 2017 Apr;18(3):340-344. doi: 10.5811/westjem.2016.12.30854. Epub 2017 Mar 7.

33.

Lung Homeostasis: Influence of Age, Microbes, and the Immune System.

Lloyd CM, Marsland BJ.

Immunity. 2017 Apr 18;46(4):549-561. doi: 10.1016/j.immuni.2017.04.005. Review.

34.

The development of novel LTA4H modulators to selectively target LTB4 generation.

Low CM, Akthar S, Patel DF, Löser S, Wong CT, Jackson PL, Blalock JE, Hare SA, Lloyd CM, Snelgrove RJ.

Sci Rep. 2017 Mar 17;7:44449. doi: 10.1038/srep44449.

35.

Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH.

Dis Model Mech. 2017 Apr 1;10(4):409-423. doi: 10.1242/dmm.028175. Epub 2017 Feb 24.

36.

Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors.

Weiss G, Lai C, Fife ME, Grabiec AM, Tildy B, Snelgrove RJ, Xin G, Lloyd CM, Hussell T.

Mucosal Immunol. 2017 Jul;10(4):1021-1030. doi: 10.1038/mi.2016.104. Epub 2016 Dec 14.

PMID:
27966555
37.

A critical role for IRF5 in regulating allergic airway inflammation.

Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA.

Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19.

38.

Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CM.

J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.

39.

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

Löser S, Gregory LG, Zhang Y, Schaefer K, Walker SA, Buckley J, Denney L, Dean CH, Cookson WOC, Moffatt MF, Lloyd CM.

J Allergy Clin Immunol. 2017 May;139(5):1496-1507.e3. doi: 10.1016/j.jaci.2016.07.033. Epub 2016 Sep 10.

40.

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

Byrne AJ, Maher TM, Lloyd CM.

Trends Mol Med. 2016 Apr;22(4):303-316. doi: 10.1016/j.molmed.2016.02.004. Epub 2016 Mar 12. Review.

41.

Location, Location, Location: Localized Memory Cells Take Residence in the Allergic Lung.

Lloyd CM, Harker JA.

Immunity. 2016 Jan 19;44(1):13-15. doi: 10.1016/j.immuni.2015.12.012.

42.

Prostacyclin as a Potential Novel Means to Manipulate Type 2 Innate Lymphoid Cell Function.

Saglani S, Lloyd CM.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):2-4. doi: 10.1164/rccm.201509-1773ED. No abstract available.

PMID:
26720782
43.

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

Denney L, Byrne AJ, Shea TJ, Buckley JS, Pease JE, Herledan GM, Walker SA, Gregory LG, Lloyd CM.

Immunity. 2015 Nov 17;43(5):945-58. doi: 10.1016/j.immuni.2015.10.012.

44.

Novel concepts in airway inflammation and remodelling in asthma.

Saglani S, Lloyd CM.

Eur Respir J. 2015 Dec;46(6):1796-804. doi: 10.1183/13993003.01196-2014. Epub 2015 Nov 5. Review.

45.

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.

Akthar S, Patel DF, Beale RC, Peiró T, Xu X, Gaggar A, Jackson PL, Blalock JE, Lloyd CM, Snelgrove RJ.

Nat Commun. 2015 Sep 24;6:8423. doi: 10.1038/ncomms9423.

46.

Pulmonary macrophages: key players in the innate defence of the airways.

Byrne AJ, Mathie SA, Gregory LG, Lloyd CM.

Thorax. 2015 Dec;70(12):1189-96. doi: 10.1136/thoraxjnl-2015-207020. Epub 2015 Aug 18. Review.

PMID:
26286722
47.

Type 2 innate lymphoid cells in induced sputum from children with severe asthma.

Nagakumar P, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2016 Feb;137(2):624-626.e6. doi: 10.1016/j.jaci.2015.06.038. Epub 2015 Aug 12. No abstract available.

48.

Special delivery: how macrophages get the message across.

Lloyd CM.

J Exp Med. 2015 May 4;212(5):598. doi: 10.1084/jem.2125insight1. No abstract available.

49.

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.

50.

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.

Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, Ullmann N, Grychtol R, Campbell G, Maglione M, Koo S, Fleming L, Gregory L, Snelgrove RJ, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.

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